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  3. Supposits P-80 Suppositories 2x5's

Supposits P-80 Suppositories 2x5's, Pack of 10 SUPPOSITORYS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Supposits P-80 Suppositories 2x5's is an antipyretic and analgesic medicine used in the treatment of mild to moderate pain and fever in adults and children. This medicine contains paracetamol, which works by inhibiting the release of chemical messengers called prostaglandins that cause pain and inflammation. Some of the common side effects include rash, soreness in or around the rectum/anus, and itching.

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Composition :

PARACETAMOL-80MG

Manufacturer/Marketer :

Gi Pharma

Consume Type :

RECTAL

Return Policy :

Not Returnable

Expires on or after :

About Supposits P-80 Suppositories 2x5's

Supposits P-80 Suppositories 2x5's is used to treat mild to moderate pain and fever in adults and children weighing at least 7kgs. Pain and fever are caused by the activation of pain receptors due to the release of certain natural chemicals in the body like prostaglandins. 

Supposits P-80 Suppositories 2x5's contains 'Paracetamol' which prevents the release of chemical messengers (prostaglandins) that cause pain and inflammation. Thus, relieves pain. Supposits P-80 Suppositories 2x5's also acts as an antipyretic agent by affecting the chemical messengers in the brain that regulate body temperature. Thereby, reduces fever.

Not everyone who is taking Supposits P-80 Suppositories 2x5's will get these side effects. In some cases, Supposits P-80 Suppositories 2x5's may cause side effects like rash, soreness in or around the rectum/anus, and itching. Most of these side effects do not require medical attention and will resolve gradually over time. However, if these side effects persist, please consult a doctor.

Do not swallow Supposits P-80 Suppositories 2x5's; it is for anal administration only. Your doctor will recommend how often you should take Supposits P-80 Suppositories 2x5's, based on your medical condition. You can take Supposits P-80 Suppositories 2x5's with or without food. It is recommended not to exceed the recommended dose of Supposits P-80 Suppositories 2x5's.

Do not take Supposits P-80 Suppositories 2x5's if you are allergic to any of its components. Inform your doctor if you have kidney or liver problems, alcoholism, infections or any other medical conditions. Consult your doctor if you are pregnant or breastfeeding. Do not exceed the recommended dosage as an overdose may be injurious to the liver. Do not swallow Supposits P-80 Suppositories 2x5's; it is for anal administration only.

Uses of Supposits P-80 Suppositories 2x5's

Supposits P-80 Suppositories 2x5's is used in the treatment of Pain and Fever. The detailed uses of Supposits P-80 Suppositories 2x5's are as follows:

  • Relieve Pain: Supposits P-80 Suppositories 2x5's relieves pain by blocking the release of prostaglandins, which activate pain receptors, especially in situations where oral administration is difficult or not possible.
  • Reduce Fever: Supposits P-80 Suppositories 2x5's helps to reduce fever, providing relief from discomfort and promoting recovery.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • The suppository should be inserted into the rectum (back passage) by removing the plastic wrapper.
  • Wash your hands before and after inserting the suppository.
  • Try to sit still for a minute or two and then wash your hands.

Medicinal Benefits

  • Supposits P-80 Suppositories 2x5's contains Paracetamol, an analgesic (pain killer) and antipyretic (reduces fever).
  • Supposits P-80 Suppositories 2x5's affects an area of the brain that regulates body temperature known as the hypothalamic heat-regulating centre, reducing fever. 

How Supposits P-80 Suppositories 2x5's Works

Supposits P-80 Suppositories 2x5's contains 'Paracetamol' which prevents the release of chemical messengers (prostaglandins) that cause pain and inflammation. Thus, relieves pain. Supposits P-80 Suppositories 2x5's also acts as an antipyretic agent by affecting the chemical messengers in the brain that regulate body temperature. Thereby, reduces fever.

Storage

• Store in a cool and dry place away from sunlight.• Keep Supposits P-80 Suppositories 2x5's out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Supposits P-80 Suppositories 2x5's
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

What if I have taken an overdose of Supposits P-80 Suppositories 2x5's

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, flu-like symptoms, yellowing of the skin or eyes, and pain in the upper right part of the stomach. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Avoid taking Supposits P-80 Suppositories 2x5's if allergic to it.
  • If you have an impaired nutritional state caused by anorexia (eating disorder), wrong nutrition or alcohol abuse or if you are dehydrated, inform your doctor before taking Supposits P-80 Suppositories 2x5's.
  • Avoid taking more than the recommended doses, as it may increase the risk of serious liver damage.
  • If you have a high fever or signs of infection after using Supposits P-80 Suppositories 2x5's for more than 3 days or if pain persists after using Supposits P-80 Suppositories 2x5's for more than 5 days, please consult a physician.
  • Do not swallow Supposits P-80 Suppositories 2x5's; it is for anal administration only.

Drug-Drug Interactions

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ParacetamolMipomersen
Severe
ParacetamolOxazepam
Severe

Drug-Drug Interactions

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ParacetamolMipomersen
Severe
How does the drug interact with Supposits P-80 Suppositories 2x5's:
Co-administration of Mipomersen with Supposits P-80 Suppositories 2x5's may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Supposits P-80 Suppositories 2x5's and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Supposits P-80 Suppositories 2x5's:
Co-administration of Supposits P-80 Suppositories 2x5's may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Supposits P-80 Suppositories 2x5's, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolKetamine
Severe
How does the drug interact with Supposits P-80 Suppositories 2x5's:
Co-administration of ketamine and Supposits P-80 Suppositories 2x5's may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Supposits P-80 Suppositories 2x5's together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolLomitapide
Severe
How does the drug interact with Supposits P-80 Suppositories 2x5's:
Co-administration of Lomitapide and Supposits P-80 Suppositories 2x5's may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Supposits P-80 Suppositories 2x5's and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolValdecoxib
Severe
How does the drug interact with Supposits P-80 Suppositories 2x5's:
Co-administration of Supposits P-80 Suppositories 2x5's and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Supposits P-80 Suppositories 2x5's and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with Supposits P-80 Suppositories 2x5's:
Co-administration of Supposits P-80 Suppositories 2x5's and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Supposits P-80 Suppositories 2x5's and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolLeflunomide
Severe
How does the drug interact with Supposits P-80 Suppositories 2x5's:
Co-administration of Supposits P-80 Suppositories 2x5's and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Supposits P-80 Suppositories 2x5's and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolTeriflunomide
Severe
How does the drug interact with Supposits P-80 Suppositories 2x5's:
Co-administration of Teriflunomide with Supposits P-80 Suppositories 2x5's may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Supposits P-80 Suppositories 2x5's with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Rest well, and get plenty of sleep.
  • Stay hydrated; drink plenty of water.
  • Mild exercises such as jogging and walking are helpful for muscle stretching.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Hot or cold therapy can help treat pain. Apply an ice pack or hot pack on the muscle for 15-20minutes.

Habit Forming

No

Therapeutic Class

ANALGESIC AND ANTIPYRETIC AGENT

Supposits P-80 Suppositories 2x5's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is not known if alcohol affects Supposits P-80 Suppositories 2x5's. Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Please consult your doctor if you are pregnant; your doctor will prescribe Supposits P-80 Suppositories 2x5's only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Please consult your doctor if you are breastfeeding; your doctor will decide if Supposits P-80 Suppositories 2x5's can be taken by lactating mothers or not.

bannner image

Driving

Safe if prescribed

Supposits P-80 Suppositories 2x5's is unlikely to affect your ability to drive.

bannner image

Liver

Consult your doctor

Dose adjustment may be needed. Please consult your doctor if you have liver problems or any concerns regarding this. Avoid using Supposits P-80 Suppositories 2x5's if you have severe liver problems.

bannner image

Kidney

Consult your doctor

Dose adjustment may be needed. Please consult your doctor if you have kidney problems or any concerns regarding this.

bannner image

Children

Safe if prescribed

Supposits P-80 Suppositories 2x5's is safe for use in children if prescribed by the doctor. The dose and duration of the medicine will be decided by the physician

Have a query?

FAQs

Supposits P-80 Suppositories 2x5's belongs to the group of analgesics (pain killers), and antipyretics (fever-reducing agents) used to treat mild to moderate pain and fever in adults and children.

Supposits P-80 Suppositories 2x5's prevents the release of chemical messengers (prostaglandins) that cause pain and inflammation. Thus, relieves pain.

Supposits P-80 Suppositories 2x5's acts as an antipyretic agent by affecting the chemical messengers in the brain that regulate body temperature. Thereby, reduces fever.

Consult your doctor before taking Supposits P-80 Suppositories 2x5's with warfarin or blood thinners as taking them together may increase the risk of bleeding.

Avoid using Supposits P-80 Suppositories 2x5's for longer durations as it may cause headache. Also, do not exceed the recommended dosage as an overdose may be injurious to the liver.

Supposits P-80 Suppositories 2x5's when taken with zidovudine (anti-viral medication) might lower the white blood cell count. Therefore, consult your doctor before taking Supposits P-80 Suppositories 2x5's with other medicines.

Country of origin

India

Manufacturer/Marketer address

No 9b, Survey No 310, Self Help Industrial Estate, Keelkattalai, Chennai-600117, Tamil Nadu,India, Chennai-600117, Tamil Nadu, India
Other Info - SUP0651

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Aug 8, 2025 | 11:17 AM IST

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Reference

  1. https://www.lagaay.com/Catalogus/Product%20information/025030/Paracetamol%20suppositories.pdf
  2. https://www.medicinesforchildren.org.uk/wp-content/uploads/sites/8/2021/08/Paracetamol-for-mild-to-moderate-pain.pdf
  3. https://www.typharm.com/products/paracetamol-suppositories/?user_type=public
  4. https://www.hpra.ie/img/uploaded/swedocuments/a5334f2d-96cf-4378-b2bf-815993a63c33.pdf

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