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  3. SSN 500 Tablet DR

SSN 500 Tablet DR, Pack of 1 Tablet
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

SSN 500 Tablet DR is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis) in children and adults. It contains Sulfasalazine, which works as an inflammation reducer by acting locally, inhibiting the formation of a chemical known as prostaglandins, that control pain and inflammation. Thus, it helps reduce the inflammation of the intestine, skin, and joints. In some cases, you may experience a sore throat, a fever, unexplained bruising, or ringing in your ears (tinnitus). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

SULFASALAZINE-500MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About SSN 500 Tablet DR

SSN 500 Tablet DR is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis) in children and adults. 

SSN 500 Tablet DR contains sulfasalazine, which works by inhibiting the formation of a chemical known as prostaglandins, which control pain and inflammation.

In some cases, you may experience common side effects like a sore throat, a fever, unexplained bruising, or ringing in your ears (tinnitus). Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please reach out to your doctor.

Avoid taking SSN 500 Tablet DR if you are allergic to it. SSN 500 Tablet DR can lower your sperm count, leading to a temporary decrease in male fertility. In this case, you can speak to your doctor. Your doctor might arrange a blood test before you start taking SSN 500 Tablet DR. Inform your doctor if you are pregnant or are breastfeeding before taking SSN 500 Tablet DR.

Uses of SSN 500 Tablet DR

SSN 500 Tablet DR is used in the treatment of Ulcerative colitis, Crohn's disease, Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Juvenile idiopathic arthritis. The detailed uses of SSN 500 Tablet DR are as follows:

  • Ulcerative Colitis Treatment: SSN 500 Tablet DR treats ulcerative colitis by reducing inflammation and healing the lining of the gut, relieving symptoms like diarrhoea and abdominal pain.
  • Rheumatoid Arthritis Treatment: SSN 500 Tablet DR used to slow disease progression and provide relief from joint pain, stiffness, and swelling in rheumatoid arthritis.
  • Juvenile Idiopathic Arthritis: SSN 500 Tablet DR helps to treat juvenile idiopathic arthritis in children by reducing joint inflammation, relieving pain and stiffness, and improving mobility and quality of life.
  • Ankylosing Spondylitis Treatment: SSN 500 Tablet DR alleviates pain and stiffness in ankylosing spondylitis by reducing spinal inflammation and improving mobility.
  • Crohn's Disease Treatment: SSN 500 Tablet DR helps manage Crohn's disease by controlling inflammation, alleviating symptoms, and improving gut health.
  • Psoriatic Arthritis Treatment: SSN 500 Tablet DR provides relief from joint pain, swelling, and skin symptoms associated with psoriatic arthritis.

Directions for Use

  • SSN 500 Tablet DR should be taken after meals. 
  • Follow your doctor's instructions on the dosage and timing of this medication. 
  • Swallow SSN 500 Tablet DR as a whole with a glass of water. 
  • Do not crush, break, or chew it.

Medicinal Benefits

  • SSN 500 Tablet DR works by reducing the inflammation in the colon.
  • It inhibits the formation of a chemical, prostaglandin, which controls inflammation. Together, they help in reducing the inflammation at all the sites like joints, skin, and bowel (intestines),
  • This medicine treats a wider range of joint, skin and bowel diseases, including ulcerative colitis, Crohn's disease, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, juvenile idiopathic arthritis.
  • SSN 500 Tablet DR is not a painkiller. Rather, it is an anti-inflammatory.

How SSN 500 Tablet DR Works

SSN 500 Tablet DR works as an inflammation reducer by acting locally, inhibiting the formation of a chemical known as prostaglandins, which control pain and inflammation. Together, it helps reduce the inflammation of the intestine, skin, and joints.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of SSN 500 Tablet DR
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Firstly, consult a fertility specialist to identify the underlying cause of low sperm count and discuss possible treatment options.
  • To improve overall health and fertility do exercises regularly.
  • Improve hormone levels and semen quality by reducing stress through yoga, meditation, or deep breathing.
  • Maintain a healthy weight to support hormone levels and improve sperm count.
  • To enhance the quality of semen, increase antioxidants such as vitamins C and E.
  • Eat omega-3-rich foods like salmon and walnuts to improve sperm count.
  • Avoid smoking and excessive drinking to protect semen quality and fertility.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Boost your immunity by including immune-rich foods in your diet, and always remember to stay hydrated.
  • Get sufficient sleep and manage stress, which helps improve white blood cell count.
  • Consult your doctor for an effective treatment to improve immunity and get regular body check-ups to monitor changes in the count.
  • Exercise regularly to lower stress and improve stamina and immunity.
  • Smoking can affect immunity. It is advisable to avoid such a habit.
  • Practice good hygiene practices to lower the chances of falling sick.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of SSN 500 Tablet DR

Do not take more than the prescribed dose of SSN 500 Tablet DR as it may cause an overdose. The symptoms of overdose include stomach pain, seizures (fits), tiredness, nausea and vomiting. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not use SSN 500 Tablet DR if you are allergic to any of its components.
  • SSN 500 Tablet DR treatment is generally considered to be safe during pregnancy, but its usage in pregnant mothers should be discussed with the doctor if planning for pregnancy.
  • This medication should be avoided in breastfeeding mothers, as it passes into the milk and causes jaundice and brain problems in infants less than 2 years of age.
  • Tell your doctor if you have an allergy to any other sulfa drugs (sulfonamide antibiotics), as it may cause serious skin allergies like urticaria and Stevens-Johnson syndrome.
  • In men, an intake of SSN 500 Tablet DR may lower the sperm count, which improves after stopping this medicine.
  • Tell your doctor if you have asthma, wheezing, fever, breathing difficulties, a sudden severe skin rash, unusual bleeding, sore throat, fever, unexplained bruising, or any other symptoms of infection.
  • Use of SSN 500 Tablet DR may change the colour of your urine, contact lenses, and tears to yellow/orange and even make your skin more sensitive to the sunlight. But, this is normal, harmless, and nothing to worry about.
  • You may have low folic acid in pregnancy while taking SSN 500 Tablet DR, so your doctor might prescribe you iron or folic acid supplements.

Drug-Drug Interactions

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SulfasalazineCidofovir
Critical
SulfasalazineLidocaine
Severe

Drug-Drug Interactions

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SulfasalazineCidofovir
Critical
How does the drug interact with SSN 500 Tablet DR:
Coadministration of Cidofovir with SSN 500 Tablet DR can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking SSN 500 Tablet DR with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
SulfasalazineLidocaine
Severe
How does the drug interact with SSN 500 Tablet DR:
Combining SSN 500 Tablet DR with Lidocaine can increase the risk of methemoglobinemia (a rare red blood cell disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Co-administration of SSN 500 Tablet DR with Lidocaine can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting a doctor.
SulfasalazineWarfarin
Severe
How does the drug interact with SSN 500 Tablet DR:
Coadministration of warfarin with SSN 500 Tablet DR can increase the risk of unusual bleeding disorder.

How to manage the interaction:
Although taking SSN 500 Tablet DR and warfarin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache; and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
SulfasalazineLevobupivacaine
Severe
How does the drug interact with SSN 500 Tablet DR:
Coadministration of Levobupivacaine with SSN 500 Tablet DR can increase the risk of methemoglobinemia (a rare red blood cell disorder).

How to manage the interaction:
Taking Levobupivacaine with SSN 500 Tablet DR together can result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray discoloration, nausea, headache, dizziness, fatigue, or shortness of breath, it's best to contact a doctor right away. They can help determine the cause and provide appropriate treatment. Do not discontinue any medications without consulting a doctor.
SulfasalazineSirolimus
Severe
How does the drug interact with SSN 500 Tablet DR:
Coadministration of Sirolimus together with SSN 500 Tablet DR may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Sirolimus with SSN 500 Tablet DR together can result in an interaction, but it can be taken if a doctor has advised it. Contact a doctor if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without a doctor's advice.
SulfasalazineBupivacaine
Severe
How does the drug interact with SSN 500 Tablet DR:
Coadministration of bupivacaine and SSN 500 Tablet DR may result in methemoglobinemia, an uncommon disorder that lowers the blood's ability to carry oxygen, which can induce oxygen deprivation in tissues and essential organs.

How to manage the interaction:
Although taking bupivacaine and SSN 500 Tablet DR together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
SulfasalazineTenofovir disoproxil
Severe
How does the drug interact with SSN 500 Tablet DR:
Coadministration of SSN 500 Tablet DR and Tenofovir disoproxil can increase the risk of kidney problems.

How to manage the interaction:
Taking SSN 500 Tablet DR and Tenofovir disoproxil together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SulfasalazineProcaine
Severe
How does the drug interact with SSN 500 Tablet DR:
Coadministration of SSN 500 Tablet DR with Procaine can increase the risk of methemoglobinemia, (a rare red blood cell condition where the oxygen-carrying capacity decreases).

How to manage the interaction:
Although taking Procaine and SSN 500 Tablet DR together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
SulfasalazineCiclosporin
Severe
How does the drug interact with SSN 500 Tablet DR:
Coadministration of SSN 500 Tablet DR with ciclosporin may significantly increase the side effects on kidneys.

How to manage the interaction:
Although there is a possible interaction between SSN 500 Tablet DR and ciclosporin, they can be taken together if your doctor has prescribed them. In case you experience any unusual side effects, consult a doctor. Do not stop using any medications without first talking to a doctor.
SulfasalazineDeferasirox
Severe
How does the drug interact with SSN 500 Tablet DR:
Coadministration of Deferasirox and SSN 500 Tablet DR may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking SSN 500 Tablet DR and Deferasirox together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It is advised to drink plenty of water to prevent the occurrence of kidney stones.
  • Take low fibre foods such as white rice, white pasta, bread, egg, fish, tofu, butter, etc. to avoid triggering ulcerative colitis.
  • Exercise regularly to suppress inflammation in the body.
  • Manage stress by doing meditation and deep breathing exercises.
  • Eat smaller meals to avoid pain in the stomach.
  • Avoid foods that can increase or worsen ulcerative colitis such as milk, milk products, raw fruits and vegetables, beans, spicy foods, popcorn, artificial sweeteners, nuts, seeds, and fatty foods.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

SSN 500 Tablet DR Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

It is not recommended to consume alcohol while taking SSN 500 Tablet DR to avoid unpleasant side-effects.

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Pregnancy

Consult your doctor

SSN 500 Tablet DR should be recommended in pregnancy only if required. In case, if prescribed to a pregnant woman, it is advised to increase the folate supplementation after consulting your doctor.

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Breast Feeding

Unsafe

SSN 500 Tablet DR is excreted in breastmilk and is not recommended especially if the baby is premature or is at the risk of jaundice. It might cause kernicterus (excessive levels of bilirubin in the blood) in the new-born.

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Driving

Safe if prescribed

SSN 500 Tablet DR does not affect the ability to drive. However, if you feel drowsy after taking SSN 500 Tablet DR, it is advised not to drive.

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Liver

Unsafe

SSN 500 Tablet DR is not recommended to use in patients with a history of liver diseases. In other people, rarely, it can cause hepatitis (inflammation of the liver).

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Kidney

Unsafe

SSN 500 Tablet DR is not recommended to use in patients with a history of kidney diseases. In other people, rarely it can cause inflammation of the kidneys.

bannner image

Children

Consult your doctor

SSN 500 Tablet DR should be advised in children only if prescribed by a child specialist.

Have a query?

FAQs

SSN 500 Tablet DR is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis).

Yes, SSN 500 Tablet DR is contraindicated in patients with intestinal or urinary obstruction, patients with porphyria (liver disorders), and patients hypersensitive to sulfasalazine, its metabolites, sulfonamides, or salicylates.

Yes, SSN 500 Tablet DR is said to affect fertility in males as it can cause a fall in sperm count. However, it is only affected by the time this medicine is taken.

Yes, SSN 500 Tablet DR is safe to use in breastfeeding. However, please inform your doctor if the baby is premature or is at risk of jaundice as this medicine might not be advised in such cases.

Yes, SSN 500 Tablet DR can affect the blood count but it is rare. There is a decrease in the number of white blood cells (infection-fighting cells). In some cases, the bone marrow might completely stop producing a specific type of white blood cell, this condition is known as agranulocytosis. It occurs within two months of starting this medicine and might be accompanied by symptoms such as fever and rash. This condition resolves within one or two weeks after this medicine is discontinued.

No, SSN 500 Tablet DR is a disease-modifying anti-rheumatic drug’ (DMARD) and not a painkiller. So, if you are taking a painkiller before starting this medicine, you can continue taking it along with SSN 500 Tablet DR.

No, SSN 500 Tablet DR should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side-effects. If you think your symptoms are not improving, please consult your doctor.

SSN 500 Tablet DR in rare cases may cause blood disorders so your doctor may ask you to have blood count, electrolytes, urea, creatinine, and liver function tests every 3 months for the first year and every 6 months next year onwards.

If well tolerated you should take a prescribed dose of SSN 500 Tablet DR while the disease remains in remission. Do not stop taking your medicine unless your doctor tells you to do so.

SSN 500 Tablet DR may cause central nervous system adverse effects such as serious psychiatric problems including mania, depression, and psychosis, and these symptoms have been reported to occur only infrequently.

The side effects of SSN 500 Tablet DR include headache, nausea, indigestion and watery diaarhoea. If these side effects persist or worsen, please consult your doctor.

SSN 500 Tablet DR takes about 6 to 12 weeks to show the full effect. After using SSN 500 Tablet DR, you might feel better in 4 weeks, although this can vary from person to person and some patients may notice improvement after 3 months. Do not stop taking SSN 500 Tablet DR without first consulting your doctor.

SSN 500 Tablet DR may affect the kidney function, although it is rare. Therefore, before using SSN 500 Tablet DR, it is important that your kidney function remains normal. If your kidney functions become abnormal during treatment with SSN 500 Tablet DR, please consult your doctor.

You are recommended to avoid using azathioprine along with SSN 500 Tablet DR as it may decrease blood cell count, which can be a serious side effect. However, please consult your doctor before taking other medicines with SSN 500 Tablet DR to avoid drug interactions.

Country of origin

India
Other Info - SS95040

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 6, 2025 | 9:16 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/007073s124lbl.pdf
  2. https://www.uptodate.com/contents/sulfasalazine-and-the-5-aminosalicylates-beyond-the-basics#:~:text=How%20it%20works%20%E2%80%94%20Sulfasalazine%20acts,control%20of%20pain%20and%20inflammation.
  3. https://www.gwh.nhs.uk/media/190766/sulphaslazine2.pdf
  4. https://www.drugs.com/drug-interactions/sulfasalazine.html
  5. https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwiV06S7guvsAhVAzDgGHZbsBPUQFjACegQIARAC&url=https%3A%2F%2Fwww.rheumatology.org%2FPortals%2F0%2FFiles%2FSulfasalazine-Azulfidine-Fact-Sheet.pdf&usg=AOvVaw3bdBuZJ3NTnYctOyiWUJZQ
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