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Spexib Capsule is used to treat non-small cell lung cancer. It contains Ceritinib, which works by slowing or stopping the spread of cancer cells. Common side effects of this medication include diarrhoea, nausea, vomiting, abdominal pain, fatigue, decreased appetite, and weight loss. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CERITINIB-150MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Spexib Capsule

Spexib Capsule is an oral prescription medicine used to treat ALK-positive non-small cell lung cancer (NSCLC) that has spread to other parts of the body. ALK-positive means the cancer cells have an abnormal change involving a gene called ALK that causes them to grow. This medicine blocks the abnormal ALK protein and helps slow or stop cancer growth.

Take this medicine every day exactly as prescribed by your doctor. Ceritinib is generally taken once daily with food. Taking it consistently helps maintain the amount of medicine needed to control the cancer.

Common side effects include diarrhoea, nausea, vomiting, tiredness, and reduced appetite. Consult your doctor right away if you develop serious symptoms such as yellowing of the skin or eyes, severe stomach pain, a new or worsening cough, difficulty breathing, or a fast or irregular heartbeat.

Before starting treatment, tell your doctor if you have liver problems, diabetes or high blood sugar, pancreas problems, or heart or heart rhythm problems. Do not take this medicine if you have had an allergic reaction to ceritinib or any ingredient in the medicine.

Tell your doctor about all medicines, vitamins, supplements, and herbal products you take because some can affect how ceritinib works. This medicine can harm an unborn baby. Women who can become pregnant should use effective contraception during treatment and for at least 6 months after the last dose. Men with female partners who can become pregnant should use condoms during treatment and for at least 3 months after the last dose. Tell your doctor if you are pregnant, planning a pregnancy, breastfeeding, or are an older adult.

Uses of Spexib Capsule

Your doctor may prescribe Spexib Capsule to help manage the following condition:

  • ALK-positive non-small cell lung cancer (NSCLC): Spexib Capsule blocks the abnormal ALK protein that helps certain lung cancer cells grow, helping slow or stop the progression of the cancer.

Key Benefits

Spexib Capsule provides targeted treatment for ALK-positive non-small cell lung cancer by blocking a specific protein that helps the cancer grow.

  • Helps control cancer growth: This medicine blocks ALK signals that cancer cells need to grow and multiply.
  • May shrink tumours: Treatment can reduce the size of tumours in some people and help keep the cancer under control.
  • May reduce cancer-related symptoms: As the cancer responds to treatment, symptoms caused by the tumour may improve.
  • Provides an oral treatment option: Because this medicine is taken by mouth, it can usually be taken at home according to your treatment plan.
Side effects of Spexib 150 mg Capsule
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.

Directions for Use

  • Spexib Capsule should be taken with meals to reduce stomach upset and improve absorption.
  • It is usually taken once a day; however, follow your doctor's advice regarding the dosage and duration.
  • Swallow the capsule as a whole with a glass of water.
  • Do not crush, chew or break Spexib Capsule.

How Spexib Capsule Works

Spexib Capsule contains ceritinib, a targeted medicine called an ALK inhibitor. In ALK-positive lung cancer, an abnormal ALK protein sends continuous signals that tell cancer cells to grow and divide. Ceritinib blocks this protein and reduces these growth signals, helping slow cancer-cell growth and control the disease.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Spexib Capsule.

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Pregnancy

Unsafe

Spexib Capsule should not be used during pregnancy as it may cause embryo-fetal toxicity. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking this medication.

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Breast Feeding

Unsafe

You should not breastfeed during the treatment with Spexib Capsule and for two weeks after your last dose of this medication.

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Driving

Caution

Spexib Capsule may cause tiredness and weakness (fatigue), impacting the ability to drive or use machines.

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Liver

Caution

Spexib Capsule may cause liver problems. Please consult your doctor if you have liver problems before starting Spexib Capsule.

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Kidney

Consult your doctor

It is not known how Spexib Capsule affects when used in kidney-impaired patients. Please consult your doctor if you have kidney problems.

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Children

Unsafe

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

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Heart

Caution

If you have a history of heart disease, please inform the doctor before receiving Spexib Capsule.

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Geriatrics

Caution

Spexib Capsule can be used in the elderly when prescribed by a doctor. If you have any concerns about using Spexib Capsule, please consult a doctor.

What if I have taken an overdose of Spexib Capsule

If you take more medicine than prescribed, contact your doctor or seek medical care promptly. Take the medicine packaging with you if possible.

Diet & Lifestyle Advise

  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice because it can increase the amount of ceritinib in your blood and raise the risk of side effects.
  • Stay hydrated: Drink enough fluids, particularly if you develop diarrhoea or vomiting, unless your doctor has advised you to limit fluids.
  • Eat smaller meals when needed: Smaller, more frequent meals may be easier to manage if you experience nausea or reduced appetite.
  • Maintain good nutrition: Choose a balanced diet that provides enough energy, protein, and nutrients during cancer treatment.
  • Stay active as tolerated: Gentle physical activity may help support your general wellbeing, but follow your healthcare team's advice based on how you feel.
     
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How Soon It Starts Working

The time required for Spexib Capsule to start to work: Spexib Capsule ideally shows its action within 4 to 6 hours after administration.

The time for which the effects of Spexib Capsule last: The duration of action for Spexib Capsule is unknown.

What if you forget to take Spexib Capsule

If you miss a dose and your next dose is more than 12 hours away, take the missed dose as soon as you remember. If your next dose is within 12 hours, skip the missed dose and take your next dose at the usual time. Do not take two doses together to make up for a missed dose.

Storage

•Store Spexib Capsule according to the storage instructions on the specific product label, typically between 20°C and 25°C.

Drug Warnings

  • Keep up with monitoring: Your doctor may regularly check your liver function, blood sugar, pancreas enzymes, and other blood tests during treatment.
  • Monitor your heart: Your doctor may perform an electrocardiogram (ECG), a test that checks your heart rhythm, and may monitor certain minerals in your blood.
  • Report breathing problems: Consult your doctor right away if you develop a new or worsening cough, fever, shortness of breath, or difficulty breathing.
  • Report severe stomach symptoms: Tell your doctor promptly about severe or persistent diarrhoea, vomiting, or stomach pain.
  • Avoid grapefruit: Grapefruit and grapefruit juice can increase ceritinib levels and raise the risk of side effects.
  • Prevent pregnancy: Women who can become pregnant should use effective contraception during treatment and for at least 6 months after the last dose.
  • Use condoms when required: Men with female partners who can become pregnant should use condoms during treatment and for at least 3 months after the last dose.
  • Discuss family planning: Tell your doctor before treatment if you or your partner are planning a pregnancy. Contact your doctor promptly if pregnancy occurs during treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Ketoconazole, itraconazole, clarithromycin, or ritonavir: These medicines can increase ceritinib levels in your blood and may increase the risk of side effects.
  • Rifampicin, carbamazepine, phenytoin, or St John's wort: These can reduce ceritinib levels and may make the treatment less effective.
  • Medicines that affect heart rhythm: Some medicines can increase the risk of abnormal heart rhythms when taken with ceritinib. Tell your doctor about all medicines you take so this risk can be assessed.
  • Medicines that slow the heart rate: Taking certain medicines that reduce heart rate with ceritinib may increase the risk of an unusually slow heartbeat and require closer monitoring.

Drug-Drug Interactions

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How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Ziprasidone is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with isavuconazole may significantly increase the blood levels of isavuconazole.

How to manage the interaction:
Taking Isavuconazole with Spexib 150 mg Capsule is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loose stools, yellow discoloration of skin and eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Spexib 150 mg Capsule:
Co-administration of Alprazolam with Spexib 150 mg Capsule may considerably increase the blood levels and effects of Alprazolam.

How to manage the interaction:
Although there is a interaction between Alprazolam and Spexib 150 mg Capsule, it can be taken if prescribed by a doctor. Consult a doctor if you experience excessive or prolonged drowsiness or difficulty in breathing. Do not discontinue any medications without consulting a doctor.
CeritinibVenetoclax
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Venetoclax may increase the risk of side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Venetoclax is not recommended as it can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like nausea; vomiting; diarrhea; weakness; and pain while urinating, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CeritinibVoclosporin
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Voclosporin may increase the blood levels of voclosporin and irregular heart rhythm.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Voclosporin is not recommended as it can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CeritinibErgotamine
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking ergotamine with Spexib 150 mg Capsule can significantly increase the blood levels and effects of ergotamine.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Ergotamine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and trouble speaking. Do not discontinue any medications without consulting a doctor.
CeritinibHalofantrine
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Halofantrine can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Halofantrine is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
CeritinibConivaptan
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking conivaptan with Spexib 150 mg Capsule can significantly increase the blood levels and effects of conivaptan.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Conivaptan is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience difficulty swallowing, speaking, muscle weakness, controlling body movements, confusion, mood changes, and seizures(fits). Do not discontinue any medications without consulting a doctor.
How does the drug interact with Spexib 150 mg Capsule:
Co-administration of Spexib 150 mg Capsule and Silodosin together can increase the effect of Silodosin and increase the risk for side effects.

How to manage the interaction:
Taking Silodosin and Spexib 150 mg Capsule together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
CeritinibLomitapide
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking lomitapide with Spexib 150 mg Capsule may significantly increase the blood levels of lomitapide.

How to manage the interaction:
Although there is a interaction between Spexib 150 mg Capsule with lomitapide, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • Grapefruit: Avoid grapefruit and grapefruit juice because they can increase the amount of ceritinib in your blood and increase the risk of side effects.
  • Food: Take this medicine with food as directed. Follow the instructions for your prescribed dose and formulation.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[KINASE INHIBITORS]

FAQs

Spexib Capsule is used to treat a type of lung cancer called non-small cell lung cancer.
Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.
Elevations of lipase and/or amylase and pancreatitis can occur during treatment. Your doctor monitors lipase and amylase prior to treatment and periodically thereafter, as clinically indicated. If clinically insignificant values are observed, your doctor either withholds them or reduces the Spexib Capsule.
In some cases, Spexib Capsule can cause bradycardia. Monitoring heart rate and blood pressure regularly is recommended. If this condition persists, consult your doctor immediately.
Spexib Capsule can cause hyperglycemia. Your doctor monitors fasting glucose prior to treatment and periodically after that. Your doctor may prescribe anti-hyperglycemic medications, reduce the dose, or permanently discontinue Spexib Capsule if required.
ALK-positive lung cancer is a specific type of non-small cell lung cancer (NSCLC) that has a mutation in the ALK (Anaplastic lymphoma kinase) gene, resulting in uncontrolled cell replication-cancer.
Spexib Capsule should be swallowed as a whole with water.
Lab tests will help you know the body’s response to Spexib Capsule. Keep taking Spexib Capsule for the duration advised by the doctor for effective results.
Spexib Capsule may cause serious side effects like stomach and gastrointestinal problems, liver injury, pneumonitis (lung inflammation), and abnormal heartbeats. Consult the doctor if you experience any unusual symptoms.
Spexib Capsule may cause liver problems such as liver injury. The doctor will advise regular blood tests to check for liver health during the treatment. Consult the doctor if you experience symptoms such as tiredness, itchy skin, nausea, vomiting, yellowing of eyes, decreased appetite, dark or brown urine, bleeding or bruising easily than usual, and pain on the right side of the stomach.
Spexib Capsule may cause severe or life-threatening lung inflammation (pneumonitis). Seek medical attention if you experience chest pain, fever, cough with or without mucous, shortness of breath or trouble breathing.
Eat non-spicy food and drink enough fluids if you have diarrhoea. You can take anti-diarrhoeal medicines if advised by the doctor.
Spexib Capsule may cause vision problems. Do not drive, operate machinery or do any work that requires alertness until you know how the medicine affects you. Consult the doctor if you notice any vision problems.
Spexib Capsule might cause itchy skin or rash. Use moisturiser and wear loose cotton clothes if you experience this. Consult the doctor if you notice yellow skin as this could be a sign of liver problems.
Do not take another dose to replace the one you vomited. Take your next dose at the usual scheduled time. Consult your doctor if vomiting is frequent or severe.
There is no well-established direct interaction between ceritinib and alcohol. However, because this medicine can affect the liver and cause stomach-related side effects, ask your doctor whether alcohol is appropriate for you.
Treatment may continue for as long as it is controlling the cancer and side effects remain manageable. Your doctor will regularly assess your response and decide whether treatment should continue or change.
No. Ceritinib is a targeted cancer medicine called an ALK inhibitor. It blocks an abnormal ALK protein that helps certain lung cancer cells grow.
Ceritinib may cause tiredness or other side effects that could affect your ability to drive safely. Avoid driving or operating machinery if you feel unwell, dizzy, or unable to concentrate normally.
Women who can become pregnant should use effective contraception while taking this medicine and for at least 6 months after the last dose. Ask your doctor which method is appropriate for you.
Men with female partners who can become pregnant should use condoms during treatment and for at least 3 months after the last dose.
Discuss your plans with your doctor before trying to conceive. This medicine can harm an unborn baby, so the recommended contraception period must be completed after the last dose before attempting pregnancy.

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Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - SPE0179
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