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compositionComposition:STREPTOKINASE-1.5MILLION IU
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Prescription Medicine
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Solonase 1.5MIU Injection is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis. Solonase 1.5MIU Injection contains Streptokinase, which works by dissolving the harmful blood clots in the blood vessels; this restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

STREPTOKINASE-1.5MILLION IU

Manufacturer/Marketer :

Leechem Biotech Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Solonase 1.5MIU Injection

Solonase 1.5MIU Injection is a prescription injection used to dissolve harmful blood clots that block blood flow in emergencies. Depending on the specific medicine prescribed, it may be used to treat conditions such as acute heart attack (myocardial infarction), acute ischaemic stroke, pulmonary embolism (blood clot in the lungs), or blocked blood vessels. By rapidly dissolving the clot, it helps restore blood flow, reduce tissue damage, and improve the chances of recovery.

Because Solonase 1.5MIU Injection is an emergency medicine, it is administered only by trained healthcare professionals in a hospital or emergency care setting. It is given as an intravenous injection or infusion, depending on the specific medicine and condition being treated. After treatment, your doctor may recommend long-term medicines, lifestyle changes, and rehabilitation to reduce the risk of future blood clots.

While receiving Solonase 1.5MIU Injection, some people may experience mild bruising, bleeding from the injection site, nausea, or a temporary fall in blood pressure. However, serious bleeding can occur and requires immediate medical attention. Tell your healthcare provider immediately if you notice severe headache, sudden weakness, blood in your urine or stools, coughing up blood, or prolonged bleeding.

Before receiving this medicine, tell your doctor if you have had a recent stroke (unless being treated for an acute ischaemic stroke), major surgery, severe uncontrolled high blood pressure, bleeding disorders, stomach ulcers, or recent serious injuries. Do not receive this medicine if you have active internal bleeding or any condition where thrombolytic therapy is contraindicated.

This medicine can interact with blood thinners, antiplatelet medicines, and medicines that increase bleeding risk. If you are pregnant, breastfeeding, elderly, or have kidney or liver disease, your doctor will carefully assess the benefits and risks before treatment.

Uses of Solonase 1.5MIU Injection

Your doctor may prescribe Solonase 1.5MIU Injection to treat the following conditions:

  • Acute heart attack (myocardial infarction): Helps dissolve blood clots blocking the heart's arteries to restore blood flow and reduce heart muscle damage.
  • Acute ischaemic stroke (where indicated): Restores blood flow to affected areas of the brain when given within the recommended treatment window.
  • Pulmonary embolism: Dissolves blood clots in the lungs to improve circulation and reduce strain on the heart.
  • Blocked blood vessels: Helps restore blood flow in selected patients with severe arterial or catheter-related blockages.

Key Benefits

Solonase 1.5MIU Injection provides rapid clot-dissolving treatment during life-threatening medical emergencies. By restoring blood flow to affected organs, it helps limit permanent tissue damage and improves the chances of recovery when administered promptly.

  • Restores blood circulation: Quickly dissolves blood clots that obstruct blood flow to the heart, lungs, brain, or other vital organs.
  • Reduces organ damage: Early treatment helps minimise permanent injury to the heart muscle, brain tissue, or lungs.
  • Relieves severe symptoms: Helps improve symptoms such as chest pain, shortness of breath, or neurological deficits caused by blocked blood vessels.
  • Supports recovery: By restoring circulation quickly, it improves the likelihood of better long-term outcomes following a thrombotic emergency.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication, to improve effectiveness.
  • Solonase 1.5MIU Injection will be administered by a healthcare professional.
  • Do not self-administer it.

How Solonase 1.5MIU Injection Works

Solonase 1.5MIU Injection belongs to a group of medicines called thrombolytics (fibrinolytic agents). It works by converting plasminogen into plasmin, an enzyme that breaks down fibrin, the protein framework that holds blood clots together. As the fibrin network dissolves, the clot gradually breaks apart, allowing blood to flow normally again. Restoring circulation helps reduce damage to affected organs and improves recovery.
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Alcohol

Caution

Solonase 1.5MIU Injection may not interact with alcohol. However, avoid the consumption of alcohol as it may worsen your health condition.

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Pregnancy

Caution

Solonase 1.5MIU Injection is contra-indicated in pregnancy, especially within the first 18 weeks of pregnancy.

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Breast Feeding

Caution

It is unknown whether streptokinase is excreted in human milk. Breast milk should be discarded during the first 24 hours following thrombolytic therapy.

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Driving

Caution

It is not known whether Solonase 1.5MIU Injection alters the ability to drive. Do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Inform your doctor before receiving Solonase 1.5MIU Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Solonase 1.5MIU Injection if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Solonase 1.5MIU Injection is not recommended in neonates, infants and children.

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Heart

Caution

Solonase 1.5MIU Injection is used to treat heart conditions like myocardial infarction by dissolving clots. However, it may cause bleeding or arrhythmias, so it must be given under strict medical supervision.

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Geriatrics

Caution

Geriatric patients can receive Solonase 1.5MIU Injection, especially in cases like acute myocardial infarction. While risks like bleeding and hypotension are higher with age, studies show the benefits often outweigh the risks when used with proper medical supervision.

What if I have taken an overdose of Solonase 1.5MIU Injection

Overdose is extremely rare because the medicine is administered under continuous medical supervision. Excess dosing may increase the risk of severe bleeding and requires immediate specialist management.

Diet & Lifestyle Advise

  • Follow a heart-healthy diet: Eat plenty of vegetables, fruits, whole grains, lean proteins, and limit salt and saturated fat.
  • Take prescribed blood-thinning medicines exactly as directed: Do not stop them without consulting your doctor.
  • Avoid activities with a high risk of injury: Bruising and bleeding may occur more easily after thrombolytic treatment.
  • Stop smoking and limit alcohol intake: Both increase the risk of future cardiovascular disease and bleeding complications.
  • Attend all follow-up appointments: Regular monitoring helps reduce the risk of future clotting events.
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Have a query?

How Soon It Starts Working

The time required for Solonase 1.5MIU Injection to start to work: Solonase 1.5MIU Injection ideally shows its action within 20 minutes after administration. The time for which the effects of Solonase 1.5MIU Injection last: The effect of Solonase 1.5MIU Injection lasts for 6 to 12 hours.

What if you forget to take Solonase 1.5MIU Injection

Since this medicine is administered only in hospitals during emergency treatment, missed doses are unlikely.

Storage

• Solonase 1.5MIU Injection injections are stored and prepared by healthcare professionals in hospitals or healthcare facilities according to the manufacturer's recommendations.

Drug Warnings

  • Inform your healthcare provider about any recent surgery, injury, or bleeding problems before treatment begins.
  • Avoid unnecessary injections or invasive procedures after receiving this medicine unless advised by your doctor.
  • Report any unusual bleeding immediately, including nosebleeds, blood in urine or stools, or prolonged bleeding from cuts.
  • Use a soft toothbrush and an electric razor if recommended to reduce the risk of minor bleeding after treatment.
  • Carry information about your recent thrombolytic treatment if you require emergency medical care within the following days.

verifiedApollotooltip
  • Anticoagulants (e.g., warfarin, heparin, apixaban, rivaroxaban): Significantly increase the risk of serious bleeding.
  • Antiplatelet medicines (e.g., aspirin, clopidogrel, ticagrelor): May further increase bleeding risk when used together.
  • NSAIDs (e.g., ibuprofen, diclofenac, naproxen): Increase the risk of gastrointestinal bleeding and should be used cautiously.

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  • Alcohol: Limit or avoid alcohol after treatment because it may increase the risk of bleeding, particularly if you are also taking blood-thinning medicines.

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Habit Forming

No

Therapeutic Class

[ANTIFIBRINOLYTIC AGENTS]

FAQs

Yes. Bleeding is one of the most common adverse effects of Solonase 1.5MIU Injection. Minor bleeding or bruising may occur, but severe or persistent bleeding requires immediate medical attention. Contact your medical team immediately if you have heavy or continuous bleeding, unusual or extensive bruising, blood in your urine or stool, vomiting blood, or other signs of serious bleeding.
Tell your doctor about all medicines you are taking before receiving Solonase 1.5MIU Injection. Anticoagulants and medicines that inhibit platelet function, such as aspirin, may increase the risk of bleeding and should only be used if specifically advised by your doctor. Do not start any new medicine without consulting your doctor or medical team.
Solonase 1.5MIU Injection starts working almost immediately after it is injected into the vein to dissolve the blood clot. Talk to your doctor for more details about your specific recovery timeline.
No, Solonase 1.5MIU Injection must be injected by a trained healthcare professional in a hospital or specialized clinic where you can be closely monitored. Talk to your doctor if you have questions about where your treatment will take place.
Solonase 1.5MIU Injection is generally avoided during pregnancy unless it is a life-saving emergency, as it carries a risk of bleeding for both mother and baby. Talk to your doctor to understand the risks and benefits.
The active effects of Solonase 1.5MIU Injection on your body's clotting system can last for several hours to a day after the infusion is stopped. Talk to your doctor to learn more about post-treatment monitoring.
The most serious risk associated with Solonase 1.5MIU Injection is severe internal bleeding, including bleeding in the brain. Your medical team will monitor you constantly during treatment to minimise this risk. Talk to your doctor if you have concerns.
Your body can develop defence proteins (antibodies) against Solonase 1.5MIU Injection after you receive it, making a second dose less effective or more likely to cause allergic reactions if given within 5 days to 12 months. Talk to your doctor if you have received this medicine in the past.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MIMS Drug Reference Compendium. Streptokinase Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026]Check here
  2. DrugBank Online. Db00086 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Print Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Streptokinase Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Zachary Edwards; Shivaraj Nagalli. Streptokinase. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 20th March 2023]Check here
  6. Tetris Pharma Ltd. Streptokinase 2,50,000 IU. Electronic Medicines Compendium (EMC). [Revised in September 2019]. [Accessed on 20th March 2023]Check here

Manufacturer/Marketer address

3M India Ltd, Concorde Block, Ub City, #24, Vittal Mallya Road, Bangalore, Karnataka - 560001 India.
Other Info - SO31236
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