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compositionComposition:CLOZAPINE-25MG
prescriptionPrescription Medicine
Sizep 25 mg Tab 10's

Sizep 25 mg Tab is used to treat schizophrenia. Additionally, it is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. It contains Clozapine, which helps in improving mood, behaviour and thoughts. It may cause side effects such as tachycardia (fast heartbeat), dizziness, headache, tremor, sweating, dry mouth, nausea, constipation and visual disturbances. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

CLOZAPINE-25MG

Manufacturer/Marketer :

Tripada Lifecare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Sizep 25 mg Tab

Sizep 25 mg Tab is used to treat schizophrenia. Additionally, Sizep 25 mg Tab is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Schizophrenia is a medical condition in which the person may feel, hear or see things that are not there, believe things that are not true, or feel unusually suspicious or confused.

Sizep 25 mg Tab contains Clozapine, which works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin. Thus, it helps improve mood, behaviour, and thoughts.

Depending on your medical condition, you are advised to take Sizep 25 mg Tab for as long as your doctor has prescribed it for you. In some cases, Sizep 25 mg Tab may cause side effects, including tachycardia (a fast heartbeat), dizziness, headache, tremors, sweating, dry mouth, nausea, constipation, and visual disturbances. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Sizep 25 mg Tab suddenly, as it might cause withdrawal symptoms. Consult your doctor if you are pregnant. Do not take Sizep 25 mg Tab if you are breastfeeding, as it may pass into breastmilk. Avoid driving as Sizep 25 mg Tab may cause drowsiness and dizziness. Sizep 25 mg Tab should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol with Sizep 25 mg Tab as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and any medications you are taking to minimise the risk of side effects.

Uses of Sizep 25 mg Tab

Sizep 25 mg Tab is used in the treatment of schizophrenia. The detailed uses of Sizep 25 mg Tab are as follows:

  • It is used in patients with schizophrenia when other antipsychotic medications have been ineffective or have caused serious side effects.
  • It is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar mental health conditions.
  • It is used in the management of psychotic disorders in people with Parkinson’s disease when other treatments have failed.

Key Benefits

Sizep 25 mg Tab belongs to a group of medicines called antipsychotics. Sizep 25 mg Tab is used to treat schizophrenia and to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Sizep 25 mg Tab works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby helping improve mood, behaviour, and thoughts. Sizep 25 mg Tab is used to treat schizophrenia when other antipsychotic drugs are ineffective or have caused severe adverse effects. Sizep 25 mg Tab is also used to treat psychotic disorders in patients with Parkinson’s disease when standard treatments have failed.

Side effects of Sizep 25 mg Tab
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Regularly brush your tongue and teeth to prevent Excessive Saliva Production.
  • Avoid eating foods high in sugar or acid since these foods might increase saliva production, which increases the Excessive Saliva Production.
  • Keep your head up straight and maintain proper posture to prevent saliva from collecting in your mouth.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Sizep 25 mg Tab can be taken with or without food.
  • It is usually taken 1-2 times daily at the same time each day or as prescribed by your doctor.
  • Swallow Sizep 25 mg Tab as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Sizep 25 mg Tab Works

Sizep 25 mg Tab contains Clozapine, which works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin. Thus, it helps in improving mood, behaviour and thoughts.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Sizep 25 mg Tab as it may cause increased drowsiness.

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Pregnancy

Caution

Sizep 25 mg Tab belongs to pregnancy category B. Please consult your doctor if you are pregnant before taking this medicine; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Sizep 25 mg Tab is not recommended for use during breastfeeding.

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Driving

Unsafe

Sizep 25 mg Tab causes tiredness, dizziness and vision problems. Do not drive or operate machinery if you experience these symptoms.

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Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

Sizep 25 mg Tab should not be given to children as safety and effectiveness have not been established.

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Heart

Caution

Sizep 25 mg Tab should be taken with extreme caution in patients with heart disease. Please consult your physician.

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Geriatrics

Caution

Sizep 25 mg Tab can be given in elderly patients with caution due to increased risk of adverse effects.

What if I have taken an overdose of Sizep 25 mg Tab

Please do not take more than the prescribed dose of Sizep 25 mg Tab as it may cause an overdose. The symptoms of overdose include sedation, fast heart rate, high blood pressure, respiratory depression or failure, delirium (serious changes in mental abilities), coma or excess saliva production. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include fruits, vegetables, and fibre-rich food in your diet.
  • Cut down on sugars, salts and saturated fats.
  • Drink enough fluids to stay hydrated.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Have a query?

How Soon It Starts Working

The time required for Sizep 25 mg Tab to start to work: Sizep 25 mg Tab ideally shows its action within 1.5 to 2.5 hours after administration. The time for which the effects of Sizep 25 mg Tab last: The effect of Sizep 25 mg Tab lasts for 4 to 12 hours.

What if you forget to take Sizep 25 mg Tab

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue back to your regular dosage routine. Avoid taking two doses at once.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not take Sizep 25 mg Tab if you are allergic to any of its contents if you have galactose intolerance, total lactase deficiency, glucose-galactose malabsorption, low number of white blood cells or if you are taking medicines that can cause low levels of white blood cells, bone marrow disorder, epilepsy, circulatory collapse (pronounced fall in blood pressure that can lead to unconsciousness), brain disorders, severe kidney disease, heart disease, liver disease with jaundice, liver failure or paralytic ileus (small intestine disorder). Inform your doctor if you have a low number of white blood cells or platelet count, orthostatic hypotension, epilepsy, enlarged prostate or difficulty urinating, glaucoma, severe constipation, diabetes, heart, liver or kidney problems. Consult your doctor if you are pregnant. Do not take Sizep 25 mg Tab if you are breastfeeding, as it may pass into breastmilk.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Sizep 25 mg Tab may interact with antipsychotic (aripiprazole, haloperidol, lurasidone, lithium, risperidone, quetiapine, olanzapine), anti-anxiety (lorazepam, alprazolam), anti-cholinergic (benztropine), anti-depressant (duloxetine, escitalopram, sertraline), anti-convulsant (divalproex sodium, clonazepam, lamotrigine),  muscle relaxants (carisoprodol, cyclobenzaprine),  antihistamines (cetirizine, diphenhydramine).

Drug-Food Interactions: Avoid consuming alcohol, as it could lead to increased dizziness.

Drug-Disease Interactions: Inform your doctor if you have dementia (memory loss), CNS depression, liver disease, seizures, low blood pressure, diabetes, lipid alterations, weight gain, parkinsonism, acute alcohol intoxication, neuroleptic malignant syndrome (occurs due to reaction with antipsychotic drugs), tardive dyskinesia (repetitive, involuntary movements), QT interval prolongation, kidney impairment/disease, blood abnormalities, or hyperprolactinemia (higher levels of prolactin in the blood).

ClozapineMetoclopramide
Critical
ClozapineSparfloxacin
Critical

Drug-Drug Interactions

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ClozapineMetoclopramide
Critical
How does the drug interact with Sizep 25 mg Tab:
Co-administration of Metoclopramide with Sizep 25 mg Tab can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Sizep 25 mg Tab is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
ClozapineSparfloxacin
Critical
How does the drug interact with Sizep 25 mg Tab:
When Sizep 25 mg Tab is taken with Sparfloxacin, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Sizep 25 mg Tab with Sparfloxacin there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
ClozapinePotassium citrate
Critical
How does the drug interact with Sizep 25 mg Tab:
Taking Sizep 25 mg Tab and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and other gastrointestinal injury.

How to manage the interaction:
Co-administration of Potassium citrate with Sizep 25 mg Tab is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ClozapineRopinirole
Critical
How does the drug interact with Sizep 25 mg Tab:
When Ropinirole is taken with Sizep 25 mg Tab, it may not work as well.

How to manage the interaction:
Taking Ropinirole with Sizep 25 mg Tab is not recommended as it can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as drowsiness, low blood pressure, dizziness, and lightheadedness. Do not stop using any medications without consulting doctor.
ClozapineFlibanserin
Critical
How does the drug interact with Sizep 25 mg Tab:
When Flibanserin and Sizep 25 mg Tab are taken together, may increase side effects.

How to manage the interaction:
There may be a possibility of interaction between Sizep 25 mg Tab and Flibanserin, but it can be taken if prescribed by a doctor. If you notice any of these signs - like dizziness, drowsiness, fatigue, and difficulty concentrating, call a doctor right away. Do not stop using any medications without a doctor's advice.
ClozapineCisapride
Critical
How does the drug interact with Sizep 25 mg Tab:
When Sizep 25 mg Tab is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Sizep 25 mg Tab with Cisapride there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
ClozapinePimozide
Critical
How does the drug interact with Sizep 25 mg Tab:
When Sizep 25 mg Tab is taken with Pimozide, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Sizep 25 mg Tab with Pimozide there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
ClozapinePrimaquine
Severe
How does the drug interact with Sizep 25 mg Tab:
Taking Sizep 25 mg Tab with primaquine may increase the risk of serious infections.

How to manage the interaction:
Although taking Sizep 25 mg Tab with primaquine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in the coughing fluid, weight loss, red or irritated skin, body sores, or discomfort or burning when urinating, you must consult a doctor immediately.
Clozapinesulfamethoxazole
Severe
How does the drug interact with Sizep 25 mg Tab:
The combined use of sulfamethoxazole and Sizep 25 mg Tab may increase the risk or severity of toxicity.

How to manage the interaction:
There may be a possibility of interaction between Sizep 25 mg Tab and sulfamethoxazole, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not discontinue any medications without first consulting your doctor.
ClozapineCladribine
Severe
How does the drug interact with Sizep 25 mg Tab:
The combined cladribine with Sizep 25 mg Tab can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Cladribine with Sizep 25 mg Tab can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[PSYCHOTHERAPEUTICS]

FAQs

Sizep 25 mg Tab is used to treat schizophrenia. Additionally, it is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders.

Sizep 25 mg Tab works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby improving mood, behaviour and thoughts.

Do not discontinue Sizep 25 mg Tab without consulting your doctor, as it could cause withdrawal symptoms. To treat your condition effectually, continue taking Sizep 25 mg Tab for as long as prescribed. Do not hesitate to consult your doctor if you experience any difficulties while taking Sizep 25 mg Tab .

Sizep 25 mg Tab may cause agranulocytosis (low levels of white blood cells), making you more prone to infections. Consult your doctor immediately if you experience flu-like symptoms, such as a sore throat or fever.

Dry mouth could be a side effect of Sizep 25 mg Tab . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum or candy might stimulate saliva and prevent dry mouth.

Orthostatic hypotension could be a side-effect of Sizep 25 mg Tab . Orthostatic hypotension is a sudden drop in blood pressure that occurs when standing, leading to dizziness. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better.

Sizep 25 mg Tab may cause tachycardia (fast heartbeat). Talk to your doctor if you experience an irregular or rapid heartbeat, even at rest, chest pain, unexplained tiredness, or breathing problems.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take your regular dose as scheduled. Please don't take a double dose to make up for a missed one.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Santoshini Reddy GDoctor badge

Written By

  • Santoshini Reddy G

    M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

  • Bayyarapu Mahesh Kumar

    M Pharmacy

Last Updated

Doctor imageWe provide you with authentic, trustworthy and relevant information

Country of origin

India

Manufacturer/Marketer address

3 Yogi Complex, Nr Doordarshan, Kendra, Thaltej, Ahmedabad, India 380054.
Other Info - SIZ0030
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