Sisliptin M 500mg/20mg Tablet ER belongs to the group of medications called ‘antidiabetic agents’ used to treat type 2 diabetes mellitus. This medication improves glycaemic control in diabetic patients who do not react well to Metformin alone.

Sisliptin M 500mg/20mg Tablet ER contains Metformin and Teneligliptin. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. On the other hand, Teneligliptin increases the insulin levels in the body and reduces the glucagon levels. Together, Sisliptin M 500mg/20mg Tablet ER helps treat type 2 diabetes.

Sisliptin M 500mg/20mg Tablet ER may cause side effects such as nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, weight gain, and sweating. Most of these side effects may not require medical attention and will likely resolve over time. However, if the side effects persist or worsen, consult your doctor.

Do not take Sisliptin M 500mg/20mg Tablet ER if you are allergic to any of its contents. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Let your doctor know if you are taking any other medicines or have pre-existing medical conditions to prevent any potential interactions.

• Sisliptin M 500mg/20mg Tablet ER can be taken with or without food. However, taking it with food may help reduce stomach upset.
• It is recommended to take Sisliptin M 500mg/20mg Tablet ER once daily or as advised by your doctor.
• Swallow Sisliptin M 500mg/20mg Tablet ER as a whole with a glass of water.
• Do not crush, chew, or break it.

• Sisliptin M 500mg/20mg Tablet ER is indicated for the management of type 2 diabetes mellitus in adults. It contains Metformin and Teneligliptin.
• Metformin is a biguanide, which works by reducing the production of glucose in the liver and decreasing its absorption from the intestines, thereby lowering blood sugar levels.
• Teneligliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor that increases insulin secretion and decreases glucagon levels in the blood, especially after meals.
• It is used when patients are unable to achieve sufficient glycemic control through lifestyle modifications such as diet and physical activity alone.
• Sisliptin M 500mg/20mg Tablet ER is suitable for patients who have not responded adequately to treatment with sulfonylureas (e.g., glimepiride, gliclazide) in combination with dietary control and exercise.
• It may also be prescribed when treatment with thiazolidinediones (e.g., pioglitazone) along with diet and exercise has failed to achieve satisfactory blood glucose control.

• Do not take Sisliptin M 500mg/20mg Tablet ER if you are allergic to any of its components, or if you have severe ketosis, type 1 diabetes, diabetic coma, or a history of diabetic coma.
• Inform your doctor if you have liver, kidney or heart problems, severe infection, severe trauma, adrenal insufficiency, bowel obstruction, irregular heartbeat, or are due to undergo surgery.
• Sisliptin M 500mg/20mg Tablet ER may cause ‘lactic acidosis’ (buildup of lactic acid in the blood). Consult your doctor if you experience abdominal pain, muscle cramps, vomiting, severe fatigue, or difficulty breathing. It is a life-threatening condition that requires immediate medical attention.
• Do not consume excess alcohol, as it increases the risk of lactic acidosis.
• Sisliptin M 500mg/20mg Tablet ER may lower vitamin B12 levels, so it is recommended to take blood tests regularly to identify any vitamin deficiencies.