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SIMVOTIN EZ 10MG TABLET is used to treat high cholesterol and Prevent heart attacks and strokes. It contains Ezetimibe and Simvastatin. Ezetimibe works by reducing the cholesterol absorbed in the digestive tract. Simvastatin belongs to the class of statins or HMG-CoA reductase inhibitors that work by inhibiting the HMG-CoA reductase enzyme in the body that is essential to make cholesterol. Thereby, it decreases the liver's LDL (bad cholesterol) production. Also, it reduces the risk of stroke or heart attack by lowering the excess cholesterol deposition in the major blood vessels of the brain and heart.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About SIMVOTIN EZ 10MG TABLET

SIMVOTIN EZ 10MG TABLET is a prescription oral medication used to lower high levels of cholesterol and other fats in the blood. It helps reduce low-density lipoprotein (LDL) or 'bad' cholesterol and triglycerides while raising high-density lipoprotein (HDL) or 'good' cholesterol. This medication is commonly prescribed to help lower the risk of heart attacks and strokes in individuals with high cholesterol levels.

For the best results, you must take SIMVOTIN EZ 10MG TABLET consistently every day, typically in the evening. You can take this tablet with or without food, but keeping a regular schedule is key to managing your cholesterol levels effectively. Combining this treatment with a heart-healthy diet low in saturated fats, regular physical exercise, and weight management will significantly improve your overall outcomes.

While taking this medicine, you might experience some mild side effects such as headache, mild muscle aches, or an upset stomach. However, if you experience unexplained muscle pain, tenderness, weakness, or dark-colored urine, you must contact your doctor immediately, as these could be signs of a rare but serious muscle condition.

Do not take this if you have active liver disease or unexplained, persistent elevations in your liver enzymes. Before starting, talk to your doctor if you have a history of kidney disease, thyroid problems, diabetes, or heavy alcohol use. Women who are pregnant, planning to become pregnant, or breastfeeding must not take this medication.

This medicine can interact with certain other treatments, such as specific antibiotics, antifungals, or other cholesterol drugs, which can increase the risk of serious muscle issues. You should also avoid consuming large amounts of grapefruit juice and limit alcohol intake while on this medication. Pregnant, breastfeeding, or elderly individuals should always consult their healthcare provider before using this product.
 

Uses of SIMVOTIN EZ 10MG TABLET

Your doctor may prescribe this medicine to help manage the following conditions:

  • Primary hypercholesterolaemia: SIMVOTIN EZ 10MG TABLET helps lower elevated levels of LDL ('bad') cholesterol, total cholesterol, triglycerides, and apolipoprotein B while increasing HDL ('good') cholesterol when diet and lifestyle changes alone are not sufficient.
  • Homozygous familial hypercholesterolaemia (HoFH): It is used alongside other cholesterol-lowering treatments to reduce extremely high cholesterol levels in people with this inherited genetic disorder.
  • Prevention of cardiovascular events: This medicine helps reduce the risk of major cardiovascular events, such as heart attack, stroke, hospitalisation for unstable angina, or the need for coronary revascularisation in people with established coronary heart disease or those at high cardiovascular risk.
     

Key Benefits

When used as prescribed, SIMVOTIN EZ 10MG TABLET offers several important cardiovascular benefits.
 

  • Provides greater cholesterol reduction: By lowering cholesterol through two complementary mechanisms, this medicine reduces LDL cholesterol more effectively than either treatment alone.
  • Slows the progression of atherosclerosis: Lowering harmful cholesterol levels helps reduce plaque formation within the arteries, supporting healthier blood flow and protecting blood vessels over time.
  • Reduces the risk of cardiovascular complications: Long-term treatment helps lower the risk of serious cardiovascular events such as heart attack, stroke, and the need for coronary artery procedures.
  • Supports long-term heart health: When combined with a healthy diet, regular exercise, and other lifestyle measures, SIMVOTIN EZ 10MG TABLET helps improve cholesterol control and supports long-term cardiovascular health.
     

Directions for Use

  • SIMVOTIN EZ 10MG TABLET can be taken with or without food as advised by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Swallow SIMVOTIN EZ 10MG TABLET as a whole with a glass of water.
  • Do not chew, crush or break it.

How SIMVOTIN EZ 10MG TABLET Works

SIMVOTIN EZ 10MG TABLET works through a dual mechanism that combines two active ingredients: ezetimibe and simvastatin. The first active ingredient, ezetimibe, works in your digestive tract. It reduces the amount of cholesterol your body absorbs from the food you eat, preventing it from entering your bloodstream. The second active ingredient, simvastatin, belongs to a group of medicines called statins. It works directly in your liver, which is where most of your body's cholesterol is made. Simvastatin blocks an enzyme that the liver needs to produce cholesterol, thereby lowering the amount of cholesterol circulating in your blood. Together, these two ingredients attack high cholesterol from two fronts—the gut and the liver, making SIMVOTIN EZ 10MG TABLET highly effective at keeping your cholesterol levels within a healthy range.
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Alcohol

Unsafe

Avoid consumption of alcohol with SIMVOTIN EZ 10MG TABLET as it may increase the risk of liver damage. Inform your doctor if you consume alcohol daily.

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Pregnancy

Unsafe

SIMVOTIN EZ 10MG TABLET is not recommended in pregnancy as it may harm your unborn baby. If pregnancy occurs while on treatment with SIMVOTIN EZ 10MG TABLET, it should be discontinued immediately and seek medical advice.

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Breast Feeding

Consult your doctor

It is unknown whether SIMVOTIN EZ 10MG TABLET is excreted in the breast milk. Therefore, if you are a breastfeeding mother, inform your doctor before taking SIMVOTIN EZ 10MG TABLET.

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Driving

Caution

SIMVOTIN EZ 10MG TABLET usually does not affect your ability to drive or operate machinery. However, if you feel dizzy after taking SIMVOTIN EZ 10MG TABLET, avoid driving or operating machinery.

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Liver

Caution

SIMVOTIN EZ 10MG TABLET is contraindicated in patients with active liver disease or unexplained persistent elevations in liver transaminases. If you have liver problems, inform your doctor before taking this medicine.

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Kidney

Consult your doctor

If you have chronic kidney disease, inform your doctor before taking SIMVOTIN EZ 10MG TABLET. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

SIMVOTIN EZ 10MG TABLET is not recommended for children below 10 years of age as the safety and effectiveness were not established.

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Heart

Safe if prescribed

SIMVOTIN EZ 10MG TABLET is generally safe for heart patients if prescribed, but should be used under medical supervision.

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Geriatrics

Safe if prescribed

SIMVOTIN EZ 10MG TABLET is generally safe for elderly patients. However, please consult your doctor if you have any concerns.

What if I have taken an overdose of SIMVOTIN EZ 10MG TABLET

If you accidentally take too much of this medicine, seek immediate medical attention or contact your local poison control centre right away, even if you do not feel any symptoms.

Diet & Lifestyle Advise

  • Eat a heart-healthy diet: Focus on foods low in saturated fat and cholesterol. Increase your intake of soluble fibre, which is found in oats, beans, and fruits, as it helps block cholesterol absorption.
    Incorporate healthy fats: Replace saturated fats (like butter or lard) with healthier unsaturated fats found in olive oil, avocados, and nuts.
  • Engage in regular exercise: Aim for at least 150 minutes of moderate-intensity aerobic exercise, like brisk walking or cycling, every week to help raise your 'good' (HDL) cholesterol.
  • Avoid grapefruit: Grapefruit contains compounds that interfere with how your body breaks down simvastatin, which can lead to higher levels of the drug in your blood and increase the risk of muscle damage.
  • Limit alcohol and quit smoking: Reducing alcohol consumption supports your liver, while stopping smoking significantly improves your cardiovascular health and raises HDL cholesterol.

 

health query

Have a query?

How Soon It Starts Working

The time required for SIMVOTIN EZ 10MG TABLET to start to work: The onset time of SIMVOTIN EZ 10MG TABLET has not been clinically established. The time for which the effects of SIMVOTIN EZ 10MG TABLET last: The duration of SIMVOTIN EZ 10MG TABLET’s effect is clinically not established.

What if you forget to take SIMVOTIN EZ 10MG TABLET

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store SIMVOTIN EZ 10MG TABLET tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Check your liver function: Your doctor may perform blood tests to check your liver enzymes before you start taking this medicine and periodically during treatment.
  • Watch for muscle pain: Be highly alert for any unexplained muscle pain, tenderness, or weakness. This is crucial because it can rarely lead to a serious muscle-wasting condition.
  • Tell all healthcare providers: Inform any dentist, surgeon, or doctor you visit that you are taking SIMVOTIN EZ 10MG TABLET, especially if you are scheduled for surgery or a medical procedure.
  • Avoid pregnancy: If you are a woman of childbearing age, use effective birth control while taking this medicine. Stop taking it immediately and contact your doctor if you suspect you are pregnant.
  • Disclose all medications: Provide your pharmacist with a complete list of all medications, supplements, and herbal products you take to check for dangerous interactions.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, clarithromycin, erythromycin, and certain HIV protease inhibitors): These medicines can significantly increase simvastatin levels, greatly increasing the risk of muscle injury (myopathy) and rhabdomyolysis. Their use with simvastatin is generally contraindicated.
  • Other lipid-lowering medicines: Combining SIMVOTIN EZ 10MG TABLET with fibrates (especially gemfibrozil) or high-dose niacin may further increase the risk of muscle-related side effects and requires careful medical supervision.
  • Warfarin and other vitamin K antagonists: SIMVOTIN EZ 10MG TABLET may enhance the anticoagulant effect of these medicines. Your doctor may monitor your INR more frequently when starting, stopping, or changing the dose.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Avoid grapefruit products during treatment, as they inhibit the metabolism of simvastatin and can markedly increase the risk of muscle toxicity.
  • Excessive alcohol consumption: Drinking large amounts of alcohol may increase the risk of liver problems while taking this medicine. Limit alcohol intake and consult your doctor if you have a history of heavy alcohol use.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTILIPEMICS]

FAQs

SIMVOTIN EZ 10MG TABLET is used to treat high cholesterol and Prevent heart attacks and strokes.
SIMVOTIN EZ 10MG TABLET contains Ezetimibe and Simvastatin. Ezetimibe works by reducing the cholesterol absorbed in the digestive tract. Simvastatin works by inhibiting the production of cholesterol your body makes by itself. Also, it reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart.
You are recommended to inform your doctor if you are taking niacin or niacin-containing product, as it may increase the risk of muscle problems.
SIMVOTIN EZ 10MG TABLET may increase the risk of rhabdomyolysis (the breakdown of muscle tissue) in some patients. It is not common for everyone who takes SIMVOTIN EZ 10MG TABLET. However, if you experience unexplained muscle pain, weakness or tenderness, especially along with fever, dark-coloured urine or unusual tiredness, please consult your doctor immediately.
You are not recommended to stop taking SIMVOTIN EZ 10MG TABLET without consulting your doctor as it may worsen the condition and increase the risk of heart attack and stroke. Therefore, take SIMVOTIN EZ 10MG TABLET for as long as your doctor has prescribed it, and if you experience any difficulty while taking SIMVOTIN EZ 10MG TABLET, please consult your doctor so that the dose may be gradually reduced.
While some cholesterol medications can be taken at any time, SIMVOTIN EZ 10MG TABLET contains simvastatin, which is more effective when taken in the evening because your body produces the most cholesterol during the night. If you prefer a different time, talk to your doctor or pharmacist.
Yes, it is highly recommended to avoid eating grapefruit or drinking grapefruit juice. Grapefruit interferes with the enzymes that break down this medication, which can cause the drug to build up in your body and increase the risk of serious muscle pain. Talk to your doctor if you have further concerns.
If you develop unexplained muscle pain, tenderness, or weakness—especially if you also have a fever or feel unusually tired—contact your doctor immediately. This could be a sign of a rare but serious muscle injury. Talk to your doctor to determine if you need to stop the medicine.
You should limit your alcohol intake while taking this medication. Drinking large amounts of alcohol can increase your risk of liver damage and muscle problems. If you drink alcohol regularly, talk to your doctor or pharmacist about how much is safe for you.
No, SIMVOTIN EZ 10MG TABLET should not be used during pregnancy or breastfeeding, as it may cause harm to the unborn baby or infant. If you plan to become pregnant or find out you are pregnant while taking this medicine, stop taking it and contact your healthcare provider immediately. Talk to your doctor about safer alternatives.
SIMVOTIN EZ 10MG TABLET starts working to lower your cholesterol within 1 to 2 weeks, with maximum effects usually seen after about 4 weeks. Your doctor will likely perform routine blood tests to monitor your cholesterol levels and ensure the medication is working properly. Talk to your doctor for personalised advice.
Yes, this medication works best when combined with a low-fat, heart-healthy diet. Medication alone cannot completely manage your cholesterol or provide the full cardiovascular benefits of a healthy lifestyle. Talk to your doctor or a dietitian for guidance on meal planning.
In rare cases, this medication can affect your liver enzymes. Your doctor will likely order blood tests to check your liver function before you start treatment and if you show symptoms of liver issues, such as yellowing of your skin or eyes. Talk to your doctor if you notice any unusual symptoms.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - SIM0018
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