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Simponi 50 mg Injection 0.5 ml is primarily used in treating moderate to severe rheumatoid arthritis, active ankylosing spondylitis, active ulcerative colitis, and active psoriatic arthritis in adult patients. This medicine is used in combination with methotrexate for the treatment of autoimmune disorders. It consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive; this helps reduce inflammation and pain caused by various autoimmune diseases.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GOLIMUMAB-50MG

Manufacturer/Marketer :

Baxter India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Simponi 50 mg Injection 0.5 ml

Simponi 50 mg Injection 0.5 ml is a prescription medicine used to treat chronic inflammatory conditions where the immune system mistakenly attacks healthy tissues. It is commonly prescribed to manage conditions such as moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and moderate to severe ulcerative colitis. By targeting the underlying cause of inflammation, this medication helps control joint damage, swelling, and bowel irritation.

Because Simponi 50 mg Injection 0.5 ml is an injection, it must be used consistently and at the exact regular intervals prescribed by your doctor to keep your symptoms under control. Since it is injected, its absorption does not depend on meals, so you do not need to worry about taking it with or without food. Along with your medication, making healthy daily choices—such as eating an anti-inflammatory diet and doing gentle, regular exercises—can help improve your long-term results.

While taking Simponi 50 mg Injection 0.5 ml, some people may experience mild side effects, such as irritation around the injection site or cold-like symptoms. However, because this medicine affects your immune system, it can also increase your risk of serious infections. It is very important to contact your doctor right away if you develop a fever, persistent cough, or other signs of illness.

Before you begin treatment, talk to your doctor if you have a history of chronic infections, tuberculosis, hepatitis B, heart failure, or nervous system disorders. Do not take this if you currently have a severe, active infection. Your doctor will perform tests to make sure it is safe for you to start this medication.

This medicine can interact with other treatments. Let your doctor know about all the medicines you use, especially other biologic therapies, as combining them can increase your risk of severe infections. You should also avoid receiving live vaccines while using this medicine. If you are pregnant, planning a pregnancy, breastfeeding, or are an elderly patient, talk to your doctor or pharmacist to discuss your specific safety plan.

Uses of Simponi 50 mg Injection 0.5 ml

Your doctor may prescribe Simponi 50 mg Injection 0.5 ml to help manage the following conditions:

  • Rheumatoid arthritis: Reduces joint pain, stiffness, and swelling in adults with moderate to severe forms of this disease, helping to slow down permanent joint damage.
  • Psoriatic arthritis: Helps control joint inflammation and can improve skin symptoms associated with psoriasis.
  • Ankylosing spondylitis: Relieves chronic back pain and stiffness in the spine, helping to improve your physical mobility.
  • Ulcerative colitis: Reduces inflammation in the lining of the large intestine, helping to achieve and maintain symptom control in moderate to severe cases.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Controls Inflammation: Simponi 50 mg Injection 0.5 ml acts directly on the source of swelling and pain to offer meaningful, everyday relief. By controlling the overactive immune response, it helps you regain physical comfort and stability.
  • Supports Joint Mobility: For individuals living with joint conditions, this medicine enables more comfortable, pain-free movement. Everyday tasks such as walking, writing, or climbing stairs become much easier to manage. Furthermore, by slowing the progression of joint damage, it helps preserve your mobility and independence for the future.
  • Promotes Digestive Comfort: For those dealing with bowel inflammation, Simponi 50 mg Injection 0.5 ml helps calm the digestive tract, leading to fewer flare-ups, reduced bowel urgency, and a better overall quality of life.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Simponi 50 mg Injection 0.5 ml will be administered by a nurse or doctor.
  • Do not self-administer.

How Simponi 50 mg Injection 0.5 ml Works

Simponi 50 mg Injection 0.5 ml contains golimumab, which belongs to a group of medicines called monoclonal antibodies. It works by targeting and blocking a specific protein in your body called tumour necrosis factor alpha (TNF-alpha). In a healthy body, TNF-alpha plays a role in helping the immune system fight off actual threats. However, in people with autoimmune conditions, the body produces too much of this protein, which triggers constant, harmful inflammation in the joints, skin, or bowels. Simponi 50 mg Injection 0.5 ml acts like a key that locks onto these excess proteins, neutralising them before they can bind to cells and trigger the inflammation process. By putting a stop to these inflammatory chemical signals, the medicine reduces pain, swelling, and tissue damage, helping your body heal.
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Alcohol

Unsafe

It is not known if alcohol interacts with Simponi 50 mg Injection 0.5 ml. Please consult the doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving Simponi 50 mg Injection 0.5 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is not known whether Simponi 50 mg Injection 0.5 ml passes into human milk. Hence, if you are breastfeeding, inform your doctor before receiving Simponi 50 mg Injection 0.5 ml.

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Driving

Caution

Simponi 50 mg Injection 0.5 ml will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

Simponi 50 mg Injection 0.5 ml may cause liver disease. Inform your doctor if you have a poor appetite, yellow discolouration of the skin or eyes, and abdominal pain. If you have pre-existing or a history of liver problems, let your doctor know, as this medicine may worsen your condition.

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Kidney

Consult your doctor

Limited data on the effects of Simponi 50 mg Injection 0.5 ml in patients with kidney impairment is available. If you have a pre-existing or a history of kidney disease, inform your doctor before taking Simponi 50 mg Injection 0.5 ml.

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Children

Unsafe

Simponi 50 mg Injection 0.5 ml is not recommended for use in children below 18 years of age as safety and efficacy are not established.

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Heart

Consult your doctor

Please consult your doctor before receiving Simponi 50 mg Injection 0.5 ml if you have pre-existing heart problems. Your doctor will prescribe Simponi 50 mg Injection 0.5 ml if the benefits outweigh the risks.

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Geriatrics

Caution

Simponi 50 mg Injection 0.5 ml should be used with caution in geriatric patients. Therefore, please consult your doctor before giving Simponi 50 mg Injection 0.5 ml to elderly individuals.

What if I have taken an overdose of Simponi 50 mg Injection 0.5 ml

In case of an accidental overdose, seek immediate medical attention, even if you do not feel any immediate discomfort or symptoms.

Diet & Lifestyle Advise

  • Follow an anti-inflammatory diet: Focus on nutrient-rich foods that naturally help ease inflammation, such as green leafy vegetables, berries, walnuts, olive oil, and fish rich in omega-3 fatty acids.
  • Keep moving with low-impact exercise: Gentle activities like swimming, cycling, or walking help keep your joints flexible and strengthen supporting muscles without placing heavy stress on your body.
  • Practice strict hygiene: Because Simponi 50 mg Injection 0.5 ml lowers your body's ability to fight off germs, wash your hands frequently, cook foods thoroughly, and try to avoid close contact with anyone who has an active cold or infection.
  • Manage stress levels: High emotional stress can trigger symptom flare-ups. Try incorporating calming practices like deep breathing exercises, meditation, or gentle stretching into your daily routine.
health query

Have a query?

How Soon It Starts Working

The time required for Simponi 50 mg Injection 0.5 ml to start to work: The time required for Simponi 50 mg Injection 0.5 ml to show its action is not clinically established. The time for which the effects of Simponi 50 mg Injection 0.5 ml last: The duration of action for Simponi 50 mg Injection 0.5 ml is not clinically established.

What if you forget to take Simponi 50 mg Injection 0.5 ml

If you miss a dose of Simponi 50 mg Injection 0.5 ml, inject it as soon as you remember. After taking the missed dose, talk to your doctor or pharmacist to find out when to take your next dose and to establish a new, safe schedule. Do not inject a double dose to make up for a missed one.

Storage

• Store Simponi 50 mg Injection 0.5 ml in the refrigerator between 2°C and 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Check the liquid before use: Look through the viewing window of the device. The liquid should be clear to slightly yellow; do not inject it if it is cloudy, discoloured, or contains floating particles.
  • Rotate your injection sites: Choose a different spot for every injection to help prevent skin irritation, bruising, or thickening at the injection site.
  • Complete all pre-treatment screenings: Ensure you are tested for tuberculosis (TB) and hepatitis B before starting Simponi 50 mg Injection 0.5 ml, as this medicine can reactivate latent infections.
  • Avoid live vaccines: Do not get any live vaccines (such as the shingles vaccine or nasal spray flu vaccine) while using Simponi 50 mg Injection 0.5 ml, as your lowered immune system can make the vaccine unsafe.
  • Report signs of illness early: Contact your doctor at the first sign of any infection—even minor ones like a scratch that becomes red, swollen, or warm.

verifiedApollotooltip
  • Other biologic medicines: Combining Simponi 50 mg Injection 0.5 ml with other biologic medications (such as abatacept or anakinra) is not recommended because it severely increases your risk of developing serious infections.
  • Live vaccines: Taking this medicine while receiving live vaccines may reduce the vaccine’s effectiveness or cause a vaccine-related infection.

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verifiedApollotooltip

No clinically significant food interactions are known with Simponi 50 mg Injection 0.5 ml when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Simponi 50 mg Injection 0.5 ml is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Ulcerative colitis.
Simponi 50 mg Injection 0.5 ml contains Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive.
Simponi 50 mg Injection 0.5 ml affects your immune system and makes you more susceptible to infections. It is not recommended in people with active infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, or weak immune system. Hence, inform your doctor if you have any history of these conditions beforehand.
Yes, you can travel with Simponi 50 mg Injection 0.5 ml, but you must keep it cool. Use a travel cooler bag with ice packs to maintain a safe temperature between 2°C and 8°C (36°F to 46°F), making sure the medicine does not touch the ice directly to prevent freezing. Talk to your pharmacist for more detailed travel tips.
Because Simponi 50 mg Injection 0.5 ml lowers your immune response, a fever can be a sign of a serious underlying infection. Stop using the medicine temporarily and contact your doctor immediately for advice.
There is no direct chemical interaction between alcohol and Simponi 50 mg Injection 0.5 ml. However, regular or heavy alcohol use can strain your liver and worsen certain underlying conditions. Talk to your doctor or pharmacist to see if drinking alcohol is safe for you.
The safety of Simponi 50 mg Injection 0.5 ml during pregnancy is not fully established. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor or pharmacist to weigh the benefits of treatment against any potential risks.
Yes, your doctor will likely schedule regular blood tests to check your liver function, blood cell counts, and overall health while you are on Simponi 50 mg Injection 0.5 ml. Talk to your doctor to ensure you keep all your scheduled checkup appointments.
If you have a mild cold without a fever, you may still be able to use Simponi 50 mg Injection 0.5 ml, but it is always safest to talk to your doctor or pharmacist first. If your cold is accompanied by a fever, deep cough, or congestion, your doctor may advise you to delay your dose until you recover.
Yes, you can perform the injection yourself at home once your healthcare provider has properly trained you on the correct technique. Do not attempt to self-inject until you feel fully comfortable and confident. Talk to your doctor if you need a refresher on the steps.

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Country of origin

India

Manufacturer/Marketer address

5Th Floor, Tower A, Building No 9, Dlf Cyber City, Dlf Phase - 3, Gurgaon, Haryana - 122002, India
Other Info - SIM0135
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