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compositionComposition:GOLIMUMAB-50MG
prescriptionPrescription Medicine

Simponi 50 mg Injection 0.5 ml is primarily used in treating moderate to severe rheumatoid arthritis, active ankylosing spondylitis, active ulcerative colitis, and active psoriatic arthritis in adult patients. This medicine is used in combination with methotrexate for the treatment of autoimmune disorders. It consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive; this helps reduce inflammation and pain caused by various autoimmune diseases.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GOLIMUMAB-50MG

Manufacturer/Marketer :

Baxter India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Simponi 50 mg Injection 0.5 ml

Simponi 50 mg Injection 0.5 ml belongs to the Anti-monoclonal TNF (Tumor necrosis factor) class of medicines that help reduce signs and symptoms of autoimmune disorders. It is primarily used in the treatment of moderate to severe rheumatoid arthritis, active ankylosing spondylitis, active ulcerative colitis, and active psoriatic arthritis in adult patients. This medicine is used in combination with methotrexate for the treatment of autoimmune disorders.

Simponi 50 mg Injection 0.5 ml consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Simponi 50 mg Injection 0.5 ml may cause certain side effects such as nausea, headache, upper respiratory tract infections, dizziness, constipation, rash, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor. A trained healthcare doctor will administer Simponi 50 mg Injection 0.5 ml. Hence, do not self-administer. Your physician will decide the dose and duration of the medicine based on the type and severity of the condition.

Simponi 50 mg Injection 0.5 ml should be avoided if you are allergic to any of its components. Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50 mg Injection 0.5 ml may cause dizziness, so drive only if you are alert and focused. Simponi 50 mg Injection 0.5 ml is not recommended for use in children below 18 years of age as safety has not been established. If you are pregnant or breastfeeding, consult your doctor before taking Simponi 50 mg Injection 0.5 ml.

Uses of Simponi 50 mg Injection 0.5 ml

Simponi 50 mg Injection 0.5 ml is used in the treatment of Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Ulcerative colitis. The detailed uses of Simponi 50 mg Injection 0.5 ml are as follows:

  • Rheumatoid Arthritis (RA) : Simponi 50 mg Injection 0.5 ml is used to reduce joint pain, swelling, and prevent joint damage.
  • Psoriatic Arthritis (PsA): Simponi 50 mg Injection 0.5 ml helps manage joint and skin symptoms in adults, either alone or with other medications.
  • Juvenile Idiopathic Arthritis (JIA): Simponi 50 mg Injection 0.5 ml is approved for use in children 2 years and older with polyarticular JIA, often when other treatments haven’t worked.
  • Ankylosing Spondylitis (AS): Simponi 50 mg Injection 0.5 ml reduces spinal inflammation and stiffness in adults with this chronic condition.
  • Ulcerative Colitis (UC) : Simponi 50 mg Injection 0.5 ml is used in adults with moderate to severe UC who haven’t responded well to other treatments.

Key Benefits

Simponi 50 mg Injection 0.5 ml contains Golimumab, as an active ingredient that belongs to the class of monoclonal TNF inhibitors. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation, pain and redness caused by various autoimmune diseases.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Simponi 50 mg Injection 0.5 ml will be administered by a nurse or doctor.
  • Do not self-administer.

How Simponi 50 mg Injection 0.5 ml Works

Simponi 50 mg Injection 0.5 ml consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.
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Alcohol

Unsafe

It is not known if alcohol interacts with Simponi 50 mg Injection 0.5 ml. Please consult the doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving Simponi 50 mg Injection 0.5 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is not known whether Simponi 50 mg Injection 0.5 ml passes into human milk. Hence, if you are breastfeeding, inform your doctor before receiving Simponi 50 mg Injection 0.5 ml.

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Driving

Caution

Simponi 50 mg Injection 0.5 ml will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

Simponi 50 mg Injection 0.5 ml may cause liver disease. Inform your doctor if you have a poor appetite, yellow discolouration of the skin or eyes, and abdominal pain. If you have pre-existing or a history of liver problems, let your doctor know, as this medicine may worsen your condition.

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Kidney

Consult your doctor

Limited data on the effects of Simponi 50 mg Injection 0.5 ml in patients with kidney impairment is available. If you have a pre-existing or a history of kidney disease, inform your doctor before taking Simponi 50 mg Injection 0.5 ml.

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Children

Unsafe

Simponi 50 mg Injection 0.5 ml is not recommended for use in children below 18 years of age as safety and efficacy are not established.

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Heart

Consult your doctor

Please consult your doctor before receiving Simponi 50 mg Injection 0.5 ml if you have pre-existing heart problems. Your doctor will prescribe Simponi 50 mg Injection 0.5 ml if the benefits outweigh the risks.

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Geriatrics

Caution

Simponi 50 mg Injection 0.5 ml should be used with caution in geriatric patients. Therefore, please consult your doctor before giving Simponi 50 mg Injection 0.5 ml to elderly individuals.

What if I have taken an overdose of Simponi 50 mg Injection 0.5 ml

Since Simponi 50 mg Injection 0.5 ml is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well and get plenty of sleep.
  • Stay hydrated; drink plenty of water.

Have a query?

How Soon It Starts Working

The time required for Simponi 50 mg Injection 0.5 ml to start to work: The time required for Simponi 50 mg Injection 0.5 ml to show its action is not clinically established. The time for which the effects of Simponi 50 mg Injection 0.5 ml last: The duration of action for Simponi 50 mg Injection 0.5 ml is not clinically established.

What if you forget to take Simponi 50 mg Injection 0.5 ml

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Simponi 50 mg Injection 0.5 ml out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.

Drug Warnings

Simponi 50 mg Injection 0.5 ml should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, blood disorders, nervous system problems, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50 mg Injection 0.5 ml may cause dizziness, so drive only if you are alert and focused. Simponi 50 mg Injection 0.5 ml is not recommended for use in children below 18 years of age as safety has not been established. It is not known whether Simponi 50 mg Injection 0.5 ml can be given to pregnant and breastfeeding women. Hence, consult your doctor if you are pregnant, planning to become pregnant or are breastfeeding. Do not take live vaccines while being treated with Simponi 50 mg Injection 0.5 ml to prevent any serious consequences.

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Drug-Drug Interaction: Simponi 50 mg Injection 0.5 ml may interact with other immunosuppressants (certolizumab, infliximab, rituximab), medicines used to treat rheumatoid arthritis (anakinra), live vaccines, and other TNF inhibitors (abatacept).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: Simponi 50 mg Injection 0.5 ml should be used with caution in patients with liver or kidney disease, heart failure, diabetes, weak immune system (HIV), hepatitis B, cancer, and active serious infections.

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FAQs

Simponi 50 mg Injection 0.5 ml is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Ulcerative colitis.

Simponi 50 mg Injection 0.5 ml contains Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive.

Simponi 50 mg Injection 0.5 ml affects your immune system and makes you more susceptible to infections. It is not recommended in people with active infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, or weak immune system. Hence, inform your doctor if you have any history of these conditions beforehand.

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Author Details

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Country of origin

India

Manufacturer/Marketer address

5Th Floor, Tower A, Building No 9, Dlf Cyber City, Dlf Phase - 3, Gurgaon, Haryana - 122002, India
Other Info - SIM0135
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