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compositionComposition:GANCICLOVIR-1.5MG
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Simplovir Ophthalmic Gel 5 gm is used to treat Herpes simplex keratitis (an infection that affects the eye cornea). It contains Gancyclovir, which kills and stops the growth of the herpes simplex virus on the cornea. Thereby helping to treat herpes simplex keratitis. Common side effects of Simplovir Ophthalmic Gel 5 gm include eye irritation, burning/stinging sensation at the application site, temporary blurred vision, sensitivity to the light, swollen and runny eyes, inflammation of the eyelids, and foreign body sensation.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GANCICLOVIR-1.5MG

Manufacturer/Marketer :

Sunways (India) Pvt Ltd

Consume Type :

Ophthalmic

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Simplovir Ophthalmic Gel 5 gm

Simplovir Ophthalmic Gel 5 gm is an antiviral eye medication used to treat acute external eye infections caused by the herpes simplex virus. Specifically, it is prescribed to treat corneal ulcers, which are open sores on the outer layer of the eye. This medication works by stopping the virus from multiplying, which helps your eye heal and prevents further damage to your vision.

For the medicine to work effectively, you must apply it consistently and exactly at the intervals recommended by your doctor. Because viral eye infections can make your eyes highly sensitive, resting your eyes and avoiding prolonged screen use can support your recovery. It is also helpful to wear sunglasses when outdoors to protect your healing eye from bright sunlight and wind.

Most patients tolerate this eye gel well, though you may experience temporary blurred vision or a mild, brief stinging sensation immediately after application. If you experience severe eye pain, worsening redness, or changes in your vision that do not go away, you should stop using the gel and contact your doctor immediately.

Before using this medicine, talk to your doctor if you have any pre-existing eye conditions, such as severe dry eyes. Do not use this if you have a known allergy to Simplovir Ophthalmic Gel 5 gm or similar antiviral medications. You should also avoid wearing contact lenses throughout your entire course of treatment.

Tell your healthcare provider about any other eye drops or ointments you are using, as they can interfere with how this medicine works. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this eye gel to ensure it is safe for you and your baby.

Uses of Simplovir Ophthalmic Gel 5 gm

This medicine is used to treat viral eye infections caused by the herpes simplex virus and helps promote healing of the cornea. The detailed uses of this medicine are as follows:

  • Herpes simplex keratitis: Simplovir Ophthalmic Gel 5 gm helps treat corneal ulcers caused by the herpes simplex virus (HSV), reducing eye pain, promoting healing, and helping protect the cornea from long-term scarring and vision problems.

Key Benefits

Simplovir Ophthalmic Gel 5 gm helps control viral eye infections and supports healing of the cornea. Its benefits include:

  • Helps stop the herpes simplex virus from multiplying, limiting the spread of the infection within the eye.
  • Reduces symptoms such as eye pain, irritation, watering, redness, and sensitivity to light.
  • Promotes healing of the corneal surface while helping preserve healthy eye tissue.
  • Lowers the risk of complications, such as corneal scarring and vision impairment, when used as prescribed.
  • Supports a faster and more comfortable recovery, helping you return to your daily activities sooner.
Side effects of Simplovir Ophthalmic Gel 5 gm
  • Stop taking the medication you suspect for causing a burning sensation and talk to your doctor about other treatment options.
  • Use creams or ointments with corticosteroids on the affected area to help reduce swelling and itching.
  • Stay out of the sun and avoid extreme temperatures, as they can make the burning sensation worse.
  • Applying a cool compress to the area can help soothe it temporarily.
  • Drink lots of fluids or water to keep your skin hydrated.
  • Avoid harsh soaps, strong chemicals, hot water, and tight clothing that can irritate your skin.
  • Eat foods that are high in antioxidants and omega-3 to help keep your skin healthy.
Here are the steps to manage medication-triggered Stinging:
  • If you experience burning or stinging sensations and suspect that they may be related to medication, consult a doctor or healthcare expert to determine the cause and best course of treatment.
  • Avoid harsh products, extreme temperatures, and other potential irritants that may exacerbate burning or stinging.
  • Your healthcare professional may recommend applying a soothing or protective agent, such as a cream, gel, or ointment, to help alleviate burning or stinging.
  • Follow your healthcare professional's advice on how to care for the affected area, as gentle cleaning and care instructions may vary depending on the location and severity of the burning or stinging.
  • Schedule follow-up appointments with your doctor to monitor your symptoms and adjust your treatment plan as needed. If the burning or irritation persists or worsens, seek medical attention.
  • Eat a healthy, well-balanced diet full of vitamins, minerals, and omega-3 fatty acids to help maintain eye health.
  • Wear UV-protecting sunglasses when you are outside or in bright light.
  • Avoid touching or rubbing your eyes it may increase irritation.
  • Seek medical care if you are experiencing extreme eye pain or discomfort.
  • Wear protective eye glasses to prevent infections.
  • Avoid rubbing and touching the eyes frequently.
  • Maintain eye hygiene by cleaning them with fresh water.
  • Take food rich in vitamin-A like carrots, fish and green leafy vegetables.
  • Wash hands before touching eyes.
  • Apply a cold compress for relief.
  • Use lubricating eye drops.
  • Try over-the-counter decongestant or antihistamine drops.
  • Avoid wearing contact lenses during redness.
  • Refrain from using mobile phones or laptops at a distance that is too close to your eyes.
  • See an ophthalmologist if symptoms worsen, hurt, or affect vision.

Directions for Use

  • Simplovir Ophthalmic Gel 5 gm is typically used 1-2 times a day, or as prescribed by your healthcare provider, based on the severity of the infection.
  • Tilt your head back, gently pull down your lower eyelid to create a small pocket, and instill the prescribed number of drops into the affected eye. Close your eyes for 1-2 minutes.
  • Avoid touching the dropper tip to prevent contamination.

How Simplovir Ophthalmic Gel 5 gm Works

Simplovir Ophthalmic Gel 5 gm is an antiviral medication that specifically targets cells infected by the virus. Once applied to the eye, the active component enters the infected cells and is transformed into its active form. This active substance blocks the virus from copying its genetic material (DNA), which stops the virus from replicating and spreading. Because the medication requires viral enzymes to become fully active, it selectively treats the infection while leaving your healthy eye cells undamaged.
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Alcohol

Caution

It is unknown whether it is safe to consume alcohol with Simplovir Ophthalmic Gel 5 gm. However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Caution

Please visit your doctor. There are no competent and well-controlled studies on pregnant women. Your doctor will only provide a prescription if the benefits outweigh the risks.

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Breast Feeding

Caution

Please visit your doctor. There are no competent and well-controlled studies. Your doctor will only provide a prescription if the benefits outweigh the risks.

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Driving

Caution

Simplovir Ophthalmic Gel 5 gm may cause side effects like blurry vision, affecting your driving ability. Hence do not drive or operate machinery in such cases or Drive only when you are alert and have clear vision.

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Liver

Caution

Inform your doctor if you have any history of liver diseases or hepatic impairment before starting the use of Simplovir Ophthalmic Gel 5 gm. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor if you have any history of kidney diseases before starting the use of Simplovir Ophthalmic Gel 5 gm. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Simplovir Ophthalmic Gel 5 gm should be used for children only when advised by a doctor and in doses as prescribed, depending on the child's age and weight.

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Heart

Safe if prescribed

Simplovir Ophthalmic Gel 5 gm is generally safe for people with heart problems because it acts locally in the eye and has minimal systemic absorption. Still, it's best to consult your doctor to rule out any rare interactions or sensitivities.

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Geriatrics

Safe if prescribed

Geriatric patients can use Simplovir Ophthalmic Gel 5 gm, as it is generally well tolerated and acts locally in the eye. However, regular monitoring is advised to watch for any irritation or sensitivity.

What if I have taken an overdose of Simplovir Ophthalmic Gel 5 gm

An overdose of eye gel is highly unlikely to cause serious bodily harm. However, if you accidentally apply too much, rinse your eye thoroughly with clean, lukewarm water. If the gel is swallowed accidentally, contact a doctor or a local poison control center immediately for advice.

Diet & Lifestyle Advise

  • Avoid wearing contact lenses: Do not wear contact lenses while using Simplovir Ophthalmic Gel 5 gm or during an active viral eye infection, as they can trap the virus, delay healing, and irritate the cornea.
  • Protect your eyes from bright light: Wear sunglasses outdoors to reduce discomfort from bright light and protect your eyes from wind and dust during the healing process.
  • Avoid rubbing your eyes: Do not rub or touch your eyes, as this may worsen irritation and increase the risk of spreading the virus to the other eye or to other people.
  • Maintain good hand hygiene: Wash your hands thoroughly with soap and water before and after applying the eye medicine to reduce the spread of infection.
  • Prevent transmission: Do not share towels, pillows, eye makeup, or other personal items while you have an active viral eye infection.
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Have a query?

How Soon It Starts Working

The time required for Simplovir Ophthalmic Gel 5 gm to start to work: The exact onset time of Simplovir Ophthalmic Gel 5 gm has not been clinically established. The time for which the effects of Simplovir Ophthalmic Gel 5 gm last: The duration of Simplovir Ophthalmic Gel 5 gm’s effect is clinically not established.

What if you forget to take Simplovir Ophthalmic Gel 5 gm

If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and resume your regular schedule. Do not apply a double dose to make up for a missed one.

Storage

•Store Simplovir Ophthalmic Gel 5 gm at room temperature between 15°C and 25°C (59°F to 77°F). • Do not freeze the medication, and keep the tube tightly closed when not in use to maintain sterility.

Drug Warnings

  • Avoid contaminating the applicator: Do not let the nozzle of the tube touch your eye, fingers, or any other surface, as this can contaminate the remaining gel.
  • Space other eye medicines: Wait at least 5 to 10 minutes before applying any other eye drops or eye ointments to ensure Simplovir Ophthalmic Gel 5 gm is not washed out of the eye.
  • Complete the full course: Continue using the medicine for the full duration prescribed by your doctor, even if your symptoms improve earlier, to help prevent the infection from returning.
  • Avoid driving until vision clears: Do not drive or operate machinery immediately after applying the gel if your vision becomes temporarily blurred. Wait until your vision is completely clear.
  • Use only for prescribed viral infections: Do not use this medicine for other eye infections unless specifically instructed by your doctor, as it is effective only against certain viral infections.

Drug-Drug Interactions

verifiedApollotooltip
  • Other Ophthalmic Medications: Applying other eye drops or ointments immediately after Simplovir Ophthalmic Gel 5 gm may dilute or wash away the medicine. Always space different eye treatments at least 10 minutes apart.
GanciclovirCidofovir
Critical
GanciclovirAdalimumab
Severe

Drug-Drug Interactions

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GanciclovirCidofovir
Critical
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Coadministration of cidofovir with Simplovir Ophthalmic Gel 5 gm can increase the risk of kidney problems.

How to manage the interaction:
Although there is a interaction between Simplovir Ophthalmic Gel 5 gm and Cidofovir hence it is not recommended to be taken together, but it can be taken only if advised by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
GanciclovirAdalimumab
Severe
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Using Simplovir Ophthalmic Gel 5 gm together with adalimumab may increase the risk of serious infections.

How to manage the interaction:
Taking Simplovir Ophthalmic Gel 5 gm with adalimumab together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GanciclovirDeferiprone
Severe
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Simplovir Ophthalmic Gel 5 gm can cause higher levels of Deferiprone in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Simplovir Ophthalmic Gel 5 gm and Deferiprone together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms - like a sore throat, fever, or muscle aches - it's important to let a doctor know right away. Do not stop using any medications without a doctor's advice.
GanciclovirZidovudine
Severe
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Using zidovudine together with Simplovir Ophthalmic Gel 5 gm may increase the risk of side effects affecting the blood leading to decreased levels of blood cells.

How to manage the interaction:
Taking Simplovir Ophthalmic Gel 5 gm with zidovudine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, sore throat, rashes, tiredness, headaches, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
GanciclovirClozapine
Severe
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Clozapine can cause higher levels of Simplovir Ophthalmic Gel 5 gm in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Simplovir Ophthalmic Gel 5 gm and Clozapine, you can take these medicines together if prescribed by a doctor. If you're having any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, weight loss, or pain, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
GanciclovirGolimumab
Severe
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Using Simplovir Ophthalmic Gel 5 gm together with golimumab may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Simplovir Ophthalmic Gel 5 gm and Golimumab, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms like fever, chills, diarrhea, a sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee contact a doctor immediately. Do not stop using any medications without a doctor's advice.
GanciclovirMaribavir
Severe
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Coadministration of Simplovir Ophthalmic Gel 5 gm with Maribavir may alter the effectiveness of both these medications. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Maribavir and Simplovir Ophthalmic Gel 5 gm together can possibly result in an interaction; it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
GanciclovirEtanercept
Severe
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Using Simplovir Ophthalmic Gel 5 gm together with etanercept may increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Simplovir Ophthalmic Gel 5 gm and Etanercept, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor.
GanciclovirInfliximab
Severe
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Combining Infliximab with Simplovir Ophthalmic Gel 5 gm can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Simplovir Ophthalmic Gel 5 gm and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate contact your doctor immediately. Don't hesitate to reach out to a doctor if you experience any of these. Do not stop using any medications without a doctor's advice.
GanciclovirCertolizumab
Severe
How does the drug interact with Simplovir Ophthalmic Gel 5 gm:
Using Simplovir Ophthalmic Gel 5 gm together with certolizumab may increase the risk of serious infections.

How to manage the interaction:
Taking Simplovir Ophthalmic Gel 5 gm with certolizumab together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Simplovir Ophthalmic Gel 5 gm when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Simplovir Ophthalmic Gel 5 gm is used to treat Herpes simplex keratitis.
Simplovir Ophthalmic Gel 5 gm works by killing and stopping the growth of the herpes simplex virus on the cornea.
It is advised to remove your contact lens while using Simplovir Ophthalmic Gel 5 gm. Also, remember to wash your hands before and after using the medication to avoid contamination.
If you use other eye formulations along with Simplovir Ophthalmic Gel 5 gm, it is advised to maintain a gap of at least 5-10 minutes between each administration. Also, use eye drops before applying any eye ointments.
Avoid the contact of the dropper or tip with fingers, eyes, and eyelids when using Simplovir Ophthalmic Gel 5 gm. Topical eye products, when contaminated by patients with eye diseases, bacterial keratitis (an infection of the cornea) and ocular infections (eye infections) may occur, which result in vision loss.
Yes, Simplovir Ophthalmic Gel 5 gm is effective in the treatment of herpetic keratitis (eye ulcers caused by a herpes simplex virus infection).
Avoid using Simplovir Ophthalmic Gel 5 gm if you are allergic to any of its ingredients. However, it’s always best to consult your doctor before using Simplovir Ophthalmic Gel 5 gm if you have any allergies to medicines.
Simplovir Ophthalmic Gel 5 gm should be stored in a cool and dry place away from sunlight. Dispose of any expired or unused medicine according to local regulations and guidelines.
Yes, Simplovir Ophthalmic Gel 5 gm is safe when used as prescribed by your doctor. However, it may cause common side effects like redness, swelling, irritation, and itchy or teary eyes while using it.
No, do not stop using Simplovir Ophthalmic Gel 5 gm without consulting your doctor, even if you start feeling better. Continue using it as directed by your doctor to ensure the best results.
The common side effects of Simplovir Ophthalmic Gel 5 gm may include redness, swelling, irritated, itchy or teary eyes. Most of these side effects of Simplovir Ophthalmic Gel 5 gm do not require medical attention. However, if they persist or worsen consult your doctor immediately.
A mild, temporary burning or stinging sensation is a common side effect and usually goes away within a few minutes after application. However, if the burning is severe, worsens, or is accompanied by swelling or severe pain, stop using the gel and talk to your doctor.
You should not drive or operate machinery immediately after applying Simplovir Ophthalmic Gel 5 gm. The gel can cause temporary blurred vision for a few minutes. Wait until your vision is completely clear and sharp before driving. Talk to your doctor if you have questions about your daily activities.
No, Simplovir Ophthalmic Gel 5 gm is an antiviral medicine that is only effective against specific viral infections like herpes simplex. It will not cure bacterial, fungal, or allergic eye infections. Talk to your doctor for an accurate diagnosis of your eye symptoms.
The safety of Simplovir Ophthalmic Gel 5 gm during pregnancy and breastfeeding has not been fully established. It should only be used if the potential benefit to the mother outweighs the potential risk to the baby. Talk to your doctor to discuss your options.
You must discard the tube of Simplovir Ophthalmic Gel 5 gm 4 weeks after first opening it, even if there is still gel left inside. This is because the gel can become contaminated with bacteria over time, which could cause a new eye infection. Talk to your doctor or pharmacist if you need a new prescription.
Apply the missed dose as soon as you remember. If it is almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one. Talk to your doctor if you frequently miss doses.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

1002-1003, 10th Floor, Windfall, Sahar Plaza, J.B.Nagar, Andheri-Kurla Road, Andheri (East), Mumbai-400059. Maharashtra, India.
Other Info - SIM0097
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