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Simbrinza Opthalmic Suspension 5 ml is used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It works by decreasing the production of aqueous humour; this helps lower the increased pressure in the eye. In some cases, this medicine may cause side effects such as blurred vision, eye redness, discomfort, drowsiness and bad taste in the mouth. Avoid touching the container's tip to the eye, eyelids, or surrounding areas, as it may contaminate the product.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

Ophthalmic

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Simbrinza Opthalmic Suspension 5 ml

Simbrinza Opthalmic Suspension 5 ml is a prescription eye drop used to lower high pressure inside the eyes. It is primarily prescribed for people with open-angle glaucoma or ocular hypertension, conditions where fluid buildup can damage the optic nerve. By reducing this internal eye pressure, the medicine helps prevent progressive vision loss.

To get the best results, you must use Simbrinza Opthalmic Suspension 5 ml consistently every day at the same times as directed by your doctor. Because these are eye drops, they do not need to be taken with food, but maintaining a healthy routine is key. Making lifestyle adjustments, like eating a diet rich in leafy greens and managing stress, can also support overall eye health.

Some people using this medicine may experience mild, temporary issues like blurred vision, a bitter taste in the mouth, or slight eye irritation. If you experience serious side effects, such as severe eye pain, redness, or swelling, stop using the drops and contact your doctor immediately.

Do not take this if you have severe kidney problems or are allergic to sulfonamide medicines. Before starting, talk to your doctor if you have a history of liver damage, heart disease, depression, or dry eye syndrome.

Let your doctor know if you take central nervous system depressants, heart medicines, or other eye drops, as these can interact and cause unwanted drowsiness or blood pressure changes. Pregnant women, breastfeeding mothers, and elderly patients should consult their healthcare provider before using this medicine.

Uses of Simbrinza Opthalmic Suspension 5 ml

The following are the common eye conditions for which Simbrinza Opthalmic Suspension 5 ml may be prescribed to reduce pressure inside the eye and protect your vision:

  • Ocular Hypertension: By lowering increased pressure inside the eye, Simbrinza Opthalmic Suspension 5 ml helps prevent optic nerve damage in individuals with elevated intraocular pressure.
  • Open-Angle Glaucoma: Simbrinza Opthalmic Suspension 5 ml helps control fluid levels in the eye to maintain a safe internal pressure and protect long-term vision.
     

Key Benefits

Simbrinza Opthalmic Suspension 5 ml helps lower raised pressure inside the eye, reducing the risk of optic nerve damage and supporting long-term vision. Its dual-action formula provides effective pressure control while simplifying glaucoma treatment.

Key benefits include:

  • Protects Your Vision: By consistently lowering high pressure inside your eyes, Simbrinza Opthalmic Suspension 5 ml helps prevent gradual, irreversible damage to your optic nerve, preserving your sight.
  • Dual-Action Relief: It combines two effective pressure-lowering agents to manage fluid levels in your eye, providing more efficient pressure control than some single-ingredient drops.
  • Convenient Daily Control: It simplifies your daily routine by combining two active components into one convenient eye drop, reducing the number of bottles you need to manage.
     

Directions for Use

  • Simbrinza Opthalmic Suspension 5 ml is for ophthalmic (for eye) use only.
  • It is recommended to apply one drop of Simbrinza Opthalmic Suspension 5 ml thrice daily or as prescribed by your doctor.
  • Check the label for directions before using this medication.
  • Lie down and tilt your head backwards. Gently pull your lower eyelid with your index finger to form a pocket. Instil the prescribed number of drops into the pocket. Close your eyes for 1-2 minutes.
  • Replace the cap tightly after each use.
  • Avoid touching the container tip to the eye or eyelids to prevent contamination.

How Simbrinza Opthalmic Suspension 5 ml Works

Simbrinza Opthalmic Suspension 5 ml contains two active medicines, brinzolamide and brimonidine, that work together to lower the pressure inside the eye by reducing the production of fluid and improving its drainage. Brinzolamide is a carbonic anhydrase inhibitor. It works by reducing the amount of aqueous humour (the clear fluid inside the eye) produced by the eye. This helps lower the pressure within the eye and reduces the risk of damage to the optic nerve. Brimonidine is an alpha-2 adrenergic agonist. It works by decreasing the production of aqueous humour while also improving the drainage of fluid from the eye. These dual actions help reduce intraocular pressure more effectively. Together, these medicines help lower raised pressure inside the eye, protect the optic nerve from damage, and help preserve vision in people with ocular hypertension or open-angle glaucoma.
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Alcohol

Caution

Avoid consuming alcohol while using Simbrinza Opthalmic Suspension 5 ml as it might cause increased dizziness and drowsiness. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Simbrinza Opthalmic Suspension 5 ml belongs to pregnancy category C. Use effective contraception while using Simbrinza Opthalmic Suspension 5 ml. Avoid using Simbrinza Opthalmic Suspension 5 ml during pregnancy unless clearly indicated by the doctor. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Simbrinza Opthalmic Suspension 5 ml might pass into breastmilk. Avoid breastfeeding while using Simbrinza Opthalmic Suspension 5 ml.

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Driving

Unsafe

Simbrinza Opthalmic Suspension 5 ml might cause dizziness, drowsiness, and blurred/abnormal vision. So, avoid driving or operating machinery until your vision is clear.

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Liver

Caution

Please consult your doctor if you have any concerns regarding the usage of Simbrinza Opthalmic Suspension 5 ml in patients with liver impairment.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding the usage of Simbrinza Opthalmic Suspension 5 ml in patients with kidney impairment. Simbrinza Opthalmic Suspension 5 ml is not recommended for patients with severe kidney disease.

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Children

Unsafe

Simbrinza Opthalmic Suspension 5 ml is not recommended for children below 18 years, as the safety and effectiveness have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Simbrinza Opthalmic Suspension 5 ml. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Simbrinza Opthalmic Suspension 5 ml should be used in elderly patients only if prescribed by a doctor. If you have any concerns about using Simbrinza Opthalmic Suspension 5 ml in older adults, please consult your doctor.

What if I have taken an overdose of Simbrinza Opthalmic Suspension 5 ml

If you accidentally put too many drops in your eye, rinse it thoroughly with warm water. If the medicine is swallowed by accident, seek medical attention or contact a poison control center immediately, especially if it involves a child, as it can cause serious side effects like drowsiness or slowed breathing.

Diet & Lifestyle Advise

  • Eat eye-healthy foods: Focus on foods rich in antioxidants, vitamins, and minerals, such as dark leafy greens (spinach, kale) and fish high in omega-3 fatty acids, which support optic nerve health.
  • Exercise moderately: Regular, moderate aerobic exercise like walking can help reduce eye pressure, but avoid intense activities or yoga poses that involve head-down positions, as these can increase pressure.
  • Stay hydrated gradually: Drink water throughout the day rather than consuming large quantities of fluids all at once, which can temporarily spike eye pressure.
  • Elevate your head: Use a wedge pillow to keep your head slightly elevated (about 20 degrees) while sleeping, which may help lower eye pressure during the night.
  • Avoid rubbing your eyes: Rubbing your eyes can irritate them further and potentially interfere with how the medicine works.
     
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How Soon It Starts Working

The time required for Simbrinza Opthalmic Suspension 5 ml to start to work: Simbrinza Opthalmic Suspension 5 ml ideally shows its action within 1 hour of administration.

The time for which the effects of Simbrinza Opthalmic Suspension 5 ml last: Simbrinza Opthalmic Suspension 5 ml effect lasts for 12 hours.

What if you forget to take Simbrinza Opthalmic Suspension 5 ml

If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed drop and continue with your regular routine. Do not apply double the amount of medicine to make up for a missed dose.

Storage

•Store Simbrinza Opthalmic Suspension 5 ml upright at room temperature, ideally between 2°C and 25°C (36°F to 77°F).

Drug Warnings

  • Remove contact lenses: If you wear soft contact lenses, remove them before applying Simbrinza Opthalmic Suspension 5 ml. Wait at least 15 minutes after using the drops before putting your lenses back in, as the preservative in the drops can discolour lenses.
  • Inspect the bottle: Shake the bottle well before each use. Do not use the drops if the solution looks discoloured, cloudy, or contains particles.
  • Keep the dropper sterile: Never touch the dropper tip to your eye, fingers, or any surface. A contaminated dropper can cause a serious eye infection.
  • Wait between medications: If you use other eye drops, wait at least 10 minutes between using Simbrinza Opthalmic Suspension 5 ml and your other eye medications to prevent the drops from washing each other out.
  • Avoid driving immediately: Your vision may be temporarily blurry after applying the drops. Wait until your vision clears completely before driving or operating machinery.
     

Drug-Drug Interactions

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  • Oral carbonic anhydrase inhibitors: Taking these medications systemically alongside Simbrinza Opthalmic Suspension 5 ml may increase the risk of side effects like fluid and electrolyte imbalances.
  • Central nervous system depressants: Combining these drops with alcohol, sleeping pills, or sedative pain medicines may increase drowsiness and fatigue.
  • Heart and blood pressure medicines: Taking these with beta-blockers or cardiac glycosides may lead to low blood pressure or an abnormally slow heart rate.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No clinically significant food interactions are known with Simbrinza Opthalmic Suspension 5 ml when used as directed.     
 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIGLAUCOMA AGENTS]

FAQs

Simbrinza Opthalmic Suspension 5 ml is used to lower high intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Simbrinza Opthalmic Suspension 5 ml decreases the production of aqueous humour, thereby helping to lower the increased pressure in the eye.
Simbrinza Opthalmic Suspension 5 ml might cause blurred or abnormal vision. So, avoid driving or operating machinery until your vision is clear to prevent any mishap.
Dry mouth could be a side effect of Simbrinza Opthalmic Suspension 5 ml. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Simbrinza Opthalmic Suspension 5 ml can be used with other eye medications if prescribed by the doctor. However, maintain a gap of 5-10minutes between Simbrinza Opthalmic Suspension 5 ml and other eye medications.
Simbrinza Opthalmic Suspension 5 ml may cause common side effects such as blurred vision, eye redness, discomfort, drowsiness, and a bad taste in the mouth. In most cases, these side effects are temporary and don't require medical attention, resolving on their own over time. However, if you experience persistent side effects, it's best to consult your doctor for guidance.
Yes, Simbrinza Opthalmic Suspension 5 ml requires a prescription. It is a combination of brinzolamide and brimonidine, used to treat elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Simbrinza Opthalmic Suspension 5 ml is not recommended for individuals allergic to its components, those taking monoamine oxidase inhibitors or antidepressants, and people with severe kidney problems or excess acidity in the blood. Additionally, children under 18 years old should not take Simbrinza Opthalmic Suspension 5 ml, as its safety and effectiveness have not been established. If you have liver problems, narrow-angle glaucoma, dry eyes, cornea problems, coronary heart disease, depression, or poor blood circulation, inform your doctor before taking pramipexole.
Lie down and tilt your head backwards. Gently pull your lower eyelid with your index finger to form a pocket. Instil the number of drops advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes.
No, you should remove your contact lenses before applying these eye drops because they contain preservatives that can damage or discolour soft lenses. You can safely reinsert your lenses 15 minutes after applying the drops. Talk to your doctor if your eyes feel excessively dry.
Yes, because Simbrinza Opthalmic Suspension 5 ml is an ophthalmic suspension, the active ingredients can settle at the bottom. Shaking the bottle well before each use ensures you get the correct, even mixture of the medicine. Talk to your doctor or pharmacist if you are unsure how to use it.
It is common to experience mild, temporary stinging or burning immediately after applying the drops. If this discomfort is severe, does not go away after a few minutes, or worsens over time, stop using the drops and talk to your doctor.
Yes, a bitter or unusual taste in the mouth is a common side effect. This happens because the drops can drain through your tear ducts into the back of your throat. To minimize this, press gently on the inner corner of your eye for 1 to 2 minutes after applying. Talk to your doctor if this becomes too bothersome.
No, you must not stop using this medicine suddenly, even if your eye pressure has returned to normal. Stopping the drops can cause your eye pressure to spike again, which can lead to permanent vision loss. Talk to your doctor before making any changes.
Yes, some people may feel drowsy, dizzy, or fatigued after using these drops, especially since one of the active ingredients can affect the central nervous system. Avoid driving or operating machinery until you know how this medicine affects you, and talk to your doctor if you feel excessively tired.
The safety of this medicine during pregnancy or breastfeeding is not fully established, and it could potentially affect the baby. You should weigh the benefits and risks with your healthcare provider. Talk to your doctor to find the safest option for your eye health.

Disclaimer

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Country of origin

INDIA

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India.
Other Info - SIM0163
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