Sigrima 420 mg Injection 14 ml

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MRP ₹74995

(Inclusive of all Taxes)

₹11249.3 Cashback (15%)

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Written By Lakshmithulasi Yarragunta ,

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Sigrima 420 mg Injection 14 ml is used in the treatment of Breast cancer. It contains Pertuzumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in mammalian cells; this causes inhibition of the cancer cell growth and, finally, initiating apoptosis. Sigrima 420 mg Injection 14 ml is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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About Sigrima 420 mg Injection 14 ml

Sigrima 420 mg Injection 14 ml is an anti-cancer medicine used in the treatment of Breast cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. The abnormal growth of cancer (malignant) cells in the breast is known as breast cancer. Sigrima 420 mg Injection 14 ml is combined with trastuzumab and docetaxel for treating patients with HER2-positive metastatic breast cancer who have not received any chemotherapy for metastatic breast cancer. This medicine is also used in combination with docetaxel and trastuzumab as a neoadjuvant treatment of breast cancer in patients with HER2-positive (human epidermal growth factor receptor 2) or as part of a complete treatment regimen for early breast cancer.

Sigrima 420 mg Injection 14 ml contains Pertuzumab as a active ingredient which belongs to the class of monoclonal antibodies. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Sigrima 420 mg Injection 14 ml may cause certain side effects such as fatigue, nausea, headache, vomiting, dizziness, hair loss, constipation, dry skin, myalgia, upper respiratory tract infections, diarrhea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Sigrima 420 mg Injection 14 ml. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Sigrima 420 mg Injection 14 ml should be avoided if you are allergic to it or any other components of this medicine. Sigrima 420 mg Injection 14 ml may cause left ventricular dysfunction, anaphylaxis, or hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. If any changes or hypersensitivity reactions occur, treatment should be discontinued. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Sigrima 420 mg Injection 14 ml is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand. The use of Sigrima 420 mg Injection 14 ml along with the doxorubicin-containing regimen is not established. Hence, if you are on such treatment, inform your doctor before starting the treatment. Sigrima 420 mg Injection 14 ml is not recommended for use in children as the safety and efficacy are not established.

Uses of Sigrima 420 mg Injection 14 ml

Sigrima 420 mg Injection 14 ml is used in the treatment of Breast Cancer. The detailed uses of Sigrima 420 mg Injection 14 ml are as follows:

Metastatic HER2-Positive Breast Cancer: Sigrima 420 mg Injection 14 ml is used in combination with trastuzumab and docetaxel as a first-line treatment for patients who haven’t received prior anti-HER2 therapy for metastatic disease.
Neoadjuvant Therapy: Sigrima 420 mg Injection 14 ml is given before surgery to shrink tumors in locally advanced or early-stage HER2-positive breast cancer.
Adjuvant Therapy: Sigrima 420 mg Injection 14 ml is used after surgery in patients with early-stage HER2-positive breast cancer who are at high risk of recurrence.

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Directions for Use

Follow your doctor’s instructions on the dosage and timing of this medication.
Sigrima 420 mg Injection 14 ml will be administered by a nurse or doctor.
Do not self-administer.

Medicinal Benefits

Sigrima 420 mg Injection 14 ml contains Pertuzumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis. Sigrima 420 mg Injection 14 ml is used in combination with trastuzumab and docetaxel for the treatment of breast cancer.

How Sigrima 420 mg Injection 14 ml Works

Sigrima 420 mg Injection 14 ml contains Pertuzumab as a active ingredient which belongs to the class of monoclonal antibodies. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Storage

• Store in a cool and dry place away from sunlight.• Keep Sigrima 420 mg Injection 14 ml out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.

Side effects of Sigrima 420 mg Injection 14 ml

Itching

Here are the few steps for dealing with itching caused by drug use:

Report the itching to your doctor immediately; they may need to change your medication or dosage.
Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
Try not to scratch, as this can worsen the itching and irritate your skin.
If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Hair Loss

Eat protein-rich foods like fish, poultry, eggs, and legumes.
Include foods with minerals and vitamins essential for hair health.
Join a support group to connect with others experiencing hair loss.
Openly discuss your feelings about hair loss.
Consider covering up with wigs, hats, or scarves.
Be patient and avoid seeking miracle cures.

Rash

Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
Protect your skin from extreme heat and try to apply wet compresses.
Soak in the cool bath, which gives a soothing impact to the affected area.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Less Hunger

Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
Prefer foods high in fiber to help feel full for a long time.
If you have decreased appetite, eat only when you are hungry.
Eat several small meals or snacks all day.
Try to take only small sips of fluids while eating.

Cough

Here are the steps to manage the medication-triggered Cough:

Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

What if I have taken an overdose of Sigrima 420 mg Injection 14 ml

Since Sigrima 420 mg Injection 14 ml is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Sigrima 420 mg Injection 14 ml may cause diarrhoea, alopecia, neutropenia, nausea, fatigue, rash, and/or peripheral neuropathy, and left ventricular dysfunction (i.e. cardiotoxicity).

Drug Warnings

Sigrima 420 mg Injection 14 ml should be avoided if you are allergic to it or any other components of this medicine. Sigrima 420 mg Injection 14 ml may cause left ventricular dysfunction, anaphylaxis, or hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. If any changes or hypersensitivity reactions occur, treatment should be discontinued. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Sigrima 420 mg Injection 14 ml is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand. The use of Sigrima 420 mg Injection 14 ml along with the doxorubicin-containing regimen is not established. Hence, if you are on such treatment, inform your doctor before starting the treatment. Sigrima 420 mg Injection 14 ml is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy.
Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired.
Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

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Alcohol

Unsafe

Alcohol intake might increase the risk of worsening your condition. Hence, avoid alcohol consumption till your condition improves.

Pregnancy

Unsafe

Sigrima 420 mg Injection 14 ml is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Sigrima 420 mg Injection 14 ml. Use reliable methods of birth control while on treatment with Sigrima 420 mg Injection 14 ml.

Breast Feeding

Caution

It is not known whether Sigrima 420 mg Injection 14 ml is excreted in breast milk. Hence, if you are breastfeeding, inform your doctor before receiving Sigrima 420 mg Injection 14 ml. Your doctor will weigh the benefits and the risks before prescribing this medicine.

Driving

Caution

Sigrima 420 mg Injection 14 ml will be administered in the hospital setting. Driving is not recommended while on therapy.

Liver

Caution

No clinical trials have assessed the impact of hepatic impairment on the pharmacokinetics of Sigrima 420 mg Injection 14 ml. Hence, if you have a pre-existing or a history of liver disease, inform your doctor.

Kidney

Caution

Limited data are available on the effect of Sigrima 420 mg Injection 14 ml in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

Children

Unsafe

Sigrima 420 mg Injection 14 ml is not recommended for use in children as the safety and efficacy are not established.

Heart

Sigrima 420 mg Injection 14 ml may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Sigrima 420 mg Injection 14 ml.

Geriatrics

Safe if prescribed

Sigrima 420 mg Injection 14 ml is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

FAQs

What is the use of Sigrima 420 mg Injection 14 ml?

Sigrima 420 mg Injection 14 ml is used to treat Breast Cancer.

How does Sigrima 420 mg Injection 14 ml work?

Sigrima 420 mg Injection 14 ml contains Pertuzumab, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

What are the points to be informed to the doctor before starting treatment?

Inform your doctor whether you have received any other breast cancer treatment containing doxorubicin in your medication list. Sigrima 420 mg Injection 14 ml may cause left ventricular dysfunction, anaphylaxis, hypersensitivity reactions, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, are pregnant, are planning to become pregnant, or are breastfeeding before receiving Sigrima 420 mg Injection 14 ml.

Country of origin

India

Manufacturer/Marketer address

Zydus Corporate Park, 4Th Floor, B Wing, Plot No 103, Near Nirma University,S G Highway, Ahmedabad, 382481

Other Info - SIG0147

Author Details

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 22, 2025 | 7:26 AM IST

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