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  3. Signoflam-TH 4 Tablet 10's

Signoflam-TH 4 Tablet 10's, Pack of 10 TABLETS
Signoflam-TH 4 Tablet 10's, Pack of 10 TABLETS
Signoflam-TH 4 Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Signoflam-TH 4 Tablet is used to relieve pain and inflammation associated with musculoskeletal and joint disorders. It works by relieving muscle stiffness and blocking chemical messengers that cause pain and inflammation. In some cases, this medicine may cause side effects such as nausea, vomiting, stomach pain, loss of appetite, heartburn, and diarrhoea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

ACECLOFENAC-100MG + PARACETAMOL-325MG + THIOCOLCHICOSIDE-4MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Signoflam-TH 4 Tablet

Signoflam-TH 4 Tablet is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, and bone and joint pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. Arthritis is tenderness and swelling in the joints.

Signoflam-TH 4 Tablet contains Thiocolchicoside (muscle relaxant), Aceclofenac (NSAID), and Paracetamol (Analgesic). Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation.  Together, Signoflam-TH 4 Tablet helps in relieving pain due to muscle spasms.

You are advised to take Signoflam-TH 4 Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as nausea, vomiting, stomach pain, loss of appetite, heartburn, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Signoflam-TH 4 Tablet may cause drowsiness and dizziness, so drive with caution. Signoflam-TH 4 Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Signoflam-TH 4 Tablet as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Signoflam-TH 4 Tablet

Pain and inflammation associated with musculoskeletal and joint disorders.

Directions for Use

• It is advised to take Signoflam-TH 4 Tablet with food to avoid any stomach upset or as advised by a doctor.• Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.• Swallow Signoflam-TH 4 Tablet as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Signoflam-TH 4 Tablet is a combination of three drugs, namely: Thiocolchicoside, Aceclofenac, and Paracetamol. Signoflam-TH 4 Tablet is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, bone and joint pain. Signoflam-TH 4 Tablet increases the pain threshold and blood flow across the skin. Thiocolchicoside is a muscle relaxant which works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac and Paracetamol are analgesics that block the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make another chemical, prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking COX enzymes' effect, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, Signoflam-TH 4 Tablet helps in relieving pain due to muscle spasms.

How Signoflam-TH 4 Tablet Works

Signoflam-TH 4 Tablet contains Thiocolchicoside (muscle relaxant), Aceclofenac (NSAID), and Paracetamol (Analgesic). Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation. Together, Signoflam-TH 4 Tablet helps in relieving pain due to muscle spasms.

Storage

Keep Signoflam-TH 4 Tablet out of reach and sight of children.
Side effects of Signoflam-TH 4 Tablet
  • Do not consume spicy foods, caffeine, and alcohol.
  • Choose low-acid fruits and vegetables like apples, melons, and carrots.
  • Include whole grains like whole-wheat bread, oatmeal, and brown rice.
  • Limit processed meats like hotdogs and sausages.
  • Avoid fatty, spicy, or acidic salad dressings.
  • Limit tomatoes and tomato-based products.
  • Quit smoking to promote ulcer healing.
  • Adopt a balanced diet and lifestyle to reduce the risk of peptic ulcers.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

What if I have taken an overdose of Signoflam-TH 4 Tablet

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include severe abdominal pain, nausea, vomiting, and confusion. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Signoflam-TH 4 Tablet if you are allergic to any of its contents; if you have/had severe heart problems, stomach ulcer or perforation, and bleeding problems such as bleeding from the stomach, intestine or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of intestines. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, diabetes, asthma, inflammatory bowel disease, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Signoflam-TH 4 Tablet may cause drowsiness and dizziness, so drive only if you are alert. Signoflam-TH 4 Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Signoflam-TH 4 Tablet as it could lead to increased drowsiness and increased risk of stomach bleeding. Stop taking Signoflam-TH 4 Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Signoflam-TH 4 Tablet unless prescribed.

Drug-Drug Interactions

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AceclofenacAtenolol
Severe
ParacetamolLeflunomide
Severe

Drug-Drug Interactions

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AceclofenacAtenolol
Severe
How does the drug interact with Signoflam-TH 4 Tablet:
Co-administration of Atenolol with Signoflam-TH 4 Tablet could increase the risk of low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Atenolol and Signoflam-TH 4 Tablet, you can take these medicines together if prescribed by a doctor. Consult a doctor if you experience excessive sweating, shortness of breath, palpitations, or chest discomfort. Do not discontinue any medications without consulting a doctor.
ParacetamolLeflunomide
Severe
How does the drug interact with Signoflam-TH 4 Tablet:
Co-administration of Signoflam-TH 4 Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Signoflam-TH 4 Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolValdecoxib
Severe
How does the drug interact with Signoflam-TH 4 Tablet:
Co-administration of Signoflam-TH 4 Tablet and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Signoflam-TH 4 Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Signoflam-TH 4 Tablet:
Co-administration of Mipomersen with Signoflam-TH 4 Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Signoflam-TH 4 Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with Signoflam-TH 4 Tablet:
Co-administration of Signoflam-TH 4 Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Signoflam-TH 4 Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Signoflam-TH 4 Tablet:
Co-administration of Lomitapide and Signoflam-TH 4 Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Signoflam-TH 4 Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolOxazepam
Severe
How does the drug interact with Signoflam-TH 4 Tablet:
Co-administration of Signoflam-TH 4 Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Signoflam-TH 4 Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolKetamine
Severe
How does the drug interact with Signoflam-TH 4 Tablet:
Co-administration of ketamine and Signoflam-TH 4 Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Signoflam-TH 4 Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolTeriflunomide
Severe
How does the drug interact with Signoflam-TH 4 Tablet:
Co-administration of Teriflunomide with Signoflam-TH 4 Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Signoflam-TH 4 Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.

  • Massages can also be helpful.

  • Avoid freezing and hot temperatures.

  • Avoid wearing tight-fitting clothes, instead, wear loose garments.

  • Rest well, and get plenty of sleep.

  • To avoid developing pressure sores, change your position every two hours.

  • Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.

  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS

Signoflam-TH 4 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Signoflam-TH 4 Tablet as it may cause increased drowsiness. It can also increase the risk of stomach bleeding.

bannner image

Pregnancy

Caution

Please consult your doctor if you are pregnant; your doctor will prescribe Signoflam-TH 4 Tablet only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Signoflam-TH 4 Tablet can be taken by breastfeeding mothers or not.

bannner image

Driving

Caution

Signoflam-TH 4 Tablet may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Signoflam-TH 4 Tablet should not be given to children as safety and effectiveness were not established.

Have a query?

FAQs

Signoflam-TH 4 Tablet is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, bone and joint pain.

Signoflam-TH 4 Tablet contains Thiocolchicoside, Aceclofenac, and Paracetamol. Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac and Paracetamol work by blocking the chemical messengers that cause pain and inflammation at the injured or damaged site.

Signoflam-TH 4 Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Arthritis is tenderness and swelling in the joints.

Diarrhoea might be a side-effect of Signoflam-TH 4 Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Signoflam-TH 4 Tablet should not be taken for longer durations unless prescribed by the doctor. If Signoflam-TH 4 Tablet has been prescribed for longer durations, regular monitoring of kidney function, liver function, and blood count is advised, particularly in elderly patients.

Signoflam-TH 4 Tablet may cause abnormal chromosome numbers in the sperm cells, which might damage sperm. This might cause problems with male fertility. Consult your doctor before taking Signoflam-TH 4 Tablet if you plan to become a father.

Dry mouth could be a side-effect of Signoflam-TH 4 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of mouth.

Do not take Signoflam-TH 4 Tablet with other painkillers, such as aspirin, ibuprofen, naproxen, celecoxib, or etoricoxib, unless your doctor advises it. Combining Signoflam-TH 4 Tablet with other painkillers can increase the risk of serious side effects, including stomach irritation, liver damage, or kidney problems, and may also interact with other medications.

Signoflam-TH 4 Tablet is not an antibiotic. It is a combination medication containing Aceclofenac (a non-steroidal anti-inflammatory drug), Paracetamol (a pain and fever reliever), and Thiocolchicoside (a muscle relaxant). None of these ingredients have antibacterial properties.

The common side effects of Signoflam-TH 4 Tablet include nausea, vomiting, stomach pain, loss of appetite, heartburn, and diarrhoea. Most of these side effects of Signoflam-TH 4 Tablet do not require medical attention and will resolve gradually over time. However, if the side effects persist, please consult your doctor.

Although Signoflam-TH 4 Tablet contains pain-relieving ingredients Thiocolchicoside, Aceclofenac, and Paracetamol, this specific combination is not designed to treat period pain. If you're experiencing menstrual cramps or discomfort, consult your healthcare provider for proper diagnosis and treatment. They will help identify the underlying cause of your pain and recommend appropriate treatment options to address it. Don't rely solely on painkillers; seek medical attention to receive personalized care and find relief from your period pain.

No, do not take Signoflam-TH 4 Tablet for toothache pain unless your doctor or dentist has specifically advised you to do so. Toothaches can be a symptom of various underlying conditions, and Signoflam-TH 4 Tablet may not address the root cause of your pain. Additionally, using Signoflam-TH 4 Tablet without a proper diagnosis and guidance from a healthcare professional may lead to delayed or inadequate treatment, potentially causing more severe problems. Always consult your doctor or dentist to determine the best course of treatment for your specific needs.

Signoflam-TH 4 Tablet is a painkiller medication that combines three active ingredients: Aceclofenac, an anti-inflammatory, Paracetamol, a pain reliever, and Thiocolchicoside, a muscle relaxant.

When your pain subsides, you can discontinue taking Signoflam-TH 4 Tablet . However, it's crucial to adhere to the treatment duration recommended by your doctor to ensure the medication's effectiveness. Abruptly stopping Signoflam-TH 4 Tablet may compromise its pain-relieving and anti-inflammatory benefits.

Signoflam-TH 4 Tablet is contraindicated in patients who are allergic to any of its components. Do not take Signoflam-TH 4 Tablet if you have severe heart problems, stomach ulcers or perforations, bleeding problems (such as bleeding from the stomach, intestine, or brain), a history of bypass surgery, heart attack, blood circulation issues, or inflammation of the intestines.

It is generally safe to take Signoflam-TH 4 Tablet with a vitamin B-complex supplement, as there are no significant known interactions between them. However, please consult your doctor before taking any supplements to ensure they are safe based on your health condition.

The use of Signoflam-TH 4 Tablet may cause kidney damage if taken in high doses or for a long time. Normally, the kidneys produce prostaglandins, a chemical that helps protect them from damage. Prolonged use of Signoflam-TH 4 Tablet (painkillers) reduces the levels of prostaglandins, increasing the risk of kidney damage. If you have a history of kidney problems, please consult your doctor, as they may need to adjust your dosage.

Taking a higher dose of Signoflam-TH 4 Tablet may increase the risk of side effects without significantly improving its effectiveness. It may lead to adverse effects such as liver damage (from Paracetamol) or gastrointestinal problems (from Aceclofenac). Please follow the recommended dosage and consult your doctor before making any changes.

The use of Signoflam-TH 4 Tablet can cause liver damage if taken in high doses or for a long time. Its ingredients, particularly Paracetamol and Aceclofenac, are known to be harmful to the liver when overused. If you have a history of liver problems, please consult your doctor, as they may need to adjust your dosage.

Signoflam-TH 4 Tablet should be stored in a cool and dry place, away from direct sunlight. Keep it out of reach of children.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - SIG0079

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 18, 2025 | 6:46 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://mri.cts-mrp.eu/human/downloads/PT_H_2236_001_FinalPI_2of3.pdf
  2. https://tajgenerics.com/portfolio-item/aceclofenac-and-paracetamol-tablets-b-p-100mg-325mg-acetaj-p/
  3. https://vibcare.co.in/aceclofenac-thiocolchicoside/

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