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  3. Siglipol 50 Tablet

Siglipol 50 Tablet, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Siglipol 50 Tablet is used to lower high blood sugar levels in patients who consistently follow a balanced diet and exercise. It contains Sitagliptin, which works by increasing the amount of insulin in the body. It may cause side effects such as upper respiratory tract infections, headaches, and nasopharyngitis (inflammation of the nasal passages). Before starting this medicine, inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Composition :

SITAGLIPTIN-50MG

Manufacturer/Marketer :

Medipol Pharmaceutical India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Siglipol 50 Tablet

Siglipol 50 Tablet belongs to the group of anti-diabetic medicines called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors) used to treat type-2 diabetes mellitus. Type 2 diabetes mellitus is a condition in which blood sugar is too high because the body does not produce or use insulin normally.

Siglipol 50 Tablet contains Sitagliptin, which works by blocking the action of DPP-4 (dipeptidyl peptidase-4) and increasing the amount of insulin made by the body. Thus, it helps lower blood glucose levels.

In some cases, Siglipol 50 Tablet may cause side effects such as upper respiratory tract infections, headache, and nasopharyngitis (inflammation of the nasal passages). Most of these side effects may not require medical attention and resolve gradually over time. However, you are advised to consult the doctor if any side effects persist or worsen.

Do not take Siglipol 50 Tablet if you are allergic to any of its components. Consult the doctor if you are pregnant or breastfeeding. Siglipol 50 Tablet is not recommended for children below 18 years. Keep your doctor informed about your health condition and medications to rule out any unpleasant side effects/interactions.

Uses of Siglipol 50 Tablet

Siglipol 50 Tablet is used in the treatment of type 2 diabetes mellitus. The detailed uses of Siglipol 50 Tablet are as follows:

  • Type 2 Diabetes Management: Siglipol 50 Tablet is used alongside diet and exercise to regulate blood sugar.
  • Improved Insulin Response: Siglipol 50 Tablet enhances insulin production and reduces glucose levels.

Directions for Use

  • Siglipol 50 Tablet can be taken with or without food.
  • It is usually taken once daily or as prescribed by your doctor.
  • Swallow Siglipol 50 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Siglipol 50 Tablet contains Sitagliptin, a DPP-4 (dipeptidyl peptidase-4) inhibitor used in the management of type 2 diabetes mellitus.
  • It is typically prescribed as an adjunct to diet and exercise to improve blood sugar control in adults.
  • It increases insulin production by the pancreas, especially after meals, to better regulate blood sugar spikes.
  • Reduces the secretion of glucagon, a hormone that raises blood sugar levels, thereby helping maintain better glucose balance.
  • When used with diet and exercise, it helps in maintaining consistent blood glucose levels over time. 
  • Siglipol 50 Tablet lowers the chances of long-term complications such as diabetic retinopathy (eye damage), nephropathy (kidney damage), and neuropathy (nerve damage) by maintaining stable blood sugar levels.

How Siglipol 50 Tablet Works

Siglipol 50 Tablet contains Sitagliptin, which works by blocking the action of DPP-4 (dipeptidyl peptidase-4) and increasing the amount of insulin made by the body. Thus, it helps lower blood glucose levels.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Siglipol 50 Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

What if I have taken an overdose of Siglipol 50 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose: you may be at higher risk of serious side effects such as a low blood sugar reaction and severe gastrointestinal problems. Seek immediate medical attention if you experience these symptoms.

Drug Warnings

  • Do not take Siglipol 50 Tablet if you are allergic to any of its components.
  • Inform your doctor if you have kidney or liver problems, pancreatitis (inflammation of the pancreas), gallstones, type 1 diabetes, diabetic ketoacidosis (a complication of diabetes with high blood sugar, rapid weight loss, nausea or vomiting), a history of alcoholism, heart problems/heart failure, or high blood triglyceride levels.
  • Consult your doctor if you are pregnant or breastfeeding.
  • Seek medical attention if you experience symptoms of pancreatitis (severe abdominal pain) or heart failure (shortness of breath, swelling in the legs, unusual tiredness).
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
SitagliptinGatifloxacin
Critical
SitagliptinIvacaftor
Severe

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
How does the drug interact with Siglipol 50 Tablet:
Co-administration of Siglipol 50 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Taking Siglipol 50 Tablet with Gatifloxacin is not recommended as it can lead to a possible interaction, However, it can be taken if advised by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not stop using any medications without a doctor's advice.
SitagliptinIvacaftor
Severe
How does the drug interact with Siglipol 50 Tablet:
When Siglipol 50 Tablet is taken with Ivacaftor, the amount of Siglipol 50 Tablet in the blood can go up.

How to manage the interaction:
Taking Siglipol 50 Tablet with Ivacaftor together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
SitagliptinTirzepatide
Moderate
How does the drug interact with Siglipol 50 Tablet:
As tirzepatide and Siglipol 50 Tablet both work through similar pathways in the body, it is possible that using them together may result in an increase in side effects.

How to manage the interaction:
It is essential to inform your doctor about all other medications you are taking, including vitamins and herbal supplements. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include fruits, vegetables, whole grains, and beans in your diet.
  • Try eating food at regular intervals. Do not skip meals. Also, try not to overeat.
  • Maintain a healthy weight by exercising regularly.
  • Rest properly.
  • Avoid stress by doing meditation or yoga.
  • Limit saturated and processed food.
  • Stay physically active as it helps manage blood glucose levels.
  • Avoid/limit the consumption of alcohol as it may affect blood sugar levels.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Siglipol 50 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

It is not known if alcohol interacts with Siglipol 50 Tablet. However, avoid/limit alcohol consumption as it might affect blood sugar levels.

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Pregnancy

Caution

Sitagliptin belongs to pregnancy category B. There are no adequate and well-controlled studies in pregnant women. Please consult your doctor if you are pregnant or planning to become pregnant.

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Breast Feeding

Caution

Siglipol 50 Tablet should be taken with caution if you are breastfeeding. Please consult your doctor for more information about using Siglipol 50 Tablet during lactation.

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Driving

Caution

This medicine may cause dizziness and drowsiness. Drive or operate machinery only if you are alert.

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Liver

Consult your doctor

If you have liver disease, inform your doctor before taking Siglipol 50 Tablet.

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Kidney

Caution

Dose adjustment may be needed in patients with moderate or severe renal insufficiency. Please consult the doctor if you have kidney problems.

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Children

Unsafe

Siglipol 50 Tablet is not recommended for children below 18 years as the safety and effectiveness have not been established.

Have a query?

FAQs

Siglipol 50 Tablet is used to treat type 2 diabetes mellitus. It helps manage blood sugar levels.

Siglipol 50 Tablet works by increasing the amount of insulin made by the body. Thus, it helps lower blood glucose levels.

Do not stop taking Siglipol 50 Tablet without consulting your doctor, as it may cause an increase in blood glucose levels. Continue taking Siglipol 50 Tablet for as long as your doctor has prescribed it to you. Speak with your doctor if you experience any difficulty while taking Siglipol 50 Tablet.

Some people taking Siglipol 50 Tablet may develop joint pain that could be severe. Consult the doctor if you have severe joint pain.

Siglipol 50 Tablet may cause hypoglycaemia (low blood sugar) when taken in combination with other anti-diabetic medications. Talk to the doctor if you experience symptoms of low blood sugar, such as headache, dizziness, sweating, hunger, irritability, confusion, and fast heartbeat.

Eat healthy by including fruits, vegetables and whole grains in your diet. Maintain an active lifestyle by exercising regularly. Manage stress by doing deep breathing or yoga. Avoid smoking and alcohol consumption.

Siglipol 50 Tablet should be swallowed as a whole with water; do not crush or chew it.

Siglipol 50 Tablet can be taken during pregnancy only if prescribed by the doctor.

Siglipol 50 Tablet may not cause weight gain. Maintain proper weight by eating healthy food and exercising regularly.

Siglipol 50 Tablet may cause kidney problems, sometimes requiring dialysis. The doctor will monitor kidney function before and during treatment with Siglipol 50 Tablet.

Siglipol 50 Tablet is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Therefore, it is important to stay on the diet and exercise recommended by your doctor while taking Siglipol 50 Tablet.

You may experience hypoglycaemia (low blood sugar) if you take more than the prescribed dose of Siglipol 50 Tablet. Monitor your blood sugar levels regularly and consult the doctor if you have overdosed.

If you miss a dose of Siglipol 50 Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.

Yes, it is safe to take Siglipol 50 Tablet for the long term if prescribed by the doctor.

You are advised to take Siglipol 50 Tablet for the duration prescribed by the doctor. As type 2 diabetes is a lifelong condition, Siglipol 50 Tablet may be prescribed for a longer duration.

Siglipol 50 Tablet may cause serious side effects like pancreatitis (inflammation of the pancreas), and heart failure. Consult the doctor if you experience severe and persistent pain in the abdomen as it could be a sign of an inflamed pancreas. Seek immediate medical attention if you have signs of heart failure like shortness of breath or trouble breathing, fluid retention, unusually fast increase in weight, and unusual tiredness.

Siglipol 50 Tablet may cause side effects such as upper respiratory tract infections, headache, and nasopharyngitis (inflammation of nasal passages). Consult the doctor if any side effects persist or worsen.

Avoid using Siglipol 50 Tablet if you are allergic to any of its components. It should not be used in patients with type 1 diabetes, or pancreatitis.

Siglipol 50 Tablet may interact with some medicines, hence, let the doctor know if you are taking any other medicines during treatment with Siglipol 50 Tablet. Particularly, inform the doctor if you are using insulin, digoxin, furosemide or levothyroxine.

Regular monitoring of blood sugar levels is advised. It is recommended to stay on your prescribed diet and exercise program while taking Siglipol 50 Tablet. Consult the doctor if you have stress, fever, trauma, infection or surgery; the doctor may adjust the dose in such cases.

On prolonged use, Siglipol 50 Tablet may increase the risk of pancreatitis and kidney problems.

Country of origin

India
Other Info - SI51717

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 6, 2025 | 10:58 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021995s019lbl.pdf
  2. https://www.medicines.org.uk/emc/product/7887/pil
  3. https://www.merck.com/product/usa/pi_circulars/j/januvia/januvia_mg.pdf
  4. https://medlineplus.gov/druginfo/meds/a606023.html
  5. https://medlineplus.gov/druginfo/meds/a606023.html
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