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Serocit-46.7% Injection 5 ml is used as a locking solution for catheters to prevent blood coagulation in various types of intravenous catheters. It works by preventing clot formation in the catheter lumen, ensuring the catheter remains open for future use. Serocit-46.7% Injection 5 ml is not recommended for use in patients allergic to polyhexanide or chlorhexidine, as it may trigger an anaphylactic reaction.

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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Manufacturer/Marketer :

La Renon Healthcare Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Serocit-46.7% Injection 5 ml

Serocit-46.7% Injection 5 ml is a sterile liquid solution given by injection or infusion to prevent blood clots from forming during kidney dialysis treatments. It is designed to keep blood flowing smoothly through the dialysis tubing and can also be used to keep central venous catheters clear when they are not in use. This medicine plays an essential role in keeping life-support filtration equipment working properly without blockages.

Because Serocit-46.7% Injection 5 ml is used during clinical procedures, it is given by healthcare professionals in a hospital or clinic setting. The frequency of your treatment depends entirely on your specific dialysis schedule or how often your catheter needs to be flushed. While receiving this treatment, your medical team may ask you to follow specific kidney-friendly dietary guidelines, such as managing your fluid intake and monitoring minerals like potassium and sodium.

While this medicine is very effective, it can sometimes cause mild side effects related to changes in your blood chemistry, such as temporary tingling around the mouth or a warm feeling. If you experience more severe symptoms like muscle spasms, severe weakness, or an irregular heartbeat, you must notify your healthcare provider immediately. Always discuss any unusual symptoms with your doctor or nurse during your treatment session.

Do not take this if you have severe liver damage, as your liver is responsible for clearing this medicine from your body. It is also not recommended for individuals who have extremely low calcium levels unless they are being continuously monitored by a specialist. Before your treatment begins, talk to your doctor if you have a history of heart failure, severe kidney disease, or high sodium levels.

If Serocit-46.7% Injection 5 ml is not suitable for you, such as in some people with severe liver disease, your healthcare team may recommend another anticoagulant, such as heparin, or another appropriate treatment based on your medical condition.

This medicine can interact with other prescription drugs, especially those that affect calcium levels, blood pressure, or kidney function. It is important to avoid drinking alcohol or smoking while undergoing treatments, as these habits can worsen kidney and heart strain. If you are pregnant, breastfeeding, or an older adult, consult your doctor to discuss how this treatment may affect you.

Serocit-46.7% Injection 5 ml may also be used in children receiving dialysis when considered appropriate by a specialist. The dose and treatment plan are carefully adjusted according to the child's age, weight, and medical condition.

Uses of Serocit-46.7% Injection 5 ml

Your doctor may prescribe Serocit-46.7% Injection 5 ml to help manage the following conditions:

  • Prevention of blood clots during kidney dialysis: Serocit-46.7% Injection 5 ml stops blood from clotting inside the dialysis machine and tubing, ensuring your treatment runs continuously and safely.
  • Maintaining catheter flow: It is used as a catheter lock solution to prevent blood clots from forming inside central venous catheters between your scheduled treatments.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Interruption-free dialysis: By stopping clots from forming in the tubing, this medicine prevents machine alarms and sudden treatment interruptions, making your sessions smoother and more comfortable.
  • Preservation of red blood cells: It helps prevent blood loss that can occur when a dialysis circuit becomes blocked with clots and has to be replaced.
  • Fewer catheter complications: Keeping your catheters clear reduces the risk of blockages, lowering the need for painful catheter replacements or additional surgeries.
  • Lower bleeding risk: Because it works locally inside the dialysis machine or catheter, it does not thin the blood in your entire body, reducing your overall risk of internal bleeding.

Directions for Use

  • Serocit-46.7% Injection 5 ml is administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Serocit-46.7% Injection 5 ml Works

Serocit-46.7% Injection 5 ml works by temporarily stopping your blood's natural ability to form clots. For blood to clot, it requires several active components, including calcium. When this medicine is injected into the dialysis tubing or your catheter, it binds to the free calcium in the blood, making it unavailable to the clotting system. Without calcium, the clotting process stops, keeping the blood in a fluid state. This prevention of clotting happens almost entirely outside your body within the dialysis machine. Before the blood is returned to your body, your healthcare team typically adds calcium back into the bloodstream. This restored calcium allows your body's normal clotting and healing systems to function properly, giving you local protection where it is needed most.
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Alcohol

Not applicable

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Pregnancy

Not applicable

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Breast Feeding

Not applicable

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Driving

Not applicable

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Liver

Not applicable

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Kidney

Not applicable

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Children

Caution

The safety and effectiveness of Serocit-46.7% Injection 5 ml for children have not been established.

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Heart

Caution

Serocit-46.7% Injection 5 ml could be dangerous for those who have heart problems. Therefore, please inform your doctor if you have any pre-existing heart problems before prescribing Serocit-46.7% Injection 5 ml.

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Geriatrics

Caution

Serocit-46.7% Injection 5 ml should be used with caution in geriatric people due to increased risk of side effects. Therefore, please consult your doctor before using Serocit-46.7% Injection 5 ml.

What if I have taken an overdose of Serocit-46.7% Injection 5 ml

Because this medicine is given in a monitored medical setting, an overdose is very rare. If too much medicine enters your bloodstream, it can cause your calcium levels to drop quickly. Your medical team monitors your blood chemistry continuously and is prepared to inject corrective treatments, such as calcium, immediately if needed.

Diet & Lifestyle Advise

  • Monitor your mineral intake: Follow your dietitian's advice closely regarding your intake of calcium, sodium, and potassium, as Serocit-46.7% Injection 5 ml can temporarily alter these electrolyte levels in your blood.
  • Stick to your fluid limits: If you are on dialysis, strictly adhere to your daily fluid restriction limits to prevent fluid buildup and ease the strain on your heart.
  • Avoid unapproved supplements: Do not take over-the-counter calcium supplements, antacids containing calcium, or vitamin D unless your doctor specifically tells you to.
  • Reduce dietary sodium: Limit high-sodium foods to help manage your blood pressure and reduce swelling or fluid retention.
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How Soon It Starts Working

The time required for Serocit-46.7% Injection 5 ml to start to work: Serocit-46.7% Injection 5 ml ideally begins after a few minutes of administration. The time for which the effects of Serocit-46.7% Injection 5 ml last: The effect of Serocit-46.7% Injection 5 ml shows its action approximately for 5 minutes.

What if you forget to take Serocit-46.7% Injection 5 ml

Since this medicine is given by healthcare professionals during scheduled dialysis sessions, it is highly unlikely that you will miss a dose. If you must miss a scheduled dialysis or catheter maintenance appointment, contact your clinic immediately to reschedule.

Storage

•This medicine is stored in clinical settings by healthcare professionals at controlled room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Verify solution clarity: Always ensure your healthcare provider checks the solution before use. The liquid must be completely clear; do not use if there is any cloudiness or discolouration.
  • Report tingling immediately: Tell your nurse or doctor right away if you feel tingling around your lips or fingers during your treatment, as this is an early sign of low calcium.
  • Never reuse single-dose containers: Ensure that any vial or bag of Serocit-46.7% Injection 5 ml is discarded immediately after a single use to prevent bacterial contamination.
  • Protect your access site: Keep your dialysis catheter or IV site clean and dry at all times to prevent serious skin or blood infections.
  • Check catheter clamps: If using this medicine as a catheter lock under clinical supervision, verify that all clamps are securely closed to keep the solution from leaking.

 

verifiedApollotooltip
  • Calcium supplements or calcium-containing medicines: May directly reduce the anti-clotting effect of Serocit-46.7% Injection 5 ml by neutralising its ability to bind calcium.
  • Other blood thinners (such as heparin or warfarin): May increase your overall risk of bleeding when used at the same time.
  • Corticosteroids: May cause your body to retain extra sodium when combined with Serocit-46.7% Injection 5 ml.

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verifiedApollotooltip
  • No clinically significant food interactions are known with Serocit-46.7% Injection 5 ml when used as directed.

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Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Serocit-46.7% Injection 5 ml is used as a catheter locking solution that prevents blood clots in any type of intravenous catheter. It helps keep the catheter clear by preventing clot formation inside the lumen, reducing the need for catheter replacement. It provides an effective locking mechanism without heparin, offering a safer option for patients at risk of heparin-induced thrombocytopenia (HIT).
Serocit-46.7% Injection 5 ml contains Trisodium Citrate (TSC). It prevents coagulation by binding ionized calcium in the extracorporeal circuit, which stops the activation of coagulation factors and fibrin formation. It does not cause systemic anticoagulation and also helps reduce biofilms by binding calcium in the surrounding.
Serocit-46.7% Injection 5 ml is generally used after each catheter use. However, your healthcare provider will decide the exact frequency based on your treatment requirements.
If you are allergic to sodium citrate or any other ingredient in the solution, it is important to consult your doctor. They will help identify an alternative treatment that is safe for you, ensuring that you receive appropriate care while avoiding any allergic reactions. Always tell your healthcare provider about any known allergies before starting a new medication.
Serocit-46.7% Injection 5 ml is suitable for central venous and dialysis catheters. It should not be used with arterial catheters or in situations not recommended by your healthcare provider.
If the catheter becomes blocked, contact your healthcare provider for assessment and possible treatment to restore its function. They may suggest alternative therapies or recommend catheter removal and replacement.
Serocit-46.7% Injection 5 ml is intended only for use as a catheter lock solution. It should not be administered through direct intravenous injection or mixed with an infusion. Proper use is essential to ensure the effectiveness and safety of the treatment.
Serocit-46.7% Injection 5 ml is given as an injection or infusion directly into the dialysis circuit or your catheter by a trained healthcare professional. It is not meant for self-injection at home. Talk to your doctor or nurse for more details.
Yes, because Serocit-46.7% Injection 5 ml works by binding to calcium, it can temporarily lower the calcium levels in your blood. Your medical team will monitor your blood levels closely during treatment and can give you calcium if your levels drop too low. Talk to your doctor if you have concerns.
Citrate accumulation is a rare complication that can happen if your body cannot break down Serocit-46.7% Injection 5 ml properly, most commonly in people with severe liver failure or very poor blood circulation. Your healthcare team will monitor your blood tests closely during treatment and adjust or stop the medicine if needed. If citrate is not suitable for you, another anticoagulant may be used.
Serocit-46.7% Injection 5 ml works locally inside the dialysis machine's tubing rather than thinning your entire bloodstream. This prevents clots in the equipment while keeping your risk of bleeding in the rest of your body very low. Talk to your doctor to see if this is the right choice for you.
Serocit-46.7% Injection 5 ml can be used during pregnancy if your doctor decides it is necessary for your dialysis. However, your calcium and other mineral levels must be monitored very closely to keep both you and your baby safe. Talk to your doctor to discuss the risks and benefits.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Behind Rajpath Club, Kensville Road, Opp. Infostretch Building, Off S.G. Highway, Ahmedabad- 380059, Gujarat- India
Other Info - SER0418
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