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compositionComposition:SEMAGLUTIDE-15MG/3ML
prescriptionPrescription Medicine
Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles)
Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles)
Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles)
Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles)

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is used for weight management in adults and adolescents aged 12 years and above. Additionally, it is used to reduce the risk of serious heart problems in adults. It contains Semaglutide, which helps reduce hunger and calorie consumption. Nausea, vomiting, diarrhoea, constipation, abdominal discomfort, dizziness, and altered taste are common side effects associated with this medication. It contains 4 doses, which are intended to provide coverage for the entire month.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SEMAGLUTIDE-15MG/3ML

Manufacturer/Marketer :

Lupin Limited

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles)

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is used along with a reduced-calorie diet and increased physical activity for long-term weight management. In adults, it is indicated for individuals with obesity/overweight and have at least one weight-related health condition, such as high blood pressure, type 2 diabetes, or abnormal cholesterol levels.

In adolescents aged 12 years and older, Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is indicated for weight management when used together with a reduced-calorie diet and increased physical activity in those who have obesity and a body weight greater than 60 kg.

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is also used to reduce the risk of major cardiovascular events, including heart attack, stroke, and cardiovascular death, in adults with established cardiovascular disease who are overweight or obese.

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) contains Semaglutide, a GLP-1 receptor agonist that mimics a natural hormone involved in appetite regulation. It works by slowing down gastric emptying, increasing the feeling of fullness, and reducing food cravings, which helps lower overall calorie intake.

In some cases, Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) may cause side effects such as nausea, vomiting, diarrhoea, constipation, abdominal discomfort, dizziness, or altered taste. Talk to your doctor if the side effects persist or worsen.

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) should also not be used during pregnancy and while breastfeeding. The pen contains 4 doses, designed to provide coverage for an entire month since it is administered once weekly.

Uses of Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles)

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is used to treat various medical conditions. The detailed uses are as follows:

  • Chronic weight management: Used in adults and adolescents above 12 years with obesity or overweight to help achieve and maintain long-term weight loss.
  • Cardiovascular risk reduction: Used to lower the risk of major adverse cardiovascular events such as heart attack or stroke in adults with obesity or overweight and established heart disease.

Key Benefits

  • Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) contains semaglutide, a GLP-1 receptor agonist that mimics a natural hormone responsible for regulating appetite and digestion.
  • It helps reduce calorie intake by slowing gastric emptying, increasing feelings of fullness, and decreasing hunger and food cravings, thereby supporting weight loss.
  • Promotes long-term weight management when combined with a reduced-calorie diet and physical activity, helping patients achieve and maintain a healthy body weight.
  • Improves metabolic health by aiding in better blood sugar control, lowering cholesterol levels, and reducing blood pressure in patients with obesity or overweight.
  • Reduces cardiovascular risk by lowering the chance of major heart-related events (such as heart attack or stroke) in adults with established heart disease who are overweight or obese.
Side effects of Semanext 15 mg Injection (3ml Cartridge + 10 Needles)
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Directions for Use

  • A qualified healthcare professional will instruct you on how to administer Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles).
  • It is a once-weekly subcutaneous injection in the abdomen, thigh, or upper arm. It should not be injected intravenously or intramuscularly.
  • Kindly do not self-administer without proper training and medical guidance.

How Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) Works

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) contains semaglutide, a GLP-1 receptor agonist that mimics a natural hormone involved in appetite regulation. It slows gastric emptying, increases feelings of fullness, and reduces food cravings, leading to reduced calorie intake and weight loss. Additionally, it helps improve blood sugar control and reduces the risk of cardiovascular events in high-risk patients.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles). It could lead to increased adverse events.

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Pregnancy

Unsafe

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) should not be used during pregnancy as there is a potential risk of harm to the unborn baby. Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is not recommended for women who are pregnant, planning to conceive soon, or not using reliable contraception during therapy.

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Breast Feeding

Unsafe

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is not recommended during breastfeeding as its safety is not established.

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Driving

Caution

Generally does not impair ability to drive; however, dizziness or low blood sugar (if combined with other drugs) may affect alertness.

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Liver

Caution

Inform your doctor before receiving Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) if you have a pre-existing or a history of liver disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) if you have a pre-existing or a history of kidney disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Consult your doctor

It is not known if Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is safe and effective: • to reduce the risk of heart disease in people under 18 years. • to lose weight and keep the weight off in children under 12 years of age.

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Heart

Safe if prescribed

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is used in patients with heart disease to help reduce the risk of major adverse events such as heart attack and stroke. However, people who have an irregular heartbeat or a very fast heart rate may need closer monitoring during treatment to make sure the medicine is safe and working properly.

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Geriatrics

Caution

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) should be used with caution in elderly patients, as it may be associated with a higher risk of fractures.

What if I have taken an overdose of Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles)

An overdose may lead to severe nausea, vomiting, or low blood sugar levels. In case of overdose, patients must be closely monitored for symptoms, and appropriate supportive treatment should be given.

Diet & Lifestyle Advise

  • Follow a calorie-controlled, balanced diet as advised by your doctor or dietitian. This is essential for weight loss and to maximise the effect of Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles).
  • Choose high-fibre, nutrient-dense foods like vegetables, fruits, whole grains, and lean proteins. These help you feel full longer and support blood sugar control.
  • Avoid high-sugar and high-fat foods, which can slow weight loss and affect blood sugar levels. Limit processed snacks, fried foods, and sugary drinks.
  • Eat smaller, frequent meals and chew slowly to reduce nausea and discomfort, as Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) slows stomach emptying.
  • Stay hydrated by drinking plenty of water throughout the day. This helps prevent dehydration, especially if you experience vomiting or diarrhoea, which are possible side effects.
  • Limit or avoid alcohol, as it can increase the risk of low blood sugar (if you have diabetes or take insulin/sulfonylureas) and may worsen gastrointestinal side effects.
  • Be physically active for at least 150 minutes a week (e.g., brisk walking, cycling, swimming), as regular exercise enhances weight loss and improves blood pressure, cholesterol, and blood sugar.
  • Monitor your blood sugar regularly if you have type 2 diabetes or are taking other diabetes medications, as weight loss and Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) may change your insulin needs.
  • Keep regular follow-up appointments so your doctor can track your progress, adjust your dose if necessary, and check for side effects or complications.
  • Adopt long-term healthy habits, to help keep the weight off after stopping Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles), continue following a healthy diet and regular physical activity.

Have a query?

How Soon It Starts Working

The time required for Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) to start to work: Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) ideally shows its action within 1 hour after administration.

The time for which the effects of Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) last: The duration of action for Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is about 24-48 hours.

What if you forget to take Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles)

If you miss a dose of Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles), consult your doctor or healthcare professional. They will reschedule the missed dose and may adjust the timing of your next doses if necessary.

Storage

• Store in a refrigerator (2°C to 8°C).
• Do not freeze or use if previously frozen.
• Keep this medicine out of the sight and reach of children.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Do not use Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) if you or a close family member has ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC), if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you have ever experienced a severe allergic reaction to semaglutide or any of its ingredients.
  • Let your doctor know about all your medical conditions before using Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles), including if you have or have ever had pancreatitis (inflamed pancreas), gallbladder problems or gallstones, kidney disease, severe digestive issues like gastroparesis (slow stomach emptying), diabetic eye disease (retinopathy), or any mental health concerns such as depression or suicidal thoughts.
  • Inform your doctor about every medicine, vitamin, or herbal supplement you are taking, as Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) may change how other medicines are absorbed. For instance, using Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) with insulin or sulfonylureas can increase the risk of low blood sugar, so your doctor may need to adjust other treatments.
  • Do not use Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) if you are pregnant, planning pregnancy, or breastfeeding. Stop the medicine at least 2 months before trying to conceive due to its long-lasting effect in the body. If you find out you are pregnant while using Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles), stop it immediately and call your doctor.
  • It is not known if Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is safe and effective in children under 12 years of age.
  • Contact your doctor immediately if you experience any severe or persistent side effects, such as ongoing stomach pain (which may signal pancreatitis), signs of an allergic reaction (swelling, rash, difficulty breathing), severe vomiting or diarrhoea leading to dehydration, or mood changes such as depression or suicidal thoughts.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) potentially interacts with certain medications used to treat certain cancers (e.g., bexarotene, capivasertib), certain general anaesthetics (e.g., desflurane, enflurane, etomidate, fospropofol, halothane, isoflurane, ketamine), antibiotics (e.g., gatifloxacin), certain insulin or sulfonylureas (e.g., glimepiride, glyburide) and certain GLP‑1 receptor agonists or similar weight-loss medications (e.g., liraglutide, tirzepatide).

Drug-Food Interactions: There are no significant food restrictions with Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles). However, limit alcohol intake as it can worsen nausea and vomiting and may increase the risk of low blood sugar, particularly if you are using other diabetes medicines.

Drug-Disease Interactions: If you have a history of suicidal behaviour and ideation, thyroid cancer, hypoglycemia, pancreatitis, retinopathy and GI adverse reactions. Inform your doctor before starting treatment with Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles). These conditions may require close monitoring or adjustments to your therapy.

SemaglutideGatifloxacin
Critical
SemaglutideBexarotene
Severe

Drug-Drug Interactions

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SemaglutideGatifloxacin
Critical
How does the drug interact with Semanext 15 mg Injection (3ml Cartridge + 10 Needles):
Coadministration of Semanext 15 mg Injection (3ml Cartridge + 10 Needles) with Gatifloxacin may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Semanext 15 mg Injection (3ml Cartridge + 10 Needles) can be taken with Gatifloxacin if prescribed by the doctor. Consult the doctor if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremor, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue any medications without first consulting your doctor.
SemaglutideBexarotene
Severe
How does the drug interact with Semanext 15 mg Injection (3ml Cartridge + 10 Needles):
Co-administration of Bexarotene and Semanext 15 mg Injection (3ml Cartridge + 10 Needles) can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Bexarotene and Semanext 15 mg Injection (3ml Cartridge + 10 Needles) can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like persistent nausea, vomiting, abdominal tenderness, and upper abdominal pain, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) is used along with a reduced-calorie diet and increased physical activity for weight management in adults and adolescents aged 12 years and older. It is also used to reduce the risk of major cardiovascular events, such as heart attack, stroke, and cardiovascular death, in adults with established cardiovascular disease who are overweight or obese.

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) works by slowing the emptying of the stomach, helping to reduce appetite and promote weight loss. It decreases hunger, helps you feel full sooner and for longer, and reduces food cravings. These effects can help you eat less and lose weight when combined with a healthy diet and regular physical activity.

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) may cause side effects like nausea, vomiting, diarrhoea, abdominal pain, headache and fatigue. Consult your doctor if any of the side effects persist or worsen.

Pancreatitis (inflammation of the pancreas) is a possible side effect of Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles). Stop using Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) and contact your healthcare provider immediately if you develop severe, persistent stomach pain, with or without nausea or vomiting. The pain may also spread from your abdomen to your back.

Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) may increase the risk of low blood sugar, especially in people with type 2 diabetes who also take insulin or certain diabetes medicines such as sulfonylureas. Checking your blood sugar levels before starting Semanext 15mg/3ml Injection (3ml Cartridge + 10 Needles) and during treatment is recommended. Symptoms of low blood sugar may include dizziness, sweating, shakiness, blurred vision, weakness, hunger, headache, anxiety, irritability, confusion, drowsiness, a fast heartbeat, slurred speech, or feeling jittery. If you experience these symptoms, contact your healthcare provider for advice on managing low blood sugar.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

3rd Floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India
Other Info - SEM0096

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