apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. Samplus Capsule

Samplus Capsule, Pack of 10 CapsuleS
Offers on medicine orders
All offers
axis icici
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Samplus Capsule is used to treat liver disease, depression, and osteoarthritis. It works by protecting the liver from toxins, regulating mood and stimulating the production of cartilage. In some cases, this medicine may cause side effects such as headache, vomiting, diarrhoea, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Read more
rxMedicinePrescription drug

Whats That

tooltip

Also Explore

Momverse
Ask Apollo
insurance

Synonym :

S ADENOSYL L METHIONINE

Composition :

ADEMETIONINE-100MCG

Manufacturer/Marketer :

Elder Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Samplus Capsule

Samplus Capsule is used in the treatment of depression, biliary cholangitis (an autoimmune disease of the liver), liver diseases caused by cystic fibrosis, and to reduce pain and swelling in the joints. It is also used to treat liver disease during pregnancy and improve symptoms in people with fibromyalgia.

Samplus Capsule contains Ademetionine, a naturally occurring substance, produced from methionine (amino acid). Samplus Capsule ensures sufficient levels of glutathione in the liver are maintained to minimize liver damage. It stimulates the production of cartilage, reduces inflammatory mediators, and has analgesic properties.

In some cases, you may experience common side effects such as abdominal discomfort, abdominal pain, diarrhoea, nausea, dizziness, and insomnia. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if these side effects persist.

Take Samplus Capsule as recommended by your doctor. It should be taken with a meal for better absorption. Your doctor will decide the dose and duration of medicine based on the type of condition. Do not chew, crush, or break the medicine.

Avoid taking Samplus Capsule if you are allergic to it. Do not discontinue Samplus Capsule without consulting your doctor. Consult the doctor if you are pregnant or breastfeeding. Samplus Capsule can be given to children with extreme caution if recommended by the doctor. Avoid consuming alcohol with Samplus Capsule as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Samplus Capsule

Samplus Capsule is used for the treatment of depression, primary biliary cholangitis, and osteoarthritis. The detailed uses of Samplus Capsule are as follows:<br/>

  • Depression & Mood Disorders: Samplus Capsule helps regulate neurotransmitters like serotonin and dopamine and treat depression & mood disorders.<br/>
  • Arthritis Management: Samplus Capsule helps to manage arthritis by reducing inflammation and pain, improving joint function and mobility in conditions like rheumatoid arthritis and osteoarthritis.<br/>
  • Treatment for Cholestasis: Samplus Capsule is frequently recommended to treat pregnancy-related cholestasis, a disorder marked by decreased bile flow that usually results in elevated blood bile acids.<br/>
  • Promote Liver Function: Samplus Capsule may be used to enhance bile production and promote liver function, which will help with fat digestion.<br/>
  • Liver Diseases: To improve liver function, Samplus Capsule is occasionally included in treatment plans for a number of liver disorders, including fatty liver disease.<br/>



 

Directions for Use

• Samplus Capsule should be taken before a meal, as food may affect its absorption. • It is recommended to take Samplus Capsule once daily or as advised by your doctor. • Swallow the whole Samplus Capsule with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

  • Samplus Capsule contains Ademetionine, a naturally occurring substance in cells, tissue, and body fluids.
  • In liver disease, Samplus Capsule ensures sufficient glutathione levels in the liver to minimize liver damage.
  • It prevents the increase of lipids associated with cirrhosis outside the liver. 
  • In depression, it affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, thereby regulating mood and treating depression.
  • In osteoarthritis, it stimulates the production of cartilage components, reduces inflammatory mediators, and has analgesic properties. Samplus Capsule is also effective in treating nerve problems in people with AIDS, or sexual dysfunction in men with depression.

How Samplus Capsule Works

Samplus Capsule contains Ademetionine, a naturally occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid) and is used to treat liver disease, depression, and osteoarthritis. Samplus Capsule ensures sufficient levels of glutathione in the liver are maintained to minimize liver damage. It also prevents the increase of lipids associated with cirrhosis outside the liver. It also affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, regulating mood and treating depression. It stimulates the production of parts of cartilage, reduces the inflammatory mediator, and has painkilling properties.

Storage

• Store in a cool and dry place away from sunlight.• Keep Samplus Capsule out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Samplus Capsule

Take Samplus Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Samplus Capsule if you are allergic to any of its contents
  • Do not use Samplus Capsule if you have used an MAO inhibitor (antidepressant) in the past 14 days, as a dangerous drug interaction could occur.
  • Let your doctor know if you have any conditions like inflammation of gall bladder and bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer, heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, or kidney and liver problems.
  • Do not take Samplus Capsule if you are pregnant or breastfeeding unless advised by your doctor.
  • Samplus Capsule can be given to children with caution if recommended by the doctor.
  • Avoid consuming alcohol along with Samplus Capsule as it could lead to increased drowsiness and liver damage.
  • Keep your doctor informed about your health condition and medicines to rule out any unpleasant side effects.
  • Your doctor may advise a regular liver function test to monitor the liver's function and the treatment progress.

Diet & Lifestyle Advise

Liver disease:

  • Include foods such as bell peppers, citrus fruits, leafy vegetables, tomatoes, milk, fish, low-fat dairy, beans, nuts, lentils, tofu, and tempeh in your diet.
  • Foods rich in vitamins B and C and calcium are good for the gallbladder.
  • Plant-based protein foods such as beans, nuts, lentils, tofu, and tempeh help prevent gallbladder disease.
  • Avoid high-fat, trans-fat, processed foods, white bread, white pasta, and sugars.
  • Avoid tobacco and alcohol consumption.

Depression:

  • Maintaining a healthy diet and regular exercise helps improve overall health and boost self-esteem.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help properly maintain neurotransmitters. 
  • Avoid smoking and alcohol consumption.

Osteoarthritis:

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.

Habit Forming

No

Therapeutic Class

NUTRITIONAL SUPPLEMENT
bannner image

Alcohol

Unsafe

Avoid consumption of alcohol while taking Samplus Capsule as it may cause increased dizziness and liver damage.

bannner image

Pregnancy

Consult your doctor

Avoid taking Samplus Capsule if you are pregnant unless advised by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will recommend only if the benefits outweigh the risks.

bannner image

Breast Feeding

Consult your doctor

Consult your doctor before taking Samplus Capsule, your doctor will decide whether Samplus Capsule can be taken by breastfeeding mothers or not.

bannner image

Driving

Safe if prescribed

Samplus Capsule does not affect your ability to drive. However, you are advised to be cautious while driving if you experience dizziness.

bannner image

Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

Samplus Capsule can be given to children with caution only if recommended by the doctor.

Have a query?

FAQs

Samplus Capsule is used to treat various medical conditions, including depression, osteoarthritis, biliary cholangitis (an autoimmune disease of the liver), and excess cholesterol in bile and biliary and liver diseases caused by cystic fibrosis. It is also used to treat liver disease during pregnancy, improve symptoms in people with fibromyalgia, and treat nerve problems in people with AIDS or sexual dysfunction in men with depression.

Samplus Capsule contains Ademetionine is used in the treatment of liver disease, depression, and osteoarthritis. It is used in liver conditions associated with reduced bile formation (intrahepatic cholestasis). It restores the balance of serotonin, a natural chemical present in the brain. It also blocks the production of certain inflammatory chemical substances that cause pain and swelling in osteoarthritis.

If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.

Do not discontinue Samplus Capsule without consulting your doctor. To treat your condition effectively, continue taking Samplus Capsule for as long as advised. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Samplus Capsule.

Do not take Samplus Capsule if you have used MAO inhibitors (like isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others) in the last 14 days as the co-administration of Samplus Capsule and MAO inhibitor cause serious drug interaction. Let know doctor know about this.

No, the Samplus Capsule does not cure arthritis. Samplus Capsule is only used to relieve symptoms of arthritis, such as joint pain, swelling and stiffness.

Yes, Samplus Capsule is good for the liver. It aids liver function, minimises liver damage and treats liver disease.

Samplus Capsule contains Ademetionine, a naturally occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid).

Do not take Samplus Capsule if you are allergic to any of its components, if you have used an MAO inhibitor in the past 14 days, or if you have inflammation of gall bladder and bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer.

Samplus Capsule may cause side effects such as abdominal discomfort, abdominal pain, diarrhoea, nausea, dizziness, and insomnia. Talk to your doctor if you experience these side effects persistently.

It is not known if Samplus Capsule is safe to use for the long term. Take Samplus Capsule for the duration prescribed by the doctor.

Country of origin

India

Manufacturer/Marketer address

“Elder House” Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai – 400053.
Other Info - SAM0047

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 23, 2025 | 1:43 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/mtm/s-adenosylmethionine-same.html
  2. https://www.webmd.com/vitamins/ai/ingredientmono-786/same

Buy best Health & Nutrition products by

whatsapp Floating Button