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  3. Samlodon AT 2.5mg/50mg Tablet

Samlodon AT 2.5mg/50mg Tablet, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Samlodon AT 2.5mg/50mg Tablet is used to treat hypertension (high blood pressure). It contains Amlodipine and Atenolol, which relaxes and widens the constricted blood vessels. This ultimately reduces the heart's workload and makes the heart more efficient in pumping blood throughout the body. Also, it blocks stress hormones like adrenaline and epinephrine, thereby slowing down the increased heart rate. Thus, it helps lower raised blood pressure, reduces the chances of heart attack or stroke in the future. It may cause common side effects such as nausea, sleepiness, ankle swelling, headache, palpitations, low blood pressure, cold extremities, flushing (sense of warmth in the ears, face, neck, and trunk), slow heart rate, oedema (swelling), constipation, tiredness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

AMLODIPINE-2.5MG + ATENOLOL-50MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

ORAL

Return Policy :

Not Returnable

About Samlodon AT 2.5mg/50mg Tablet

Samlodon AT 2.5mg/50mg Tablet is an anti-hypertensive medication that is used to treat hypertension (high blood pressure). Hypertension is a lifelong or chronic condition in which the blood pressure against the artery walls becomes too high.

Samlodon AT 2.5mg/50mg Tablet contains Amlodipine and Atenolol. Samlodon AT 2.5mg/50mg Tablet reduces the workload on the heart and makes the heart more efficient at pumping blood throughout the body. It also blocks stress hormones like adrenaline and epinephrine, thereby slowing down the increased heart rate.

The most common side effects of Samlodon AT 2.5mg/50mg Tablet are nausea, sleepiness, ankle swelling, headache, palpitations, low blood pressure, cold extremities, flushing (sense of warmth), slow heart rate, swelling, constipation, tiredness. They do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Take Samlodon AT 2.5mg/50mg Tablet with or without food as prescribed by your doctor with a full glass of water. Samlodon AT 2.5mg/50mg Tablet may be prescribed alone or in combination with other blood pressure-lowering medicines depending upon your blood pressure levels. Do not chew, bite, or break the medicine.

Inform your doctor if you have had an allergic reaction to Samlodon AT 2.5mg/50mg Tablet, are pregnant or are planning to get pregnant, are breastfeeding, have liver disease, kidney disease, heart failure, a heart valve problem or a history of a heart attack.

Uses of Samlodon AT 2.5mg/50mg Tablet

Samlodon AT 2.5mg/50mg Tablet is used in the treatment of Hypertension (high blood pressure). The detailed uses of Samlodon AT 2.5mg/50mg Tablet are as follows:

  • Hypertension Management: Samlodon AT 2.5mg/50mg Tablet is frequently prescribed to control high blood pressure, promoting better cardiovascular health.
  • Angina Prevention: Samlodon AT 2.5mg/50mg Tablet helps prevent angina attacks by relaxing blood vessels and improving blood flow to the heart.
  • Heart Failure Treatment: Samlodon AT 2.5mg/50mg Tablet may be recommended to manage heart failure symptoms by reducing the workload on the heart. Improving Blood Circulation: Samlodon AT 2.5mg/50mg Tablet enhances overall blood circulation, ensuring better oxygen delivery to the body's organs and tissues.

Directions for Use

  • Samlodon AT 2.5mg/50mg Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Samlodon AT 2.5mg/50mg Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

Medicinal Benefits

Samlodon AT 2.5mg/50mg Tablet is used to treat heart-related conditions like angina (chest pain) and high blood pressure (hypertension).

It is a calcium channel blocker that inhibits the entry of calcium (ions) across the heart that relaxes and widens the smooth muscles for better blood flow.

Besides this, Samlodon AT 2.5mg/50mg Tablet helps prevent sudden spasm of the coronary artery (blood vessels of the heart) and reduces how hard the heart has to work to pump blood around the body, lowering its oxygen requirements.

Samlodon AT 2.5mg/50mg Tablet improves an individual’s tolerance to physical activity and exercise and keeps their blood pressure normal during exercise. As a result, it overall protects your heart and keeps it healthy.

This medicine helps to lower high blood pressure, reducing the chances of heart attack or stroke.

How Samlodon AT 2.5mg/50mg Tablet Works

Samlodon AT 2.5mg/50mg Tablet contains Amlodipine (a calcium channel blocker) and Atenolol (a beta-blocker). Amlodipine acts by relaxing and widening the constricted blood vessels. This ultimately reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Atenolol works by blocking stress hormones like adrenaline and epinephrine, thereby slowing down the increased heart rate. Thus, it helps lower raised blood pressure, reducing the chances of heart attack or stroke in the future.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Samlodon AT 2.5mg/50mg Tablet

Do not take more than the prescribed dose of Samlodon AT 2.5mg/50mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Samlodon AT 2.5mg/50mg Tablet should not be given to the people allergic to Samlodon AT 2.5mg/50mg Tablet.
  • Inform your physician if you have low blood pressure (less than 90 mm of Hg), have had heart attack, or have kidney disease or liver disease before taking Samlodon AT 2.5mg/50mg Tablet.
  • Besides this, it is contraindicated in patients with aortic stenosis (heart valve problem).
  • Samlodon AT 2.5mg/50mg Tablet can pass into breast milk, but its effect on the baby is not known. So, it is better to tell your doctor if you are taking Samlodon AT 2.5mg/50mg Tablet and breastfeeding.
  • Samlodon AT 2.5mg/50mg Tablet is to be used in pregnant women only if suggested by the physician.
  • Lifestyle changes are beneficial in achieving optimum outcomes with Samlodon AT 2.5mg/50mg Tablet and keeping blood pressure under check.
  • A low-salt diet, daily physical activity (even 20-30 minute brisk walking for 5 days a week can help!), losing weight in the case of people who are obese, etc, are the mainstay of treatment of hypertension.
  • This medicine is not recommended for children below 6 years of age.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
AtenololClonidine
Severe

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
Using Samlodon AT 2.5mg/50mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Samlodon AT 2.5mg/50mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
AtenololClonidine
Severe
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
Co-administration of Clonidine and Samlodon AT 2.5mg/50mg Tablet may lower blood pressure and slower heart rate.

How to manage the interaction:
Although there is a possible interaction between Clonidine and Samlodon AT 2.5mg/50mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience headaches, slow heartbeat, dizziness, contact a doctor. Do not discontinue the medication without consulting a doctor.
AtenololVerapamil
Severe
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
Taking verapamil with Samlodon AT 2.5mg/50mg Tablet can increase the risk or severity of verapamil side effects.

How to manage the interaction:
Taking Samlodon AT 2.5mg/50mg Tablet and Verapamil together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience, fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AtenololCarvedilol
Severe
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
Taking Samlodon AT 2.5mg/50mg Tablet and carvedilol may increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Samlodon AT 2.5mg/50mg Tablet and Carvedilol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any shortness of breath, palpitations, or chest discomfort, contact a doctor immediately. Do not stop taking any medication without checking with a doctor.
AtenololSaquinavir
Severe
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
Coadministration of Samlodon AT 2.5mg/50mg Tablet with saquinavir increase the risk of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Samlodon AT 2.5mg/50mg Tablet and saquinavir together can result in an interaction, it can be taken if a doctor has advised it. However, if you happen to experience sudden dizziness, lightheadedness, fainting, slow pulse, or irregular heartbeat, you should seek immediate medical attention. Do not discontinue the use of any medication without a doctor's advice.
AtenololPropranolol
Severe
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
Taking Samlodon AT 2.5mg/50mg Tablet and propranolol together may lower your blood pressure excessively which may lead to side effects.

How to manage the interaction:
Combined use of Samlodon AT 2.5mg/50mg Tablet and propranolol may result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
AtenololTheophylline
Severe
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
Using Samlodon AT 2.5mg/50mg Tablet with theophylline, could increase the effects of theophylline.

How to manage the interaction:
Taking Samlodon AT 2.5mg/50mg Tablet and theophylline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, insomnia, shaking of hands and legs, restlessness, uneven heartbeats, or difficulty breathing, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
AtenololDisopyramide
Severe
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
When disopyramide is used with Samlodon AT 2.5mg/50mg Tablet, it may increase the effects of disopyramide.

How to manage the interaction:
When Samlodon AT 2.5mg/50mg Tablet is used with disopyramide, it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, fainting, heart palpitations, slow or fast pulse, or irregular heartbeats, consult the doctor immediately. Do not stop using any medication without consulting a doctor.
AtenololTizanidine
Severe
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
Coadministration of Tizanidine and Samlodon AT 2.5mg/50mg Tablet can increase the risk or severity of side effects like low blood pressure.

How to manage the interaction:
Taking Samlodon AT 2.5mg/50mg Tablet and tizanidine together may result in an interaction, it can be taken if your doctor has recommended it. However, if you experience headache, dizziness, lightheadedness, sweating, or palpitations, consult the doctor. Do not discontinue any medications without consulting a doctor.
AtenololDiltiazem
Severe
How does the drug interact with Samlodon AT 2.5mg/50mg Tablet:
Taking Samlodon AT 2.5mg/50mg Tablet and diltiazem together may lead to increased side effects.

How to manage the interaction:
Taking Samlodon AT 2.5mg/50mg Tablet and diltiazem together can result in an interaction, it can be taken if a doctor has recommended it. However, if you experience tiredness, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest discomfort, increased or reduced heartbeat, or irregular heartbeat, consult the doctor. Do not discontinue any medications without consulting doctor.

Drug-Food Interactions

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AMLODIPINE-2.5MG+ATENOLOL-50MGFruit juices, Fruits
Mild

Drug-Food Interactions

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AMLODIPINE-2.5MG+ATENOLOL-50MGFruit juices, Fruits
Mild
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
The consumption of grapefruit juice may slightly increase plasma concentrations of amlodipine. Avoid consumption of grapefruit juice while being treated with Samlodon AT 2.5mg/50mg Tablet.

Diet & Lifestyle Advise

  • Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.

  • Keep your weight under control with a BMI of 19.5-24.9.

  • Avoid chronic stress, as it can raise your blood pressure.

  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.

  • Be mindful of salt; consume no more than 2,300 mg each day.

  • Limit or avoid alcohol consumption.

  • Quitting smoking is the best strategy to lower the risk of heart disease.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Samlodon AT 2.5mg/50mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol and Samlodon AT 2.5mg/50mg Tablet to avoid unpleasant side effects like lowering blood pressure (hypotension).

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Pregnancy

Unsafe

Samlodon AT 2.5mg/50mg Tablet contains atenolol, which is a pregnancy category D drug. It is known to harm the baby if taken during pregnancy. So it is better to avoid intake of Samlodon AT 2.5mg/50mg Tablet in pregnant women in their second and third trimesters.

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Breast Feeding

Consult your doctor

Samlodon AT 2.5mg/50mg Tablet can pass through the breast milk and harm the baby, so it should not be taken while breastfeeding.

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Driving

Caution

Drive with caution. Samlodon AT 2.5mg/50mg Tablet usually causes drowsiness and affects driving ability.

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Liver

Caution

Samlodon AT 2.5mg/50mg Tablet to be taken with caution, especially if you have had a history of liver disease.

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Kidney

Caution

Samlodon AT 2.5mg/50mg Tablet to be taken with caution, especially if you have had a history of kidney disease.

bannner image

Children

Caution

Samlodon AT 2.5mg/50mg Tablet is not recommended for children below six years of age without a doctor's consent. The dose is to be adjusted and guided by a child specialist only for children above six years.

Have a query?

FAQs

Samlodon AT 2.5mg/50mg Tablet belongs to the class of anti-hypertensive medication used to treat hypertension (high blood pressure).

Samlodon AT 2.5mg/50mg Tablet is a combination of anti-hypertensive medications. Amlodipine acts by relaxing and widening the constricted blood vessels. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Atenolol works by slowing down the heart rate of the heart. Thus, it collectively helps lower high blood pressure, reducing the chances of heart attack or stroke.

No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it. If you suddenly stop taking Samlodon AT 2.5mg/50mg Tablet, it may cause a jump in blood pressure, chest pain, or can even lead to a heart attack.

Yes, Samlodon AT 2.5mg/50mg Tablet is known to cause ankle swelling upon long-term use. Please try to keep your feet up when sitting for long hours. If the problem persists still, consult your doctor and do as advised.

High blood pressure during pregnancy is called 'Pregnancy-induced hypertension (PIH). It is harmful to both the baby and the mother. In the mother, very high blood pressure can cause seizures (fits), headache, swelling of feet, kidney damage, and a higher risk of bleeding during pregnancy and during delivery. This can also affect the baby by causing abnormal fetal heart rate, risk of stillbirth and a small baby. So, during pregnancy, you should have regular blood pressure monitoring. Visit your Obstetrician if you have any concerns about blood pressure during pregnancy.

It is also known as fluid retention or fluid overload. Due to oedema, the affected area starts swelling up. If it does not subside, please consult your doctor immediately.

Yes, Samlodon AT 2.5mg/50mg Tablet can cause dizziness sometimes, so it is advised to avoid driving or operating heavy machinery while taking Samlodon AT 2.5mg/50mg Tablet. In case you feel dizzy or lightheaded, it is recommended to rest for some time until you feel better.

Yes, Samlodon AT 2.5mg/50mg Tablet is contraindicated in people with known allergies to any of this medicine's components. It should be avoided in people with severe kidney or liver impairment and people with anuria (reduction or absence of urine). It should also be avoided for use in pregnant women who are in the second and third trimesters of their pregnancy.

The effect of this medicine can be observed within 2 to 4 hours.

Usually, treatment with Samlodon AT 2.5mg/50mg Tablet is long-term, even for the rest of your life. Talk to your doctor if you want to stop taking Samlodon AT 2.5mg/50mg Tablet.

You should take your medications regularly at the same time. In addition, changing your lifestyle may also help to control blood pressure. These changes include eating a healthy diet low in fat and salt, exercising at least half an hour every day, maintaining a healthy weight, reducing alcohol consumption, and quitting smoking habits.

The most common side effects of Samlodon AT 2.5mg/50mg Tablet are nausea, sleepiness, ankle swelling, headache, palpitations, low blood pressure, cold extremities, flushing (sense of warmth in the ears, face, neck, and trunk), slow heart rate, oedema (swelling), constipation, tiredness. They do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Samlodon AT 2.5mg/50mg Tablet contains Amlodipine (a calcium channel blocker) and Atenolol (a beta-blocker).

You should take your medications regularly at the same time. In addition, changing your lifestyle may also help to control blood pressure. These changes include eating a healthy diet low in fat and salt, exercising at least half an hour every day, maintaining a healthy weight, reducing alcohol consumption, and quitting smoking habits.

Dizziness may also occur, especially when you get up suddenly from a lying or sitting position. If you feel dizzy, lie down so you do not faint. Then, sit for a few moments before standing to prevent the dizziness from returning. If you faint, call your doctor right away.

Samlodon AT 2.5mg/50mg Tablet is generally safe to take for a long time. In fact, it works best when you take it for a long time. Consult your doctor if you experience any side effects that persist.

You can eat and drink normally while taking Samlodon AT 2.5mg/50mg Tablet. Eating a healthy, balanced diet can help if you have high blood pressure or another heart condition.

Country of origin

India
Other Info - SA46695

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 1:56 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.healthline.com/health/atenolol/oral-tablet#important-warnings
  2. https://www.medicines.org.uk/emc/files/pil.6024.pdf
  3. https://www.medicines.org.uk/emc/files/pil.5701.pdf
  4. https://www.medicines.org.uk/emc/files/pil.5701.pdf
  5. https://www.drugs.com/amlodipine.html
  6. https://www.drugs.com/atenolol.html
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