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compositionComposition:METHYLENE BLUE-10MG
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Prescription Medicine
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Sam MB 10mg Injection is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy. It contains Methylene Blue, which works by converting methemoglobin to a more efficient type of haemoglobin to better carry oxygen throughout the body. Common side effects of this medication are mild to moderate pain at the site of injection, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METHYLENE BLUE-10MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Sam MB 10mg Injection

Sam MB 10mg Injection is a specialised injectable prescription medicine primarily used to treat acute methemoglobinemia, a serious blood disorder where red blood cells cannot deliver oxygen effectively to the rest of your body. It is typically given in urgent situations to restore proper oxygenation to your organs and tissues. Because it is a rescue therapy, it is usually given as a single dose or a short series of injections rather than a regular daily medication.

This medicine is injected directly into a vein, so there are no restrictions regarding taking it with or without food. Because the underlying condition is often triggered by exposure to certain chemicals or drugs, your care team will recommend lifestyle adjustments such as avoiding industrial dyes, specific local anaesthetics, and high-nitrate water to prevent the condition from returning.

While receiving Sam MB 10mg Injection, you may notice that your urine, stool, or skin temporarily turns a blue or green colour. While this is a normal and harmless side effect, you must contact your doctor or nurse immediately if you experience serious symptoms such as severe confusion, rapid heart rate, muscle twitching, or difficulty breathing.

Before you receive this injection, it is vital to tell your healthcare provider about your complete medical history. Do not receive this medicine if you have a genetic enzyme disorder called G6PD deficiency, as it can cause a severe blood reaction. You should also tell your doctor if you have kidney disease or a history of severe allergies.

This medication can interact dangerously with other substances, particularly prescription antidepressants such as SSRIs or MAOIs, potentially causing a life-threatening brain chemical imbalance. It is also important to tell your doctor if you are pregnant, breastfeeding, or if the patient is an elderly individual, so they can carefully weigh the risks and benefits. Talk to your doctor or pharmacist if you have any questions about these interactions.

Uses of Sam MB 10mg Injection

Your doctor may prescribe Sam MB 10mg Injection to treat the following conditions to help restore the blood's ability to carry oxygen and improve oxygen delivery throughout the body:

  • Methemoglobinemia: Sam MB 10mg Injection helps by quickly converting abnormal methemoglobin back into functional hemoglobin, restoring your blood's capacity to transport oxygen to vital organs.
  • Drug-induced blood disorders: It reverses acute oxygen-delivery failure triggered by accidental exposure to certain toxic chemicals, nitrates, or specific medications.

Key Benefits

Using Sam MB 10mg Injection as prescribed helps restore the blood's ability to carry oxygen during medical emergencies. Here are the key benefits you can expect:

  • Restores oxygen delivery quickly: Helps rapidly convert abnormal methemoglobin into functional haemoglobin, allowing oxygen to reach vital organs.
  • Provides fast symptom relief: Helps reduce symptoms such as bluish skin discolouration, shortness of breath, and extreme fatigue by improving oxygen levels.
  • Protects vital organs: By restoring normal oxygen flow, Sam MB 10mg Injection helps protect the brain, heart, and kidneys from damage caused by prolonged oxygen deprivation and supports a faster recovery.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Sam MB 10mg Injection will be administered by a healthcare professional.
  • Do not self-administer it.

How Sam MB 10mg Injection Works

Sam MB 10mg Injection contains methylene blue, which acts as an electron donor in the body. When you have methemoglobinemia, the iron in your red blood cells is modified, making it unable to release oxygen to your tissues. Once injected, Sam MB 10mg Injection utilises a natural enzyme pathway inside your red blood cells to rapidly convert this inactive iron back to its normal state. This process restores the cells' natural ability to bind and release oxygen, allowing your tissues to breathe normally again.
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Alcohol

Caution

It is not known whether Sam MB 10mg Injection interacts with alcohol. However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Caution

Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Sam MB 10mg Injection.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking Sam MB 10mg Injection; your doctor may suggest stopping breastfeeding for a certain period.

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Driving

Safe if prescribed

Sam MB 10mg Injection usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Limited information was available about using Sam MB 10mg Injection in patients with liver disease. Inform your doctor before receiving Sam MB 10mg Injection if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Use with caution in patients with kidney failure, as methylene blue is primarily excreted through the kidneys. Inform your doctor before receiving Sam MB 10mg Injection if you have a history of kidney diseases. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Please consult your doctor. Your doctor will prescribe this medicine based on your child's condition.

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Heart

Consult your doctor

Sam MB 10mg Injection may be used in individuals with heart conditions, but its cardiac effects depend on timing and underlying disease. Thorough cardiovascular evaluation is essential to ensure safe and appropriate administration.

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Geriatrics

Caution

Sam MB 10mg Injection can be administered to geriatric patients, but careful dosing and monitoring are essential due to age-related changes in renal and hepatic function. Lower doses are typically recommended, and clinicians should assess for potential drug interactions and adverse effects such as serotonin syndrome or hypotension.

What if I have taken an overdose of Sam MB 10mg Injection

Because this medication is injected under close clinical supervision, an overdose is rare. However, if too much medicine is given, it can worsen methemoglobinemia or cause breathing difficulties and chest pain. The medical team will monitor you closely and treat any symptoms immediately.

Diet & Lifestyle Advise

  • Avoid triggers: Stay away from known triggers of methemoglobinemia, such as topical benzocaine sprays, certain nitrate preservatives in foods, and well water that has not been tested for nitrates.
  • Increase fluid intake: Drink plenty of water after your treatment to help your kidneys safely flush the blue dye out of your body.
  • Avoid aniline dyes: Limit exposure to industrial chemical solvents, certain paints, and chemical dyes, as these can reactivate the blood condition.
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How Soon It Starts Working

The time required for Sam MB 10mg Injection to start to work: Sam MB 10mg Injection ideally shows its action within 30 minutes after administration. The time for which the effects of Sam MB 10mg Injection last: The duration of action for Sam MB 10mg Injection is unknown.

What if you forget to take Sam MB 10mg Injection

Since this medicine is given by a healthcare professional in an emergency or hospital setting, it is highly unlikely that you will miss a dose. If your treatment plan requires multiple injections, the medical staff will maintain a strict schedule.

Storage

• Sam MB 10mg Injection is usually stored and handled by healthcare professionals. Store it at 20°C to 25°C (68°F to 77°F) in its original carton. Do not freeze.

Drug Warnings

  • Inspect the solution: Ensure the solution is clear, deep blue, and free of visible particles before administration.
  • Report injection site problems: Tell your healthcare provider immediately if you feel burning, stinging, pain, or swelling around the injection site, as leakage from the vein may damage surrounding tissue.
  • Avoid driving: Do not drive or operate machinery for at least 24 hours after receiving this injection, as it may cause temporary dizziness, confusion, or blurred vision.
  • Inform your doctor about G6PD deficiency: Tell your doctor if you have a history of G6PD deficiency, as Sam MB 10mg Injection may cause severe destruction of red blood cells in affected individuals.
  • Expect urine colour changes: Your urine and sweat may turn blue-green for a few days after treatment. This is a normal effect and will resolve as the medicine leaves your body.
  • Expect monitoring in hospital: Your healthcare team may check your oxygen levels continuously and repeat blood tests to ensure the medicine is working properly and that methemoglobin levels are falling.

verifiedApollotooltip

  • Antidepressants (SSRIs, SNRIs, and MAOIs): Taking these medicines with Sam MB 10mg Injection can increase serotonin levels and may cause serotonin syndrome, a serious condition with symptoms such as high fever, confusion, muscle stiffness, and agitation.

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verifiedApollotooltip
  • No clinically significant food interactions are known with Sam MB 10mg Injection when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Sam MB 10mg Injection is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy.
Sam MB 10mg Injection contains Methylene Blue. Methylene blue converts methemoglobin into a more efficient type of haemoglobin to better carry oxygen throughout the body. Thus, it efficiently treats a condition called methemoglobinemia.
Injection site reactions, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm are the common side effects of Sam MB 10mg Injection.
If you are currently taking anti-depressant medications such as escitalopram, notify your doctor before receiving methylene blue. Combining these medications can increase the risk of an uncommon but deadly disease known as serotonin syndrome, which can cause symptoms such as confusion, hallucination, seizure, dramatic fluctuations in blood pressure, rapid heart rate, and fever.
This is a normal and harmless side effect. The medicine is a deep blue dye, and your kidneys naturally filter it out of your body through your urine. The discolouration will disappear once the medication has fully left your system. Talk to your doctor if it persists.
No, this medicine must be injected into a vein by a trained healthcare professional in a hospital or clinical setting. This allows your medical team to monitor your blood oxygen levels and heart rate during treatment. Talk to your doctor for more information.
This medicine is generally avoided during pregnancy unless it is a life-saving emergency, as it may harm an unborn baby. If you are pregnant or think you might be, talk to your doctor about the risks and benefits.
Tell your healthcare provider immediately. Pain, redness, or swelling can mean the fluid is leaking into the tissues around your vein, which requires quick medical attention to prevent irritation. Talk to your doctor if you experience this.
It generally takes a few days for the medicine to be completely cleared from your body, mostly through your urine. You may notice blue-green urine during this time. Talk to your doctor if you have concerns about clearance.
Yes, like any medicine, it can cause an allergic reaction in some people. Inform the medical staff immediately if you develop a rash, hives, itching, or difficulty breathing during or after the injection. Talk to your doctor if you have a history of allergies.
Yes, alcohol can worsen side effects like dizziness, drowsiness, and nausea. It is best to avoid alcohol until the medicine has completely cleared from your system. Talk to your doctor or pharmacist for specific advice.
Your healthcare team may monitor your oxygen levels, heart rate, blood pressure, and repeat blood tests such as co-oximetry to measure methemoglobin levels and confirm that the treatment is working.
Yes, it may be used in certain emergency situations, including severe methemoglobinemia in newborns or infants, but dosing and monitoring are very different from adults. Treatment in babies must always be supervised by a specialist doctor.
If methemoglobin levels do not improve sufficiently, doctors may give another dose, provide additional supportive treatment, or consider other options such as exchange transfusion in severe cases. The decision depends on the cause of the methemoglobinemia, your blood test results, and your overall condition.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

C-122,,Delhi Road,Yamuna Puram, Bulandshahr-203001, Uttar Pradesh, India
Other Info - SA75515
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