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  3. SAFEGUARD TABLET

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SAFEGUARD TABLET, Pack of 10 TABLETS
SAFEGUARD TABLET, Pack of 10 TABLETS
SAFEGUARD TABLET, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
SAFEGUARD TABLET is used to reduce pain and swelling associated with conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It contains diclofenac and misoprostol which works by inhibiting the release of chemical messengers that cause pain and protecting the stomach lining from acid. In some cases, this medicine may cause side effects such as diarrhoea, stomach/abdominal pain, nausea, heartburn, drowsiness, and dizziness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

DICLOFENAC-50MG + MISOPROSTOL-200MCG

Manufacturer/Marketer :

Pulse Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About SAFEGUARD TABLET

SAFEGUARD TABLET belongs to a class of non-steroidal anti-inflammatory drugs used to reduce pain and swelling in the joints associated with conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (pain and stiffness in the backbone). Arthritis is a condition that causes swelling of one or more joints resulting in pain and stiffness of joints that worsen over time. The arthritis symptoms include joint pain, stiffness, redness, tenderness, swelling in and around joints, and reduced movement of joints.

SAFEGUARD TABLET is a combination drug containing diclofenac and misoprostol. Diclofenac works by blocking the chemical effect of an enzyme called cyclo-oxygenase (COX), which produces prostaglandins (mediators of pain and inflammation) that are responsible for the sense of pain and inflammation (redness and swelling). Misoprostol is a prostaglandin that helps to protect the stomach from diclofenac's irritating effects. It works by protecting the stomach lining by reducing the amount of acid in contact with it.

Take SAFEGUARD TABLET as prescribed by your doctor. Depending on your medical conditions, you are advised to take SAFEGUARD TABLET for as long as your doctor has prescribed it for you. You may experience diarrhoea, stomach/abdominal pain, nausea, heartburn, drowsiness, and dizziness. Most of the side effects of SAFEGUARD TABLET do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before using the SAFEGUARD TABLET, tell your doctor if you have had a heart attack or stroke, stomach or bowel disorder, liver disease, porphyria ( inherited blood disorder), asthma, high blood pressure, diabetes, and stomach or intestinal bleeding. Do not take SAFEGUARD TABLET if you are a pregnant or breastfeeding woman. Consumption of alcohol should be avoided during the treatment with SAFEGUARD TABLET as it may lead to an increased risk of liver damage. SAFEGUARD TABLET is not recommended for use in children. Limit alcoholic beverages while on this medication.

Uses of SAFEGUARD TABLET

Treatment of Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis.

Have a query?

Directions for Use

• Take SAFEGUARD TABLET with food or as advised by your doctor.• It is advised to take SAFEGUARD TABLET 2 to 4 times daily; however, follow your doctor’s recommendation regarding the dosage and duration.• Swallow it as a whole with a glass of water.• Do not crush, chew or break it.

Medicinal Benefits

SAFEGUARD TABLET is used to treat aches and pains and musculoskeletal and joint pain problems due to arthritis. SAFEGUARD TABLET contains diclofenac and misoprostol. Diclofenac works by blocking the chemical effect of an enzyme called cyclo-oxygenase (COX), which produces prostaglandins (mediators of pain and inflammation) that are responsible for the sense of pain and inflammation (redness and swelling). Misoprostol is a prostaglandin that helps to protect the stomach from diclofenac's irritating effects. It works by protecting the stomach lining by reducing the amount of acid in contact with it.

How SAFEGUARD TABLET Works

SAFEGUARD TABLET is a combination drug containing diclofenac and misoprostol. Diclofenac works by blocking the chemical effect of an enzyme called cyclo-oxygenase (COX), which produces prostaglandins (mediators of pain and inflammation) that are responsible for the sense of pain and inflammation (redness and swelling). Misoprostol is a prostaglandin that helps to protect the stomach from diclofenac's irritating effects. It works by protecting the stomach lining by reducing the amount of acid in contact with it.

Storage

Keep SAFEGUARD TABLET out of the sight and reach of children.

What if I have taken an overdose of SAFEGUARD TABLET

Take SAFEGUARD TABLET only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include stomach pain, nausea, vomiting, diarrhoea, confusion, drowsiness, low muscle tone, uncontrollable shaking of a part of the body, seizures, shortness of breath, fever, and fast, pounding, or slow heartbeat. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Consumption of alcohol should be avoided during the treatment with SAFEGUARD TABLET. Patients with stomach ulcers, gastric bleeding, heart failure, and high blood pressure should not take SAFEGUARD TABLET. If pregnant or breastfeeding, do not take SAFEGUARD TABLET without talking with the doctor. SAFEGUARD TABLET is not recommended for children below 18 years old. Seek medical help immediately if you have signs of a heart attack or stroke. Stop using SAFEGUARD TABLET and call your doctor immediately if you notice heart problems, kidney problems, liver problems, or stomach bleeding signs.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
MisoprostolDinoprostone
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Safeguard Tablet:
Co-administration of Safeguard Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Safeguard Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
MisoprostolDinoprostone
Severe
How does the drug interact with Safeguard Tablet:
Combined use of Safeguard Tablet and Dinoprostone can affect the metabolism of Safeguard Tablet.

How to manage the interaction:
Taking Safeguard Tablet and Dinoprostone together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MisoprostolOxytocin
Severe
How does the drug interact with Safeguard Tablet:
Coadministration of Safeguard Tablet and Oxytocin can enhance the action of oxytocin. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Safeguard Tablet and Oxytocin together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden or severe stomach pain, unexplained vaginal bleeding, Fast heart rate or low blood pressure in the pregnant person, diarrhea, or dehydration, consult to a doctor. Do not discontinue any medications without consulting a doctor.
DiclofenacMipomersen
Severe
How does the drug interact with Safeguard Tablet:
Co-administration of Safeguard Tablet with Mipomersen may cause liver problems.

How to manage the interaction:
Co-administration of Safeguard Tablet and Mipomersen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DiclofenacAmiloride
Severe
How does the drug interact with Safeguard Tablet:
Taking amiloride with Safeguard Tablet can increase the risk of kidney problems, hyperkalemia(high potassium levels in blood), and high blood pressure.

How to manage the interaction:
There could be a possible interaction between Safeguard Tablet and amiloride, but they can be taken together if your doctor has prescribed them. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
DiclofenacCelecoxib
Severe
How does the drug interact with Safeguard Tablet:
Co-administration of Safeguard Tablet with Celecoxib may increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although there is a interaction between Safeguard Tablet and Celecoxib, but it can be taken if your doctor has advised it. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Do not discontinue any medication without consulting a doctor.
DiclofenacDeferasirox
Severe
How does the drug interact with Safeguard Tablet:
Co-administration of Safeguard Tablet and deferasirox may increase your risk of developing stomach bleeding.

How to manage the interaction:
There may be a possible interaction between Safeguard Tablet and deferasirox but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms such as severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, increased or decreased urination, fluid retention, swelling, shortness of breath, muscle cramps, weakness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
DiclofenacFurosemide
Severe
How does the drug interact with Safeguard Tablet:
Concomitant administration of Safeguard Tablet and furosemide may decrease the therapeutic efficacy of furosemide and adversely affect renal function.

How to manage the interaction:
There may be a possible interaction between Safeguard Tablet and furosemide, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms like nausea, dizziness, irregular heartbeats, altered blood pressure, tingling. Do not stop using any medications without first talking to your doctor.
DiclofenacPrasugrel
Severe
How does the drug interact with Safeguard Tablet:
Taking prasugrel together with Safeguard Tablet may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Safeguard Tablet and Prasugrel can lead to an interaction; it can be taken if advised by a doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacAcalabrutinib
Severe
How does the drug interact with Safeguard Tablet:
Taking acalabrutinib together with Safeguard Tablet may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Safeguard Tablet and Acalabrutinib can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulfate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
  • Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.
  • In chronic arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize the level of cytokines, which ramp up inflammation.
  • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel to minimise pain at the back of your curve. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESICS

SAFEGUARD TABLET Substitute

Substitutes safety advice
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Alcohol

Unsafe

Do not consume alcohol along with SAFEGUARD TABLET as it can cause unpleasant side-effects like gastric bleeding.

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Pregnancy

Unsafe

Please consult your doctor if you are pregnant; your doctor will prescribe SAFEGUARD TABLET only if the benefits outweigh the risks. Taking SAFEGUARD TABLET in the last 20 weeks of pregnancy may cause serious kidney or heart problems in the unborn baby.

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Breast Feeding

Caution

While SAFEGUARD TABLET may pass in the lactating mother's breast milk, So, do it is advisable to take it only if prescribed by your doctor.

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Driving

Caution

SAFEGUARD TABLET may cause dizziness and drowsiness. So, if you observe such symptoms, do not drive.

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Liver

Caution

Limited information was available for the use of SAFEGUARD TABLET in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using SAFEGUARD TABLET in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Limited information was available for the use of SAFEGUARD TABLET in patients suffering from kidney impairment. Please consult your doctor if you have any concerns regarding using SAFEGUARD TABLET in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

SAFEGUARD TABLET not recommended for children under 18 years of age.

FAQs

SAFEGUARD TABLET is used to reduce pain and swelling associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

SAFEGUARD TABLET contains diclofenac and misoprostol. Diclofenac works by blocking the action of cyclo-oxygenase (COX) enzyme in the body involved in the production of certain chemical substances such as prostaglandins that cause pain and swelling. Misoprostol is a prostaglandin that helps to protect the stomach from diclofenac's irritating effects. Thereby, SAFEGUARD TABLET helps in relieving pain and swelling associated with different types of arthritis.

No, SAFEGUARD TABLET is not a narcotic pain killer. It belongs to the non-steroidal anti-inflammatory drugs (NSAIDs) group of medications.

Yes, SAFEGUARD TABLET can cause dizziness in some patients. They may experience symptoms such as the feeling of fainting, weakness, or lightheadedness.

SAFEGUARD TABLET may increase the risk of heart problems such as heart attack, especially when used in high doses or for a prolonged duration, and in patients who are smokers, have high blood pressure, diabetes, or high cholesterol. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking SAFEGUARD TABLET. However, it is recommended to take SAFEGUARD TABLET in the dose and for the duration as prescribed by your doctor.

SAFEGUARD TABLET is not recommended for asthma patients as it may worsen the condition. Therefore, please inform your doctor if you have asthma or a history of asthma due to the use of aspirin or any other non-steroidal drugs.

No, SAFEGUARD TABLET does not cure arthritis. SAFEGUARD TABLET is only used to relieve symptoms of arthritis such as joint pain, swelling, and stiffness.

SAFEGUARD TABLET is used to treat pain associated with arthritis. If you have a toothache, it is recommended that you consult your doctor before using SAFEGUARD TABLET.

SAFEGUARD TABLET may cause gastrointestinal problems. Therefore, do not take SAFEGUARD TABLET if you have acid reflux or abdominal pain without consulting the doctor.

It's generally not recommended to take SAFEGUARD TABLET with blood pressure medication without consulting your doctor as it may increase blood pressure and reduce the effectiveness of blood pressure medications.

The common side effects of SAFEGUARD TABLET include diarrhoea, stomach or abdominal pain, nausea, heartburn, drowsiness, and dizziness. Most of the side effects of SAFEGUARD TABLET do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

4F10, Ballad Estates, Tarnaka, Hyderabad - 500017, TS, India.
Other Info - SAF0014

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:49 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/diclofenac.html
  2. https://www.medicines.org.uk/emc/files/pil.2660.pdf
  3. https://www.medicines.org.uk/emc/files/pil.1642.pdf

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