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compositionComposition:SACUBITRIL-50MG
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Prescription Medicine
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Sacufav-50 Tablet 10's is used to treat heart failure. It is indicated to lower the risk of hospitalisation and cardiovascular death in patients with chronic heart failure. It contains Sacubitril, which relaxes and widens the blood vessels making it easier for the heart to pump blood to all body parts. In some cases, this medicine may cause side effects such as dizziness, lightheadedness, diarrhoea, headache, weakness, and nausea. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SACUBITRIL-50MG

Manufacturer/Marketer :

Signova Pharma

Consume Type :

Oral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Sacufav-50 Tablet 10's

Sacufav-50 Tablet 10's + VALSARTAN is a prescription medicine used to treat chronic heart failure with reduced ejection fraction (HFrEF) in adults. It is typically prescribed for patients with a left ventricular ejection fraction (LVEF) of 40% or less who have New York Heart Association (NYHA) class II–IV symptoms. It helps reduce the risk of cardiovascular death and hospitalisation due to heart failure while improving symptoms such as shortness of breath, fatigue, and reduced exercise capacity. This medicine combines two active ingredients that work together to reduce strain on the heart and improve its pumping ability.


For the best results, take Sacufav-50 Tablet 10's exactly as prescribed by your healthcare provider and continue taking it regularly, even if you feel well. You can take this medicine with or without food, but taking it at the same time(s) each day helps maintain consistent levels in your body. Following a heart-healthy lifestyle, including limiting salt intake, staying physically active as advised by your doctor, and taking your other heart medications as prescribed, can further improve treatment outcomes.


While Sacufav-50 Tablet 10's is generally well tolerated, some people may experience dizziness, low blood pressure, or a mild cough, especially when starting treatment or after a dose increase. Contact your doctor immediately if you develop swelling of the face, lips, tongue, or throat, difficulty breathing, severe dizziness, fainting, or signs of kidney problems.


Before taking Sacufav-50 Tablet 10's, inform your doctor if you have kidney disease, liver disease, low blood pressure, high potassium levels, or a history of angioedema. Do not take this medicine if you have previously experienced angioedema related to an ACE inhibitor or ARB, or if you are pregnant, as it can seriously harm the unborn baby.


This medicine may interact with potassium supplements, potassium-containing salt substitutes, NSAID pain relievers, ACE inhibitors, aliskiren, and certain diuretics, which may increase the risk of side effects or reduce treatment effectiveness. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your healthcare provider before taking this medicine.

Uses of Sacufav-50 Tablet 10's

Your doctor may prescribe this medicine to treat:

  • Chronic Heart Failure with Reduced Ejection Fraction (HFrEF): Helps reduce the risk of cardiovascular death and heart failure-related hospitalisation while improving symptoms and physical function in eligible adults with HFrEF. 

Key Benefits

Sacufav-50 Tablet 10's + VALSARTAN helps improve heart function, relieve symptoms of chronic heart failure, and reduce the risk of serious complications. Clinical studies have shown that it lowers the risk of cardiovascular death and hospitalisation due to worsening heart failure compared with standard ACE inhibitor therapy. Key benefits include:

  • Reduces the Risk of Hospitalisation: Regular use helps lower the risk of hospitalisation due to worsening heart failure.
  • Supports Better Heart Function: Helps reduce the workload on the heart, allowing it to pump blood more efficiently and improving overall cardiovascular function.
  • Improves Heart Failure Symptoms: Helps relieve symptoms such as shortness of breath, fatigue, and reduced exercise capacity, making daily activities easier to perform.

Directions for Use

  • Sacufav-50 Tablet 10's can be taken with or without food as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Sacufav-50 Tablet 10's as a whole with a glass of water.
  • Do not chew, crush or break it.

How Sacufav-50 Tablet 10's Works

Sacufav-50 Tablet 10's + VALSARTAN combines two medicines that work together to treat heart failure. Sacufav-50 Tablet 10's blocks an enzyme called neprilysin, allowing beneficial natural hormones (natriuretic peptides) to remain active for longer. These hormones help widen blood vessels, remove excess salt and water through the kidneys, and reduce the workload on the heart. Valsartan blocks the action of angiotensin II, a hormone that narrows blood vessels and increases blood pressure. By blocking this hormone, valsartan helps relax blood vessels, lower blood pressure, and reduce strain on the heart. Together, these complementary actions improve heart function, reduce fluid build-up, lower the risk of worsening heart failure, and reduce the risk of cardiovascular death and hospitalisation.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Sacufav-50 Tablet 10's to avoid unpleasant side effects.

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Pregnancy

Unsafe

Sacufav-50 Tablet 10's is not recommended for use during pregnancy. Please consult your doctor if you are pregnant; your doctor will prescribe alternate medicine.

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Breast Feeding

Unsafe

Avoid taking Sacufav-50 Tablet 10's if you are breastfeeding. Please consult your doctor if you are breastfeeding; your doctor will prescribe alternate medicine.

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Driving

Caution

Sacufav-50 Tablet 10's may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Sacufav-50 Tablet 10's should not be used in patients with severe liver disease. Please consult your doctor if you have any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Sacufav-50 Tablet 10's should be used with caution in patients with kidney disease. Please consult your doctor if you have any concerns regarding this.

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Children

Unsafe

Sacufav-50 Tablet 10's is not recommended for children as the efficacy and safety have not been established.

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Heart

Caution

Sacufav-50 Tablet 10's should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Sacufav-50 Tablet 10's.

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Geriatrics

Caution

Sacufav-50 Tablet 10's should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Sacufav-50 Tablet 10's.

What if I have taken an overdose of Sacufav-50 Tablet 10's

If you accidentally take more than the prescribed dose, seek emergency medical attention immediately. Symptoms of overdose may include severe dizziness, fainting, or dangerously low blood pressure.

Diet & Lifestyle Advise

  • Limit sodium intake: Follow a low-salt diet to help reduce fluid retention and decrease the workload on your heart.
  • Monitor your weight daily: Weigh yourself at the same time each morning and report sudden weight gain (such as 2–3 pounds in one day or 5 pounds in one week) to your doctor, as it may indicate worsening heart failure.
  • Stay physically active: Engage in regular, doctor-approved physical activities such as walking or cardiac rehabilitation exercises to improve heart health and physical endurance.
  • Avoid potassium supplements unless prescribed: Since this medicine may increase potassium levels, avoid potassium-containing salt substitutes or supplements unless recommended by your healthcare provider.
  • Take your medicines regularly and attend follow-up appointments: Monitor your blood pressure, kidney function, and potassium levels as advised by your doctor to ensure safe and effective treatment.
health query

Have a query?

How Soon It Starts Working

The time required for Sacufav-50 Tablet 10's to start to work: The time required for Sacufav-50 Tablet 10's to show its action is unknown. The time for which the effects of Sacufav-50 Tablet 10's last: The duration of action for Sacufav-50 Tablet 10's is clinically unknown.

What if you forget to take Sacufav-50 Tablet 10's

If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time.

Storage

• Store Sacufav-50 Tablet 10's tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Follow the 36-hour rule: Do not take Sacufav-50 Tablet 10's if you have taken an ACE inhibitor (such as lisinopril, enalapril, or ramipril) within the last 36 hours. Combining these medicines too close together can increase the risk of severe, life-threatening swelling of the face, throat, and airways (angioedema).
  • Monitor your blood pressure regularly: Check your blood pressure at home and keep a record for your doctor. Contact your healthcare provider if your readings are consistently low or if you experience dizziness or fainting when standing.
  • Attend routine blood tests: Keep all scheduled appointments so your doctor can monitor your kidney function and potassium levels to ensure Sacufav-50 Tablet 10's remains safe and effective.
  • Stand up slowly: Rise gradually from a sitting or lying position to reduce the risk of dizziness or fainting caused by a sudden drop in blood pressure.

verifiedApollotooltip

Inform your doctor if you are using any of the following medicines, as they may interact with Sacufav-50 Tablet 10's.

  • ACE inhibitors: Taking these together with Sacufav-50 Tablet 10's significantly increases the risk of severe swelling of the face, lips, tongue, and throat (angioedema). Always allow at least a 36-hour interval between these medicines.
  • Potassium-sparing diuretics or potassium supplements: Combining these with Sacufav-50 Tablet 10's can lead to dangerously high potassium levels in the blood, increasing the risk of abnormal heart rhythms.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs): Medicines such as ibuprofen or naproxen may reduce the effectiveness of Sacufav-50 Tablet 10's and increase the risk of kidney damage.
  • Lithium: Taking Sacufav-50 Tablet 10's with lithium may increase lithium levels in the body, raising the risk of lithium toxicity.
  • Aliskiren: Combining Sacufav-50 Tablet 10's + VALSARTAN with aliskiren is contraindicated in patients with diabetes because it increases the risk of kidney problems, high potassium levels, and low blood pressure. It should also generally be avoided in patients with renal impairment. 

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verifiedApollotooltip
  • Potassium-rich salt substitutes: Salt substitutes containing potassium may increase the risk of high blood potassium levels when used together with Sacufav-50 Tablet 10's.

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Dizziness, particularly when standing up quickly (postural or orthostatic hypotension), is a common side effect of Sacufav-50 Tablet 10's. Rise slowly from sitting or lying positions to reduce the chance of dizziness or fainting. Your doctor may also recommend monitoring your blood pressure regularly. If the dizziness is severe, persistent, or causes you to faint, contact your doctor immediately.
No. Even if your symptoms improve, continue taking Sacufav-50 Tablet 10's exactly as prescribed unless your doctor tells you to stop. Heart failure is a long-term condition, and stopping treatment on your own may cause your symptoms to return or your heart function to worsen. Speak with your doctor before making any changes to your treatment.
No, you must not take Sacufav-50 Tablet 10's if you are pregnant or planning to become pregnant. This medicine can cause severe injury, developmental issues, or death to an unborn baby. If you suspect you are pregnant, stop taking the medicine and talk to your doctor immediately.
While the medicine begins to work in your body within a few hours of your first dose, it may take several weeks of consistent use before you notice a physical improvement in your heart failure symptoms, such as having more energy or breathing easier. Talk to your doctor if you have concerns about your progress.
It is highly recommended to limit or completely avoid alcohol while using this medicine. Alcohol can lower your blood pressure further, increasing the risk of severe dizziness and fainting, and can also directly weaken your heart muscle. Talk to your doctor or pharmacist about safe choices.
Yes, you will need to undergo routine blood tests as prescribed by your healthcare provider. These tests allow your doctor to monitor your kidney function and measure your blood potassium levels to ensure the medication is working safely. Talk to your doctor if you have questions about your testing schedule.
It depends on the specific medication. While some blood pressure medicines can be taken together with this treatment, others, like ACE inhibitors, are extremely dangerous due to the high risk of severe swelling. Always provide your doctor with a complete list of all medications you take to avoid dangerous combinations.
Breastfeeding is not recommended while taking Sacufav-50 Tablet 10's + VALSARTAN because it is not known whether the medicine passes into breast milk, and there is a potential risk to the infant. If you are breastfeeding or planning to breastfeed, discuss alternative treatment options with your doctor.
A cough can occur while taking Sacufav-50 Tablet 10's + VALSARTAN, but it is less common than with ACE inhibitors. If you develop a persistent or bothersome cough, do not stop taking the medicine on your own. Talk to your doctor so they can determine the cause and decide whether any change in treatment is needed.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 207620S008Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.7751 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Entresto 97 mg/103 mg film-coated tablets- Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 22 August 2025]Check here
  4. Entresto 97 mg/103 mg film-coated tablets- Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 2025 Dec 16]Check here
  5. Peter Khalil, Ghazal Kabbach, Sarmad Said and Debabrata Mukherje. Entresto, a New Panacea for Heart Failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on November 24th 2025]Check here
  6. CDSCO [Internet]. Cdscoonline.gov.in. 2025 [Accessed on 28 August 2025]Check here

Country of origin

India

Manufacturer/Marketer address

House No-44, Ground Floor, Barthakur Mill Road, Ulubari, Guwahati, Kamrup,Assam, Pin -781007
Other Info - SAC0217
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