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  3. SA-Don 400 mg Tablet 10's

SA-Don 400 mg Tablet 10's, Pack of 10 TABLETS
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

SA-Don 400 mg Tablet is used to help manage mild to moderate alcoholic liver disease, osteoarthritis, and depression. SA-Don 400 mg Tablet plays a crucial role in supporting cellular functions, regulating key physiological activities, increasing glutathione (a vital antioxidant for liver health), and enhancing overall liver metabolism. Some common side effects may include nausea, diarrhoea, stomach discomfort, and gas (flatulence).

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Composition :

S ADENOSYL L METHIONINE-400MG

Manufacturer/Marketer :

Grapple Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About SA-Don 400 mg Tablet

SA-Don 400 mg Tablet is used in the treatment of mild to moderate alcoholic liver disease, osteoarthritis, and depression. Alcoholic liver disease occurs due to liver damage caused by excessive alcohol consumption. Osteoarthritis is a condition that affects the joints. Depression is a mood disorder and a psychological, physiological and emotional experience that affects the way we think, the things we do and the way we act.

SA-Don 400 mg Tablet contains S-Adenosyl-L-Methionine, an essential amino acid required for optimal cellular functioning. SA-Don 400 mg Tablet is believed to monitor and regulate important physiological functions in living cells. It increases glutathione concentration and enhances liver metabolism. SA-Don 400 mg Tablet increases chondrocyte proteoglycan synthesis, thereby helping treat osteoarthritis.

SA-Don 400 mg Tablet may be taken with or without food, but it is better to take it at a designated time. It should be swallowed whole and not crushed or chewed. In some cases, SA-Don 400 mg Tablet may cause certain common side effects such as nausea, diarrhoea, stomach pain, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

It is advisable to inform the doctor if you are allergic to any of the components of SA-Don 400 mg Tablet . Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding. Exercise caution when taking SA-Don 400 mg Tablet with any anti-Parkinsonian drugs or anti-depressants. It is not advisable to take alcohol with SA-Don 400 mg Tablet as there may be an interaction. Discuss your entire surgical history with your treating doctor and keep them informed of any pending surgical procedure.

Uses of SA-Don 400 mg Tablet

SA-Don 400 mg Tablet is used to treat various medical conditions. The detailed uses are as follows:

Treatment of Alcoholic Liver Disease: SA-Don 400 mg Tablet helps in managing mild to moderate alcoholic liver disease by enhancing glutathione levels, supporting liver detoxification, and improving overall liver metabolism.

Relief from Osteoarthritis Symptoms: SA-Don 400 mg Tablet supports joint health by promoting the production of proteoglycans in cartilage cells, which helps reduce joint pain and stiffness associated with osteoarthritis.

Management of Depression: SA-Don 400 mg Tablet may be used as an adjunct treatment for mild to moderate depression. It supports the production of neurotransmitters like serotonin and dopamine, which help regulate mood and emotional balance.

Directions for Use

  • SA-Don 400 mg Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor's instructions regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow SA-Don 400 mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • SA-Don 400 mg Tablet contains S-Adenosyl-L-Methionine (SAMe), classified as a nutritional and metabolic agent.
  • It works by participating in key biochemical processes such as methylation, antioxidant defence, and neurotransmitter synthesis.
  • It supports liver health by enhancing detoxification, increasing glutathione levels, and promoting healthy liver metabolism.
  • It helps in osteoarthritis by stimulating proteoglycan production in cartilage cells, reducing joint pain and stiffness.
  • It aids in managing mild to moderate depression by supporting the production of mood-related neurotransmitters like serotonin and dopamine.

How SA-Don 400 mg Tablet Works

SA-Don 400 mg Tablet contains S-Adenosyl-L-Methionine; an essential amino acid required for optimal cellular functioning. SA-Don 400 mg Tablet is believed to monitor and regulate important physiological functions in living cells. It increases glutathione concentration and the metabolism of the liver. SA-Don 400 mg Tablet increases chondrocyte proteoglycan synthesis, thereby helping treat osteoarthritis.

Storage

• Store in a cool and dry place away from sunlight.• Keep SA-Don 400 mg Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of SA-Don 400 mg Tablet

Do not take more than the suggested dose. Using more medication will not improve your symptoms; rather, they may cause poisoning or serious side effects. If you suspect that you may have overdosed of SA-Don 400 mg Tablet or if you experience any adverse events, please go to the emergency department of the closest hospital.

Drug Warnings

  • Do not take SA-Don 400 mg Tablet if you are allergic to any of its ingredients.
  • Inform your doctor about your complete medical history, especially if you have liver problems, kidney issues, bipolar disorder, or a weakened immune system.
  • Consult your doctor before using SA-Don 400 mg Tablet if you are pregnant, planning to become pregnant, or breastfeeding.
  • Use caution if you are taking antidepressants, anti-Parkinson’s medications, or any drugs that affect serotonin levels, as interactions may occur.
  • Avoid alcohol while taking SA-Don 400 mg Tablet , as it may interfere with liver function and the effectiveness of the supplement.
  • Tell your doctor about all suggested, over-the-counter, or herbal medicines you are taking.
  • Let your doctor know if you are scheduled for any surgery, as SA-Don 400 mg Tablet may affect anaesthesia or recovery.

Diet & Lifestyle Advise

  • Eat a liver-friendly diet: Include leafy greens, cruciferous vegetables (such as broccoli), garlic, and citrus fruits to support liver detoxification and maintain optimal antioxidant levels.
  • Limit alcohol completely: Alcohol worsens liver damage and interferes with the effectiveness of SA-Don 400 mg Tablet , strictly avoid it.
  • Include anti-inflammatory foods: Add fatty fish (rich in omega-3 fatty acids), turmeric, berries, and nuts to help manage joint pain and inflammation associated with osteoarthritis.
  • Avoid processed and sugary foods: These can worsen liver health, increase inflammation, and negatively impact mood.
  • Ensure adequate protein intake: Moderate intake of lean protein supports muscle strength (important for joint support) and cellular repair.
  • Stay well-hydrated: Proper hydration supports metabolism and the liver's ability to eliminate toxins.
  • Engage in regular physical activity: Low-impact exercises, such as walking, swimming, or yoga, improve joint flexibility and reduce symptoms of depression.
  • Maintain a healthy weight: Excess weight puts pressure on joints and worsens both liver disease and osteoarthritis.
  • Get adequate sunlight or vitamin D: It helps in bone and joint health and may enhance mood.
  • Practice stress-reducing techniques: Meditation, deep breathing, or mindfulness can support mental health and reduce depressive symptoms.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

SA-Don 400 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

It is not known whether it is safe to consume alcohol with SA-Don 400 mg Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Caution

SA-Don 400 mg Tablet should be used with caution in pregnant women. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

The use of SA-Don 400 mg Tablet should be exercised with caution in nursing mothers. Please consult a doctor.

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Driving

Caution

SA-Don 400 mg Tablet may cause drowsiness and dizziness in rare cases. Exercise caution while driving in case of these side effects.

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Liver

Consult your doctor

SA-Don 400 mg Tablet is possibly safe on the liver. Please consult your doctor if you have any concerns.

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Kidney

Consult your doctor

SA-Don 400 mg Tablet is possibly safe on the kidney. Please consult your doctor in case of any concerns.

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Children

Caution

It is not established if SA-Don 400 mg Tablet is safe to use in children. Please consult the treating doctor in case of any concerns.

Have a query?

FAQs

SA-Don 400 mg Tablet is used in the treatment of mild to moderate alcoholic liver disease, osteoarthritis‚ and depression.

Please see an orthopaedic doctor if you have had a fracture. SA-Don 400 mg Tablet is used in the case of arthritis and has limited use in the treatment of fractures, as fractures are more often a surgical concern.

Yes, SA-Don 400 mg Tablet finds a lot of benefit in treating depression. However, if you are on any antidepressants, keep your doctor informed to avoid any interactions.

In case you miss a dose of SA-Don 400 mg Tablet , take it as soon as possible. However, if it is too close to the next dose, revert to the original schedule.

SA-Don 400 mg Tablet is probably safe for the kidneys; however, in the case of CKD, it is best to consult your treating doctor before using SA-Don 400 mg Tablet .

SA-Don 400 mg Tablet works by synthesising methionine, an essential amino acid required for cellular energy.

SA-Don 400 mg Tablet may cause side effects such as nausea, diarrhoea, stomach pain, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

SA-Don 400 mg Tablet should not be used by people who are allergic to any of its components. It is also not recommended for people with bipolar disorder, HIV, pregnant and nursing women.

SA-Don 400 mg Tablet contains S-Adenosylmethionine, a naturally occurring compound found in almost every tissue and fluid in the body. It is made in the body from methionine, an amino acid found in foods.

It is unknown whether SA-Don 400 mg Tablet is safe for long-term use. Take SA-Don 400 mg Tablet for the duration suggested by the doctor.

Country of origin

India

Manufacturer/Marketer address

Grapple Life Sciences Private Limited, Scf 1025, 1St & 2Nd Floor, Motor Market, Manimajra, Chandigarh 160101, India
Other Info - SAD0013

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 25, 2025 | 8:22 AM IST

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Reference

  1. https://www.webmd.com/vitamins/ai/ingredientmono-786/same
  2. https://www.drugs.com/npp/same.html
  3. https://www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth

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