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compositionComposition:AMIVANTAMAB-350MG
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Prescription Medicine
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Rybrevant 50 mg/ml Injection 7 ml used in the treatment of non-small cell lung cancer (NSCLC). It contains amivantamab, which works by blocking the signals that help cancer cells grow and divide. Common side effects may include rash, itching, muscle/joint pain, edema, shortness of breath, cough, constipation, changes in vision, chest discomfort, fever, and flushing. Inform the doctor if you are pregnant, breastfeeding, taking other medicines or have pre-existing medical conditions.

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Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

AMIVANTAMAB-350MG

Manufacturer/Marketer :

Johnson & Johnson Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rybrevant 50 mg/ml Injection 7 ml

Rybrevant 50 mg/ml Injection 7 ml is a prescription medicine used to treat advanced non-small cell lung cancer with specific genetic mutations, especially when the cancer has spread or cannot be removed by surgery. It works by blocking proteins that cancer cells need to grow and multiply.

This medicine is given by intravenous infusion, so your healthcare provider will schedule and manage your treatment sessions. Attend all scheduled appointments to maintain treatment effectiveness. Depending on the cancer type, it may be used with lazertinib or certain chemotherapy medicines, as decided by your oncologist.

Since it is given directly into a vein, it does not need to be taken with or without food. Staying well hydrated before treatment is recommended. Protect your skin from the sun and keep it moisturised during treatment.

Common side effects include skin rash, dry skin, nail problems, and tiredness. Contact your healthcare team immediately if you develop sudden breathing difficulties, severe cough, fever, or vision changes. It can cause serious blood clots in the legs or lungs. Your doctor may consider preventive blood-thinning treatment and monitor for leg swelling, chest pain, or sudden difficulty breathing.

Before treatment, tell your doctor if you have lung or breathing problems, as this medicine can cause serious lung inflammation. Do not use it if you have had a severe allergic reaction to medicine or any of its ingredients. It may harm an unborn baby and should not be used during pregnancy unless specifically advised by your doctor.

Tell your healthcare team about all medicines you take, as some may increase the risk of lung or skin side effects. Avoid smoking during treatment because it can further irritate your lungs. If you are pregnant, planning pregnancy, breastfeeding, or are an older adult, discuss the appropriate safety measures with your doctor.

Uses of Rybrevant 50 mg/ml Injection 7 ml

Your doctor may recommend this infusion to help manage the following conditions:

  • Advanced non-small cell lung cancer (NSCLC): It targets and blocks mutated proteins that cause cancer cells to grow and multiply rapidly, helping to control the spread of the disease when other standard therapies have stopped working.
  • Metastatic lung cancer: For cases where the cancer has spread to other parts of the body, it helps shrink or slow the growth of tumours, providing systemic management of the disease.

Key Benefits

When taken consistently as directed, this infusion may provide the following physiological benefits:

  • Slows cancer growth: Targets specific signals that help certain lung cancer cells grow and may slow tumour progression.
  • May reduce tumour size: In some patients, treatment may shrink existing tumours.
  • May improve symptoms: By controlling the cancer, it may help relieve symptoms such as persistent cough or chest discomfort and improve daily comfort.
Side effects of Rybrevant 50 mg/ml Injection 7 ml
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Rybrevant 50 mg/ml Injection 7 ml is administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Rybrevant 50 mg/ml Injection 7 ml Works

Rybrevant 50 mg/ml Injection 7 ml is a bispecific antibody, which means it is designed to target two different proteins on the surface of cancer cells simultaneously. These two proteins are called EGFR (epidermal growth factor receptor) and MET (mesenchymal-epithelial transition factor). In certain lung cancers, these proteins are overactive, sending constant signals that cause cancer cells to multiply and spread rapidly. Once injected, it binds tightly to both EGFR and MET on the tumour cells. This action blocks the growth signals, essentially starving the cells of the instructions they need to multiply. Additionally, by binding to these proteins, it marks the cancer cells so that your body’s own immune system can easily find and destroy them. This two-pronged approach helps slow down tumour growth and combat the spread of the disease.
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Alcohol

Consult your doctor

It is unknown if alcohol interacts with Rybrevant 50 mg/ml Injection 7 ml. Please consult a doctor if you have any concerns.

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Pregnancy

Unsafe

Rybrevant 50 mg/ml Injection 7 ml is not recommended for use during pregnancy as it may cause fetal harm. Therefore, please inform your doctor if you are pregnant or planning to become pregnant before using Rybrevant 50 mg/ml Injection 7 ml.

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Breast Feeding

Unsafe

It is not known if amivantamab passes into breast milk. Avoid breastfeeding during treatment with Rybrevant 50 mg/ml Injection 7 ml and for 3 months after the last dose.

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Driving

Caution

Rybrevant 50 mg/ml Injection 7 ml may cause dizziness, tiredness or temporary vision problems. Avoid driving or operating heavy machinery if you experience any of these.

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Liver

Caution

Inform your doctor if you have liver impairment. Your doctor will weigh the benefits and any potential risks before prescribing Rybrevant 50 mg/ml Injection 7 ml.

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Kidney

Caution

Inform your doctor if you have kidney impairment. Your doctor will weigh the benefits and any potential risks before prescribing Rybrevant 50 mg/ml Injection 7 ml.

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Children

Caution

Rybrevant 50 mg/ml Injection 7 ml is not recommended for children, as its safety and efficacy have not been established.

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Heart

Caution

If you have heart problems, Rybrevant 50 mg/ml Injection 7 ml can still be used, but with careful monitoring and under strict medical supervision.

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Geriatrics

Caution

Please inform your doctor if you are geriatric before administering Rybrevant 50 mg/ml Injection 7 ml, as there is limited information available on its safety in this age group.

What if I have taken an overdose of Rybrevant 50 mg/ml Injection 7 ml

Because a trained healthcare professional prepares and injects this medicine, an accidental overdose is highly unlikely. However, if you suspect an error has occurred or experience severe, unusual symptoms after an infusion, seek immediate medical attention.

Diet & Lifestyle Advise

  • Protect your skin from the sun: This medicine makes your skin highly sensitive to sunlight. Wear protective clothing, hats, and use a broad-spectrum sunscreen with an SPF of 30 or higher daily, even on cloudy days.
  • Keep your skin and nails moisturised: Apply a thick, alcohol-free moisturiser to your body daily to manage dry skin. Avoid harsh soaps, hot showers, and wear protective gloves when doing household chores to protect your nails.
  • Stay hydrated: Drink plenty of water and clear fluids throughout the day. Proper hydration supports your kidneys and helps your body cope with the physical strain of cancer treatment.
  • Eat small, frequent meals: If you experience mild nausea or a loss of appetite, eating smaller portions throughout the day rather than three large meals can help maintain your energy levels and nutrient intake.
  • Gentle physical activity: Engage in light exercises like short walks if you feel up to it. This can help combat treatment-related fatigue, but always listen to your body and rest when needed.
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Have a query?

How Soon It Starts Working

The time required for Rybrevant 50 mg/ml Injection 7 ml to start to work: The peak effect of Rybrevant 50 mg/ml Injection 7 ml is seen within 1 hour of administration. The time for which the effects of Rybrevant 50 mg/ml Injection 7 ml last: The effect of Rybrevant 50 mg/ml Injection 7 ml usually lasts for hours to a few days.

What if you forget to take Rybrevant 50 mg/ml Injection 7 ml

Since this medicine is given by a healthcare provider at a clinic, it is very important to keep all your appointments. If you miss an appointment or need to reschedule, call your doctor's office immediately. They will guide you on how to reschedule your infusion to ensure your treatment remains effective.

Storage

• It must be stored in a refrigerator at 2°C to 8°C (36°F to 46°F) in its original carton to protect it from light. It must never be frozen or shaken.

Drug Warnings

  • Report skin changes early: Skin reactions are very common. Let your healthcare team know at the first sign of a rash or nail pain so they can prescribe appropriate creams or treatments early.
  • Monitoring: Your doctor may perform regular blood tests, eye examinations, and lung assessments during treatment to check for side effects and monitor your response.
  • Watch the injection site: Notify the nurse immediately if you feel pain, burning, swelling, or redness at the site where the IV line is inserted during your infusion.
  • Avoid live vaccines: Talk to your doctor before getting any vaccinations, especially live vaccines, as your immune system may be affected during treatment.
  • Use reliable birth control: Use highly effective birth control during your treatment and for several months after your last dose, as this medicine can cause severe harm to a developing baby.
  • Inform your doctor: Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins, herbal products, and immunosuppressive medicines you take before starting treatment.
  • Treatment adjustments: If you develop significant side effects, your doctor may pause, slow, delay, or stop the infusion or adjust your treatment until it is safe to continue.

Drug-Drug Interactions

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  • Other skin-sensitising medications: Combining this medicine with other drugs that make your skin sensitive to light can worsen skin rashes and blistering.
  • Medicines that cause lung inflammation: Using this medicine alongside other cancer therapies or drugs known to irritate the lungs can increase the risk of severe lung damage.
  • Other medicines: Tell your doctor if you take other EGFR medicines (such as osimertinib), blood thinners (such as warfarin), immunosuppressants, or supplements, as these may affect your treatment or side-effect risk.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • No clinically significant food interactions are known with Rybrevant 50 mg/ml Injection 7 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Rybrevant 50 mg/ml Injection 7 ml used in the treatment of non-small cell lung cancer (NSCLC). Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, growing more slowly than small cell lung cancer.
Rybrevant 50 mg/ml Injection 7 ml contains amivantamab, which targets and inhibits the activity of EGFR (epidermal growth factor receptor) and MET (mesenchymal-epithelial transition factor), both of which are involved in cancer cell growth and spread. Rybrevant 50 mg/ml Injection 7 ml disrupts pathways that promote cancer cell growth, helping to reduce tumor size and slow disease progression.
Rybrevant 50 mg/ml Injection 7 ml is an antibody targeting EGFR mutations. Your doctor may recommend a biomarker test to determine if this treatment is suitable for you. These tests identify specific biomarkers, including EGFR, to help guide the best treatment approach.
EGFR mutation is an alteration in the epidermal growth factor receptor (EGFR) gene, which can lead to uncontrolled cell growth and is commonly associated with cancers like non-small cell lung cancer (NSCLC).
Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer. It grows more slowly than small cell lung cancer and includes subtypes like adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. NSCLC is often diagnosed in later stages and may cause symptoms such as a persistent cough, chest pain, difficulty breathing, and weight loss.
Rybrevant 50 mg/ml Injection 7 ml may cause harm to an unborn baby and should not be used during pregnancy unless specifically determined appropriate by your healthcare professional. If you are pregnant, think you may be pregnant, or plan to become pregnant, tell your doctor before starting treatment. If you could become pregnant, discuss effective contraception with your healthcare team and how long it should be used after treatment.
Rybrevant 50 mg/ml Injection 7 ml is administered as a slow intravenous (IV) infusion into a vein by a trained healthcare professional in a clinic or hospital. The treatment schedule and infusion duration depend on your condition, treatment regimen, and how you respond to treatment. It should not be self-administered at home.
You are recommended to inform your doctor before using any other medicines with Rybrevant 50 mg/ml Injection 7 ml. This helps ensure that there are no potential interactions or adverse effects between Rybrevant 50 mg/ml Injection 7 ml and the other medicines you may be using.
Common side effects may include rash, itching, muscle/joint pain, edema, shortness of breath, cough, constipation, changes in vision, chest discomfort, fever, and flushing. Seek medical care if the symptoms persist or worsen.
Some patients may feel dizzy, tired, or have mild reactions after their infusion. It is best to have someone drive you to and from your appointments, especially during the first few weeks of treatment. Talk to your doctor about whether it is safe for you to drive.
Yes. Rybrevant 50 mg/ml Injection 7 ml may cause skin reactions such as rash, itching, dryness, or acne-like skin changes. Use a gentle, alcohol-free moisturiser and protect your skin from excessive sun exposure with protective clothing and sunscreen. Avoid harsh or irritating skin products unless recommended by your healthcare team. Contact your healthcare team if you develop a rash, particularly if it is severe, painful, blistering, or worsening, as you may need specific treatment.
While this medicine is not a cure, it is designed to help control the growth and spread of specific cancer cells. This can help shrink tumours, delay the progression of the disease, and manage your symptoms. Talk to your doctor to understand what treatment success looks like for you.
It is not known if this medicine passes into breast milk, but because of the potential risk of serious side effects in a nursing infant, you should not breastfeed during treatment and for several months after your final dose. Talk to your doctor about the safest way to feed your baby.
Pre-medications like antihistamines, pain relievers, or steroids are given to reduce the likelihood and severity of infusion-related reactions, which are common during the first few sessions. Talk to your doctor if you want to know more about these preparatory medicines.
Eye problems, such as dry eyes or inflammation, can occur with this medicine. Avoid wearing contact lenses if you develop eye irritation, and use preservative-free lubricating eye drops if recommended by your healthcare provider. Talk to your doctor right away if you experience eye pain, redness, or changes in your vision.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Corporate Communications, Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Other Info - RYB0008
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