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compositionComposition:FENTANYL-50MCG
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Rufenyl 50 mcg Injection 2 ml is used to relieve pain. It contains Fentanyl, which works by blocking a chemical messenger in the brain responsible for causing pain. In some cases, this medicine may cause side effects such as dizziness, sleepiness, increased or decreased blood pressure, and irregular heartbeat. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

FENTANYL-50MCG

Manufacturer/Marketer :

Rusan Healthcare Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Rufenyl 50 mcg Injection 2 ml

Rufenyl 50 mcg Injection 2 ml is a powerful prescription pain medicine given by injection. Doctors use it to manage severe pain, often during or after surgery, or as part of anaesthesia to help you stay comfortable during a medical procedure. It belongs to a group of medicines called opioid pain relievers and works directly on the central nervous system.

Since this medicine is given as an injection or continuous drip in a clinic or hospital, a healthcare provider will manage your schedule and doses. Because it is injected directly into a vein or muscle, food intake does not affect how it works. Following your medical team's recovery plan, which may include physical therapy and gentle rest, can help support your healing process.

While receiving Rufenyl 50 mcg Injection 2 ml, you might experience common side effects like sleepiness, dizziness, or mild nausea. However, you must tell your medical team immediately if you experience breathing difficulties, severe itching, or extreme confusion, as these can be signs of a serious reaction.

Before receiving Rufenyl 50 mcg Injection 2 ml, tell your doctor if you have a history of breathing problems like asthma, head injuries, or kidney disease. Do not take this if you have a known allergy to similar strong pain medicines or if you are currently experiencing severe breathing difficulties.

Using alcohol, sleeping pills, or anxiety medications while receiving Rufenyl 50 mcg Injection 2 ml is highly dangerous because it can cause life-threatening breathing issues. If you are pregnant, breastfeeding, or an older adult, talk to your doctor, as this medicine requires extra caution and close monitoring in these situations.

Uses of Rufenyl 50 mcg Injection 2 ml

Rufenyl 50 mcg Injection 2 ml is used to relieve pain. The detailed uses of Rufenyl 50 mcg Injection 2 ml are as follows:

  • Severe pain after surgery: Rufenyl 50 mcg Injection 2 ml helps by blocking intense pain signals in the brain and spinal cord, allowing you to rest and recover comfortably.
  • Anaesthesia during medical procedures: Rufenyl 50 mcg Injection 2 ml helps by working alongside other numbing medicines to keep you relaxed, pain-free, and stable during surgical operations.
  • Severe acute pain management: Rufenyl 50 mcg Injection 2 ml helps by providing immediate, powerful relief when other standard pain medicines fail to control short-term pain in clinical settings.

Key Benefits

Rufenyl 50 mcg Injection 2 ml helps provide rapid relief from severe pain, making patients more comfortable during and after medical procedures.

The following are the benefits of Rufenyl 50 mcg Injection 2 ml:

  • Because Rufenyl 50 mcg Injection 2 ml is injected directly into your bloodstream or muscle, it starts working almost instantly to relieve severe, agonising pain.
  • By keeping pain under tight control right after surgery, this medicine allows you to wake up more comfortably and begin necessary post-operative movement sooner.
  • Helps keep your heart rate and blood pressure stable during stressful medical procedures, making operations safer and less distressing for your body.
Side effects of Rufenyl 50 mcg Injection 2 ml
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.

Directions for Use

  • This medicine is given only as an injection into a muscle (intramuscular) or directly into a vein (intravenous) by a trained healthcare professional.
  • You will typically receive Rufenyl 50 mcg Injection 2 ml in a hospital, surgical centre, or clinical setting where your breathing, heart rate, and blood pressure can be closely monitored.
  • Do not attempt to self-inject or use this medicine at home unless you have received specialised training and explicit instructions from your doctor.
  • Always follow your doctor's exact instructions regarding your recovery and any follow-up pain management plans.

How Rufenyl 50 mcg Injection 2 ml Works

Rufenyl 50 mcg Injection 2 ml contains Fentanyl, which works by binding to specific proteins in your brain and spinal cord called opioid receptors. These receptors act like biological gates for pain. When Rufenyl 50 mcg Injection 2 ml attaches to them, it closes these gates, effectively blocking the pain messages that your body sends to your brain. Additionally, this action changes how your brain perceives and emotionally responds to pain, bringing rapid comfort. Because it is injected directly, it bypasses your digestive system entirely, allowing the active ingredients to reach your nervous system immediately for highly efficient relief.
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Alcohol

Unsafe

Rufenyl 50 mcg Injection 2 ml with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit intake of alcoholic beverages with Rufenyl 50 mcg Injection 2 ml.

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Pregnancy

Unsafe

Rufenyl 50 mcg Injection 2 ml is a pregnancy category C drug. Generally, it is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Rufenyl 50 mcg Injection 2 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It may be unsafe to use during breastfeeding as it may cause sleepiness and decreased heart rate in your infant. It is not recommended for use in breastfeeding. Hence, if you are breastfeeding, inform your doctor before receiving Rufenyl 50 mcg Injection 2 ml. Your doctor may suggest you to stop feeding while on treatment with this medicine.

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Driving

Unsafe

Rufenyl 50 mcg Injection 2 ml causes dizziness, sleepiness, and drowsiness. So, do not drive or operate any machinery after taking this medicine until you are alert.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Rufenyl 50 mcg Injection 2 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Rufenyl 50 mcg Injection 2 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Caution

Rufenyl 50 mcg Injection 2 ml is not recommended for children below the age of 18 years.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Rufenyl 50 mcg Injection 2 ml. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Rufenyl 50 mcg Injection 2 ml in elderly patients. Please consult your doctor.

What if I have taken an overdose of Rufenyl 50 mcg Injection 2 ml

Because Rufenyl 50 mcg Injection 2 ml is highly potent, an overdose can be life-threatening and requires immediate medical attention. If you receive too much, emergency medical personnel will treat you immediately with rescue medications and breathing support. Symptoms of an overdose include extremely slow or shallow breathing, pinpoint pupils, severe sleepiness, and loss of consciousness.

Diet & Lifestyle Advise

  • Stay Hydrated: Strong pain medicines can slow down your digestion. Drink plenty of water throughout the day to prevent severe constipation, unless your doctor advises otherwise.
  • Eat High-Fibre Foods: Include fruits, vegetables, and whole grains in your daily diet to keep your bowel movements regular while recovering.
  • Avoid Sudden Movements: To prevent dizziness or fainting when getting up from a bed or chair, sit up slowly and pause for a moment before standing.
  • Rest Safely: Give your body ample time to rest and heal. Avoid driving, operating heavy machinery, or performing tasks that require mental alertness for at least 24 hours after receiving this medicine.
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How Soon It Starts Working

  • The time required for Rufenyl 50 mcg Injection 2 ml to start to work: Rufenyl 50 mcg Injection 2 ml ideally shows its action within 7 to 8 minutes after administration.
  • The time for which the effects of Rufenyl 50 mcg Injection 2 ml last: The effect of Rufenyl 50 mcg Injection 2 ml lasts for 30 to 60 minutes for an intravenous dose and 1 to 2 hours for intramuscular administration.

What if you forget to take Rufenyl 50 mcg Injection 2 ml

Since this medicine is usually given by a healthcare provider in a clinical setting, it is highly unlikely that you will miss a scheduled dose. If you are on a continuous injection plan and suspect a dose was missed or delayed, tell your nurse or doctor right away.

Storage

• Store in a cool and dry place away from sunlight.• Keep Rufenyl 50 mcg Injection 2 ml out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check the solution: Before injecting, always inspect the liquid. It must be clear and colourless. Do not use if you see particles, cloudiness, or discolouration.
  • Monitor breathing closely: If you are caring for someone receiving this medicine at home, watch their breathing patterns carefully. Very slow, shallow breathing is a medical emergency.
  • Prevent accidental needle sticks: Use safe disposal containers (sharps bins) for all used syringes and needles. Never reuse needles.
  • Sit or lie down during administration: Since this medicine can cause sudden drops in blood pressure and dizziness, it is safest to receive the injection while lying down or sitting securely.
  • Be aware of dependency risks: Rufenyl 50 mcg Injection 2 ml is a Schedule II opioid with a high potential for misuse and addiction. Even when used exactly as prescribed, prolonged treatment can lead to physical dependence, meaning your body becomes accustomed to the medicine. Over time, you may also develop tolerance, where higher doses are needed to achieve the same pain-relieving effect. Never increase your dose or stop treatment suddenly without medical advice.

Drug-Drug Interactions

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  • Other opioids or sedatives (e.g., morphine, oxycodone, zolpidem): Combining Rufenyl 50 mcg Injection 2 ml with other strong pain relievers, sleeping pills, or muscle relaxers can cause dangerous slowing of your breathing, extreme drowsiness, or coma.
  • Antidepressants (e.g., sertraline, tranylcypromine): Taking certain mood medicines alongside this drug can cause a rare but serious condition called serotonin syndrome, which involves high fever, rapid heart rate, and confusion.
  • Certain antifungal or antibiotic medications (e.g., ketoconazole, erythromycin): These medicines can slow down how your liver processes Rufenyl 50 mcg Injection 2 ml, increasing the drug's levels in your body and raising the risk of severe side effects.

Drug-Drug Interactions

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How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Taking Safinamide with Rufenyl 50 mcg Injection 2 ml can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Rufenyl 50 mcg Injection 2 ml is not recommended as it can result in an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain, stomach cramps, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Taking Linezolid with Rufenyl 50 mcg Injection 2 ml may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is an interaction between Linezolid and Rufenyl 50 mcg Injection 2 ml, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, muscle pain, stomach cramps, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Taking Rufenyl 50 mcg Injection 2 ml and mifepristone may significantly increase the blood levels of Rufenyl 50 mcg Injection 2 ml, which may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between mifepristone and Rufenyl 50 mcg Injection 2 ml, they can be taken together if advised by a doctor. Do not stop using any medications without talking to your doctor.
How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Taking Rufenyl 50 mcg Injection 2 ml and Ketamine together can increase the risk of adverse effects.

How to manage the interaction:
Taking Ketamine with Rufenyl 50 mcg Injection 2 ml together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - sleepy, confused, or having trouble focusing- contact your doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Taking primidone and Rufenyl 50 mcg Injection 2 ml can increase the risk of side effects.

How to manage the interaction:
Although taking Rufenyl 50 mcg Injection 2 ml together with primidone can result in an interaction, they can be taken together if prescribed by your doctor. However, consult a doctor if you experience watery eyes, a runny nose, sneezing, excessive sweating, fever, chills, fast heartbeat, body aches, abdominal pain, vomiting, or diarrhea. Do not stop taking any medication without consulting your doctor.
How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Taking Rufenyl 50 mcg Injection 2 ml with clomipramine may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking clomipramine and Rufenyl 50 mcg Injection 2 ml together can cause an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience increased heart rate, fever, excessive sweating, muscle pain, stiffness, stomach cramps, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Taking buspirone along with Rufenyl 50 mcg Injection 2 ml can result in significant adverse effects such as respiratory difficulty, unconsciousness.

How to manage the interaction:
Concomitant administration of buspirone alongside Rufenyl 50 mcg Injection 2 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, difficulty concentrating, or impaired judgment, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Coadministration of Rufenyl 50 mcg Injection 2 ml with clotrimazole may increases the blood levels of Rufenyl 50 mcg Injection 2 ml.

How to manage the interaction:
Taking Clotrimazole with Rufenyl 50 mcg Injection 2 ml may possibly result in an interaction, but they can be taken together if prescribed by your doctor. However, if you experience dizziness, fainting, confusion, excessive drowsiness, a slow heart rate, shallow or difficult breathing, and/or shortness of breath, consult your doctor immediately. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Using Hydroxyzine together with Rufenyl 50 mcg Injection 2 ml can increase the risk of side effects.

How to manage the interaction:
Although taking Rufenyl 50 mcg Injection 2 ml together with Hydroxyzine can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you feel sleepy or have difficulty breathing. Do not stop taking any medication without consulting a doctor.
How does the drug interact with Rufenyl 50 mcg Injection 2 ml:
Using Rufenyl 50 mcg Injection 2 ml together with mirtazapine may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Rufenyl 50 mcg Injection 2 ml with Mirtazapine can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain, stomach cramps, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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  • Grapefruit and grapefruit juice: Grapefruit can interfere with how your body breaks down this medicine, potentially leading to dangerously high levels in your blood.
  • Alcohol: Drinking alcohol or consuming products containing alcohol can cause severe drowsiness, breathing failure, and can be fatal.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[NARCOTIC (OPIOID) ANALGESIC]

FAQs

Rufenyl 50 mcg Injection 2 ml is used to relieve pain.
Rufenyl 50 mcg Injection 2 ml contains Fentanyl, which works by blocking a chemical messenger in the brain responsible for causing pain. Hence, changing the way the brain and nervous system respond to pain.
Yes, Rufenyl 50 mcg Injection 2 ml sometimes may make you breathe more slowly than usual or can cause shortness of breath. If you feel so, please inform your doctor immediately. Also, people with any breathing problems should inform their doctor before starting Rufenyl 50 mcg Injection 2 ml.
Elderly patients (aged more than 65 years) are more likely to have confusion and sleepiness or age-related health issues, which may require caution and an adjustment in the dose for patients receiving Rufenyl 50 mcg Injection 2 ml. So, it is better to consult a doctor before receiving this medicine.
Rufenyl 50 mcg Injection 2 ml is a habit-forming drug. It is not likely to be addictive if you take it for 2-4 weeks. However, if the doctor has prescribed you for more than 2-4 weeks, your doctor may reduce your dose before completely stopping it.
Do not stop receiving Rufenyl 50 mcg Injection 2 ml until instructed by your doctor. You may get side effects like confusion, depression, nervousness, sweating, and diarrhoea. Your doctor may lower the dose of Rufenyl 50 mcg Injection 2 ml if using it for more than 2-4 weeks of treatment to reduce side effects.
Be careful while receiving Rufenyl 50 mcg Injection 2 ml as it may cause dizziness, light-headedness, and fainting when you get up too quickly from a lying position. This is more common when you first start receiving Rufenyl 50 mcg Injection 2 ml. To overcome this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Avoid consumption of alcohol while treatment with Rufenyl 50 mcg Injection 2 ml as it may lead to dangerous side effects.
The side effects of Rufenyl 50 mcg Injection 2 ml include sleepiness, dizziness, increased or decreased blood pressure, and irregular heartbeat in some cases. Most of these side effects resolve on their own over time. However, consult the doctor if any of these side effects persist or worsen.
Rufenyl 50 mcg Injection 2 ml is typically reserved for short-term use in hospitals, clinics, or under highly controlled surgical settings. It is not designed for routine, long-term chronic pain management at home. Talk to your doctor to explore long-term pain management options that are safe for home use.
Rufenyl 50 mcg Injection 2 ml is generally not recommended during pregnancy unless the benefits clearly outweigh the risks, as it can pass to the unborn baby and cause withdrawal symptoms after birth. It is also used with caution during labour. Talk to your doctor about the risks and benefits of pain management during pregnancy.
You must avoid driving, operating machinery, or performing any hazardous tasks for at least 24 hours after receiving this medicine, as it causes severe drowsiness and slows reaction times. You must also avoid alcohol and any sedative medications. Talk to your doctor for specific guidance based on your recovery.
Yes, like all strong opioid pain medicines, Rufenyl 50 mcg Injection 2 ml can significantly slow down your digestive system and cause constipation. Your healthcare team may recommend drinking plenty of fluids, eating fibre-rich foods, or taking a mild laxative to prevent this. Talk to your doctor or pharmacist if you experience severe constipation.
An overdose is a medical emergency treated with a rescue medication that quickly blocks the effects of the medicine in the brain. Emergency medical teams will also provide breathing support and monitor heart function. If you suspect an overdose, call emergency services immediately or talk to your doctor.
Because this medicine is extremely potent, it can cause your breathing rate to slow down dangerously, a condition known as respiratory depression. Doctors and nurses monitor your breathing and oxygen levels closely in the hospital to ensure you remain safe. Talk to your doctor if you have pre-existing lung conditions.
No, you must not drink alcohol after receiving this medicine. Alcohol increases the sedative effects of Rufenyl 50 mcg Injection 2 ml, which can lead to life-threatening breathing problems, extreme drowsiness, coma, or death. Talk to your doctor about when it is safe to resume drinking alcohol after your treatment has ended.

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Country of origin

India

Manufacturer/Marketer address

58-D, Government Industrial Estate, Charkop, Kandivali (West), Mumbai - 400 067, Maharashtra, India
Other Info - RUF0034
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