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compositionComposition:RITUXIMAB-500MG
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Prescription Medicine
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Rixilta 500 Injection is used to treat Non-Hodgkin's disease, rheumatoid arthritis, chronic lymphocytic leukaemia, granulomatosis and pemphigus vulgaris. It contains Rituximab, which works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, It works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

RITUXIMAB-500MG

Manufacturer/Marketer :

Halsted Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rixilta 500 Injection

Rixilta 500 Injection is a specialised prescription medication used to treat certain types of blood cancers, such as non-Hodgkin's lymphoma and chronic lymphocytic leukaemia. It is also prescribed for specific autoimmune conditions, including severe rheumatoid arthritis and certain blood vessel disorders. By targeting and clearing out abnormal immune cells, this medicine helps control cellular overgrowth and reduces painful joint inflammation.

Because of how this medicine works, it is not a daily therapy but is instead given in structured treatment cycles spaced weeks or months apart. Since it is given directly into a vein as an infusion, you do not need to worry about taking it with or without food, though being well-hydrated before your appointment is highly recommended. Making healthy lifestyle choices, such as eating a balanced diet and avoiding contact with sick individuals, can help your body get the best results from your treatment.

While many people tolerate this medication well, it is common to experience temporary side effects during the infusion, such as mild fever, chills, or headache. However, you must contact your doctor immediately if you experience serious side effects, such as a severe skin rash, difficulty breathing, or signs of a new infection. Your healthcare team will monitor you closely during and after each session to manage these symptoms safely.

Before starting your first session, talk to your doctor if you have a history of heart disease, breathing disorders, or recurring viral infections like hepatitis B. Do not take this if you currently have a severe, active infection or a severely weakened immune system. Your medical team will perform specific blood tests beforehand to confirm that this treatment is safe for you.

This medicine can interact with other drugs that lower your body's immune response, which can significantly raise your risk of getting sick. It is also important to avoid smoking and limit alcohol consumption, as these habits can place extra strain on your organs and worsen treatment-related fatigue. If you are pregnant, breastfeeding, or are an older adult, consult your doctor to discuss how this therapy may affect you or your baby.

Uses of Rixilta 500 Injection

Rixilta 500 Injection is used to treat certain cancers and autoimmune conditions. Your doctor may prescribe it for the following conditions:

  • Non-Hodgkin’s Lymphoma (NHL): Rixilta 500 Injection helps target and destroy cancer-causing white blood cells to slow down or stop the progression of the disease.
  • Chronic Lymphocytic Leukaemia (CLL): This medication works alongside other therapies to reduce the number of abnormal leukaemia cells in your blood and bone marrow.
  • Rheumatoid Arthritis (RA): It reduces joint pain, swelling, and physical damage in adults who have not found sufficient relief from other standard arthritis medicines.
  • Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA): Rixilta 500 Injection works to reduce severe blood vessel inflammation caused by these rare, overactive immune system disorders.
  • Pemphigus Vulgaris: It helps clear up severe, painful skin and mouth blisters by lowering the levels of the proteins that cause the body to attack its own skin cells.

Key Benefits

Using Rixilta 500 Injection as prescribed helps target the cells responsible for your condition while reducing disease activity. Here are the key benefits you can expect:

  • Provides targeted treatment: Specifically targets the cells causing the disease, helping to preserve healthy tissues while effectively managing the condition.
  • Supports long-lasting symptom relief: Helps reduce joint pain, swelling, and damage, improving mobility and making everyday activities easier. The benefits may last for several months after a treatment course.
  • Helps achieve disease remission: Can help bring certain blood cancers and autoimmune conditions into remission, reducing symptoms and supporting a better quality of life.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Rixilta 500 Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Rixilta 500 Injection Works

Rixilta 500 Injection contains rituximab, a monoclonal antibody that targets a protein called CD20 found on the surface of B-cells, a type of white blood cell. When rituximab binds to CD20, it signals the body's immune system to identify and destroy these B-cells. In conditions such as non-Hodgkin's lymphoma and chronic lymphocytic leukaemia, rituximab helps eliminate abnormal B-cells that are growing uncontrollably. In autoimmune diseases such as rheumatoid arthritis, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and pemphigus vulgaris, it reduces the number of overactive B-cells that attack healthy tissues. Over time, the bone marrow produces new, healthy B-cells, helping to control the disease and reduce inflammation.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Rixilta 500 Injection. Please consult the doctor.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Rixilta 500 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Rixilta 500 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Rixilta 500 Injection will be administered in the hospital setting. Hence, avoid driving.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Rixilta 500 Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Rixilta 500 Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Consult your doctor

Rixilta 500 Injection will be given to the children only if needed. If administered, careful monitoring of the child is needed.

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Heart

Caution

Rixilta 500 Injection may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Rixilta 500 Injection.

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Geriatrics

Caution

Rixilta 500 Injection should be used with caution in elderly people. Therefore, please consult your doctor before using Rixilta 500 Injection.

What if I have taken an overdose of Rixilta 500 Injection

An overdose is highly unlikely because your doses are carefully measured, prepared, and given by trained healthcare professionals in a controlled environment. However, if you feel unwell or experience severe symptoms after returning home from your infusion, seek emergency medical care or contact your doctor immediately.

Diet & Lifestyle Advise

  • Prioritise Infection Prevention: Wash your hands frequently with warm water and soap, and avoid large crowds or close contact with anyone who is visibly sick or has a cold.
  • Practice Food Safety: Since your immune system will be temporarily lowered, eat only fully cooked meats, pasteurised dairy, and thoroughly washed produce to avoid foodborne illnesses.
  • Stay Well Hydrated: Drink plenty of water before and for several days after your infusion to support your kidneys as they process and clear the medication.
  • Incorporate Gentle Movement: If you are treating rheumatoid arthritis, engage in low-impact activities like swimming, walking, or gentle stretching to keep your joints flexible without overworking them.
  • Protect Your Skin: Use a broad-spectrum sunscreen and wear protective clothing when outdoors, as your skin may be more sensitive during treatment.
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Have a query?

How Soon It Starts Working

The time required for Rixilta 500 Injection to start to work: The exact onset of time for Rixilta 500 Injection is unknown. The time for which the effects of Rixilta 500 Injection last: The duration of Rixilta 500 Injection effect is unknown.

What if you forget to take Rixilta 500 Injection

Because this medication is given on a precise schedule under medical supervision, missing an appointment can disrupt your treatment progress. If you must miss a scheduled infusion, call your clinic or prescribing doctor immediately to reschedule. They will help you set up a new appointment as close to the original date as possible.

Storage

• Rixilta 500 Injection is stored in a healthcare facility at 2°C–8°C (36°F–46°F). Do not freeze, shake, or expose the medicine to direct sunlight.

Drug Warnings

  • Speak up during your infusion: Tell your nurse immediately if you start to feel itchy, warm, dizzy, short of breath, or if you develop a sudden cough or throat tickle.
  • Avoid live vaccines: Do not receive any live vaccines (such as the nasal spray flu vaccine or MMR) while on this medication, as your immune system may not be strong enough to handle them.
  • Get screened for Hepatitis B: Ensure your doctor tests your blood for hepatitis B before starting treatment, as this medicine can cause an old, inactive infection to become active again.
  • Use effective birth control: Women of childbearing age must use highly effective birth control during treatment and continue using it for at least 12 months after the final infusion to prevent harm to an unborn baby.
  • Check your skin daily: Report any new sores, painful blisters, or peeling areas inside your mouth or on your skin to your doctor right away.

verifiedApollotooltip
  • Immunosuppressants and Biologics: Combining Rixilta 500 Injection with other medicines that lower your immune system can significantly raise your risk of developing severe, life-threatening infections.
  • Blood Pressure Medications: Because Rixilta 500 Injection can cause a temporary drop in blood pressure during the infusion, your doctor may advise you to stop taking your daily blood pressure pills for a few hours before your session.

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  • No clinically significant food interactions are known with Rixilta 500 Injection when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Rixilta 500 Injection is used to treat Non-Hodgkin’s disease, rheumatoid arthritis, chronic lymphocytic leukaemia, granulomatosis and pemphigus vulgaris.
Rixilta 500 Injection may cause bowel obstruction and perforation, reactivation of Hepatitis B infection, Cardiac arrhythmias, tumour lysis syndrome, and angina in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.
Rixilta 500 Injection contains the active substance rituximab, which is a monoclonal antibody. Rituximab works by binding to the CD20 protein found on certain B cells. This helps the body's immune system destroy these cells, making it effective in treating conditions such as certain blood cancers and autoimmune diseases.
The common side effects of Rixilta 500 Injection are pale skin, painful urination, night sweats, flushing, back pain, nausea, vomiting, diarrhoea, stomach pain, mouth sores, peeling of skin, injection site reactions and pain at the site of injection. If any of these side effects persist or worsen, please consult your doctor.
It is given as a slow liquid drip directly into a vein (intravenous infusion) by a trained healthcare professional in a clinic or hospital. Talk to your doctor to understand your specific treatment schedule.
When used alone, Rixilta 500 Injection does not typically cause hair loss. However, if you are receiving it alongside chemotherapy drugs for cancer, hair thinning or loss may occur. Talk to your doctor about your specific combination of medicines.
You can receive inactive (killed) vaccines like the standard flu shot, but they may not work as well since your immune cells are lowered. You must avoid live vaccines entirely. Talk to your doctor before scheduling any vaccination.
You may feel tired or dizzy after your session, especially if you were given allergy medicines beforehand to prevent a reaction. It is highly recommended to have someone else drive you home after your first few appointments. Talk to your doctor for personalised advice.
There is no direct drug interaction, but alcohol can worsen side effects like headaches, fatigue, and dehydration. It can also place extra strain on your liver, so it is best to limit or avoid alcohol. Talk to your doctor or pharmacist for guidance.
This medicine is not recommended if you are pregnant or planning to become pregnant, as it can temporarily lower the immune system of the developing baby. You should use highly effective birth control during treatment and for 12 months after your last dose. Talk to your doctor to discuss family planning options.

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Country of origin

India
Other Info - RIX0014
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