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compositionComposition:ISONIAZID-300MG+PIPERINE-10MG+RIFAMPICIN-200MG
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Prescription Medicine
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Risorine Capsule is used to treat tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs but can also spread to other body parts such as kidneys, brain, spine, and bone marrow. It contains Rifampicin, Isoniazid, and Piperine, which works by killing the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis). Thus, it helps treat tuberculosis. Sometimes, this medication may cause side effects such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, and gas.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ISONIAZID-300MG+PIPERINE-10MG+RIFAMPICIN-200MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Risorine Capsule

Risorine Capsule is an oral prescription medicine used to treat active tuberculosis infections in the body. Its primary medical purpose is to target and eliminate the specific bacteria that cause this serious respiratory and systemic disease. By clearing these bacteria, the medication helps resolve persistent symptoms and prevents the infection from spreading to others.

To achieve the best results, you must take Risorine Capsule daily and with strict consistency, without skipping any doses. It is highly recommended to take this medication on an empty stomach, either one hour before or two hours after a meal, to ensure proper absorption. Additionally, avoiding alcohol completely and eating a nutrient-dense diet are crucial lifestyle changes that support your body's recovery and protect your health during treatment.

While taking this medicine, you may notice common side effects such as nausea, loss of appetite, or a harmless orange-red discoloration of your urine and sweat. However, you must consult your doctor immediately if you experience serious side effects like yellowing of your eyes or skin, severe abdominal pain, or persistent vomiting.

Before starting this treatment, talk to your doctor if you have a history of nerve pain, gout, or kidney issues. Do not take this if you have severe, active liver disease or have experienced a severe allergic reaction to any of the active ingredients in this medication.

This medication can interact with blood thinners, birth control pills, and alcohol, as it alters how your liver processes these substances. If you are pregnant, breastfeeding, or an older adult, you should consult your healthcare provider to discuss the risks and benefits before starting treatment.

Uses of Risorine Capsule

This medicine is used to treat active tuberculosis (TB) by eliminating the bacteria that cause the infection and preventing its spread. The detailed uses of this medicine are as follows:

  • Tuberculosis (TB): Risorine Capsule is prescribed to treat active tuberculosis infections affecting the lungs and other parts of the body. It works by stopping the growth and multiplication of the bacteria that cause TB, helping clear the infection when taken as part of the prescribed treatment regimen.

Key Benefits

Risorine Capsule helps treat tuberculosis effectively by eliminating the bacteria causing the infection and supporting successful treatment outcomes. Its benefits include:

  • Helps kill the bacteria that cause tuberculosis (TB), preventing the infection from spreading and promoting recovery.
  • Relieves common TB symptoms such as persistent cough, fever, night sweats, fatigue, and unintended weight loss as the infection comes under control.
  • Contains piperine, which helps improve the absorption and bioavailability of the anti-tuberculosis medicines, supporting their effectiveness.
  • Helps reduce the risk of disease progression and serious complications when taken regularly as prescribed.
  • Supports complete recovery and lowers the risk of treatment failure or drug resistance by ensuring effective antibacterial action when the full course is completed.

Directions for Use

  • Take Risorine Capsule with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Risorine Capsule Works

Risorine Capsule contains Rifampicin, Isoniazid, and Piperine. Rifampicin: It is an antibiotic that blocks the bacterial DNA-dependent RNA polymerase enzyme, preventing the bacteria from producing essential proteins. This stops the tuberculosis bacteria from growing and multiplying, helping eliminate the infection. Isoniazid: It is an anti-tuberculosis medicine that prevents the bacteria from forming mycolic acids, essential components of the bacterial cell wall. Without a protective cell wall, the bacteria cannot survive and are destroyed. Piperine: It is a bioavailability enhancer that helps improve the absorption of rifampicin and isoniazid. It slows the breakdown of these medicines in the body, allowing higher amounts to reach the bloodstream and infection site, thereby supporting the overall effectiveness of the treatment.
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Alcohol

Caution

Avoid alcohol consumption, as it could lead to increased drowsiness and dizziness.

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Pregnancy

Caution

Please consult the doctor if you are pregnant; your doctor will prescribe Risorine Capsule only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Risorine Capsule may pass into breast milk. Do not breastfeed while taking Risorine Capsule .

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Driving

Caution

Risorine Capsule may cause dizziness and drowsiness. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed. Please consult the doctor if you have liver impairment.

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Kidney

Caution

Dose adjustment may be needed. Please consult the doctor if you have kidney impairment.

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Children

Caution

Please consult the doctor if you have any concerns regarding the usage of Risorine Capsule in children.

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Heart

Caution

Avoid using Risorine Capsule if you have heart problems, as it may interfere with cardiac medications and worsen certain conditions. Always consult your doctor before starting it.

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Geriatrics

Caution

Avoid using Risorine Capsule if you're geriatric without medical supervision, as it may cause dizziness, liver strain, and interact with other medications. Dose adjustments and close monitoring are often needed in older adults.

What if I have taken an overdose of Risorine Capsule

In case of an accidental overdose, seek immediate medical attention or contact your local emergency services. Symptoms of an overdose may include severe nausea, vomiting, dizziness, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid alcohol entirely: Because this medication is processed by the liver, consuming alcohol significantly increases your risk of severe liver damage.
  • Support your nervous system: Talk to your doctor about taking a Vitamin B6 (pyridoxine) supplement daily, as it helps prevent the tingling and nerve pain that can sometimes occur during this treatment.
  • Eat a balanced diet: Focus on nutrient-rich foods high in protein, vitamins, and minerals to help your immune system fight the infection and rebuild muscle mass.
  • Rest and pace yourself: Your body uses a lot of energy to heal from tuberculosis. Prioritize getting adequate sleep and avoid overexertion.
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How Soon It Starts Working

The time required for Risorine Capsule to start to work: The time required for Risorine Capsule to show its action is unknown. The time for which the effects of Risorine Capsule last: The duration of action for Risorine Capsule is unknown.

What if you forget to take Risorine Capsule

If you miss a dose, take it as soon as you remember. If your next scheduled dose is only a few hours away, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Risorine Capsule at room temperature, ideally between 15°C and 30°C.

Drug Warnings

  • Monitor your body: Regularly check your skin and the whites of your eyes for any yellowing, which could be an early sign of liver issues.
  • Do not wear soft contact lenses: The harmless orange-red discoloration of your tears can permanently stain soft contact lenses. Switch to glasses for the duration of your treatment.
  • Complete the full course: Never stop taking this medicine early, even if you feel completely better. Stopping too soon can cause the infection to return in a form that is resistant to antibiotics.
  • Avoid live vaccines: This medication can stop live bacterial vaccines (such as the oral typhoid vaccine) from working. Always tell your healthcare provider you are taking this medicine before getting any vaccinations.

Drug-Drug Interactions

verifiedApollotooltip
  • Hormonal Contraceptives: May decrease the effectiveness of birth control pills, patches, or implants. Use a reliable, non-hormonal barrier method (such as condoms) during treatment.
  • Blood Thinners: May speed up how quickly your body processes medicines like warfarin, requiring closer monitoring of your blood clotting levels.
  • Paracetamol/Acetaminophen: May increase the risk of liver damage when taken together regularly.
Rifampicin + IsoniazidIndinavir
Critical
Rifampicin + IsoniazidVoriconazole
Critical

Drug-Drug Interactions

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Rifampicin + IsoniazidIndinavir
Critical
How does the drug interact with Risorine Capsule:
Taking indinavir with Risorine Capsule can reduce the blood levels and effects of indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and Risorine Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidVoriconazole
Critical
How does the drug interact with Risorine Capsule:
Taking voriconazole with Risorine Capsule can increase the risk of infections.

How to manage the interaction:
Although there is an interaction between voriconazole and Risorine Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidRanolazine
Critical
How does the drug interact with Risorine Capsule:
Taking ranolazine with Risorine Capsule can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and Risorine Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidDarunavir
Critical
How does the drug interact with Risorine Capsule:
Taking darunavir with Risorine Capsule can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and Risorine Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidSaquinavir
Critical
How does the drug interact with Risorine Capsule:
Taking saquinavir with Risorine Capsule can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and Risorine Capsule, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidDesogestrel
Severe
How does the drug interact with Risorine Capsule:
Coadministration of desogestrel with Risorine Capsule may reduce the blood levels and effects of desogestrel.

How to manage the interaction:
Although there is an interaction between desogestrel and Risorine Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidWarfarin
Severe
How does the drug interact with Risorine Capsule:
Taking warfarin with Risorine Capsule can reduce the effectiveness and also increase the risk of side effects of Risorine Capsule.

How to manage the interaction:
Although there is an interaction between Risorine Capsule and warfarin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidMipomersen
Severe
How does the drug interact with Risorine Capsule:
Taking Risorine Capsule and mipomersen can increase the risk and severity of liver problems.

How to manage the interaction:
Although there is an interaction between Risorine Capsule and mipomersen, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, or abdominal pain. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidAbemaciclib
Severe
How does the drug interact with Risorine Capsule:
Taking abemaciclib with Risorine Capsule can reduce blood levels and also increase the risk of side effects of Risorine Capsule.

How to manage the interaction:
Although there is an interaction between Risorine Capsule and abemaciclib, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidCefamandole
Severe
How does the drug interact with Risorine Capsule:
Taking cefamandole with Risorine Capsule can increase the risk of side effects that can cause bleeding complications.

How to manage the interaction:
Although there is an interaction between Risorine Capsule and cefamandole, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Tyramine-rich foods: Avoid eating aged cheeses, red wine, cured meats, and yeast extracts, as combining them with this medication can cause a sudden, dangerous rise in blood pressure.
  • Histamine-rich foods: Avoid certain fish like tuna or mackerel, which may cause flushing, sweating, or a fast heartbeat when eaten during your treatment course.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Risorine Capsule is used to treat Tuberculosis.
Risorine Capsule works by killing the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis).
Do not stop taking Risorine Capsule despite symptomatic relief. To treat your condition effectually, continue taking Risorine Capsule for as long as it has been prescribed for you.
Risorine Capsule might decrease the effectiveness of oral contraceptives (birth control pills). Use a reliable barrier method of contraception such as condoms or the coil while taking Risorine Capsule . Consult the doctor if you have any concerns regarding this; your doctor may suggest an alternate method of contraception.
Risorine Capsule may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time, even after you stop taking Risorine Capsule . Do not worry, as it is a common side effect of Risorine Capsule .
One of the active ingredients in this medicine causes a harmless, temporary orange-red discoloration of body fluids, including urine, sweat, saliva, and tears. This is expected and is not a cause for alarm. Talk to your doctor if you notice any other changes or have concerns.
No, you should not drink alcohol while taking this medicine. Both alcohol and this medication are processed by the liver, and combining them significantly increases the risk of severe liver damage. Talk to your doctor if you have questions about this.
Take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently miss doses.
Taking this medicine with food can significantly reduce how much of the active ingredients your body absorbs, making the treatment less effective. For the best results, take it at least one hour before or two hours after a meal. Talk to your doctor or pharmacist if you struggle to manage your dosing times.
Tingling, numbness, or a "pins and needles" sensation in your extremities can sometimes happen during this treatment. Your doctor may suggest taking a daily Vitamin B6 (pyridoxine) supplement to help prevent or ease this issue. Talk to your doctor if you experience these symptoms.
This medicine can temporarily stain bodily fluids, including tears, an orange-red color. This may permanently discolor soft contact lenses. It is best to wear glasses instead of soft contact lenses during your treatment. Talk to your doctor or optician for advice.

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Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.
Other Info - RIS0060
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