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Rioci 1 Tablet is used to treat pulmonary arterial hypertension (PAH; high blood pressure in the lungs). It is also used to treat chronic thromboembolic pulmonary hypertension (high blood pressure in the lung arteries). Additionally, it may improve the ability to exercise in people with these conditions and may slow the worsening of symptoms in people with PAH. This medicine works by relaxing the blood vessels in the lungs. This allows blood to flow easily and lowers blood pressure.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RIOCIGUAT-1MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rioci 1 Tablet

Rioci 1 Tablet is a prescription medicine used to treat adults with certain types of high blood pressure in the lungs, known as pulmonary hypertension. Specifically, it helps manage chronic thromboembolic pulmonary hypertension that cannot be treated with surgery (or remains after surgery), as well as pulmonary arterial hypertension. It works by relaxing the blood vessels in the lungs to improve blood flow and lower blood pressure.

This medicine is typically taken three times a day, and it is highly important to take it consistently at the same times every day. You can take Rioci 1 Tablet with or without food, but you should choose one way and stick to it. Making dietary changes like reducing your salt intake and staying active with light, doctor-approved exercise can further support your heart and lung health.

Many people tolerate this medicine well, though some may experience mild side effects such as headaches, dizziness, or stomach upset. However, you must contact your healthcare provider immediately if you experience serious symptoms like coughing up blood, sudden breathlessness, or severe dizziness that makes you feel faint.

Before starting this treatment, tell your doctor if you have a history of heart, liver, or kidney problems, or if you have recently experienced serious bleeding. Do not take this if you are pregnant, planning to become pregnant, or if you take certain medicines for erectile dysfunction or chest pain, as these combinations can be dangerous.

This medicine can interact with several other drugs, and smoking cigarettes can significantly lower the amount of medicine in your body, making it less effective. If you belong to a specific user group, such as being elderly or having kidney issues, your doctor may monitor you more closely, and those who are breastfeeding should consult their doctor before use.

Uses of Rioci 1 Tablet

Rioci 1 Tablet is used to treat the following conditions:

  • Chronic Thromboembolic Pulmonary Hypertension (CTEPH): Rioci 1 Tablet helps improve exercise capacity and physical symptoms in adults with CTEPH who cannot have surgery, or those who still have high blood pressure in the lungs after undergoing surgery to remove blood clots.
  • Pulmonary Arterial Hypertension (PAH): Rioci 1 Tablet helps lower blood pressure in the pulmonary arteries, improving the patient's ability to exercise, walk further, and delay the worsening of physical symptoms.

Key Benefits

Rioci 1 Tablet provides meaningful relief by directly targeting the narrowed blood vessels in your lungs. By helping these vessels relax and widen, the medicine makes it easier for your heart to pump blood through your lungs, which brings significant real-world benefits to your daily life.Key benefits include:

  • Improved Breathing: By reducing the pressure in your lungs, the medicine helps decrease shortness of breath, allowing you to breathe more easily during daily tasks.
  • Increased Exercise Capacity: Many patients find they can walk longer distances and engage in physical activities with less fatigue and chest discomfort.
  • Better Quality of Life: With improved stamina and fewer symptoms, you can better manage daily routines, chores, and social activities without feeling constantly exhausted.
Side effects of Rioci 1 Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Rioci 1 Tablet can be taken with or without food because food does not significantly affect its absorption or effectiveness.
  • It is usually taken three times a day, or as prescribed by your doctor.
  • Swallow Rioci 1 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Rioci 1 Tablet Works

Rioci 1 Tablet belongs to a class of medicines that act as stimulators of an enzyme in the body called soluble guanylate cyclase (a protein that helps control how your blood vessels relax). This enzyme plays a crucial role in controlling how blood vessels expand and contract. By stimulating this enzyme, Riociguat increases the production of a natural substance that signals the blood vessels in your lungs to relax and widen. As a result, it lowers the resistance and blood pressure within your lungs, reducing the workload on the right side of your heart and making it easier for your heart to pump oxygen-rich blood throughout your body.
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Alcohol

Caution

It is advised to limit alcohol intake since alcohol consumption with Rioci 1 Tablet may increase the risk of low blood pressure and cause adverse effects, such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Caution

Consult your doctor, and there is no substantial research yet on the use of Rioci 1 Tablet in pregnant women.

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Breast Feeding

Caution

Consult your doctor, and there is no substantial research yet on the use of Rioci 1 Tablet in breastfeeding/nursing mothers.

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Driving

Caution

It is not known whether Rioci 1 Tablet alters the ability to drive. Do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Please consult your doctor if you have any concerns regarding using Rioci 1 Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding using Rioci 1 Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

There is limited information available on the use of Rioci 1 Tablet in children. Please consult your doctor.

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Heart

Caution

Rioci 1 Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Rioci 1 Tablet .

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Geriatrics

Caution

Rioci 1 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Rioci 1 Tablet .

What if I have taken an overdose of Rioci 1 Tablet

If you accidentally take too much of this medicine, you may experience severe dizziness, lightheadedness, or fainting due to a sudden drop in blood pressure. Seek emergency medical attention.

Diet & Lifestyle Advise

  • Reduce Salt Intake: Eat a low-sodium diet to help prevent fluid retention, which can put extra strain on your heart and lungs. Avoid processed foods and do not add extra salt to your meals.
  • Stay Active Wisely: Engage in gentle, low-impact exercises like walking, but only after discussing a safe physical activity plan with your doctor. Stop immediately if you feel dizzy or short of breath.
  • Avoid Smoking: Smoking cigarettes can significantly speed up how fast your body processes this medicine, making it less effective. If you smoke, talk to your doctor about support for quitting. If you stop smoking while taking this medicine, your dose may need to be adjusted.
  • Monitor Fluid Levels: Weigh yourself daily at the same time. A sudden increase in weight can be a sign of fluid buildup in your body, which you should report to your healthcare provider.
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How Soon It Starts Working

The time required for Rioci 1 Tablet to start to work: Rioci 1 Tablet ideally shows its action within 1 hour of administration. The time for which the effects of Rioci 1 Tablet last: Rioci 1 Tablet effect lasts for 8 to 12 hours.

What if you forget to take Rioci 1 Tablet

If you miss a dose, skip the missed dose and take your next regular dose at its scheduled time. Do not take a double dose to make up for the missed one. If you miss your doses for three or more days in a row, contact your doctor before resuming the medicine, as you may need to restart at a lower dose.

Storage

•Store Rioci 1 Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F and 77°F). •Keep the tablets in their original packaging to protect them from moisture and light.

Drug Warnings

  • Pregnancy Warning: This medicine can cause severe harm to an unborn baby. Female patients of childbearing potential must use highly effective birth control during treatment and for one month after stopping and undergo regular pregnancy tests.
  • Never Mix with Nitrates: Do not take this medicine if you use nitrates (such as nitroglycerin) for chest pain, or recreational drugs called 'poppers,' as this can cause a life-threatening drop in blood pressure.
  • Avoid Erectile Dysfunction Medicines: Do not use medicines for erectile dysfunction, called phosphodiesterase (PDE) inhibitors, such as sildenafil or tadalafil, while taking this medicine, as combining them can cause dangerously low blood pressure.
  • Watch for Bleeding: This medicine can increase your risk of serious bleeding. Be cautious with sharp objects, avoid contact sports, and report any unexplained bruising or bleeding to your doctor.
  • Avoid Antacids Near Dose Times: Antacids containing aluminium or magnesium can stop your body from fully absorbing this medicine. Avoid taking these antacids within one hour of taking your tablet.
  • Rise Slowly: To minimise dizziness or lightheadedness when standing up from a sitting or lying position, get up slowly and steady yourself.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Nitrates and Nitric Oxide Donors: Taking these together can cause a severe, life-threatening drop in blood pressure. Do not take them concurrently.
  • Phosphodiesterase (PDE) Inhibitors: Combining Rioci 1 Tablet with medicines like sildenafil, tadalafil, or vardenafil can lead to excessively low blood pressure and dizziness.
  • Certain antifungal medicines and HIV treatments (Strong CYP and P-gp inhibitors):  Some antifungal medicines (like ketoconazole or itraconazole) or HIV protease inhibitors can increase the levels of Rioci 1 Tablet in your blood, raising the risk of side effects.
  • Certain medicines that make your body break down Rioci 1 Tablet faster (Strong CYP Inducers): Certain medicines, such as rifampicin, can significantly lower the levels of Rioci 1 Tablet in your blood, making it less effective.
RiociguatAmyl nitrite
Critical

Drug-Drug Interactions

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RiociguatAmyl nitrite
Critical
How does the drug interact with Rioci 1 Tablet:
Using Amyl Nitrite with Rioci 1 Tablet may cause excessively low blood pressure.

How to manage the interaction:
Taking Amyl nitrite with Rioci 1 Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rioci 1 Tablet:
Taking Dipyridamole with Rioci 1 Tablet may lower blood pressure.

How to manage the interaction:
Taking Dipyridamole with Rioci 1 Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rioci 1 Tablet:
Co-administration of Theophylline with Rioci 1 Tablet can increase the risk of low blood pressure.

How to manage the interaction:
Taking Theophylline with Rioci 1 Tablet is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, flushing (a sudden reddening of the face), headache, and nasal congestion (stuffy nose). Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rioci 1 Tablet:
Taking Avanafil with Rioci 1 Tablet may significantly lower blood pressure.

How to manage the interaction:
Taking Rioci 1 Tablet with Avanafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rioci 1 Tablet:
Taking Rioci 1 Tablet with Isosorbide mononitrate can cause low blood pressure.

How to manage the interaction:
Taking Isosorbide mononitrate with Rioci 1 Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rioci 1 Tablet:
Taking Rioci 1 Tablet with Isosorbide dinitrate may lead to excessively low blood pressure.

How to manage the interaction:
Taking Isosorbide dinitrate with Rioci 1 Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rioci 1 Tablet:
Taking Vardenafil with Rioci 1 Tablet may significantly lower the blood pressure.

How to manage the interaction:
Taking Rioci 1 Tablet with Vardenafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rioci 1 Tablet:
Coadministration of Aminophylline with Rioci 1 Tablet may significantly lower your blood pressure.

How to manage the interaction:
Taking Aminophylline with Rioci 1 Tablet can cause an interaction, however, it can be taken only if a doctor has advised it. If you experience dizziness, lightheadedness, shortness of breath, fainting, flushing, headache, and nasal congestion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rioci 1 Tablet:
Co-administration of Sildenafil with Rioci 1 Tablet may lower the blood pressure.

How to manage the interaction:
Taking Rioci 1 Tablet and Sildenafil together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rioci 1 Tablet:
Taking Tadalafil with Rioci 1 Tablet may increase the risk or severity of lower the blood pressure.

How to manage the interaction:
Taking Rioci 1 Tablet with Tadalafil is generally not recommended as it can lead to an interaction, but it can be taken together if prescribed by a doctor. However, if you experience dizziness, headache, and nasal congestion consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods or drinks may affect the safety or tolerability of Rioci 1 Tablet . Important interactions include:

  • Antacids: Antacids containing magnesium or aluminium can reduce the absorption of Rioci 1 Tablet . Do not take these antacids within one hour before or after taking your medicine.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Rioci 1 Tablet is used to treat pulmonary arterial hypertension (high blood pressure in the lungs).
Rioci 1 Tablet contains ‘Riociguat’. It works by relaxing the blood vessels in the lungs to allow blood to flow easily. Thereby, it increases the blood supply to the lungs.
Please do not stop using Rioci 1 Tablet without consulting your doctor on your own. Continue using Rioci 1 Tablet for as long as your doctor has prescribed it to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Rioci 1 Tablet .
Rioci 1 Tablet is safe if used in the dose and duration recommended by your doctor. Take it exactly as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.
Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose.
Patients with lactose intolerance should exercise caution when taking Rioci 1 Tablet . If you have a rare hereditary problem such as galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption, you should not take Rioci 1 Tablet due to its lactose content. Consult your healthcare professional for guidance and concerns.
To make swallowing Rioci 1 Tablet easier, take it with a full glass of water or use a pill-swallowing aid. Please consult your doctor about alternative options, like crushing or splitting the tablet if needed.
Regular blood pressure monitoring is crucial while taking Rioci 1 Tablet to ensure its effectiveness and safety. This is because Rioci 1 Tablet can cause low blood pressure (hypotension), dizziness, fainting, or weakness. By regularly monitoring blood pressure, you can detect any sudden drops or fluctuations, allowing for timely adjustments to the dosage if needed and ensuring safe and effective treatment under your doctor's guidance.
The side effects of Rioci 1 Tablet include headache, dizziness, diarrhoea, decreased blood pressure, vomiting, nausea, anemia (low number of red blood cells), gastro-oesophageal reflux disease, and constipation. These side effects are not familiar to everyone and vary individually. Please consult the doctor if you notice any side effects that are not manageable.
No, you must not take Rioci 1 Tablet if you are pregnant or planning to become pregnant, as it can cause severe birth defects. Female patients must use reliable birth control during treatment. Talk to your doctor for safe options.
If you miss taking your medicine for three or more days in a row, do not simply restart your usual dose. Contact your healthcare provider immediately, as you may need to restart the medicine at a lower dose and gradually increase it again. Talk to your doctor.
It is best to limit or avoid alcohol while taking this medicine. Alcohol can lower your blood pressure, which may increase the risk of feeling dizzy, lightheaded, or fainting when combined with Rioci 1 Tablet . Talk to your doctor.
Smoking cigarettes causes your body to break down this medicine much faster, which lowers its level in your blood and makes it less effective. If you start or stop smoking during treatment, your dose may need to be adjusted. Talk to your doctor.
Yes, but timing is very important. Antacids containing aluminium or magnesium can prevent your body from absorbing this medicine properly. Always take these antacids at least one hour before or one hour after taking Rioci 1 Tablet . Talk to your doctor.
No, you should not take these medicines together. Combining Rioci 1 Tablet with phosphodiesterase inhibitors like sildenafil or tadalafil can cause a dangerous and sudden drop in blood pressure. Talk to your doctor.
No, Rioci 1 Tablet does not cure pulmonary hypertension, but it helps manage the symptoms and slows down the progression of the disease by lowering blood pressure in your lungs. You must continue taking it as prescribed even if you feel better. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

MSN Laboratories Pvt.Ltd., MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA
Other Info - RIO0045
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