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  3. Rifafrez 400 mg Tablet 10's

Rifafrez 400 mg Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Rifafrez 400 mg Tablet 10's is used to treat infectious traveller's diarrhoea caused by E.coli bacteria, hepatic encephalopathy (decreased brain function due to liver disease) and irritable bowel syndrome with diarrhoea (IBS-D). It contains Rifaximin, which works by working on the bowel and preventing the spread of infections caused by the loss of beneficial gut bacteria. Thus, it helps in relieving abdominal pain and diarrhoea. In some cases, you may experience common side effects such as headaches, peripheral oedema (leg swelling), nausea, dizziness, fatigue, ascites (excess fluid buildup in the abdomen), and increased liver enzymes (ALT). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

RIFAXIMIN-400MG

Manufacturer/Marketer :

Altis Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Rifafrez 400 mg Tablet 10's

Rifafrez 400 mg Tablet 10's is used to treat infectious traveller's diarrhoea, hepatic encephalopathy and irritable bowel syndrome with diarrhoea (IBS-D). Traveller’s diarrhoea is an infection in which there is a passage of unformed stools. Hepatic encephalopathy causes loss of brain function when a damaged liver is unable to remove toxins from the blood. Irritable bowel syndrome is a condition which affects the large intestine.

Rifafrez 400 mg Tablet 10's contains Rifaximin, which works by acting on the bowel and preventing the spread of infections caused by the loss of beneficial gut bacteria. 

Common side effects of Rifafrez 400 mg Tablet 10's include headache, leg swelling, nausea, dizziness, fatigue, ascites (excess fluid buildup in the abdomen), and increased liver enzymes (ALT). Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if you experience these side effects persistently.

Take Rifafrez 400 mg Tablet 10's by mouth with or without food as directed by your doctor. The dosage is based on your medical condition and response to treatment. To help you remember, take it at the same time each day. Do not chew, crush, or break the medicine.

Before starting Rifafrez 400 mg Tablet 10's, please inform your doctor if you have any allergies (to any antibiotic) or kidney or liver problems. Do not take Rifafrez 400 mg Tablet 10's for more than 3 days unless your doctor prescribes it. Inform your doctor if you are pregnant or breastfeeding without talking to your doctor. Rifafrez 400 mg Tablet 10's is not recommended for children as efficacy and safety have not been established.

Uses of Rifafrez 400 mg Tablet 10's

Rifafrez 400 mg Tablet 10's is used in the treatment of travelles' diarrhoea, liver encephalopathy, and irritable bowel syndrome due to diarrhoea. The detailed uses of Rifafrez 400 mg Tablet 10's are as follows:

  • Diarrhoea in Travellers: Rifafrez 400 mg Tablet 10's is frequently used to treat patients' diarrhoea brought on by non-invasive strains of Escherichia coli when they are visiting places with contaminated food or water.
  • Irritable Bowel Syndrome (IBS): By treating intestinal bacterial overgrowth, Rifafrez 400 mg Tablet 10's can help reduce IBS symptoms, especially those with diarrhoea as the predominant symptom.
  • Simple Infections: Rifafrez 400 mg Tablet 10's works well for treating simple gastrointestinal infections that might not be improving with other antibiotics.
  • Complications Associated with Liver Disease: By reducing the amount of ammonia-producing bacteria in the gut, this medication helps treat hepatic encephalopathy. This condition can develop in people with liver disease.

Directions for Use

  • Take Rifafrez 400 mg Tablet 10's with or without food as advised by your doctor.
  • It is advised to take Rifafrez 400 mg Tablet 10's three times daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Rifafrez 400 mg Tablet 10's as a whole with a glass of water.
  • Do not crush, chew or break it.

Medicinal Benefits

  • Rifafrez 400 mg Tablet 10's is used to treat traveller’s diarrhoea caused by noninvasive strains of E.coli.
  • Rifafrez 400 mg Tablet 10's is a broad-spectrum antibiotic that is effective against gram-positive and gram-negative bacteria, aerobic and anaerobic bacteria, and ammonia-producing bacteria.
  • This medicine is a gastrointestinal-selective antibiotic with a broad spectrum of antimicrobial activity.
  • Rifafrez 400 mg Tablet 10's is bactericidal in nature and works by killing the bacteria that cause infections. Thus, it helps in treating and preventing the spread of infections.
  • Thus, Rifafrez 400 mg Tablet 10's helps in relieving abdominal pain and diarrhoea.
  • Rifafrez 400 mg Tablet 10's should not be used in patients with diarrhoea complicated by fever or blood in the stool and diarrhoea due to pathogens other than Escherichia coli (E.coli).

How Rifafrez 400 mg Tablet 10's Works

Rifafrez 400 mg Tablet 10's contains Rifaximin, which works by working on the bowel and preventing the spread of infections caused by the loss of beneficial gut bacteria. Thus, Rifafrez 400 mg Tablet 10's helps in relieving abdominal pain and diarrhoea. Rifafrez 400 mg Tablet 10's should not be used in patients with diarrhoea complicated by fever or blood in the stool and diarrhoea due to pathogens other than Escherichia coli (E.coli).

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Rifafrez 400 mg Tablet 10's

Do not take more than the prescribed dose of Rifafrez 400 mg Tablet 10's as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Rifafrez 400 mg Tablet 10's if you are allergic to any of its contents, if you have a fever, blood in stools, passed 8 or more unformed stools in the last 24 hours, constipation, vomiting, and abdominal pain caused by blockage of the bowel.
  • Talk to your doctor if your condition does not improve, symptoms continue or re-appear even after taking Rifafrez 400 mg Tablet 10's for 3 days.
  • Do not take Rifafrez 400 mg Tablet 10's for more than 3 days unless prescribed; if there is no symptomatic improvement, consult your doctor.
  • Avoid taking Rifafrez 400 mg Tablet 10's if you are pregnant or breastfeeding; talk to your doctor; he/she may prescribe you with alternate medicine.
  • Rifafrez 400 mg Tablet 10's is not recommended for children below 12 years of age as the efficacy and safety have not been established.
  • Patients with liver complications should avoid taking Rifafrez 400 mg Tablet 10's or consult a doctor before using Rifafrez 400 mg Tablet 10's.
  • Monitor bleeding time parameters like INR and prothrombin time while using Rifafrez 400 mg Tablet 10's.

Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which helps indigestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, such as grapefruit and grapefruit juice, as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol to treat your condition effectively.
  • Avoid the usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Rifafrez 400 mg Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

Please consult your doctor as it is not known whether alcohol affects the working of Rifafrez 400 mg Tablet 10's. However, you are advised to limit or avoid alcohol consumption to prevent unpleasant side-effects.

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Pregnancy

Unsafe

It is not recommended to take Rifafrez 400 mg Tablet 10's while you are pregnant. Please consult your doctor if you have any concerns regarding this, your doctor will decide whether Rifafrez 400 mg Tablet 10's can be given to pregnant women or not.

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Breast Feeding

Consult your doctor

Please consult your doctor if you have any concerns regarding this, your doctor will decide whether Rifafrez 400 mg Tablet 10's can be given to breastfeeding mothers or not.

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Driving

Safe if prescribed

Rifafrez 400 mg Tablet 10's does not affect your ability to drive. However, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Please consult your doctor if you have any concerns regarding this or if you have liver disease before taking Rifafrez 400 mg Tablet 10's.

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Kidney

Consult your doctor

Please consult your doctor if you have any concerns regarding this or if you have kidney disease before taking Rifafrez 400 mg Tablet 10's.

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Children

Unsafe

Rifafrez 400 mg Tablet 10's is not recommended for children as the efficacy and safety have not been established.

Have a query?

FAQs

Rifafrez 400 mg Tablet 10's is used to treat infectious traveller's diarrhoea caused by E.coli bacteria, hepatic encephalopathy (decreased brain function due to liver disease) and irritable bowel syndrome with diarrhoea (IBS-D).

Rifafrez 400 mg Tablet 10's is bactericidal in nature and works by killing the harmful bacteria that cause infections in the gut or intestine like E coli bacteria. Thereby, helps in treating/preventing the spread of infections and diarrhoea with abdominal pain.

It is recommended to complete the course of Rifafrez 400 mg Tablet 10's even if you feel better as it is an antibiotic, and leaving it in between may lead to even severe infection that will, in fact, stop responding to the antibiotic as well (antibiotic resistance).

Do not take Rifafrez 400 mg Tablet 10's on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections. Take Rifafrez 400 mg Tablet 10's only if prescribed by a doctor.

Rifafrez 400 mg Tablet 10's may affect blood tests and liver function tests with increased liver enzymes. Inform the person or doctor before performing the tests that you are taking Rifafrez 400 mg Tablet 10's.

For treating traveller's diarrhoea, Rifafrez 400 mg Tablet 10's is generally prescribed for 3 days. For irritable bowel syndrome, Rifafrez 400 mg Tablet 10's is prescribed for 14 days. However, it is better to take Rifafrez 400 mg Tablet 10's only as prescribed by your doctor.

No, Rifafrez 400 mg Tablet 10's may affect the activity and working of warfarin when taken together. So tell your doctor before using Rifafrez 400 mg Tablet 10's that you are taking a blood thinner (warfarin). Your doctor might adjust the dose of warfarin to maintain the proper blood-thinning effect and prevent drug interaction.

Do not take Rifafrez 400 mg Tablet 10's for more than 3 days unless prescribed; if there is no symptomatic improvement, consult your doctor.

Rifafrez 400 mg Tablet 10's should not be used in patients with diarrhoea complicated by fever or blood in the stool and diarrhoea due to pathogens other than Escherichia coli (E. coli).

Take Rifafrez 400 mg Tablet 10's exactly as prescribed by the doctor. Take it at the same time daily as it will help you to remember taking the medication.

Rifafrez 400 mg Tablet 10's contains Rifaximin used to treat infectious traveller’s diarrhoea, hepatic encephalopathy (decrease in brain function due to liver disease) and irritable bowel syndrome.

Side effects of Rifafrez 400 mg Tablet 10's include headache, peripheral oedema (leg swelling), nausea, dizziness, fatigue, ascites (excess fluid build-up in the abdomen), increased liver enzymes (ALT), and nausea. Talk to your doctor if you experience these side effects persistently.

Rifafrez 400 mg Tablet 10's is an antimycobacterial which works by killing the bacteria that cause infection.

Rifafrez 400 mg Tablet 10's can be taken with or without food.

Rifafrez 400 mg Tablet 10's decreases the symptoms in case of liver disease by killing harmful bacteria in the gut. Thereby it helps lower the possibility of toxins.

Rifafrez 400 mg Tablet 10's may not cause weight gain. Maintain proper weight by eating healthy and doing exercise. Consult the doctor if you notice changes in your weight.

Country of origin

India

Manufacturer/Marketer address

No.101 / 2, 5TH CROSS, NEE, 3 FLOOR A,THILLAI NAGAR , TRICHY, Tamil Nadu, India - 620018.
Other Info - RIF0250

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 12:17 PM IST

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Reference

  1. https://www.xifaxan.com/about-xifaxan-ibsd
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021361s023lbl.pdf
  3. https://medlineplus.gov/druginfo/meds/a604027.html
  4. https://www.drugs.com/mtm/rifaximin.html
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737517/

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