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  3. RGM Tablet 10's

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RGM Tablet 10's, Pack of 10 TABLETS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
RGM Tablet is an anti-diabetic medicine used in the treatment of Type II diabetes. This combination medicine works by stimulating beta cells in the pancreas that produce insulin and also reduces sugar production by cells in the liver and delays sugar absorption. This medicine may cause common side effects like stomach pain, nausea, diarrhea, vomiting, headache, or low blood sugar.
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Composition :

GLIBENCLAMIDE-5MG + METFORMIN-500MG + ROSIGLITAZONE-2MG

Manufacturer/Marketer :

Micro Labs Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About RGM Tablet

RGM Tablet belongs to a class of medicines called antidiabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose. People with type 2 diabetes either do not produce enough insulin or the insulin produced is unable to perform its function in the body (insulin resistance).

RGM Tablet is a combination of three antidiabetic drugs, namely: Glibenclamide, Metformin, and Rosiglitazone. Glibenclamide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Rosiglitazone works by increasing the sensitivity of liver, muscle, and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, RGM Tablet helps to control blood sugar levels.

Take RGM Tablet as prescribed by your doctor. You are advised to take RGM Tablet for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, nausea, diarrhea, vomiting, headache, or low blood sugar. Most of these side effects of RGM Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to RGM Tablet or any other medicines, please tell your doctor. RGM Tablet is not recommended for children below 18 years of age. Avoid breastfeeding while taking RGM Tablet as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking RGM Tablet as it may harm an unborn baby. RGM Tablet should be used with caution in elderly patients. Avoid alcohol consumption with RGM Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking RGM Tablet .

Uses of RGM Tablet

Treatment of Type 2 diabetes mellitus

Directions for Use

• Take RGM Tablet with food to avoid stomach upset. • Follow your doctor's instructions on the dosage and timing of this medication.• Swallow RGM Tablet as a whole with a glass of water.• Do not crush or break it.

Medicinal Benefits

RGM Tablet contains three antidiabetic drugs (Glibenclamide, Metformin, and Rosiglitazone) used in the treatment of type 2 diabetes. Glibenclamide stimulates cells in the pancreas that produce insulin which helps to remove sugar from the blood. Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Rosiglitazone increases the sensitivity of liver, muscle, and fat cells to insulin and enables cells to remove glucose from blood more effectively. Also, it decreases the amount of glucose produced by the liver and preserves the functioning of beta cells in the pancreas that produce insulin. Thereby, RGM Tablet helps to control blood sugar levels.

How RGM Tablet Works

RGM Tablet is a combination of three antidiabetic drugs, namely: Glibenclamide, Metformin, and Rosiglitazone. Glibenclamide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Rosiglitazone works by increasing the sensitivity of liver, muscle, and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, RGM Tablet helps to control blood sugar levels.

Storage

• Store in a cool and dry place away from sunlight.• Keep RGM Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of RGM Tablet

Take RGM Tablet only as prescribed by the physician. Do not exceed the recommended dose as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to RGM Tablet or any other medicines, please tell your doctor. RGM Tablet is not recommended for children. Avoid breastfeeding while taking RGM Tablet as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking RGM Tablet as it may harm the unborn baby. RGM Tablet should be used with caution in elderly patients. Avoid alcohol consumption with RGM Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking RGM Tablet . Take short, frequent meals and avoid prolonged fasting while taking RGM Tablet . Beware of symptoms of hypoglycemia (low blood sugar) which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume 5-6 candies or 3 glucose biscuits, or 3 teaspoons of honey/sugar, and also consult your doctor. Make sure to carry these with you at all times, especially during long travels.

Drug-Drug Interactions

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MetforminIoxitalamic acid
Critical
MetforminIotroxic acid
Critical

Drug-Drug Interactions

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MetforminIoxitalamic acid
Critical
How does the drug interact with RGM Tablet:
Co-administration of RGM Tablet and Ioxitalamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking RGM Tablet with Ioxitalamic acid is not recommended, please consult your doctor before taking it.
MetforminIotroxic acid
Critical
How does the drug interact with RGM Tablet:
Co-administration of Iotroxic acid with RGM Tablet can increase the risk of side effects.

How to manage the interaction:
Taking RGM Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.
MetforminIoglycamic acid
Critical
How does the drug interact with RGM Tablet:
Co-administration of Ioglycamic acid with RGM Tablet can increase the risk of side effects.

How to manage the interaction:
Taking RGM Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIobitridol
Critical
How does the drug interact with RGM Tablet:
Co-administration of RGM Tablet and Iobitridol can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking RGM Tablet with Iobitridol is generally avoided as it can result in an interaction. Please consult your doctor before taking it.
MetforminIobenzamic acid
Critical
How does the drug interact with RGM Tablet:
Co-administration of RGM Tablet and Iobenzamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking RGM Tablet with Iobenzamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIohexol
Critical
How does the drug interact with RGM Tablet:
Co-administration of Iohexol with RGM Tablet can increase the risk of side effects.

How to manage the interaction:
Taking RGM Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIodamide
Critical
How does the drug interact with RGM Tablet:
Co-administration of RGM Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking RGM Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIodixanol
Critical
How does the drug interact with RGM Tablet:
Co-administration of Iodixanol with RGM Tablet can increase the risk of side effects.

How to manage the interaction:
Taking RGM Tablet with Iodixanol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopromide
Critical
How does the drug interact with RGM Tablet:
Co-administration of Iopromide with RGM Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with RGM Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIopanoic acid
Critical
How does the drug interact with RGM Tablet:
Co-administration of Iopanoic acid with RGM Tablet can increase the risk of side effects.

How to manage the interaction:
Taking RGM Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain healthy body weight as obesity is also related to the onset of diabetes.
  • Maintain a low-fat and low-sugar diet. Replace carbohydrates-containing foods with whole grains, fruits, and vegetables as carbohydrates turn to sugars leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with RGM Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

RGM Tablet is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking RGM Tablet as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using RGM Tablet if you are breastfeeding.

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Driving

Caution

RGM Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking RGM Tablet .

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Liver

Caution

Take RGM Tablet with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take RGM Tablet with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

RGM Tablet is not recommended for children below 18 years of age as the safety and effectiveness were not established.

Have a query?

FAQs

RGM Tablet belongs to a class of medicines called antidiabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.

RGM Tablet contains Glibenclamide, Metformin and Rosiglitazone. Glibenclamide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Rosiglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, RGM Tablet helps to control blood sugar levels.

RGM Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, when you exercise more than usual, delay or miss snacks or meal. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

You are not recommended to take RGM Tablet with levothyroxine as it may reduce the hypoglycemic (lowering blood sugar levels) effect of metformin. However, please consult a doctor before using RGM Tablet with other medicines.

In type 1 diabetes, the body doesn’t produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completed. In type 2 diabetes, though islet cells are working, the body doesn’t respond to insulin as the body becomes resistant to insulin.

You are not recommended to stop taking RGM Tablet on your own as discontinuing RGM Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking RGM Tablet , please consult your doctor so that alternative medicine may be prescribed.

Country of origin

India

Manufacturer/Marketer address

No. 28 Sundar Industrial Estate,N.T.Y Layout Mysore Road , Bangalore - 560026, India
Other Info - RGM0001

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:27 PM IST

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Reference

  1. https://www.sanofi.in/-/media/Project/One-Sanofi-Web/Websites/Asia-Pacific/Sanofi-IN/Home/science-and-innovation/for-healthcare-professionals/product-information/daonilM--PI---Aug-2018.pdf?la=en
  2. https://www.drugs.com/metformin.html#interactions
  3. https://www.drugs.com/mtm/Rosiglitazone.html#interactions

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