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  3. Rexpure Capsule 10's

Rexpure Capsule 10's, Pack of 10 CAPSULES
Rexpure Capsule 10's, Pack of 10 CAPSULES
Rexpure Capsule 10's, Pack of 10 CAPSULES
Rexpure Capsule 10's, Pack of 10 CAPSULES
Rexpure Capsule 10's, Pack of 10 CAPSULES
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Rexpure Capsule is used to reduce and relieve pain and inflammation (swelling) associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It may also be indicated in the treatment of pain associated with post-traumatic and post-operative cases. It contains Aceclofenac and Rabeprazole, which works by reducing the production of prostaglandins (chemicals) that cause pain and inflammation. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Aceclofenac has been reported to cause gastric discomfort and acidity. Hence, it is combined with Rabeprazole, which reduces the amount of acid the stomach makes, thus preventing damage to the stomach. Thus, it helps reduce pain with minimal gastric irritation caused due to Aceclofenac alone. In some cases, you may experience side effects such as indigestion, stomach pain, constipation, dizziness, nausea and diarrhoea.
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Composition :

ACECLOFENAC-200MG + RABEPRAZOLE-20MG

Manufacturer/Marketer :

Affluential Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Rexpure Capsule

Rexpure Capsule is used to reduce and relieve pain and inflammation (swelling) associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Rexpure Capsule may also be indicated in the treatment of pain associated with post-traumatic and post-operative cases.

Rexpure Capsule combines two drugs: Aceclofenac (painkiller) and Rabeprazole (antacid). Aceclofenac works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Aceclofenac has been reported to cause gastric discomfort and acidity. Hence, it is combined with Rabeprazole, a medicine belonging to a group of proton pump inhibitors that reduce the amount of acid the stomach makes, thus preventing damage to the stomach. Thus, the combination helps alleviate pain with minimal gastric irritation caused by Aceclofenac alone.

Take Rexpure Capsule as prescribed by your doctor. You are advised to take Rexpure Capsule for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience indigestion, stomach pain, constipation, dizziness, nausea and diarrhoea. Most of these side effects of Rexpure Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Before taking the Rexpure Capsule , let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. Inform your doctor if you are suffering from kidney, liver, or heart disease. Rexpure Capsule may cause dizziness, so avoid driving or operating machinery unless you are alert. Rexpure Capsule is not recommended for use during pregnancy, breastfeeding, or in children. Avoid consuming alcohol along with Rexpure Capsule as it could lead to increased dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Rexpure Capsule

Treatment of Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis.

Directions for Use

• Take Rexpure Capsule with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Swallow Rexpure Capsule as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Rexpure Capsule is a combination of two drugs: Aceclofenac (painkiller) and Rabeprazole (antacid). Aceclofenac belongs to the class of non-steroidal anti-inflammatory drugs (pain killers) that block the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical 'prostaglandins' (PG). Prostaglandins play an important role in controlling pain and inflammation. By blocking the effect of COX enzymes, fewer PGs are produced. Thereby, it helps relieve pain and swelling associated with different types of arthritis, such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis (pain and stiffness in the backbone). On the other hand, Rabeprazole belongs to proton pump inhibitors (PPIs) that help reduce the excess amount of stomach acid and bile produced. Aceclofenac has been reported to cause gastric discomfort and acidity. Hence, it is combined with Rabeprazole, a medicine that reduces the amount of acid made by the stomach, thus preventing damage to the stomach. Thus, the combination is superior as it helps alleviate pain with minimal gastric irritation caused by Aceclofenac alone. Rexpure Capsule is also used to relieve toothache and lower back, ear, and throat pain. 

How Rexpure Capsule Works

Rexpure Capsule combines two drugs: Aceclofenac (painkiller) and Rabeprazole (antacid). Aceclofenac works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Aceclofenac has been reported to cause gastric discomfort and acidity. Hence, it is combined with Rabeprazole, a medicine belonging to a group of proton pump inhibitors that reduce the amount of acid the stomach makes, thus preventing damage to the stomach. Thus, the combination helps alleviate pain with minimal gastric irritation caused by Aceclofenac alone.

Storage

Keep Rexpure Capsule out of the sight and reach of children.
Side effects of Rexpure Capsule
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Rexpure Capsule

Do not take more than the prescribed dose of Rexpure Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Rexpure Capsule if you are allergic to Rexpure Capsule , have severe heart failure, suffered bleeding problems (such as bleeding from the stomach or bowels while taking any pain killers) or liver or kidney problems, have suffered bleeding problems and clotting problems. Inform your doctor before taking Rexpure Capsule if you have or had disorders of the stomach, blood circulation problems to the brain, asthma, porphyria (a disorder in the formation of red blood pigment), diabetes, high blood pressure, systemic lupus erythematosus (an autoimmune condition that causes joint pain, fever and skin rashes), colitis or Crohn’s disease (conditions causing swelling of the bowel, diarrhoea, bowel pain, vomiting and weight loss); if you are recovering from major surgery or if you are elderly. Do not take Rexpure Capsule if you are pregnant or breastfeeding unless prescribed. Rexpure Capsule contains Aceclofenac which should not be used during the last three months of pregnancy. Rexpure Capsule may be excreted in breastmilk. Therefore, avoid breastfeeding and consult a doctor. Rexpure Capsule should not be given to children as safety has not been established. Rexpure Capsule can cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol with Rexpure Capsule as it could lead to increased drowsiness and increase the risk of stomach bleeding. Do not take other NSAIDs for pain relief or Rexpure Capsule unless prescribed. Prolonged intake of PPIs or proton pump inhibitors like Rabeprazole may cause brittle bones so intake of Vitamin D and calcium can be additionally given by your doctor while using Rexpure Capsule . 

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
RabeprazoleRilpivirine
Critical

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
How does the drug interact with Rexpure Capsule:
When used in combination with erlotinib, Rexpure Capsule may prevent the absorption of erlotinib into the circulation, which might make erlotinib less effective in treating cancer.

How to manage the interaction:
Taking Rexpure Capsule with Erlotinib is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
RabeprazoleRilpivirine
Critical
How does the drug interact with Rexpure Capsule:
Co-administration of Rexpure Capsule can make Rilpivirine less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Rexpure Capsule with Rilpivirine is not recommended, but can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
RabeprazoleDasatinib
Severe
How does the drug interact with Rexpure Capsule:
Taking Rexpure Capsule together with Dasatinib results in decreased levels of Dasatinib and its effectiveness.

How to manage the interaction:
Although taking Rexpure Capsule and Dasatinib together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazolePazopanib
Severe
How does the drug interact with Rexpure Capsule:
Taking Rexpure Capsule together with Pazopanib can result in a decreased effectiveness of Pazopanib in treating the disease.

How to manage the interaction:
Although taking Rexpure Capsule and Pazopanib together can result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to a doctor.
RabeprazoleClopidogrel
Severe
How does the drug interact with Rexpure Capsule:
Taking Clopidogrel with Rexpure Capsule can reduce the effectiveness of Clopidogrel.

How to manage the interaction:
Taking Clopidogrel and Rexpure Capsule together possibly has an interaction, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to a doctor.
RabeprazoleGefitinib
Severe
How does the drug interact with Rexpure Capsule:
Taking Rexpure Capsule together with Gefitinib results in decreased levels of gefitinib in your blood. This can result in a decreased effectiveness of gefitinib in treating the disease.

How to manage the interaction:
Although taking Rexpure Capsule and Gefitinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. To lessen the effects of the interaction, it is advised that you take gefitinib 12 hours before or 12 hours after Rexpure Capsule. Do not discontinue any medications without a doctor's advice.
RabeprazolePhenytoin
Severe
How does the drug interact with Rexpure Capsule:
When Phenytoin and Rexpure Capsule are taken in combination, Phenytoin will reduce the concentration or impact of Rexpure Capsule.

How to manage the interaction:
Although taking Phenytoin and Rexpure Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleMethotrexate
Severe
How does the drug interact with Rexpure Capsule:
Co-administration of Methotrexate with Rexpure Capsule can increase the blood levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between Rexpure Capsule and Methotrexate, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
RabeprazoleAtazanavir
Severe
How does the drug interact with Rexpure Capsule:
Co-administration of Atazanavir's blood levels and absorption can both be affected by Rexpure Capsule, which decreases the atazanavir's ability to treat HIV.

How to manage the interaction:
Although taking Rexpure Capsule and atazanavir together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleAcalabrutinib
Severe
How does the drug interact with Rexpure Capsule:
Taking Rexpure Capsule together with Acalabrutinib results in a decreased effectiveness of Acalabrutinib.

How to manage the interaction:
Although taking Rexpure Capsule and Acalabrutinib together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Foods containing flavonoids such as soy, berries, broccoli, grapes and green tea help in reducing inflammation.

  • Include high fibre-containing foods, berries, cherries, leafy green veggies, and black peppers in your meal. These foods are full of antioxidants, calcium, and vitamin B12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics that help in the prevention of excess stomach acid production.

  • Avoid intake of acid or heartburn triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes, and high-fat and spicy foods.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS

Rexpure Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Rexpure Capsule . Alcohol intake along Rexpure Capsule may cause increased drowsiness and drowsiness. It may also increase the risk of stomach bleeding. Please consult your doctor if you have any concerns regarding this.

bannner image

Pregnancy

Unsafe

Rexpure Capsule is a Category C pregnancy drug and is not recommended for pregnant women, especially in the third trimester as it may cause adverse effects in the baby. However, please consult a doctor if you are pregnant or planning for pregnancy before taking Rexpure Capsule .

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Rexpure Capsule as it may be excreted in breast milk and cause adverse effects in the baby. Please consult a doctor if you are breastfeeding.

bannner image

Driving

Caution

Rexpure Capsule may cause drowsiness, dizziness, or abnormal vision. Do not drive or operate heavy machinery if you feel dizzy or drowsy.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with severe liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Take Rexpure Capsule with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Rexpure Capsule if you have severe kidney disease.

bannner image

Children

Unsafe

Rexpure Capsule is not recommended for children below 18 years of age, as the safety and effectiveness were not established.

Have a query?

FAQs

Rexpure Capsule is used to reduce and relieve pain and inflammation (swelling) associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It may also be indicated in the treatment of pain associated with post-traumatic and post-operative cases.

Rexpure Capsule contains Aceclofenac and Rabeprazole. Aceclofenac is a pain killer called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) which works by blocking the effect of chemical messengers (prostaglandin), thereby helping in reducing pain, and inflammation. Rabeprazole works by blocking the action of an enzyme called a proton pump, which is responsible for the production of stomach acid. Thus, the combination used for pain relief, decrease stiffness in joints and reduces the release of excess stomach acid caused by aceclofenac.

Rexpure Capsule is not recommended for asthma patients as it may worsen the condition. Therefore, please inform your doctor if you have asthma or a history of asthma due to the use of aspirin or any other non-steroidal drugs.

You are not recommended to take Rexpure Capsule with warfarin as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.

Aceclofenac in Rexpure Capsule may increase the risk of heart problems such as heart attack, especially when used in high doses or for prolonged duration and in patients who are smokers, have high blood pressure, diabetes or high cholesterol. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking Rexpure Capsule . However, taking Rexpure Capsule in the dose and for the duration, as prescribed by your doctor, is recommended.

Rexpure Capsule may impair fertility in females and make it more difficult to conceive. Therefore, if you are pregnant, planning for pregnancy or have difficulties conceiving, please consult your doctor before taking Rexpure Capsule .

Do not take Rexpure Capsule for longer durations as it might increase the risk of heart problems, stomach bleeding and might increase the risk of fractures of the hip, spine, and wrist. Do not exceed the dose and duration of treatment as prescribed by the doctor.

Rexpure Capsule is a combination medicine containing Aceclofenac (painkiller) and Rabeprazole (antacid). It is used to treat osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Do not discontinue Rexpure Capsule without consulting your doctor. To treat your condition effectively, keep taking Rexpure Capsule for the prescribed duration.

Nausea and vomiting could be side effects of Rexpure Capsule . Drink enough fluids by taking frequent sips and eat small, frequent meals. If the condition persists or worsens, consult the doctor.

Store Rexpure Capsule at room temperature, in a dry place. Keep it out of sight and reach of children.

Rexpure Capsule may cause side effects like indigestion, stomach pain, constipation, dizziness, nausea and diarrhoea. Most of these side effects of Rexpure Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Rexpure Capsule may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol with Rexpure Capsule as it could lead to increased drowsiness.

Rexpure Capsule can be taken with vitamin B-complex if advised by the doctor. Talk to the doctor if you have any concerns.

Country of origin

INDIA

Manufacturer/Marketer address

4/9, Ashirvad Enclave Chakrata Road,Deharadun-248001
Other Info - REX0172

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:35 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/4240/pil#gref
  2. https://www.drugs.com/mtm/rabeprazole.html
  3. https://www.nhs.uk/medicines/rabeprazole/
  4. https://www.zoylo.com/medicines/rabeprazole-20-mg-aceclofenac-200-mg-tablet

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