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  1. Home
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  3. Renolzin-500 SR Tablet 10's

Renolzin-500 SR Tablet 10's, Pack of 10 TABLETS
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Composition :

RANOLAZINE-500MG

Manufacturer/Marketer :

Knoll Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Renolzin-500 SR Tablet

Renolzin-500 SR Tablet is used to treat angina pectoris. Angina pectoris is discomfort in the chest or chest pain, which generally occurs due to coronary artery disease (CAD) when the heart and its muscles are not receiving enough oxygen and blood.

Renolzin-500 SR Tablet contains Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels, through which calcium ions normally enter the cells.

You may sometimes experience constipation, dizziness, headache, or feeling sick. Most of these side effects of Renolzin-500 SR Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

You can take Renolzin-500 SR Tablet with food or as advised by your doctor. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Depending on your medical conditions, your doctor will advise the dose and duration of Renolzin-500 SR Tablet .

Do not take Renolzin-500 SR Tablet if you are allergic to any component in this medicine. Renolzin-500 SR Tablet should not be stopped even if you feel better for the best results, as it prevents any future harm. If you stop taking the Renolzin-500 SR Tablet on your own, your chest pain can come back in more severe form. If you plan to get pregnant or are pregnant or breastfeeding, please consult your doctor to avoid any unwanted harm to the baby. 

Side Effects of Renolzin-500 SR Tablet

  • Constipation
  • Dizziness
  • Headache
  • Feeling sick

Uses of Renolzin-500 SR Tablet

Renolzin-500 SR Tablet used in the treatment of Angina Pectoris. The detailed use of Renolzin-500 SR Tablet is as follows:

  • Treatment of Angina Pectoris: Renolzin-500 SR Tablet is used in the treatment of angina pectoris by improving oxygen supply to the heart muscle and enhancing cardiac efficiency, particularly in areas with fixed epicardial lesions, thereby decreasing chest pain episodes and improving patient quality of life.

Directions for Use

  • Renolzin-500 SR Tablet can be taken with or without food.
  • It is usually taken twice daily at the same time each day or as prescribed by your doctor.
  • Swallow Renolzin-500 SR Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

Key Benefits

  • Renolzin-500 SR Tablet is prescribed for treating angina. Renolzin-500 SR Tablet is an anti-anginal medication used to treat angina pectoris.
  • It reduces sodium ions' flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called ‘sodium-dependent calcium channels’ through which calcium ions normally enter the cells.
  • This medicine reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract.
  • Renolzin-500 SR Tablet helps improve blood flow to the heart muscle and relieve the symptoms of angina pectoris.

How Renolzin-500 SR Tablet Works

The active substance in Renolzin-500 SR Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels, through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Renolzin-500 SR Tablet is thought to help the heart relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Renolzin-500 SR Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Renolzin-500 SR Tablet

Do not take more than the prescribed dose of Renolzin-500 SR Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, confusion, dizziness, double vision, fainting, difficulty speaking, uncontrollable shaking of a part of the body, hallucinations and burning, pain, numbness, or tingling in any part of the body. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Renolzin-500 SR Tablet if you are allergic to any component in this medicine.
  • Renolzin-500 SR Tablet should not be stopped even if you feel better for the best results, as it prevents any future harm. If you stop taking the Renolzin-500 SR Tablet on your own, your chest pain can come back in a more severe form.
  • Renolzin-500 SR Tablet should be taken with caution in liver disease, kidney disease, or heart problems.
  • Inform your doctor if you are pregnant, planning for pregnancy, or breastfeeding before taking Renolzin-500 SR Tablet .
  • Also, grapefruit juice should be avoided while taking Renolzin-500 SR Tablet .
  • As a precautionary measure, avoid junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery.
  • Do regular exercise to avoid abdominal heaviness.

Drug-Drug Interactions

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RanolazineGriseofulvin
Critical
RanolazineEfavirenz
Critical

Drug-Drug Interactions

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RanolazineGriseofulvin
Critical
How does the drug interact with Renolzin-500 SR Tablet:
When Renolzin-500 SR Tablet is taken with Griseofulvin, may significantly reduce the blood levels of Renolzin-500 SR Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Griseofulvin with Renolzin-500 SR Tablet is not recommended, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
RanolazineEfavirenz
Critical
How does the drug interact with Renolzin-500 SR Tablet:
When Efavirenz is taken with Renolzin-500 SR Tablet, it can lower the levels of Renolzin-500 SR Tablet.

How to manage the interaction:
Taking Renolzin-500 SR Tablet with Efavirenz is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medication without consulting a doctor.
RanolazinePhenytoin
Critical
How does the drug interact with Renolzin-500 SR Tablet:
Using Renolzin-500 SR Tablet together with phenytoin may significantly reduce the blood levels of Renolzin-500 SR Tablet leading to dreceased effectiveness of Renolzin-500 SR Tablet in treating your condition.

How to manage the interaction:
Taking Phenytoin with Renolzin-500 SR Tablet is not recommended. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
RanolazineNafcillin
Critical
How does the drug interact with Renolzin-500 SR Tablet:
When Nafcillin is taken with Renolzin-500 SR Tablet, may significantly reduce the blood levels of Renolzin-500 SR Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Nafcillin with Renolzin-500 SR Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
RanolazineClarithromycin
Critical
How does the drug interact with Renolzin-500 SR Tablet:
When Renolzin-500 SR Tablet and Clarithromycin are taken together, significantly increases the blood levels and effects of Renolzin-500 SR Tablet.

How to manage the interaction:
Co-administration of Clarithromycin and Ranozaline can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RanolazineTroglitazone
Critical
How does the drug interact with Renolzin-500 SR Tablet:
Co-administration of Troglitazone with Renolzin-500 SR Tablet may significantly reduce blood levels of Renolzin-500 SR Tablet.

How to manage the interaction:
Taking Renolzin-500 SR Tablet with Troglitazone together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
RanolazineFosamprenavir
Critical
How does the drug interact with Renolzin-500 SR Tablet:
Co-administration of Fosamprenavir and Renolzin-500 SR Tablet may significantly can occasionally cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Fosamprenavir with Renolzin-500 SR Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineRibociclib
Critical
How does the drug interact with Renolzin-500 SR Tablet:
When Ribociclib is taken with Renolzin-500 SR Tablet, may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Renolzin-500 SR Tablet with Rifampicin is not recommended, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as excessive drowsiness, dizziness, lightheadedness, fainting, confusion, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
RanolazineGrepafloxacin
Critical
How does the drug interact with Renolzin-500 SR Tablet:
Co-administration of Grepafloxacin and Renolzin-500 SR Tablet may significantly increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grepafloxacin with Renolzin-500 SR Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineZiprasidone
Critical
How does the drug interact with Renolzin-500 SR Tablet:
Co-administration of Renolzin-500 SR Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Renolzin-500 SR Tablet with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the levels of Renolzin-500 SR Tablet, and high blood levels of food can occasionally cause an irregular heart rhythm that may be serious. Grapefruit and grapefruit juice should be avoided while taking Renolzin-500 SR Tablet if possible.

Diet & Lifestyle Advise

  • Maintain a healthy lifestyle by exercising regularly, maintaining weight, and eating a healthy diet.
  • If you suffer from kidney or liver disease, please inform your doctor before taking the Renolzin-500 SR Tablet .
  • Alcohol consumption along with Renolzin-500 SR Tablet should be avoided as it may cause excessive drowsiness and increase muscle pain.

Habit Forming

No

Therapeutic Class

ANTIANGINALS

Renolzin-500 SR Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Safe if prescribed

Renolzin-500 SR Tablet does not have any reported interaction; hence, if you experience any difficulty, discuss with your doctor.

bannner image

Pregnancy

Unsafe

Renolzin-500 SR Tablet should not be used when pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Renolzin-500 SR Tablet .

bannner image

Breast Feeding

Consult your doctor

Renolzin-500 SR Tablet should not be used in nursing mothers. Please consult the doctor if you have any concerns regarding this.

bannner image

Driving

Safe if prescribed

Renolzin-500 SR Tablet does not have any reported interaction; hence, in case you experience any difficulty, discuss with your doctor.

bannner image

Liver

Caution

Renolzin-500 SR Tablet to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Renolzin-500 SR Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

bannner image

Children

Unsafe

Renolzin-500 SR Tablet is not recommended for children below the age of 18. The safety and effectiveness of Renolzin-500 SR Tablet have not been established in children due to limited testing of this drug on children by competent authorities worldwide.

Have a query?

FAQs

Renolzin-500 SR Tablet is used alone or with other medicines to treat angina pectoris.

The active substance in Renolzin-500 SR Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called sodium-dependent calcium channels through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Renolzin-500 SR Tablet is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

No, Renolzin-500 SR Tablet does not stop acute attacks (sudden attacks) of angina, but Renolzin-500 SR Tablet helps prevent a new attack.

No, alcohol should not be taken with Renolzin-500 SR Tablet as it may lead to unwanted side effects and increase angina attacks.

Yes, smoking (tobacco) decreases the efficacy of Renolzin-500 SR Tablet , especially when taken for angina (chest pain), so it should be avoided while taking Renolzin-500 SR Tablet .

Yes, Renolzin-500 SR Tablet can cause an upset stomach when taken empty stomach. So, to avoid it, Renolzin-500 SR Tablet should be taken with a meal for best results.

Yes, Renolzin-500 SR Tablet can cause drowsiness. If you feel excessively sleepy, please consult your doctor for better advice.

Some major side effects include a rapid, pounding, or irregular heartbeat, difficulty breathing, and fainting. If you encounter any of these symptoms, contact your doctor immediately.

Do not take more than the prescribed dose of Renolzin-500 SR Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, confusion, dizziness, double vision, fainting, difficulty speaking, uncontrollable shaking of a part of the body, hallucinations and burning, pain, numbness, or tingling in any part of the body. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Renolzin-500 SR Tablet may increase the blood levels and effects of metoprolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.

Renolzin-500 SR Tablet might raise metformin levels, increasing the risk of lactic acidosis. If you are prescribed ranolazine while taking metformin, discuss it with a healthcare physician. They may offer a lesser dose of metformin as a safer alternative.

You can take it if prescribed by the doctor. However, limit simvastatin to 20 mg once daily in individuals taking any dose of Renolzin-500 SR Tablet .

Country of origin

INDIA

Manufacturer/Marketer address

M-17, Pharma Tower, Basement & Ground Floor, Badli Industrial Area, New Delhi 110 042
Other Info - REN0352

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 1:48 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.6442.pdf
  2. https://medlineplus.gov/druginfo/meds/a606015.html
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021526s029lbl.pdf
  4. https://www.ema.europa.eu/en/documents/product-information/ranexa-epar-product-information_en.pdf

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