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  1. Home
  2. Medicine

  3. Regest 40 Tablet

Prescription drug
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Regest 40 Tablet, Pack of 1 Tablet
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Extra 15% Off with Bank Offers
Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Regest 40 Tablet is used as a symptomatic treatment in patients with breast cancer and endometrial cancer. It contains Megestrol, which works similarly to the female hormone progesterone. It interferes with the production or action of hormones involved in cancer growth. This effect helps to slow down the progression of cancer and reduce the symptoms associated with cancer.

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Composition :

MEGESTROL-40MG

Manufacturer/Marketer :

Renace Pharmaceutical

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Regest 40 Tablet

Regest 40 Tablet is used as a symptomatic treatment in patients with breast cancer and endometrial cancer. Breast cancer develops in the breast cells and is characterised by a lump in the breast, a change in the shape of the nipple or breast, and bloody discharge from the nipples.

Regest 40 Tablet contains ‘Megestrol’, which interferes with the production or action of hormones involved in cancer growth. This effect helps to slow down the progression of cancer and reduce the symptoms associated with cancer.

Common side effects of Regest 40 Tablet include increased appetite, weight gain, shortness of breath, hot flushes, high blood pressure, increased blood sugar levels, a rounded face, constipation, and swelling of a vein due to a blood clot. If any of these side effects persist or get worse, inform your doctor immediately.

Do not take Regest 40 Tablet if you are allergic to Megestrol or any of its contents. Before taking Regest 40 Tablet, inform your doctor if you have severe liver problems, a history of thrombophlebitis (blood clots), stroke, adrenal gland disorder, or diabetes. Regest 40 Tablet is not recommended for children, pregnant women, and breastfeeding mothers.

Uses of Regest 40 Tablet

Regest 40 Tablet is used in the treatment of breast cancer and endometrial cancer. The detailed uses of Regest 40 Tablet are as follows:

  • Breast cancer treatment: Regest 40 Tablet is used to treat breast cancer by targeting hormone-sensitive tumours to slow or stop cancer growth, reducing tumour size, and alleviating symptoms.
  • Endometrial cancer management: Regest 40 Tablet helps to manage endometrial cancer progression in the lining of the uterus, slowing disease advancement and improving quality of life.

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Directions for Use

  • Take Regest 40 Tablet with or without food as advised by your doctor.
  • Adhere to your doctor’s guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow Regest 40 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Regest 40 Tablet contains Megestrol, which is used to treat breast and endometrial cancer.
  • It acts by interfering with the production of hormones that cause cancer's development.
  • It helps to reduce cancer symptoms effectively.
  • It can also be used to treat loss of appetite in patients with HIV/AIDS.

How Regest 40 Tablet Works

Regest 40 Tablet contains Megestrol, a Progestogen. Megestrol may work by affecting certain hormones. This may increase appetite, helping with weight loss.

Storage

• Store in a cool and dry place away from sunlight.• Keep Regest 40 Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Regest 40 Tablet
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
  • Eat a healthy balanced diet.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Keep track of your menstrual cycle any irregularities.
  • Have regular check ups to exclude other health problems.
  • Exercise but do not exercise to the extent of overheating.
  • Hydrate well, eat well (particularly iron and vitamins).
  • Vaginal bleeding can be abnormal if it is not related to menstruation, and needs immediate attention and cannot be ignored.
  • Get a physical examination and follow your doctor's instructions to get relief from bleeding.
  • Avoid using vaginal sprays or perfumed soaps that increase itching and irritation.
  • Prefer practicing yoga and meditation to reduce stress and anxiety, as it can worsen vaginal bleeding.
  • Take a balanced diet and manage your weight.
  • Record your periods to track flow, duration, and symptoms.
  • Take iron supplements for heavy bleeding.
  • Eat fruits, vegetables, and whole grains.
  • Include spinach, kale, blueberries, and nuts in your diet.
  • Drink water, exercise, and maintain a healthy weight.
  • Relax with deep breathing, yoga, or meditation.
  • Use pain relievers or heating pads for period pain.
  • See a doctor if your symptoms are severe.

What if I have taken an overdose of Regest 40 Tablet

Do not take more than the prescribed dose of Regest 40 Tablet as it may cause any side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Regest 40 Tablet increases the risk of blood clots, so it should be used cautiously in patients with a history of thrombophlebitis.
  • Also, if you notice impaired coordination, difficulty speaking, pain in the groin, pain in the arm or leg (especially in the calf of the leg), shortness of breath, general weakness, headache, and dizziness, inform your doctor immediately as it may be a sign of blood clot.
  • Regest 40 Tablet is not recommended for use in pregnancy.
  • Use a reliable contraceptive method to prevent pregnancy while using this medicine.
  • You may also need to take a pregnancy test before using this medicine.
  • Regest 40 Tablet contains lactose, so inform your doctor if you have an intolerance to any sugars.

Drug-Drug Interactions

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MegestrolDofetilide
Severe
MegestrolThalidomide
Severe

Drug-Drug Interactions

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MegestrolDofetilide
Severe
How does the drug interact with Regest 40 Tablet:
Co-administration of Regest 40 Tablet and Dofetilide can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions or electrolyte disturbances, you may be at higher risk.

How to manage the interaction:
Co-administration of Regest 40 Tablet with Dofetilide can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms like dizziness, fainting, lightheadedness, lack of breath, chest discomfort, or palpitations, consult a doctor. Do not stop using any medications without a doctor's advice.
MegestrolThalidomide
Severe
How does the drug interact with Regest 40 Tablet:
Taking Thalidomide together with Regest 40 Tablet may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Regest 40 Tablet together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet. Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Drink plenty of fluids and eat fibre-rich food to prevent constipation.
  • Manage your weight. Shed excess weight by exercising regularly if you are obese or overweight.
  • Wear loose, layered clothing at night, especially in warm weather. This prevents hot flushes.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

PROGESTINS

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Alcohol

Caution

Alcohol consumption may increase the risk of side effects and worsen the disease. So, avoid alcohol consumption while using this medicine.

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Pregnancy

Unsafe

Regest 40 Tablet should not be used in pregnant women as it may cause birth defects in the unborn baby. Women who are of childbearing potential should obtain a negative pregnancy test before using this medicine.

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Breast Feeding

Unsafe

Regest 40 Tablet is not recommended for use in breastfeeding as it may pass into breastmilk and harm your infant.

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Driving

Safe if prescribed

Regest 40 Tablet may not affect your ability to drive.

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Liver

Caution

Regest 40 Tablet should be used with caution if you have liver disease. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Regest 40 Tablet should be used with caution if you have kidney disease. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Regest 40 Tablet is not recommended for use in children below 12 years of age.

FAQs

Regest 40 Tablet is used for the treatment of Breast cancer and Endometrial cancer.

Regest 40 Tablet contains Megestrol, which works similarly to the female hormone progesterone. It interferes with the production or action of hormones involved in cancer growth. This effect helps to slow down the progression of cancer and reduce the symptoms associated with cancer.

Regest 40 Tablet may increase appetite and cause weight gain. You may gain weight, especially in the waist and the upper back. This effect usually decreases after discontinuing the treatment. However, opt for a healthy diet, exercise regularly, and maintain a normal weight while using this medicine.

Regest 40 Tablet may not affect fertility but may disrupt the menstrual cycle (periods). Though this medicine affects periods, you should take reliable contraceptive measures while using Regest 40 Tablet to prevent pregnancy as it may cause harmful effects to the unborn baby.

Regest 40 Tablet may increase blood glucose levels, so inform your doctor that you have diabetes before taking this medicine. If prescribed, you should monitor blood glucose levels regularly during the treatment.

Regest 40 Tablet is not a contraceptive and doesn't help to prevent pregnancy. It would be best to discuss the possible benefits and risks associated with this medicine with your doctor before using it.

It is recommended that you complete the course of Regest 40 Tablet even if you feel better. To treat your condition effectively, continue taking Regest 40 Tablet for as long as your doctor has prescribed it.

If you miss a dose of Regest 40 Tablet, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take twice the dose to make up for a missed dose.

Take Regest 40 Tablet at around the same time(s) every day. Follow the directions on your prescription label or as directed by the physician.

Regest 40 Tablet may disrupt the menstrual cycle (periods). If you experience any discomfort, please consult a doctor for an appropriate treatment plan.

Regest 40 Tablet is a hormonal therapy drug used to treat breast and womb cancer.

No, it is not recommended to use while pregnant. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking megestrol, call your doctor immediately. Megestrol may harm the foetus.

Regest 40 Tablet may interfere with women's normal menstrual cycle (period). However, it would be best not to assume you cannot become pregnant. Seek medical advice from your healthcare personnel if you are pregnant and plan to become pregnant.

No, do not refrigerate. It should be stored in a cool and dry place away from sunlight.

No, there is no clinically proven indication to treat hot flushes with Regest 40 Tablet.

The common side-effects of Regest 40 Tablet are an increase in appetite, weight gain, shortness of breath, hot flushes (reddening of the face and neck), high blood pressure, increased blood sugar levels, a rounded face, constipation, and swelling of a vein due to a blood clot. If any of these side effects persist or get worse, inform your doctor immediately.

Country of origin

India
Other Info - RE78362

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Nov 19, 2025 | 1:23 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.11135.pdf
  2. https://www.drugs.com/mtm/megestrol.html
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