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Rapilif-M 25 Combipack is used for the treatment of Benign prostatic hyperplasia (BPH), a condition in men that causes the enlargement of the prostate gland. It contains Mirabegron and Silodosin. Mirabegron works by reducing the activity of an overactive bladder and treats related symptoms. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rapilif-M 25 Combipack

Rapilif-M 25 Combipack is an oral medicine prescribed to treat lower urinary tract symptoms caused by an enlarged prostate, also known as benign prostatic hyperplasia, combined with an overactive bladder. Rapilif-M 25 Combipack helps ease the discomfort of having a weak urine flow, straining to urinate, and feeling a sudden, uncontrollable urge to go. It is designed to target both the physical blockage and bladder muscle instability to make urination easier.

To get the best results, you must take Rapilif-M 25 Combipack consistently every day at the same time. You should always take Rapilif-M 25 Combipack with food, preferably with the same meal each day, to help your body absorb it properly. Incorporating lifestyle adjustments, such as limiting caffeine and performing pelvic floor exercises, can further improve your urinary symptoms.

While taking Rapilif-M 25 Combipack, some people may experience mild side effects like dizziness, dry mouth, or a harmless condition where semen flows backward into the bladder during ejaculation. However, you should consult your doctor immediately if you experience severe dizziness, fainting, a fast or irregular heartbeat, or a painful erection that lasts for several hours.

Before starting Rapilif-M 25 Combipack, talk to your doctor if you have a history of heart rhythm problems, high blood pressure, or kidney or liver disease. Do not take this if you have severe kidney failure, severe liver damage, or if you are preparing to undergo cataract surgery.

Rapilif-M 25 Combipack can interact with blood pressure medications, certain antifungal drugs, and heart medications, which can increase your risk of severe side effects. Avoid drinking alcohol while taking Rapilif-M 25 Combipack, as it can significantly worsen dizziness and lightheadedness. Elderly individuals should use Rapilif-M 25 Combipack with caution due to an increased risk of falls, and should always consult a doctor before starting treatment.

Uses of Rapilif-M 25 Combipack

Rapilif-M 25 Combipack is used in the treatment of Benign prostatic hyperplasia (BPH). The detailed uses of Rapilif-M 25 Combipack are as follows:

  • Benign Prostatic Hyperplasia (BPH) with overactive bladder symptoms: Rapilif-M 25 Combipack helps by relaxing the muscles in the prostate and bladder neck, making it easier to pass urine, while simultaneously relaxing the bladder muscle to reduce the sudden, urgent need to urinate.

Key Benefits

Rapilif-M 25 Combipack helps improve urinary symptoms associated with an enlarged prostate and overactive bladder by relaxing the muscles of the prostate, bladder neck, and bladder. It supports better bladder control and makes urination more comfortable.

Benefits may include:

  • Helps improve urine flow and reduces difficulty in passing urine.
  • Relieves symptoms such as straining, weak urine stream, and incomplete bladder emptying.
  • Helps reduce urinary urgency, frequent urination, and episodes of urge incontinence.
  • Decreases nighttime urination, helping promote better sleep.
  • Improves bladder control and overall urinary function.
  • Enhances comfort and quality of life by effectively managing urinary symptoms when used as prescribed.
Side effects of Rapilif-M 25 Combipack
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Rapilif-M 25 Combipack can be taken with or without food, as advised by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow the whole Rapilif-M 25 Combipack with a glass of water.
  • Do not chew, crush, or break it.

How Rapilif-M 25 Combipack Works

Rapilif-M 25 Combipack contains Mirabegron and Silodosin. • Mirabegron: It is a beta-3 adrenergic receptor agonist that helps relax the bladder muscle while the bladder is filling. This increases the amount of urine the bladder can hold and helps reduce symptoms such as urinary urgency, frequent urination, and urge incontinence. • Silodosin: It is an alpha-blocker that relaxes the smooth muscles of the prostate and the bladder neck. This reduces resistance to urine flow, making it easier to start urination, empty the bladder more completely, and improve urinary flow.
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Alcohol

Consult your doctor

The interaction of Rapilif-M 25 Combipack with alcohol is unknown. If you have any concerns, discuss them with your doctor.

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Pregnancy

Not applicable

Rapilif-M 25 Combipack is recommended for use in men.

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Breast Feeding

Not applicable

Rapilif-M 25 Combipack is recommended for use in men.

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Driving

Caution

Rapilif-M 25 Combipack may cause dizziness in some people. Therefore, avoid driving if you feel dizzy after taking Rapilif-M 25 Combipack.

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Liver

Consult your doctor

If you are suffering from liver diseases or conditions, inform your doctor before taking Rapilif-M 25 Combipack. Your doctor may adjust the dose as necessary.

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Kidney

Consult your doctor

If you are suffering from kidney diseases or conditions, inform your doctor before taking Rapilif-M 25 Combipack. Your doctor may adjust the dose as necessary.

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Children

Unsafe

Rapilif-M 25 Combipack is not recommended for children and adolescents below 18 years as there is no relevant use for this age group.

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Heart

Caution

Rapilif-M 25 Combipack should be taken with caution if you have heart problems. It may raise blood pressure and increase the risk of arrhythmias, so always consult your doctor before starting this medication.

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Geriatrics

Caution

Rapilif-M 25 Combipack can be used by geriatric patients but only under medical supervision. Older adults may be more sensitive to side effects like dizziness, blood pressure changes, or urinary issues, so regular monitoring is essential.

What if I have taken an overdose of Rapilif-M 25 Combipack

If you suspect an overdose, seek immediate medical attention or contact a poison control center. Symptoms of an overdose may include severe dizziness, fainting, or a very rapid heartbeat.

Diet & Lifestyle Advise

  • Limit bladder irritants: Reduce your intake of caffeine, alcohol, and artificial sweeteners, as they can irritate the bladder and worsen urinary urgency.
  • Manage evening fluid intake: Avoid drinking large amounts of fluids in the evening or close to bedtime to help reduce nighttime urination.
  • Practice pelvic floor exercises: Perform pelvic floor muscle exercises (Kegel exercises) regularly to help strengthen the muscles that control urination.
  • Increase your fiber intake: Eat a high-fiber diet to help prevent constipation, as a full bowel can put pressure on the bladder and worsen BPH symptoms.
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Have a query?

How Soon It Starts Working

The time required for Rapilif-M 25 Combipack to start to work: Rapilif-M 25 Combipack ideally shows its action within few hours after administration. The time for which the effects of Rapilif-M 25 Combipack last: The duration of action for Rapilif-M 25 Combipack is not clinically established.

What if you forget to take Rapilif-M 25 Combipack

If you miss a dose, take it with food as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Rapilif-M 25 Combipack at controlled room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Stand up slowly: Rise gradually from a sitting or lying position, especially when starting Rapilif-M 25 Combipack or after the first few doses, to help reduce the risk of dizziness, lightheadedness, or fainting. If possible, take your first dose when you can rest at home, and sit or lie down if you feel dizzy until the feeling passes.
  • Inform healthcare providers before eye surgery: Tell your eye surgeon that you are taking Rapilif-M 25 Combipack before cataract surgery, as silodosin may cause Intraoperative Floppy Iris Syndrome (IFIS) during the procedure.
  • Monitor your blood pressure: Check your blood pressure regularly, particularly when starting treatment, as mirabegron may increase blood pressure in some people.
  • Use caution during activities requiring alertness: Avoid driving, operating machinery, or performing hazardous tasks until you know how Rapilif-M 25 Combipack affects you, as it may cause dizziness or drowsiness.
  • Inspect Rapilif-M 25 Combipack before use: Check the packaging before each use. Do not take the tablets or capsules if the seals are broken or if Rapilif-M 25 Combipack shows signs of moisture damage, discoloration, or other visible changes.

Drug-Drug Interactions

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  • Alpha-blockers or blood pressure medicines (e.g., tamsulosin, amlodipine): Taking these medicines alongside Rapilif-M 25 Combipack may cause an excessive drop in blood pressure, increasing the risk of dizziness or fainting.
  • Antifungal medicines (e.g., ketoconazole, itraconazole): These medicines may increase silodosin levels in the body and raise the risk of side effects.
  • HIV medicines (e.g., ritonavir): These medicines may increase silodosin levels in the body and increase the risk of side effects.
  • Antiarrhythmic medicines (e.g., amiodarone, quinidine): These medicines may interact with the mirabegron component and increase the risk of heart rhythm problems. Your doctor may monitor you more closely.
  • P-glycoprotein (P-gp) inhibitors (e.g., cyclosporine): These medicines may increase silodosin levels in the body and raise the risk of side effects. Your doctor may recommend avoiding this combination or adjusting your treatment.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Food: Take Rapilif-M 25 Combipack with food, as food improves the absorption of the silodosin component and helps reduce the risk of side effects such as low blood pressure.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[BPH AGENTS]

FAQs

Rapilif-M 25 Combipack is used for the treatment of Benign prostatic hyperplasia (BPH) complicated by overactive bladder with symptoms of urge urinary incontinence (involuntary leakage of urine), urgency, and frequency.
Rapilif-M 25 Combipack contains Mirabegron and Silodosin. Mirabegron reduces the activity of an overactive bladder and treats related symptoms. Silodosin relaxes the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.
Low blood pressure, especially when starting to take Rapilif-M 25 Combipack, may cause dizziness when standing up suddenly from a sitting or lying position. Therefore, to avoid such effects, it is advised to stand up slowly from a sitting or lying position. Regular blood pressure monitoring is recommended at the beginning of therapy to reduce the possibility of such effects.
The best time to take Rapilif-M 25 Combipack may vary based on the health condition of an individual. However, take Rapilif-M 25 Combipack at the same time each day for best results as advised by the doctor.
Consult the doctor before taking Rapilif-M 25 Combipack if you have any history of kidney disease as dose adjustment may be necessary.
The side effects of Rapilif-M 25 Combipack include constipation, nausea, dizziness, increased heart rate, abnormal ejaculation, urinary tract infections, and runny or blocked nose. Most of these side effects resolve gradually over time on their own. However, consult the doctor if any of these side effects persist or worsen.
Rapilif-M 25 Combipack is primarily intended to treat symptoms of Benign Prostatic Hyperplasia (BPH). While it may have a secondary effect on blood pressure, it is not intended to manage blood pressure. Please check with your doctor for information or to discuss your blood pressure treatment plan.
You should take sildenafil along with Rapilif-M 25 Combipack with caution, as both medications can cause low blood pressure (hypotension), leading to fainting, dizziness, or light-headedness. It’s important to consult your doctor before using them together to avoid potential interactions.
It is best to avoid or strictly limit alcohol while taking Rapilif-M 25 Combipack. Alcohol can worsen side effects like dizziness, lightheadedness, and low blood pressure. Talk to your doctor for advice tailored to your health.
Yes, silodosin in Rapilif-M 25 Combipack can cause retrograde ejaculation, a harmless condition in which semen flows backward into the bladder instead of leaving the body during orgasm. This may result in little or no semen being released during ejaculation. The effect is temporary and usually resolves after Rapilif-M 25 Combipack is stopped. Talk to your doctor if you have any concerns or if it affects your quality of life.
Many people notice an improvement in urine flow within about 1 to 2 weeks of starting Rapilif-M 25 Combipack. However, the full benefits for overactive bladder symptoms, such as urgency and frequent urination, may take several weeks and sometimes up to 4 to 8 weeks of regular treatment. Continue taking Rapilif-M 25 Combipack as prescribed and talk to your doctor if your symptoms do not improve or become worse.
No, Rapilif-M 25 Combipack is specifically formulated and approved for men experiencing symptoms associated with an enlarged prostate. It is not recommended for use in women. Talk to your doctor for appropriate bladder treatments for women.
Inform your eye surgeon (ophthalmologist) well in advance of your cataract surgery that you are taking Rapilif-M 25 Combipack. The silodosin component can cause your pupil to become floppy during surgery, and your surgeon will need to take special precautions. Talk to your doctor about whether to pause Rapilif-M 25 Combipack.
You should not stop taking Rapilif-M 25 Combipack without consulting your doctor first. Stopping Rapilif-M 25 Combipack abruptly can cause your urinary flow issues and bladder urgency to return. Talk to your doctor before making any changes.
The mirabegron component in Rapilif-M 25 Combipack can cause an increase in blood pressure in some patients. It is important to have your blood pressure checked regularly while taking Rapilif-M 25 Combipack. Talk to your doctor if you have a history of high blood pressure.
No, you must swallow Rapilif-M 25 Combipack whole. Crushing, chewing, or breaking Rapilif-M 25 Combipack can affect how it is absorbed in your body and increase the risk of severe side effects. Talk to your doctor or pharmacist if you have trouble swallowing pills.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Medline Plus. Silodosin [Revised in 15th October 2016]. [Accessed on 12th June 2026]Check here
  2. Mfll0042 00. [Accessed on 02 Jun. 2026]Check here
  3. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Rapilif M 25 Kit

Country of origin

India

Manufacturer/Marketer address

142 Ab, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - RAP0177
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