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Rabishield 100IU Injection is used to prevent rabies post-exposure. It contains rabies human monoclonal antibody, which binds to and kills the rabies virus, providing protection. This medicine may cause side effects such as injection site reactions (pain, redness, swelling), headache, muscle pain, and upper respiratory tract infections. Inform your doctor if you are allergic to any of its ingredients, taking any other medicines, or have any pre-existing medical conditions before starting Rabishield 100IU Injection .

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Written By ,
Reviewed By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
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More about the Product

Manufacturer/Marketer :

Serum Institute Of India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rabishield 100IU Injection

Rabishield 100IU Injection is a specialized injection used to help prevent rabies infection in people who have been bitten, scratched, or otherwise exposed to a potentially rabid animal. It is a form of passive immunisation that provides immediate protection against the rabies virus. This medicine is always given in combination with a full course of the rabies vaccine.

This injection is given as a single dose as soon as possible after exposure, meaning there is no ongoing daily schedule to follow. Since it is injected by a healthcare professional, it does not depend on meals or food intake. Keeping the wound clean and following your doctor's wound care instructions are the most important steps to support your recovery.

While most people tolerate the injection well, some may experience local pain, redness, or swelling at the injection site. If you experience severe symptoms like breathing difficulties, hives, or swelling of the face and throat, you must seek emergency medical help immediately.

Before receiving this injection, tell your healthcare provider if you have a history of severe allergic reactions to immunoglobulins or any other medicines. Because rabies is a fatal disease, there are no absolute reasons to avoid this medicine if you have been exposed, but your doctor needs to know your medical history to manage risks.

Tell your doctor about all medicines you are taking, especially other vaccines, as this medicine can temporarily interfere with how some live vaccines work. If you are pregnant, breastfeeding, or an older adult, talk to your doctor, although this lifesaving treatment is generally given to anyone exposed to rabies.

Uses of Rabishield 100IU Injection

Rabishield 100IU Injection is used to provide immediate protection against rabies infection following suspected exposure to the rabies virus. The detailed uses of Rabishield 100IU Injection are as follows:

  • Post-exposure rabies prevention (WHO Category III Exposures): Rabishield 100IU Injection is specifically indicated for severe exposures (WHO Category III)—such as single or multiple bites/scratches that break the skin, licks on broken skin, or direct contact with bats—to stop the rabies virus from entering the nervous system.
  • Immediate immune support: Provides ready-made antibodies that immediately neutralize the rabies virus directly at the wound site before your body's immune system can produce its own antibodies from the rabies vaccine.
  • Formulation & Brand Context: Unlike traditional Human Rabies Immunoglobulin (HRIG) extracted from human donor blood, this is a modern, recombinant monoclonal antibody produced in laboratories (available under brand names such as Rabishield or Twinrab in India), offering consistent quality, high purity, and wider accessibility.

Key Benefits

Rabishield 100IU Injection provides immediate protection against rabies infection and supports effective post-exposure prevention. The key benefits of Rabishield 100IU Injection are as follows:

  • Immediate Virus Protection: Unlike vaccines, which take several days or weeks to stimulate your body to build a defence, Rabishield 100IU Injection starts fighting the rabies virus immediately at the site of the exposure.  
  • Prevents Virus Spread: By neutralising the virus directly in the surrounding tissues of the wound, this injection helps stop the infection from travelling to the brain and spinal cord, where rabies causes irreversible damage.
  • Supports Recovery Confidence: Knowing you have immediate, active protection against a highly dangerous infection allows you to focus on healing and completing your preventative vaccine schedule with peace of mind.
Side effects of Rabishield 100IU Injection 2.5 ml
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Rabishield 100IU Injection should be administered by a nurse or doctor to ensure proper dosage, technique, and monitoring for any potential side effects or complications.
  • Do not self-administer.

How Rabishield 100IU Injection Works

Rabishield 100IU Injection contains Rabishield 100IU Injection , which consists of pre-formed antibodies that target the rabies virus directly. When a rabid animal bites or scratches a person, the virus enters the body's tissues. It takes time for the rabies vaccine to prompt your immune system to make its own antibodies. During this critical window, Rabishield 100IU Injection acts as an immediate shield. The antibodies in the injection bind specifically to the rabies virus at the wound site, neutralising it and preventing it from entering the local nerves. This halts the virus before it can travel to the central nervous system, effectively stopping the infection in its tracks.
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Alcohol

Consult your doctor

It is not known if alcohol affects the medication's effectiveness. Please consult your doctor about the safety of consuming alcohol with Rabishield 100IU Injection .

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Pregnancy

Consult your doctor

Before receiving Rabishield 100IU Injection , consult your doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Consult your doctor

Please consult your doctor if you are a breastfeeding mother. The information regarding the use of Rabishield 100IU Injection in breastfeeding mothers is not available.

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Driving

Consult your doctor

It is unclear whether Rabishield 100IU Injection affects your ability to drive. Avoid driving if you suspect any difficulty.

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Liver

Consult your doctor

There is limited information available on the use of Rabishield 100IU Injection in individuals with liver problems. You are recommended to consult a doctor for further guidance.

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Kidney

Consult your doctor

There is limited information available on the use of Rabishield 100IU Injection in individuals with kidney problems. You are recommended to consult a doctor for further guidance.

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Children

Consult your doctor

Please consult your doctor before administering Rabishield 100IU Injection to your child, as there is limited information available.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems before receiving Rabishield 100IU Injection . Your doctor will prescribe Rabishield 100IU Injection if the benefits outweigh the risk.

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Geriatrics

Safe if prescribed

Rabishield 100IU Injection is generally considered safe for use in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Rabishield 100IU Injection

Since a healthcare professional calculates and injects this medicine in a clinical setting, an overdose is highly unlikely. If you suspect an error or experience unusual symptoms after your injection, seek immediate medical attention.

Diet & Lifestyle Advise

  • Clean the Wound Properly: Keep the bite or scratch wound clean by washing it gently with soap and running water for several minutes to lower the viral load.
  • Avoid Tight Dressings: Avoid covering the wound with tight dressings or bandages unless specifically instructed by your doctor, as open wounds from animal bites need proper air exposure and monitoring.
  • Follow Vaccine Schedule: Strictly adhere to your rabies vaccine schedule; Rabishield 100IU Injection only provides temporary protection, and the vaccine is required for long-term safety.
  • Avoid Alcohol Consumption: Avoid drinking alcohol during your treatment course, as it can dehydrate your body and make it harder to monitor potential side effects like headaches or dizziness.
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How Soon It Starts Working

The time required for Rabishield 100IU Injection to start to work: The time required for Rabishield 100IU Injection to show its action is unknown. The time for which the effects of Rabishield 100IU Injection last: The duration of action for Rabishield 100IU Injection is unknown.

What if you forget to take Rabishield 100IU Injection

This medicine is given as a single injection shortly after exposure to rabies. Because it is not a daily medicine, there is no risk of missing a dose. However, if you miss a scheduled follow-up appointment for your rabies vaccine, contact your doctor immediately.

Storage

• Rabishield 100IU Injection must be stored in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F). It should never be frozen.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the Vial Before Use: Before the injection, the healthcare provider should visually inspect the vial; do not use if the solution is cloudy, discoloured, or contains visible particles.
  • Avoid Blood Vessel Injection: Ensure Rabishield 100IU Injection is not injected into a blood vessel, as it is meant only to be injected directly into the wound area and into a muscle.
  • Do Not Mix with Rabies Vaccine: Never mix Rabishield 100IU Injection in the same syringe or inject it into the exact same body site as the rabies vaccine, as this can stop the vaccine from working properly.
  • Inform Your Doctor About IgA Deficiency: Tell your doctor immediately if you have a known history of immunoglobulin A (IgA) deficiency (a condition where your body lacks a specific protective immune protein), as this may increase the risk of an allergic reaction.
  • Maintain Injection Records: Keep a record of the injection date and the specific injection sites to share with your healthcare team during your follow-up vaccine appointments.

Drug-Drug Interactions

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  • Live Vaccines: May interfere with live vaccines (such as measles, mumps, rubella, or varicella vaccines). Talk to your doctor, as you may need to delay these vaccines for several months after receiving Rabishield 100IU Injection .
  • Rabies Vaccine: Do not mix with the rabies vaccine in the same syringe or inject into the same site, as this can reduce the effectiveness of the vaccine.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • No clinically significant food interactions are known with Rabishield 100IU Injection when used as directed.     
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[IMMUNOLOGICAL AGENTS]

FAQs

Rabishield 100IU Injection is used in the prevention of rabies post-exposure.
Rabishield 100IU Injection contains rabies human monoclonal antibody as its active component. It works by binding to and neutralizing the rabies virus. It helps the body's immune system develop its response through vaccination.
No, Rabishield 100IU Injection is not habit-forming. Please talk to your doctor if you have any concerns.
Rabishield 100IU Injection may cause side effects such as injection site reactions (pain, redness, and swelling), headache, muscle pain, and upper respiratory tract infections. Contact a doctor if any of these side effects persist or worsen.
A healthcare professional will inject Rabishield 100IU Injection directly into and around the animal bite or scratch wounds. If there is any leftover medicine, it will be injected into a muscle far away from where you received your rabies vaccine. Talk to your doctor if you have questions about the injection process.
Yes, like any injection, Rabishield 100IU Injection can cause allergic reactions in some people, ranging from mild itching to severe swelling or breathing difficulties. Your healthcare provider will monitor you closely after the injection to manage any immediate reactions. Talk to your doctor if you have a history of allergies to blood products.
Yes. Because rabies is a fatal disease, Rabishield 100IU Injection is given to pregnant women who have been exposed to a potentially rabid animal. There is no evidence that it causes harm to the unborn baby when used for rabies prevention. Talk to your doctor if you have concerns.
Yes, you must still receive the complete schedule of the rabies vaccine. Rabishield 100IU Injection only provides immediate, temporary protection, while the vaccine helps your body build long-lasting immunity. Talk to your doctor to ensure you complete your vaccination schedule.
It is highly recommended to avoid alcohol after receiving Rabishield 100IU Injection . Alcohol can dehydrate your body and make it difficult to distinguish side effects like headaches or dizziness from alcohol-related symptoms. Talk to your doctor or pharmacist for personalized advice.
Rabishield 100IU Injection begins working immediately to neutralize the virus and gradually breaks down in the body over a few weeks. By that time, the rabies vaccine will have prompted your own immune system to produce long-term antibodies. Talk to your doctor if you want to know more about how your body processes this medicine.
Mild swelling, redness, and soreness at the injection site are common and usually go away on their own within a few days. You can apply a cold compress to the area to help reduce discomfort. Talk to your doctor if the swelling worsens, becomes extremely painful, or does not improve.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Serum Institute Of India. [Accessed on 02 Jun. 2026]Check here
  2. Rabishield 50 Injection. [Accessed on 02 Jun. 2026]Check here
  3. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Rabishield 100Iu Injection

Country of origin

India

Manufacturer/Marketer address

212/2, Hadapsar, Off Soli Poonawalla Road, Pune 411028 India
Other Info - RAB1096
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