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compositionComposition:PYRIMETHAMINE-25MG
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Prescription Medicine
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Pyrimethamine 25 mg Tablet is used to treat malaria. It contains Pyrimethamine, which belongs to the class of antimalarial/antiparasitic drugs. It works by increasing the harmful, toxic and highly reactive free radicals in the blood. This kills the parasite and stops the infection from spreading. In this way, it is used to prevent malaria relapse caused by parasites. Pyrimethamine 25 mg Tablet may cause side effects such as nausea, dizziness, vomiting, headache, diarrhoea, body pain, stomach discomfort, and injection site reactions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PYRIMETHAMINE-25MG

Manufacturer/Marketer :

Vikas Health Care

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pyrimethamine 25 mg Tablet

Pyrimethamine 25 mg Tablet is an oral prescription medication used primarily to treat toxoplasmosis, a serious parasitic infection that can affect the brain, eyes, or other major organs. It is also prescribed in certain cases to prevent or treat malaria, an infection spread by mosquitoes. This medication works by stopping the parasites from multiplying in your body.

To get the best results, you must take Pyrimethamine 25 mg Tablet consistently at the exact times prescribed by your doctor. It can be taken with or without food, though taking it with meals can help prevent stomach upset. Eating a balanced diet and drinking plenty of water will also support your recovery and help your body fight off the infection.

While taking Pyrimethamine 25 mg Tablet , you may experience mild side effects like a loss of appetite or vomiting. However, you must contact your doctor immediately if you notice serious symptoms like unusual bruising, pale skin, throat pain, or extreme tiredness, as these can point to serious blood-related issues.

Do not take this if you have a known history of severe anemia caused by a lack of folic acid. You must tell your doctor before starting this medication if you have liver damage, kidney disease, or a history of seizures.

This medicine can interact with other drugs that affect your blood cells or folate levels, so let your doctor know all the medications you are taking. You should avoid drinking alcohol during treatment, as it can increase the risk of liver damage and worsen stomach upset. Pregnant, breastfeeding, or elderly individuals must consult their doctor before taking Pyrimethamine 25 mg Tablet , as special monitoring is often required.

Uses of Pyrimethamine 25 mg Tablet

Your doctor may prescribe Pyrimethamine 25 mg Tablet to treat the following conditions:

  • Toxoplasmosis: Pyrimethamine 25 mg Tablet helps by stopping the parasite from reproducing, which controls the infection in vital organs like the brain and eyes.
  • Malaria: Pyrimethamine 25 mg Tablet prevents and treats malaria by targeting the malaria parasite in the bloodstream, preventing it from growing and spreading.

Key Benefits

Pyrimethamine 25 mg Tablet helps treat certain parasitic infections by preventing parasites from growing and multiplying. This allows your immune system to clear the infection more effectively, reducing symptoms and lowering the risk of serious complications.

  • Helps eliminate parasitic infections: Stops the growth and reproduction of susceptible parasites, helping the body clear the infection more effectively.
  • Protects vital organs: In conditions such as toxoplasmosis, it helps reduce the risk of damage to the brain, eyes, and other organs by controlling the spread of the parasite.
  • Relieves symptoms of infection: As the parasite is brought under control, it helps reduce symptoms such as fever, swollen lymph nodes, muscle aches, and general weakness.
  • Prevents disease progression: By interrupting the parasite's life cycle, Pyrimethamine 25 mg Tablet helps limit the spread of infection within the body and reduces the risk of serious complications when used as prescribed.
Side effects of Pyrimethamine 25 mg Tablet
  • Eat foods rich in vitamins C and E, and healthy fats.
  • Consider soft foods like smoothies, soups, and scrambled eggs.
  • Take supplements like vitamins C and E, zinc, and omega-3 fatty acids under medical supervision.
  • Include anti-inflammatory foods like omega-3 rich foods, berries, leafy greens, and spices.
  • Avoid allergens and consider an elimination diet.
  • Practice gentle skin care with non-irritating cleansers and moisturizers.
  • Keep skin well-moisturized with fragrance-free products.
  • Monitor for complications like infection and temperature regulation.
  • Let your doctor know if there are unsual symptoms after taking the medication, such as red patches on your skin.
  • Your doctor may change your medication, lower the dose, or stop the treatment to help manage the symptoms.
  • Avoid heavy physical activity and get plenty of rest to prevent further worsening of the symptoms.
  • Apply cold packs to the affected areas for relief.
  • Keep yourself hydrated or take supplements to get enough vitamins.
  • Over-the-counter pain relievers can help with discomfort.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Directions for Use

  • Pyrimethamine 25 mg Tablet should be taken after meals to prevent stomach upset or as advised by your doctor.
  • It is usually taken once daily; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the tablet as a whole with a glass of water.
  • Do not break, chew or crush Pyrimethamine 25 mg Tablet .

How Pyrimethamine 25 mg Tablet Works

Pyrimethamine 25 mg Tablet contains pyrimethamine, which works by targeting a specific enzyme that parasites need to survive and grow. This enzyme helps the parasite produce folic acid, which is essential for making their DNA. By blocking this enzyme, the medication starves the parasites of folic acid. Without it, the parasites cannot multiply or repair themselves, allowing your body's natural defense systems to target and eliminate them. Because human cells use a slightly different process to handle folic acid, the drug is highly selective in targeting the parasites.
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Alcohol

Consult your doctor

The interaction of Pyrimethamine 25 mg Tablet with alcohol is unknown. Avoiding alcohol consumption is advised.

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Pregnancy

Caution

In pregnant women, there are no favourable or well-controlled trials. Pyrimethamine 25 mg Tablet should only be used during pregnancy if the possible benefit outweighs the risk to the fetus. Concurrent use of folinic acid is strongly advised while treating toxoplasmosis during pregnancy.

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Breast Feeding

Caution

Pyrimethamine is excreted in human milk. Because of the risk of serious adverse reactions in nursing infants from pyrimethamine and concurrent use of a sulfonamide with Pyrimethamine 25 mg Tablet for the treatment of some patients with toxoplasmosis, a decision should be made whether to discontinue nursing or the drug, taking into account the benefits of the drug to the mother.

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Driving

Caution

Pyrimethamine 25 mg Tablet may decrease alertness or make you feel sleepy and dizzy. So, do not drive or operate heavy machinery after taking Pyrimethamine 25 mg Tablet until you are alert.

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Liver

Caution

Pyrimethamine 25 mg Tablet should be used with caution if you have a pre-existing or a history of liver disease. Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Pyrimethamine 25 mg Tablet should be used with caution if you have a pre-existing or a history of kidney diseases. Your doctor may adjust the dose based on your condition.

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Children

Safe if prescribed

Please consult your doctor. Your child's doctor will decide the dose of this medicine based on the age and condition of the child.

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Heart

Caution

Pyrimethamine 25 mg Tablet should be used with caution in individuals with heart problems, as it may increase the risk of adverse effects. Always consult your doctor to determine if it's safe for your condition.

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Geriatrics

Caution

Pyrimethamine 25 mg Tablet can be taken by geriatric patients, but require caution due to increased sensitivity to side effects. Regular monitoring and dose adjustments may be necessary under medical supervision.

What if I have taken an overdose of Pyrimethamine 25 mg Tablet

If you take too much of this medicine, seek emergency medical care or call a poison control center immediately. Symptoms of an overdose can include severe vomiting, seizures, or extreme breathing difficulties.

Diet & Lifestyle Advise

  • Folate Supplementation: Because this medicine can lower folate levels in your body, your doctor will likely prescribe a specific form of folic acid (such as folinic acid or leucovorin). Make sure to take this supplement exactly as directed to protect your blood cells.
  • Avoid Raw or Undercooked Meat: If you are treating toxoplasmosis, prevent reinfection by ensuring all meats are cooked to safe internal temperatures and washing all raw fruits and vegetables thoroughly.
  • Practice Safe Food Handling: Wash your hands, cutting boards, and utensils with warm, soapy water after handling raw meat to avoid contact with parasites.
  • Wear Protective Clothing: If you are taking this to prevent malaria, protect yourself from mosquito bites by using insect repellent, sleeping under a mosquito net, and wearing long-sleeved clothing.
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How Soon It Starts Working

The time required for Pyrimethamine 25 mg Tablet to start to work: Pyrimethamine 25 mg Tablet shows its action within 1 hour of administration. The time for which the effects of Pyrimethamine 25 mg Tablet last: The duration of Pyrimethamine 25 mg Tablet ’s effect is clinically not established.

What if you forget to take Pyrimethamine 25 mg Tablet

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure what to do, talk to your doctor or pharmacist.

Storage

• Store in a cool and dry place away from sunlight. • Keep Pyrimethamine 25 mg Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Attend regular blood tests: Keep all scheduled laboratory appointments so your doctor can monitor your blood cell counts and detect any treatment-related changes early.
  • Watch for skin reactions: Contact your doctor immediately if you develop a skin rash, blistering, peeling skin, or sores in the mouth, as these may be signs of a serious skin reaction.
  • Inform your healthcare providers: Always tell your doctor, dentist, pharmacist, or surgeon that you are taking Pyrimethamine 25 mg Tablet before starting any new medication or undergoing any medical or dental procedure.
  • Use effective contraception: Use reliable birth control during treatment and for the period recommended by your doctor, as Pyrimethamine 25 mg Tablet may harm an unborn baby. Inform your doctor immediately if you become pregnant.
  • Inspect the packaging before use: Check that the blister pack or bottle seal is intact before taking the medicine. Do not use the tablets if the packaging is torn, damaged, or shows signs of tampering.

Drug-Drug Interactions

verifiedApollotooltip
  • May increase the risk of severe bone marrow suppression and low blood cell counts when combined with other drugs that affect folate levels, such as methotrexate or trimethoprim-sulfamethoxazole.
  • May increase the risk of seizures when taken with certain seizure medications or other anti-malarial treatments.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Drinking alcohol while taking this medicine can increase the risk of liver damage and cause severe stomach upset.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- MALARIALS]

FAQs

Pyrimethamine 25 mg Tablet is used to treat Malaria and Toxoplasmosis.
Pyrimethamine 25 mg Tablet contains Pyrimethamine, which belongs to the class of antimalarial/ antiparasitic drugs. It works by increasing the harmful, toxic, and highly reactive free radicals in the blood. This kills the parasite and stops the infection from spreading.
No, do not stop taking Pyrimethamine 25 mg Tablet . It is recommended to take this medicine for the entire prescribed duration, even when symptoms improve or resolve. Failure to do so might result in drug resistance, and treating any subsequent infection with the same medicine would be very difficult.
The common side-effects of Pyrimethamine 25 mg Tablet are nausea, vomiting, dizziness, diarrhoea, headache and injection site reactions. These side effects usually do not require any medical attention.
This medicine is generally not recommended during early pregnancy unless the benefit outweighs the potential risk to the unborn baby, as it can interfere with folate levels. Talk to your doctor to weigh the risks and benefits.
Yes, doctors usually prescribe a special type of folic acid (leucovorin) alongside Pyrimethamine 25 mg Tablet to protect your bone marrow and prevent blood issues. Do not take standard over-the-counter folic acid supplements without consulting your doctor first.
It is best to avoid alcohol while taking this medicine, as combining them can increase the strain on your liver and worsen side effects like dizziness and nausea. Talk to your doctor or pharmacist if you have concerns.
Stop taking the medicine and seek medical help immediately. A skin rash can be a sign of an allergic reaction or a rare but severe skin condition. Talk to your doctor right away.
Yes, you can take it with or without food. However, if you experience nausea or stomach upset, taking it with a meal or a glass of milk can help. Talk to your doctor if stomach issues continue.
Yes, this medication can temporarily lower the number of red blood cells, white blood cells, and platelets in your body. Your doctor will likely order regular blood tests to monitor this. Talk to your doctor if you experience unusual bruising or fatigue.
Elderly patients can use this medicine, but they may be more sensitive to its side effects, particularly blood-related issues. Close monitoring and lower doses are sometimes necessary. Talk to your doctor about safe use.

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Country of origin

India

Manufacturer/Marketer address

Firozpur Jhirka, Haryana 122104
Other Info - PYR0191
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