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compositionComposition:ALLOPURINOL-100MG
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Prescription Medicine
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Puril 100 mg Tablet is used to reduce blood uric acid levels. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, and bladder stones. It contains Allopurinol, which stops uric acid production in the body and prevents crystal buildup. Common side effects include stomach upset, diarrhoea, skin rash, and drowsiness.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ALLOPURINOL-100MG

Manufacturer/Marketer :

Marcus Pharma

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Puril 100 mg Tablet

Puril 100 mg Tablet is a prescription medication used to prevent gout attacks and manage certain types of kidney stones. It is also prescribed to lower high uric acid levels in patients undergoing chemotherapy treatments for cancer.

To achieve the best results, you must take Puril 100 mg Tablet consistently every day as directed, even when you do not have active symptoms. It is best taken after a meal to help prevent stomach irritation, and pairing it with dietary adjustments like limiting purine-rich foods can greatly support your treatment.

While Puril 100 mg Tablet is highly effective, some people may experience mild side effects such as drowsiness or temporary stomach upset. However, you should contact your doctor immediately if you develop a skin rash, peeling skin, dark urine, or yellowing of the skin or eyes.

Before starting this medication, talk to your doctor if you have kidney or liver issues, thyroid problems, or heart conditions. Do not take this medicine if you have had a severe allergic reaction to it in the past.

This medication can interact with other treatments, such as blood thinners or certain antibiotics, which can increase your risk of severe side effects. It is important to consult your doctor or pharmacist if you are pregnant, planning to become pregnant, breastfeeding, or are an older adult.

Uses of Puril 100 mg Tablet

Puril 100 mg Tablet is prescribed to help lower uric acid levels and prevent related complications. Common uses include:

  • Gout prevention: Puril 100 mg Tablet helps prevent painful gout flare-ups by reducing the buildup of uric acid crystals in your joints.
  • Kidney stone prevention: It lowers the amount of uric acid in your urine, which helps prevent the formation of calcium oxalate or uric acid kidney stones.
  • Chemotherapy-induced hyperuricemia: It manages high uric acid levels in the blood caused by cancer treatments, protecting your kidneys from damage.
     

Key Benefits

Puril 100 mg Tablet helps lower uric acid levels in the body, preventing the formation of uric acid crystals that cause gout and certain types of kidney stones. Regular use helps provide long-term control and reduces the risk of recurrent attacks.

  • Prevents Gout Attacks: Lowers uric acid levels, helping prevent painful gout flare-ups and reducing joint inflammation over time.
  • Protects Joint Health: Helps prevent the formation of uric acid crystals, reducing the risk of long-term joint damage caused by recurrent gout.
  • Reduces the Risk of Kidney Stones: Helps prevent uric acid kidney stones by lowering the amount of uric acid in the urine.
  • Supports Kidney Function During Cancer Treatment: Helps reduce uric acid levels in patients receiving chemotherapy or radiation therapy, lowering the risk of tumour lysis syndrome and protecting kidney function.
  • Improves Long-Term Quality of Life: By preventing gout attacks and reducing uric acid-related complications, it helps maintain mobility, comfort, and overall well-being.
     
Side effects of Puril 100 mg Tablet
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Limit processed foods and eat more vegetables and fruits.
  • Exercise at least 30 minutes every day.
  • Maintain a healthy weight.
  • Quit smoking as it can worsen kidney damage.
  • Control your blood pressure and blood glucose.
  • Limit salt intake and alcohol consumption.
  • Take cold water baths avoiding soap.
  • Avoid scratching and scrubbing to prevent infections while itching.
  • Use nets to prevent insects and mosquitoes.
  • Stop using lotions and creams that cause irritation.
  • Avoid alcohol and caffeine intake.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Take Puril 100 mg Tablet with food to avoid stomach upset or as advised by a doctor.
  • Recommended to take the medicine once or twice a day or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Puril 100 mg Tablet Works

Puril 100 mg Tablet contains allopurinol, which belongs to a class of medicines called xanthine oxidase inhibitors. It works by blocking the activity of a specific natural enzyme in your body known as xanthine oxidase. This enzyme is responsible for converting chemical compounds into uric acid. By blocking this enzyme, Puril 100 mg Tablet reduces the amount of uric acid your body produces. Over time, lower blood levels of uric acid allow existing crystals in your joints and kidneys to dissolve, preventing new ones from forming. This gradual reduction is what stops gout attacks and kidney stones from recurring.
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Alcohol

Unsafe

Puril 100 mg Tablet should not be taken along with alcohol, as it increases uric acid levels.

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Pregnancy

Caution

Puril 100 mg Tablet is a Category C pregnancy drug. If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

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Breast Feeding

Unsafe

Puril 100 mg Tablet is excreted in human breast milk, so it is not recommended during breastfeeding.

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Driving

Unsafe

Puril 100 mg Tablet may cause some individuals to feel drowsy. Do not drive or operate dangerous machinery if you are affected.

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Liver

Caution

Puril 100 mg Tablet to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Puril 100 mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Puril 100 mg Tablet hasn’t been studied and shouldn’t be used in people younger than 18 years to treat gout or kidney stones.

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Heart

Caution

Puril 100 mg Tablet should be taken with caution in patients with heart disease. Please consult your physician.

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Geriatrics

Caution

Puril 100 mg Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Puril 100 mg Tablet .

What if I have taken an overdose of Puril 100 mg Tablet

If you suspect an overdose or experience severe symptoms like extreme drowsiness, vomiting, or trouble breathing, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink 8 to 10 glasses of water daily to help your kidneys flush out uric acid and reduce the risk of kidney stones.
  • Limit high-purine foods: Minimise your intake of foods that trigger uric acid production, such as red meat, organ meats (like liver), seafood (especially shellfish and anchovies), and yeast extracts.
  • Avoid high-fructose corn syrup: Limit sugary drinks, sodas, and processed sweets, as fructose can increase uric acid levels in the body.
  • Limit alcohol intake: Avoid or severely restrict beer and hard liquor, as they can interfere with how your body eliminates uric acid and can trigger sudden gout attacks.
  • Maintain a healthy weight: Gradual weight loss can lower uric acid levels, but avoid extreme fasting or rapid crash diets, which can temporarily spike uric acid and trigger gout attacks.
     
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How Soon It Starts Working

  • The time required for Puril 100 mg Tablet to start to work: Puril 100 mg Tablet ideally shows its action within 2 to 3 days after administration.
  • The time for which the effects of Puril 100 mg Tablet last: The effect of Puril 100 mg Tablet lasts for 24 hours.

What if you forget to take Puril 100 mg Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Puril 100 mg Tablet tablets at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the medication in its original container, tightly closed, to protect it from light and excess moisture. Avoid storing it in damp areas like bathroom cabinets.

Drug Warnings

  • Watch for early signs of skin rash: A rash of any kind can be a sign of a severe allergic reaction. Stop taking Puril 100 mg Tablet immediately and seek emergency medical care if you notice a skin rash, peeling, or sores on your lips or eyes.
  • Do not stop during a flare-up: It is common to experience more gout attacks during the first few months of starting Puril 100 mg Tablet . Keep taking the medication consistently and talk to your doctor, who may prescribe other temporary pain relievers to manage these flares.
  • Be cautious with activities: Since this medicine can cause drowsiness, avoid driving or operating heavy machinery until you know how it affects you.
  • Monitor your lab work: Your doctor will likely order regular blood tests to check your uric acid levels and monitor your kidney and liver function while you are on this medicine.
  • Inform all healthcare providers: Always tell any doctor, dentist, or pharmacist that you are taking Puril 100 mg Tablet before starting any new treatments or undergoing medical procedures.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Azathioprine or mercaptopurine: Puril 100 mg Tablet can significantly increase the levels of these immune-suppressing medicines in your body, which can lead to severe, life-threatening side effects. Your doctor will need to adjust the doses.
  • Amoxicillin or ampicillin: Taking these antibiotics with Puril 100 mg Tablet may increase your risk of developing a skin rash.
  • Warfarin or other blood thinners: This medicine can increase the effects of blood thinners, potentially raising your risk of bleeding.
  • Thiazide diuretics (water pills): These medications can increase the concentration of Puril 100 mg Tablet in your blood, raising the risk of severe allergic reactions, especially in people with kidney problems.
  • Cyclosporine: Puril 100 mg Tablet may increase cyclosporine levels in the body, raising the risk of side effects. Your doctor may monitor you more closely or adjust your treatment.
  • ACE inhibitors (such as captopril): Taking these medicines with Puril 100 mg Tablet may increase the risk of allergic reactions or blood-related side effects, particularly in people with kidney disease.
     
AllopurinolDidanosine
Critical
AllopurinolMoexipril
Severe

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
How does the drug interact with Puril 100 mg Tablet:
When Didanosine is taken with Puril 100 mg Tablet, can increase the blood levels of didanosine.

How to manage the interaction:
Taking Puril 100 mg Tablet with Didanosine lead to an interaction, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
AllopurinolMoexipril
Severe
How does the drug interact with Puril 100 mg Tablet:
Co-administration of Puril 100 mg Tablet with Moexipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 100 mg Tablet and Moexipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolDeferiprone
Severe
How does the drug interact with Puril 100 mg Tablet:
Co-administration of Puril 100 mg Tablet with Deferiprone may increase the risk of dangerous blood clots.

How to manage the interaction:
If you are supposed to take Puril 100 mg Tablet and Deferiprone together, your doctor may advise you to take blood thinner or monitor you more frequently to safely use both medications. However, if you experience shortness of breath, chest pain, coughing up blood, difficulty breathing, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, contact your doctor immediately as these may be signs and symptoms of blood clots. Do not discontinue any medications without consulting a doctor.
AllopurinolQuinapril
Severe
How does the drug interact with Puril 100 mg Tablet:
Co-administration of Puril 100 mg Tablet with Quinapril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 100 mg Tablet and Quinapril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolRamipril
Severe
How does the drug interact with Puril 100 mg Tablet:
Co-administration of Puril 100 mg Tablet with Ramipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 100 mg Tablet and Ramipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolPegloticase
Severe
How does the drug interact with Puril 100 mg Tablet:
Co-administration of Puril 100 mg Tablet with Pegloticase can increase the chances of side effects.

How to manage the interaction:
Co-administration of Puril 100 mg Tablet with Pegloticase can possibly result in an interaction, but it can be taken if your doctor has advised it. This is more common in people who already have high uric acid levels, which may not be obvious if they are taking other uric acid-lowering medications. Do not stop using any medications without first talking to your doctor.
AllopurinolPerindopril
Severe
How does the drug interact with Puril 100 mg Tablet:
Co-administration of Puril 100 mg Tablet with Perindopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 100 mg Tablet and Perindopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms, contact your doctor immediately . Do not discontinue any medications without consulting a doctor.
AllopurinolAzathioprine
Severe
How does the drug interact with Puril 100 mg Tablet:
Co-administration of Puril 100 mg Tablet with Azathioprine may increase the effects of azathioprine.

How to manage the interaction:
There may be a possibility of interaction between Azathioprine and Puril 100 mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience chills, fever, body pains, sore throat, weakness, muscle pain, mouth sores, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhoea, consult a doctor. Do not stop using any medications without a doctor's advice.
AllopurinolCaptopril
Severe
How does the drug interact with Puril 100 mg Tablet:
Co-administration of Puril 100 mg Tablet with Captopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 100 mg Tablet and Captopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolLisinopril
Severe
How does the drug interact with Puril 100 mg Tablet:
Co-administration of Puril 100 mg Tablet with Lisinopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 100 mg Tablet and Lisinopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness chills, sore throat, extreme tiredness, body pains, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol and high-purine foods: Consuming alcohol (especially beer) or heavy amounts of high-purine foods can lower the effectiveness of Puril 100 mg Tablet by significantly increasing uric acid levels in the body.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[GOUT THERAPY]

FAQs

Puril 100 mg Tablet is used to treat gout (increased uric acid leading to inflammation), kidney stones, and bladder stones. It decreases blood uric acid levels in the body.
Puril 100 mg Tablet contains allopurinol, which works by blocking the action of xanthine oxidase, the enzyme responsible for the production of uric acid. It stops uric acid formation inside the body and prevents crystal buildup, making it effective in managing gout and kidney/bladder stones.
If you are taking Puril 100 mg Tablet and it makes you vomit, then your contraceptive pill would not be effective, and it could lead to an unwanted pregnancy. If you are of childbearing age, inform your doctor before starting Puril 100 mg Tablet and use another form of contraceptive like condoms.
Generally, when Puril 100 mg Tablet is administered to elderly patients (aged> 65 years), the dose is reduced based on the patient’s condition. Also, if you mention all underlining disease you suffer from, which could affect Puril 100 mg Tablet , the dose will be adjusted accordingly by your doctor.
Yes, Puril 100 mg Tablet can cause drowsiness in some people. It can even make you feel dizzy or have a problem with coordination. It is advisable to avoid driving or operating machinery to avoid any unpleasant side effects.
No, Puril 100 mg Tablet is not an anti-inflammatory medicine. It works by inhibiting the enzyme xanthine oxidase, which catalyses the formation of uric acid. It inhibits uric acid formation within the body without affecting essential cellular and systemic mechanisms.
It may take several weeks to lower uric acid levels before you begin to feel better or notice a significant reduction in gout attacks.
Puril 100 mg Tablet may cause side effects such as nausea, vomiting, diarrhoea, stomach upset, or drowsiness. If these side effects persist or worsen, please consult your doctor.
If you forget to take a dose of Puril 100 mg Tablet , take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for a forgotten dose.
Store Puril 100 mg Tablet in a cool, dry and dark place. Protect from direct sunlight and moisture. Keep it out of sight and reach of children.
No, you should not stop taking this medicine when your pain resolves. Puril 100 mg Tablet is a preventive treatment that must be taken daily to keep your uric acid levels stable and prevent future attacks. Stopping it suddenly can cause your uric acid levels to spike, triggering a new gout attack. Talk to your doctor before making any changes to your medication routine.
When you first start taking this medicine, the sudden lowering of uric acid levels can cause existing crystals in your joints to shift and dissolve, which can temporarily trigger or worsen gout pain. This is a common response and does not mean the medication is not working. Your doctor may prescribe an anti-inflammatory medicine to help manage this initial phase. Talk to your doctor if the pain is severe or prolonged.
It is highly recommended to avoid or limit alcohol, especially beer, while taking this medicine. Alcohol increases uric acid production and prevents your kidneys from filtering it out, which can trigger gout attacks and reduce the effectiveness of Puril 100 mg Tablet . Talk to your doctor about what level of alcohol consumption, if any, is safe for you.
If you notice any skin rash, itching, peeling, or hives, stop taking the medication immediately and contact a doctor or seek emergency medical care. A rash can be an early sign of a rare but life-threatening allergic reaction. Do not take another dose until a healthcare professional has evaluated your skin. Talk to your doctor.
You should take Puril 100 mg Tablet after a meal to help minimise potential stomach upset, indigestion, or nausea. Drinking a full glass of water with each dose is also recommended. If stomach issues persist even when taking the medicine with food, talk to your doctor.
Puril 100 mg Tablet is actually used to protect the kidneys from damage caused by high uric acid and kidney stones. However, because the drug is cleared by the kidneys, individuals with pre-existing kidney disease require carefully adjusted doses to prevent the drug from building up in the body. Your doctor will monitor your kidney function with routine blood tests. Talk to your doctor if you have concerns about your kidney health.
The safety of Puril 100 mg Tablet during pregnancy and breastfeeding is not fully established. It should only be used if the potential benefit justifies the risk to the baby. If you are pregnant, planning to become pregnant, or are currently breastfeeding, talk to your doctor to discuss safer alternative treatments.

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Country of origin

India

Manufacturer/Marketer address

No. 1935, No. 222, 2Nd Floor, Fountain Electric Market, Bhagirath Palace, Chandni Chowk,New Delhi-110006
Other Info - PUR0039
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