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compositionComposition:AMBRISENTAN-5MG+TADALAFIL-20MG
prescription
Prescription Medicine
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Pulmonext Kit is a combination medicine used to treat pulmonary arterial hypertension (high blood pressure affecting lung arteries). This medicine works by relaxing the blood vessels in the chest, thus increasing blood supply to the lungs while decreasing the workload on the heart. You may experience common side effects, such as blood vessels in the chest. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

AMBRISENTAN-5MG+TADALAFIL-20MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pulmonext Kit

Pulmonext Kit is a prescription oral medicine used to treat pulmonary arterial hypertension, which is high blood pressure in the blood vessels of your lungs. It works to improve your physical stamina and ability to exercise, while also helping to delay the worsening of your symptoms. This combination treatment is designed to target different pathways in the body to make breathing much easier.

To get the best results, you must take Pulmonext Kit consistently at the same time every single day. You can take this medicine with or without food, depending on what is most comfortable for you. Combining your medical treatment with a low-salt diet and maintaining a light, doctor-approved daily exercise routine can significantly support your overall heart and lung health.

While taking Pulmonext Kit, you may experience common side effects such as mild headaches, a stuffy nose, or slight swelling in your ankles and legs. However, you must seek medical help immediately if you develop serious side effects like sudden vision changes, severe shortness of breath, or signs of liver problems.

Talk to your doctor before starting Pulmonext Kit if you have a history of liver disease, kidney problems, fluid retention, or heart failure. Do not take this if you are pregnant, as it can cause severe harm or birth defects to an unborn baby, or if you have severe liver damage.

This medicine can interact dangerously with nitrates used for chest pain and certain blood pressure medications, causing a sudden and severe drop in blood pressure. It is also important to talk to your doctor or pharmacist if you are breastfeeding or if you are an older adult, as your dose or monitoring schedule may need adjustment.

Uses of Pulmonext Kit

Pulmonext Kit is used to help manage pulmonary arterial hypertension (PAH) and improve exercise capacity. It may be used for: 

  • Pulmonary Arterial Hypertension (PAH): Pulmonext Kit helps reduce high blood pressure in the arteries of your lungs, making it easier for your heart to pump blood and allowing you to breathe more comfortably.

Key Benefits

Pulmonext Kit offers significant improvements in your daily physical well-being. By targeting the blood vessels in your lungs, it delivers the following benefits:

  • Easier breathing: It reduces the strain on your lungs, helping you feel less short of breath during daily physical tasks.
  • Increased stamina: It improves your ability to walk, climb stairs, and exercise without feeling overly fatigued.
  • Slower disease progression: It helps delay the worsening of your symptoms, reducing the risk of being hospitalised due to pulmonary arterial hypertension.
Side effects of Pulmonext Kit
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Pulmonext Kit can be taken with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Pulmonext Kit as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Pulmonext Kit Works

Pulmonext Kit contains ambrisentan and tadalafil, which work together to relax and widen the blood vessels in the lungs, helping lower blood pressure in the pulmonary arteries and improving blood flow. Ambrisentan is an endothelin receptor antagonist (a medicine that blocks a chemical that tightens blood vessels). It blocks the action of endothelin, a natural substance that causes blood vessels to narrow. By preventing this effect, ambrisentan helps keep the blood vessels in the lungs relaxed and open.   Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor, a medicine that helps keep blood vessels relaxed. It prevents the breakdown of cyclic guanosine monophosphate (cGMP), a natural chemical messenger that signals blood vessels to relax and widen. Higher cGMP levels help widen the pulmonary arteries, improve blood flow, and reduce the workload on the heart.
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Alcohol

Caution

It is advised to limit or quit the consumption of alcohol as it may increase the risk of low blood pressure.

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Pregnancy

Unsafe

Pulmonext Kit is not recommended in pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of Pulmonext Kit in breastfeeding/nursing mothers. Pulmonext Kit should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Pulmonext Kit causes drowsiness and dizziness, so drive only if you are alert.

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Liver

Caution

Pulmonext Kit may increase liver enzymes. Before taking Pulmonext Kit, inform your doctor if you have/had liver illness.

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Kidney

Caution

In cases of renal impairment, take Pulmonext Kit with caution. If you have kidney problems, you should consult a doctor before beginning Pulmonext Kit. Your doctor will prescribe it if the benefits outweigh the risks.

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Children

Unsafe

Safety and effectiveness of Pulmonext Kit have not been established in patients below 18 years of age.

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Heart

Caution

Pulmonext Kit should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Pulmonext Kit.

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Geriatrics

Consult your doctor

Limited data is available regarding the use of Pulmonext Kit in elderly patients. If you have any concerns about the usage of Pulmonext Kit in geriatrics, please consult your doctor.

What if I have taken an overdose of Pulmonext Kit

In case of an accidental overdose, seek immediate medical attention. Do not wait for symptoms such as dizziness, fainting, or severe headache to appear before seeking help.

Diet & Lifestyle Advise

  • Limit your sodium intake: Avoid high-salt foods to help prevent fluid retention and swelling in your legs.
  • Track your weight daily: Weigh yourself every morning. A sudden weight gain can be a sign that your body is retaining too much fluid.
  • Avoid tobacco and limit alcohol: Smoking damages your blood vessels and lungs, while alcohol can interact with your medicine to cause severe dizziness.
  • Stay active safely: Engage in low-impact, doctor-approved activities like gentle walking. Avoid heavy lifting or exercises that cause severe breathlessness.
health query

Have a query?

How Soon It Starts Working

The time required for Pulmonext Kit to start to work: Pulmonext Kit ideally shows its action within 30 to 45 minutes after administration.

The time for which the effects of Pulmonext Kit last: The effect of Pulmonext Kit lasts for 3 days.

What if you forget to take Pulmonext Kit

If you miss a dose of Pulmonext Kit, take it as soon as you remember on that day. However, if it is already the next day, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Pulmonext Kit tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Prevent pregnancy: This medicine can cause severe birth defects. Female patients who can become pregnant must use highly effective birth control and take regular pregnancy tests.
  • Check for swelling: Inspect your feet and ankles every day. Call your doctor immediately if you notice sudden or worsening swelling.
  • Avoid nitrate medications: Do not take Pulmonext Kit if you are using nitrate chest pain medicines, as this combination can cause a dangerous drop in blood pressure.
  • Get regular blood tests: Attend all scheduled medical appointments for blood tests to monitor your liver function and red blood cell counts.
  • Rise slowly: To prevent dizziness or fainting, stand up slowly when rising from a sitting or lying position.

Drug-Drug Interactions

verifiedApollotooltip
  • Nitrates (e.g., nitroglycerin): May cause a sudden, severe, and life-threatening drop in blood pressure.
  • Other blood pressure medications: May increase the risk of low blood pressure, dizziness, and fainting.
  • Certain antifungal or antiviral medicines: May increase the concentration of Pulmonext Kit in your blood, raising the risk of side effects.
Tadalafil + AmbrisentanIsosorbide mononitrate
Critical
Tadalafil + AmbrisentanNitroprusside
Critical

Drug-Drug Interactions

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Tadalafil + AmbrisentanIsosorbide mononitrate
Critical
How does the drug interact with Pulmonext Kit:
Coadministration of Tadalafil with Isosorbide mononitrate can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Isosorbide mononitrate with Tadalafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, or priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
Tadalafil + AmbrisentanNitroprusside
Critical
How does the drug interact with Pulmonext Kit:
Taking Tadalafil with Nitroprusside can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Tadalafil with Nitroprusside is generally avoided as it can lead to an interaction, but it can be taken if prescribed by your doctor. If you experience any side effects such as dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity), you should seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
Tadalafil + AmbrisentanIsosorbide dinitrate
Critical
How does the drug interact with Pulmonext Kit:
Taking Tadalafil with Isosorbide dinitrate can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Isosorbide dinitrate with Tadalafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, or priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
Tadalafil + AmbrisentanAmyl nitrite
Critical
How does the drug interact with Pulmonext Kit:
Combining Tadalafil with Amyl Nitrite can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Tadalafil with Amyl nitrite is generally avoided as it can lead to interaction. They can be taken only when advised by a doctor. Seek immediate medical attention if you experience symptoms like dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
Tadalafil + AmbrisentanRiociguat
Critical
How does the drug interact with Pulmonext Kit:
Taking Tadalafil with Riociguat may increase the risk or severity of lower the blood pressure.

How to manage the interaction:
Taking Riociguat with Tadalafil is generally not recommended as it can lead to an interaction, but it can be taken together if prescribed by a doctor. However, if you experience dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion. Do not discontinue any medications without consulting a doctor.
Tadalafil + AmbrisentanKetoconazole
Severe
How does the drug interact with Pulmonext Kit:
Coadministration of Ketoconazole with Tadalafil may increase the blood levels and effects of Tadalafil.

How to manage the interaction:
Although taking Ketoconazole and Tadalafil together can result in an interaction, it can be taken if a doctor has prescribed it. However, if your condition worsens or you experience any symptoms like chest pain or tightness, irregular heartbeat, priapism (prolonged and painful erection unrelated to sexual activity), nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision loss, or hearing loss, consult a doctor. Do not stop using any medications without a doctor's advice.
Tadalafil + AmbrisentanTizanidine
Severe
How does the drug interact with Pulmonext Kit:
Coadministration of Tizanidine with Ambrisentan may increase the risk or severity of developing low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Ambrisentan and Tizanidine, you can take these medicines together if your doctor advises. If you notice any symptoms like headache, dizziness, shortness of breath, chest pain, or sweating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Tadalafil + AmbrisentanLeflunomide
Severe
How does the drug interact with Pulmonext Kit:
Taking leflunomide and ambrisentan can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and ambrisentan, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
Tadalafil + AmbrisentanCeritinib
Severe
How does the drug interact with Pulmonext Kit:
Coadministration of Tadalafil with Ceritinib may significantly increase the blood levels and effects of tadalafil.

How to manage the interaction:
Although taking Tadalafil with Ceritinib together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity)make sure to call a doctor. Do not discontinue any medications without consulting a doctor.
Tadalafil + AmbrisentanMiconazole
Severe
How does the drug interact with Pulmonext Kit:
Coadministration of Miconazole with Tadalafil may increase blood levels and effects of tadalafil.

How to manage the interaction:
Although there is a possible interaction between miconazole and tadalafil, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), consult a doctor immediately. Do not stop using medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: May increase the levels of this medicine in your body, leading to more side effects.
  • Alcohol: May lower your blood pressure excessively, causing severe dizziness or headaches.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Pulmonext Kit is used to treat pulmonary arterial hypertension (high blood pressure affecting arteries in the lungs).
Pulmonext Kit contains Ambrisentan and tadalafil. Tadalafil aids in treating pulmonary hypertension by relaxing blood vessels in the chest. This increases blood supply to the lungs while decreasing the workload on the heart. Ambrisentan prevents endothelin, a naturally occurring substance that constricts blood vessels and raises blood pressure. It relaxes the constricted pulmonary arteries and increases blood supply to the lungs, lowering blood pressure.
Yes, Pulmonext Kit can make you feel dizzy. Dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try rising slowly when you change your posture to relieve dizziness. If the side effect persists longer, please seek medical help.
Even if you feel better, do not stop using Pulmonext Kit. It should be used exactly as prescribed by your doctor to minimise the recurrence of symptoms and worsening of the disease.
No, it is a medication recommended by a doctor to treat or prevent specific medical issues. Taking it on your own can result in unfavourable side effects.
Pulmonext Kit is safe if taken in the dose and for the term prescribed by your doctor. Take it exactly as directed and do not miss any doses. Follow your doctor's instructions carefully and notify the doctor if any of the adverse effects bother you.
Pulmonext Kit should be used with caution if you have any allergic reactions, heart failure, liver or renal disease, lung problems (pulmonary fibrosis), anaemia, oedema (fluid retention), or hypotension (low blood pressure).
It is recommended not to take Pulmonext Kit along with medications used to relieve chest pain (nitrates). Please consult your doctor if you have concerns.
Pulmonext Kit should be swallowed as a whole with a glass of water with or without food or taken as directed by the physician. Do not crush or chew it.
Don't stop taking Pulmonext Kit without completing the prescribed course. Stopping abruptly may lead to adverse side effects, withdrawal symptoms, or the condition returning. Consult your doctor if you have concerns.
Pulmonext Kit should be used with caution in patients with kidney problems. If you have renal impairment, inform your doctor before taking Pulmonext Kit. They will assess the benefits and risks and guide safe usage.
Taking more Pulmonext Kit than prescribed can lead to an overdose, which may cause serious side effects. Always follow your doctor's prescribed dosage and never take more than recommended.
Pulmonext Kit is not recommended for children under 18 years old, as its safety and effectiveness in this age group have not been established. If you have concerns about your child's health, please consult your doctor for personalized advice.
Pulmonext Kit should not be taken during pregnancy, as it may harm the fetus. Women who can become pregnant should have a negative pregnancy test before starting Pulmonext Kit and use two reliable birth control methods during treatment and for one month after stopping. If you miss a menstrual period or suspect pregnancy, contact your doctor immediately.
Follow your doctor's advice and take the right amount of medicine. Be aware of side effects and take care of yourself. If you're pregnant while on treatment, inform your doctor immediately. Don't take other medications unless instructed by the doctor. Alcohol consumption should be avoided. By following these precautions, you'll benefit most from your medicine and stay safe.
Pulmonext Kit causes dizziness and drowsiness that may affect your ability to drive. So, do not drive or operate machinery if you experience these.
Pulmonext Kit can lower blood pressure, specifically in the pulmonary arteries, which helps treat pulmonary arterial hypertension (PAH). However, it typically does not significantly lower systemic blood pressure in most individuals. If you have concerns about hypertension, consult your healthcare professional for a personalized treatment plan.
Common side effects of Pulmonext Kit may include headache, flushing, blocked nose, palpitations, diarrhoea, nausea, indigestion, muscle aches, and pain. Not everyone experiences side effects, and their severity can vary from person to person. Consult your doctor for guidance if you encounter persistent or troubling side effects.
No, you must not take Pulmonext Kit if you are pregnant or planning to become pregnant. This medicine can cause severe birth defects. Talk to your doctor immediately about safe birth control options.
Take the missed dose as soon as you remember on that same day. If it is already the next day, skip the missed one and continue your normal schedule. Do not take a double dose. Talk to your doctor or pharmacist if you are unsure.
Taking Pulmonext Kit with nitrates (often used for chest pain or heart problems) can cause your blood pressure to drop to a dangerously low level. This can lead to dizziness, fainting, heart attack, or stroke. Talk to your doctor about alternative options.
Yes, in rare cases, this medicine can cause a sudden decrease or loss of vision in one or both eyes. If you notice any sudden changes in your sight, stop taking the medicine and call your doctor right away.
It is best to avoid or limit alcohol while taking Pulmonext Kit. Alcohol can widen your blood vessels further, which can lead to a severe drop in blood pressure, dizziness, and headaches. Talk to your doctor for personalized advice.
Yes, your doctor will likely order routine blood tests to monitor your liver health and check your red blood cell levels. This helps ensure the medicine is working safely. Talk to your doctor to understand your testing schedule.
No, you should never stop taking Pulmonext Kit suddenly, even if you feel completely better. Stopping this medicine abruptly can cause your pulmonary blood pressure to rise quickly, worsening your condition. Talk to your doctor before making any changes.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

MSN Laboratories Pvt.Ltd., MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA
Other Info - PUL0120
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