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  3. Prutis 100 Softgel Capsule 10's

Prutis 100 Softgel Capsule 10's, Pack of 10 CAPSULES
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Prutis 100 Softgel Capsule is used to treat idiopathic pulmonary fibrosis (a disease that causes scarring of the lungs). It contains Nintedanib, which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. In some cases, this medicine may cause side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

NINTEDANIB-100MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Prutis 100 Softgel Capsule

Prutis 100 Softgel Capsule is primarily used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, which makes it difficult to breathe deeply.

Prutis 100 Softgel Capsule contains nintedanib, which helps reduce the scarring and swelling in the lungs by decreasing the release of naturally occurring growth factors in the body, allowing you to breathe better.

In some cases, you may experience common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if you experience these side effects persistently.

Inform your doctor if you are allergic to Prutis 100 Softgel Capsule . Consult your doctor before taking Prutis 100 Softgel Capsule if you are pregnant or breastfeeding. Prutis 100 Softgel Capsule is not recommended for children below 18 years as safety and effectiveness have not been established. Consult your doctor if you are breastfeeding; your doctor will decide whether Prutis 100 Softgel Capsule can be taken by breastfeeding mothers or not.

Uses of Prutis 100 Softgel Capsule

Prutis 100 Softgel Capsule is used in the treatment of Idiopathic pulmonary fibrosis. The detailed uses of Prutis 100 Softgel Capsule are as follows: Treatment of Idiopathic pulmonary fibrosis

  • Idiopathic pulmonary fibrosis: Prutis 100 Softgel Capsule aids in the breakdown and thinning of mucus in the airways, facilitating coughing and removal. It is especially beneficial in conditions like Idiopathic pulmonary fibrosis.

Directions for Use

  • Prutis 100 Softgel Capsule should be taken with meals to enhance its effectiveness.
  • It is recommended to take Prutis 100 Softgel Capsule twice daily or as advised by your doctor.
  • Swallow Prutis 100 Softgel Capsule as a whole with a glass of water.
  • Do not crush, chew, or open it.

Medicinal Benefits

  • Prutis 100 Softgel Capsule is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults.
  • Prutis 100 Softgel Capsule can help effectively slow the rate of lung function decline by 50%.
  • Prutis 100 Softgel Capsule helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better.
  • Prutis 100 Softgel Capsule helps in slowing down the progress of idiopathic pulmonary fibrosis.

How Prutis 100 Softgel Capsule Works

Prutis 100 Softgel Capsule contains 'Nintedanib', which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Prutis 100 Softgel Capsule helps in slowing down the progress of idiopathic pulmonary fibrosis.

Storage

• Store in a cool and dry place away from sunlight.• Keep Prutis 100 Softgel Capsule out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Prutis 100 Softgel Capsule
  • Do not scratch the affected region to avoid discomfort and infection.
  • Avoid spicy and fatty foods and caffeine and alcohol as they can worsen diarrhoea and irritate the skin.
  • Frequently wash your hands to avoid infection.
  • Clean the skin with fragrance-free, soft wipes to reduce inflammation.
  • Let your doctor know if the rash is severe, widespread, or painful.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • To minimize pain and swelling, apply an ice pack or cold compress wrapped in a cloth as soon as there is bleeding or bruises.
  • Use a warm compress 48 hours later to promote blood flow and hasten the healing process.
  • Rest and limit activity to prevent further injury.
  • Elevate the affected area above the level of your heart to reduce blood flow.
  • To treat discomfort, your doctor may offer over-the-counter pain medicines.
  • Inform your doctor if you develop large bruises without injury or experience frequent bruising, as this may indicate an underlying condition.
  • Follow a low-fiber, soft food diet with easily digestible liquids and pureed foods.
  • Begin with clear liquids like water, broth, and electrolyte drinks.
  • Progress to soft foods like mashed potatoes, applesauce, plain yogurt, scrambled eggs, and well-cooked rice.
  • Avoid high-fiber foods, raw vegetables, tough meats, spicy foods, and irritants to the digestive tract.
  • Eat smaller, frequent meals to reduce digestive strain.
  • Stay hydrated with plenty of fluids, avoiding sugary drinks.
  • Chew food thoroughly to aid digestion.
  • Avoid strenuous activities and rest when needed.
  • Before altering your diet, seek guidance from your healthcare provider.
  • Always follow your doctor's instructions on dietary restrictions and medical supervision.

What if I have taken an overdose of Prutis 100 Softgel Capsule

Take Prutis 100 Softgel Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause serious adverse effects. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not use Prutis 100 Softgel Capsule if you are allergic to any components present in Prutis 100 Softgel Capsule .
  • Prutis 100 Softgel Capsule can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Prutis 100 Softgel Capsule .
  • Consult your doctor if you are breastfeeding; your doctor will decide whether the Prutis 100 Softgel Capsule can be taken by breastfeeding mothers or not.
  • Keep your doctor informed about your health condition and medicines to rule out any side effects. 
  • Prutis 100 Softgel Capsule may cause tiredness and dizziness, so drive with caution.
  • Avoid consuming alcohol with Prutis 100 Softgel Capsule as it could lead to increased dizziness.
  • Prutis 100 Softgel Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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NintedanibFosphenytoin
Severe
NintedanibTipranavir
Severe

Drug-Drug Interactions

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NintedanibFosphenytoin
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Coadministration of Prutis 100 Softgel Capsule with Fosphenytoin can reduce the levels of Prutis 100 Softgel Capsule. This can lead to low treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Prutis 100 Softgel Capsule and Fosphenytoin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
NintedanibTipranavir
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Coadministration of Prutis 100 Softgel Capsule and Tipranavir can reduce the blood levels of Prutis 100 Softgel Capsule.

How to manage the interaction:
There may be a possibility of interaction between Prutis 100 Softgel Capsule and Tipranavir, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without first consulting your doctor.
NintedanibTeriflunomide
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Coadministration of Teriflunomide and Prutis 100 Softgel Capsule can increase the risk of liver problems.

How to manage the interaction:
Coadministration of Teriflunomide and Prutis 100 Softgel Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, loss of appetite, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately.
NintedanibCarbamazepine
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Coadministration of Prutis 100 Softgel Capsule with Carbamazepine can reduce the levels and effects of Prutis 100 Softgel Capsule.

How to manage the interaction:
Although taking carbamazepine and Prutis 100 Softgel Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
NintedanibPhenobarbital
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Taking Phenobarbital and Prutis 100 Softgel Capsule can drastically lower Prutis 100 Softgel Capsule levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Prutis 100 Softgel Capsule can lead to interaction, they can be taken if recommended by a doctor. Contact a doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.
NintedanibPhenytoin
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Coadministration of Phenytoin and Prutis 100 Softgel Capsule may decrease the blood levels of Prutis 100 Softgel Capsule, which may reduce Prutis 100 Softgel Capsule's effectiveness.

How to manage the interaction:
Although taking Phenytoin and Prutis 100 Softgel Capsule together can result in an interaction, it can be taken when your doctor has prescribed it. Contact a doctor if your symptoms do not improve. Do not stop taking any drugs without consulting a doctor.
NintedanibLomitapide
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Co-administration of Lomitapide and Prutis 100 Softgel Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Prutis 100 Softgel Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NintedanibLeflunomide
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Co-administration of Leflunomide and Prutis 100 Softgel Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Prutis 100 Softgel Capsule can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibPrimidone
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Coadministration of Prutis 100 Softgel Capsule and primidone can reduce the blood levels of Prutis 100 Softgel Capsule.

How to manage the interaction:
Although there is an interaction between Prutis 100 Softgel Capsule and primidone, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibRifapentine
Severe
How does the drug interact with Prutis 100 Softgel Capsule:
Coadministration of Prutis 100 Softgel Capsule and Rifapentine can reduce the blood levels of Prutis 100 Softgel Capsule.

How to manage the interaction:
There may be a possibility of interaction between Prutis 100 Softgel Capsule and Rifapentine, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Prutis 100 Softgel Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

It is not known if alcohol interacts with Prutis 100 Softgel Capsule . However, as a precautionary measure, you are recommended not to consume alcohol with the Prutis 100 Softgel Capsule to avoid unpleasant side effects.

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Pregnancy

Unsafe

Prutis 100 Softgel Capsule is listed as pregnancy category D. Because Prutis 100 Softgel Capsule can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Prutis 100 Softgel Capsule .

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Breast Feeding

Consult your doctor

Consult your doctor if you are breastfeeding; your doctor will decide whether Prutis 100 Softgel Capsule can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Prutis 100 Softgel Capsule may significantly influence your ability to drive and use machines. You should not drive or operate machinery if you feel sick.

bannner image

Liver

Consult your doctor

Dose adjustment may be needed. Prutis 100 Softgel Capsule is not recommended for patients with severe hepatic impairment. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Consult your doctor

Dose adjustment may be needed. Prutis 100 Softgel Capsule is not recommended for patients with an end-stage renal disease requiring dialysis. Please consult your doctor if you have kidney impairment or any concerns.

bannner image

Children

Unsafe

Prutis 100 Softgel Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

Have a query?

FAQs

Prutis 100 Softgel Capsule is used to treat idiopathic pulmonary fibrosis (IPF), a disease marked by a progressive decline in lung function.

Prutis 100 Softgel Capsule helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helping you breathe better.

Avoid smoking before starting the treatment while taking Prutis 100 Softgel Capsule as smoking might alter the effectiveness of Prutis 100 Softgel Capsule .

Prutis 100 Softgel Capsule should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking Prutis 100 Softgel Capsule until your doctor asks you to stop it.

If you have any surgery, including dental surgery, please inform your doctor if you are taking Prutis 100 Softgel Capsule as your doctor might stop Prutis 100 Softgel Capsule before undergoing surgery.

In elderly patients, the risk of side effects is higher if you are taking Prutis 100 Softgel Capsule . For the patients who are elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.

It is not recommended to discontinue the Prutis 100 Softgel Capsule without consulting your healthcare provider. Abruptly stopping the medication can lead to disease progression or other complications. Consult your healthcare provider for personalised guidance if you have concerns or experience side effects.

If you forget to take a dose of Prutis 100 Softgel Capsule , take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for the missed one, as this can increase the risk of side effects.

Common side effects of Prutis 100 Softgel Capsule may include nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity in some individuals. Most of these side effects do not require medical attention and will resolve gradually over time. However, if you experience these side effects persistently, inform your doctor.

Prutis 100 Softgel Capsule is not recommended for use in patients with severe liver impairment. Please consult your doctor if you have a liver impairment or any concerns before Prutis 100 Softgel Capsule .

Country of origin

India

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - PRU0094

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 12, 2025 | 4:43 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.nhs.uk/conditions/idiopathic-pulmonary-fibrosis/treatment/
  2. https://www.medicines.org.uk/emc/product/1786/smpc#gref
  3. https://www.medicines.org.uk/emc/files/pil.1786.pdf

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