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  3. Primiltus-20 mg Tablet 10's

Primiltus-20 mg Tablet 10's, Pack of 10
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Primiltus-20 mg Tablet 10's is used to treat Plaque psoriasis (scaly, itchy, and red patches on the skin), psoriasis arthritis (inflammation in the joints in people with psoriasis), and oral ulcers. It contains Apremilast, which blocks the action of some chemical messengers that are responsible for inflammation related to psoriatic arthritis and psoriasis and thus, lowers the signs and symptoms of these conditions.

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Composition :

APREMILAST-20MG

Manufacturer/Marketer :

Nuper Therapeutics

Consume Type :

ORAL

Return Policy :

Not Returnable

About Primiltus-20 mg Tablet 10's

Primiltus-20 mg Tablet 10's is used to treat plaque psoriasis (scaly, itchy, and red patches on the skin), psoriasis arthritis (inflammation in the joints in people with psoriasis), and oral ulcers. Psoriasis is a chronic, painful, nontransmissible, deactivating and damaging disease.

Primiltus-20 mg Tablet 10's contains Apremilast, which works by blocking the action of some chemical messengers that are responsible for inflammation related to psoriatic arthritis and psoriasis.

You may experience certain common side effects like diarrhoea, vomiting, nausea, weight loss, and back pain. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before starting Primiltus-20 mg Tablet 10's, please inform your doctor if you have any allergy to Primiltus-20 mg Tablet 10's and its parts. Primiltus-20 mg Tablet 10's not recommended for use in children and adolescents aged below 17 years. If you are pregnant or breastfeeding, ask your doctor for advice before taking this Primiltus-20 mg Tablet 10's.

Uses of Primiltus-20 mg Tablet 10's

Primiltus-20 mg Tablet 10's is used in the treatment of Plaque psoriasis, psoriasis arthritis, and oral ulcers caused by Behcet's disease.. The detailed uses of Primiltus-20 mg Tablet 10's are as follows:

  • Relief from Psoriasis Symptoms: Primiltus-20 mg Tablet 10's relieves psoriasis symptoms by alleviating scaling and dryness and promoting healthier skin.
  • Oral Thrush Treatment: Primiltus-20 mg Tablet 10's can be effective in treating oral thrush, a fungal infection that affects the mucous membranes of the mouth.

Directions for Use

  • Take Primiltus-20 mg Tablet 10's with or without food as advised by your doctor.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow Primiltus-20 mg Tablet 10's as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Primiltus-20 mg Tablet 10's is used in treating psoriatic arthritis; it decreases pain and swelling and may help improve flexibility in the affected joints.
  • It is also used to treat moderate to severe plaque psoriasis (skin disease causes red, scaly patches to form on some areas of the body) in people who may benefit from medications). 
  • It is used to treat ulcers in the mouth in persons with Behcet's syndrome (a disease that results from blood vessel swelling in the body). 
  • Primiltus-20 mg Tablet 10's works by blocking the action of some chemical messengers responsible for inflammation related to psoriatic arthritis and psoriasis, thus lowering the signs and symptoms of these conditions.

How Primiltus-20 mg Tablet 10's Works

Primiltus-20 mg Tablet 10's contains Apremilast, a phosphodiesterase 4 (PDE4) inhibitor. Primiltus-20 mg Tablet 10's works by blocking the action of some chemical messengers that are responsible for inflammation related to psoriatic arthritis (inflammation in the joints in people with psoriasis) and psoriasis (scaly, itchy, and red patches on the skin) and, thus, lower the signs and symptoms of these conditions.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Primiltus-20 Mg Tab
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • You can take your medicine with meals to lower the chances of getting stomach pain.
  • Avoid foods that are acidic, spicy, sugary, or greasy.
  • Eat foods that are easily digestible such as rice, toast, and bananas.
  • Eat your meals in smaller amounts throughout the day to prevent strain on your stomach and digestion.
  • Drink water or fluids to stay hydrated and prevent stomach upset.
  • Use a heating pad or massage your stomach area.
  • Engage in mild physical activities such as yoga and walking.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

What if I have taken an overdose of Primiltus-20 mg Tablet 10's

Do not take more than the prescribed dose of Primiltus-20 mg Tablet 10's as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor before using Primiltus-20 mg Tablet 10's, if you have previously had an allergic reaction (hypersensitivity).
  • Before starting Primiltus-20 mg Tablet 10's, please inform your doctor if you have depression and suicidal thoughts.
  • Inform your doctor before taking Primiltus-20 mg Tablet 10's if you have severe kidney problems.
  • Inform your doctor while taking Primiltus-20 mg Tablet 10's if you lose weight without meaning to. Primiltus-20 mg Tablet 10's should not be taken in conditions like severe diarrhoea, nausea, and vomiting.
  • Primiltus-20 mg Tablet 10's not recommended for use in children and adolescents aged below 17 years.
  • If you are pregnant or breastfeeding, ask your doctor for advice before taking this Primiltus-20 mg Tablet 10's. 
  • Patients with rare hereditary galactose intolerance problems, total lactase deficiency or glucose-galactose malabsorption should not take Primiltus-20 mg Tablet 10's.

Drug-Drug Interactions

verifiedApollotooltip
ApremilastNevirapine
Severe
ApremilastRifabutin
Severe

Drug-Drug Interactions

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ApremilastNevirapine
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Coadministration of Nevirapine with Primiltus-20 Mg Tab may decrease the blood levels of Primiltus-20 Mg Tab, which may make the medication less effective.

How to manage the interaction:
Although there is a possible interaction between Primiltus-20 Mg Tab and Nevirapine, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ApremilastRifabutin
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Coadministration of Primiltus-20 Mg Tab and Rifabutin may reduce the blood levels of Primiltus-20 Mg Tab.

How to manage the interaction:
Although there is a possible interaction between Primiltus-20 Mg Tab and Rifabutin, you can take these medicines together if prescribed by a doctor. In case you experience any symptoms, consult a doctor. Do not discontinue any medications without consulting a doctor.
ApremilastCarbamazepine
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Taking Primiltus-20 Mg Tab with carbamazepine can significantly reduce the blood levels of Primiltus-20 Mg Tab, which may make the medication less effective.

How to manage the interaction:
Taking Primiltus-20 Mg Tab with Carbamazepine together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
ApremilastMitotane
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Coadministration of Mitotane with Primiltus-20 Mg Tab may reduce the effectiveness of treatment.

How to manage the interaction:
Although taking Primiltus-20 Mg Tab and Mitotane together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
ApremilastRifapentine
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Rifapentine may decrease the blood levels of Primiltus-20 Mg Tab, which may make Primiltus-20 Mg Tab less effective in treating the condition.

How to manage the interaction:
Although taking Primiltus-20 Mg Tab and Rifapentine together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
ApremilastFosphenytoin
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Coadministration of Fosphenytoin with Primiltus-20 Mg Tab may reduce the effectiveness of treatment.

How to manage the interaction:
Although taking Fosphenytoin and Primiltus-20 Mg Tab together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
ApremilastPhenobarbital
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Coadministration of phenobarbital with Primiltus-20 Mg Tab can drastically lower Primiltus-20 Mg Tab levels in the blood, making the medicine less effective in treating.

How to manage the interaction:
Although taking phenobarbital with Primiltus-20 Mg Tab can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
ApremilastPrimidone
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Coadministration of Primiltus-20 Mg Tab with primidone may decrease the blood levels of Primiltus-20 Mg Tab, which may make Primiltus-20 Mg Tab less effective in treating.

How to manage the interaction:
Although there is an interaction between Primidone and Primiltus-20 Mg Tab, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ApremilastPhenytoin
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Coadministration of Phenytoin with Primiltus-20 Mg Tab may reduce the blood levels of Primiltus-20 Mg Tab, which may reduce effectiveness in treatment.

How to manage the interaction:
Although taking Phenytoin and Primiltus-20 Mg Tab together can result in an interaction, it can be taken if a doctor has prescribed it. Without consulting a doctor, never stop taking any drugs.
ApremilastRifampicin
Severe
How does the drug interact with Primiltus-20 Mg Tab:
Taking Primiltus-20 Mg Tab with rifampicin can decrease the blood levels of Primiltus-20 Mg Tab, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Primiltus-20 Mg Tab and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIPSORIATICS

Primiltus-20 mg Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Limit intake of alcohol, as this may increase the risk of serious side effects.

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Pregnancy

Caution

If you are pregnant, inform your doctor before taking Primiltus-20 mg Tablet 10's. Consult your doctor if you become pregnant while taking Primiltus-20 mg Tablet 10's.

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Breast Feeding

Caution

It is not known whether Primiltus-20 mg Tablet 10's may pass into breast milk or not. If you are breastfeeding, inform your doctor before taking Primiltus-20 mg Tablet 10's.

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Driving

Safe if prescribed

Primiltus-20 mg Tablet 10's has no or negligible influence on the ability to drive and use machines.

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Liver

Caution

Primiltus-20 mg Tablet 10's to be taken with caution, especially if you have a history of liver problems. Your doctor may adjust the dose of this medicine based on your condition.

bannner image

Kidney

Caution

Primiltus-20 mg Tablet 10's to be taken with caution, especially if you have a history of kidney diseases. Your doctor may adjust the dose of this medicine based on your condition.

bannner image

Children

Unsafe

Primiltus-20 mg Tablet 10's is not recommended for use in children and adolescents below 17 years.

Have a query?

FAQs

Primiltus-20 mg Tablet 10's is used to treat plaque psoriasis (scaly, itchy, and red patches on the skin), psoriatic arthritis (inflammation in the joints in people with psoriasis), and oral ulcers caused by Behcet's disease.

Primiltus-20 mg Tablet 10's works by blocking the action of some chemical messengers that are responsible for inflammation.

Yes, Primiltus-20 mg Tablet 10's may cause depression as a side effect. The patient may also have suicidal thoughts. Primiltus-20 mg Tablet 10's should be avoided in people with a history of depression. In case you develop any of these symptoms, Inform your doctor immediately.

Primiltus-20 mg Tablet 10's is used to treat plaque psoriasis (red, scaly, thick, itchy, painful patches on the skin) and psoriatic arthritis (a condition that causes joint pain and swelling). It is a long-period treatment and may take about 16 weeks to show an improvement.

Yes, Primiltus-20 mg Tablet 10's may cause a reduction in appetite, which may further lead to weight loss. You should monitor your weight frequently while on treatment with Primiltus-20 mg Tablet 10's. In case of big weight loss, inform your doctor. Your doctor may consider stopping Primiltus-20 mg Tablet 10's.

Rifampicin is an antibiotic. You should not take rifampicin if you are taking Primiltus-20 mg Tablet 10's. Rifampicin interferes with the working of Primiltus-20 mg Tablet 10's by reducing its levels, making it less effective. As a result, you may not see any recovery after taking Primiltus-20 mg Tablet 10's.

As soon as you recall, take the missed dose. If the next dose is approaching, skip the missing dose and resume your regular dosing regimen. Do not duplicate the dose to make up for a missing one.

No, Primiltus-20 mg Tablet 10's is not an immunosuppressant. It belongs to a class of drugs called phosphodiesterase 4 (PDE4) inhibitors which work by blocking the action of PDE4 that is found in inflammatory cells.

Take Primiltus-20 mg Tablet 10's as advised by the doctor. Swallow it as whole with a glass of water. Do not break, crush or chew it.

If you get pregnant during treatment with Primiltus-20 mg Tablet 10's, inform your doctor immediately. You are recommended to avoid pregnancy during treatment with Primiltus-20 mg Tablet 10's as it may harm unborn baby.

Primiltus-20 mg Tablet 10's may cause side effects such as nausea, vomiting, diarrhoea, back pain or weight loss. If these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

106, Emporius, Near Balewadi Stadium, Baner, Pune-411045
Other Info - PRI0713

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Aug 26, 2025 | 1:20 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.3648.pdf
  2. https://www.drugs.com/cdi/apremilast.html
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