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compositionComposition:CLINDAMYCIN-600MG
prescriptionPrescription Medicine
Premycin 600 mg Injection 4 ml

Premycin 600 mg Injection 4 ml is an antibiotic medicine used in the treatment of bacterial infections like pneumonia, empyema, lung abscess, endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, intra-abdominal infections, septicaemia, and bone and joint infections. This medicine contains clindamycin which works by inhibiting the protein synthesis of the bacterial cell and thereby helps fight infection-causing bacteria. This medicine is not effective for treating viral infections. Common side effects include stomach pain, nausea, vomiting, diarrhoea, heartburn, and skin rash.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

CLINDAMYCIN-600MG

Manufacturer/Marketer :

Preyuda Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Premycin 600 mg Injection 4 ml

Premycin 600 mg Injection 4 ml is primarily used to treat serious bacterial infections such as lower respiratory tract infections like pneumonia, empyema, and lung abscess; gynecological infections like endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infection; intra-abdominal infections; septicaemia or sepsis (blood poisoning by bacteria); and bone and joint infections.

Premycin 600 mg Injection 4 ml contains 'Clindamycin' that works by preventing bacterial protein synthesis, leading to the inhibition of bacterial growth. It exhibits a bacteriostatic effect, which prevents bacterial reproduction.

Common side effects of Premycin 600 mg Injection 4 ml include stomach pain, nausea, vomiting, diarrhoea, heartburn, skin rash, pain and swelling at the injection site, and vaginal itching or discharge. Most of these side effects do not require medical attention. If these side effects persist longer, please consult your doctor.

Brief your medical history to the doctor if you are allergic to any of the components in Premycin 600 mg Injection 4 ml. Let your doctor know if you have any liver disease, kidney disease, yellow food dye allergy, colitis, severe stomach cramps, diarrhoea, and allergic conditions. Do not use Premycin 600 mg Injection 4 ml while getting vaccinated with live bacterial vaccines (typhoid vaccine) since Premycin 600 mg Injection 4 ml may affect the vaccine's activity. Premycin 600 mg Injection 4 ml should be used only with a doctor's advice during pregnancy and breastfeeding.

Uses of Premycin 600 mg Injection 4 ml

Premycin 600 mg Injection 4 ml is used in the treatment of bacterial infections. The detailed uses of Premycin 600 mg Injection 4 ml are as follows:

  • Lower respiratory tract infections: Premycin 600 mg Injection 4 ml is used to treat lung infections, such as pneumonia, empyema, and lung abscess.
  • Gynaecological infections: Premycin 600 mg Injection 4 ml is effective in treating infections such as endometritis, tubo-ovarian abscess (non-gonococcal), pelvic cellulitis, and post-surgical vaginal cuff infections.
  • Treatment of intra-abdominal infections: Premycin 600 mg Injection 4 ml is used to treat infections in the abdominal cavity, such as peritonitis and abscesses.
  • Septicemia (sepsis): Premycin 600 mg Injection 4 ml is used to treat bloodstream infections caused by bacteria that are susceptible to it.
  • Treatment of bone and joint infections: Premycin 600 mg Injection 4 ml is effective in treating osteomyelitis and septic arthritis caused by bacteria.
  • Alternative in penicillin-allergic patients: Premycin 600 mg Injection 4 ml is an antibiotic that can be used instead of penicillin, particularly in anaerobic and gram-positive infections.

Key Benefits

  • Premycin 600 mg Injection 4 ml is an antibiotic that treats severe/serious bacterial infections.
  • It works by inhibiting bacterial protein synthesis, which inhibits bacterial growth.
  • It shows a bacteriostatic effect, which stops bacterial reproduction but doesn't kill them.
  • Premycin 600 mg Injection 4 ml effectively treats infections caused by gram-positive and anaerobic (living without air) bacteria, including susceptible strains of Staphylococcus aureus, Streptococcus pneumoniae, and Clostridium perfringens.
  • Premycin 600 mg Injection 4 ml is useful in treating lower respiratory tract infections, such as pneumonia, empyema, and lung abscess; gynaecological infections, including endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and post-surgical vaginal cuff infection; intra-abdominal infections; septicaemia or sepsis (blood poisoning by bacteria); and bone and joint infections.
Side effects of Premycin 600 mg Injection 4 ml
  • Take cold water baths avoiding soap.
  • Avoid scratching and scrubbing to prevent infections while itching.
  • Use nets to prevent insects and mosquitoes.
  • Stop using lotions and creams that cause irritation.
  • Avoid alcohol and caffeine intake.
  • Abnormal liver function requires immediate medical attention. Your doctor may recommend lifestyle modifications along with needed medication.
  • Avoid intake of alcohol as it has a direct impact on liver functioning.
  • Prevent medications like paracetamol, over-the-counter painkillers or those mentioned by your doctor, as they may have issues getting metabolised in your body.
  • If you have overweight issues, losing weight can be a good thing to manage abnormal liver function.
  • Cut down the number of fatty foods that are taken daily.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Premycin 600 mg Injection 4 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Premycin 600 mg Injection 4 ml Works

Premycin 600 mg Injection 4 ml contains 'Clindamycin' that works by preventing bacterial protein synthesis, leading to the inhibition of bacterial growth. It shows a bacteriostatic effect that stops bacterial reproduction. Premycin 600 mg Injection 4 ml effectively treats infections caused by gram-positive and anaerobic (living without air) bacteria, including susceptible strains of Staphylococcus aureus, Streptococcus pneumoniae, and Clostridium perfringens
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Alcohol

Unsafe

Avoid taking alcohol while using Premycin 600 mg Injection 4 ml since it may worsen the side effects.

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Pregnancy

Consult your doctor

Please consult your doctor before receiving Premycin 600 mg Injection 4 ml if you are pregnant or planning to conceive.

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Breast Feeding

Consult your doctor

Premycin 600 mg Injection 4 ml can be excreted into breast milk when used by a nursing mother. Please consult your doctor before receiving Premycin 600 mg Injection 4 ml if you are breastfeeding.

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Driving

Consult your doctor

There is limited data on how Premycin 600 mg Injection 4 ml affects your driving ability. Please seek medical advice for more information.

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Liver

Consult your doctor

Let your doctor know if you have any history of liver diseases before receiving Premycin 600 mg Injection 4 ml since it may cause jaundice and abnormal liver function tests.

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Kidney

Consult your doctor

Let your doctor know if you have any history of kidney diseases before receiving Premycin 600 mg Injection 4 ml.

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Children

Consult your doctor

Premycin 600 mg Injection 4 ml should be used in children only when prescribed by a doctor. Your doctor will prescribe Premycin 600 mg Injection 4 ml depending on the child's age and body weight.

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Heart

Consult your doctor

Let your doctor know if you have any history of heart disease before starting Premycin 600 mg Injection 4 ml.

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Geriatrics

Consult your doctor

Limited information available about the use of Premycin 600 mg Injection 4 ml in geriatric patients. Please consult your physician.

What if I have taken an overdose of Premycin 600 mg Injection 4 ml

Premycin 600 mg Injection 4 ml is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. If you experience any of these symptoms like peeling or blistering skin, rash, hives, itching, difficulty, breathing or swallowing, and/or hoarseness, call your doctor immediately or get emergency medical treatment.

Diet & Lifestyle Advise

  • Wash your hands often to maintain cleanliness.
  • Avoid sharing personal items like shaving razors.
  • Include whole-grain foods, such as multigrain bread and brown rice, in your diet.
  • Taking probiotics after an antibiotic treatment reduces the risk of antibiotic-associated diarrhoea.
  • Try taking yoghurt, cheese, sauerkraut, and kimchi, which help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet that is easily digested by your gut bacteria. Fibre foods may also help restore healthy gut bacteria after a course of antibiotics.
  • Avoid the intake of alcoholic beverages as it may cause dehydration and affect your sleep.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep. 

Have a query?

How Soon It Starts Working

  • The time required for Premycin 600 mg Injection 4 ml to start to work: Premycin 600 mg Injection 4 ml ideally shows its action within 1 hour after administration. 
  • The time for which the effects of Premycin 600 mg Injection 4 ml last: The effect of Premycin 600 mg Injection 4 ml lasts for 6 to 8 hours.

What if you forget to take Premycin 600 mg Injection 4 ml

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not use Premycin 600 mg Injection 4 ml if you are allergic to any of its components.
  • Let your doctor know if you have any liver or kidney diseases, gastrointestinal diseases (colitis, Clostridium difficile-associated diarrhoea), yellow food dye allergy, and allergic conditions (asthma, hay fever, eczema).
  • Do not use Premycin 600 mg Injection 4 ml while getting vaccinated with live bacterial vaccines (typhoid vaccine) since Premycin 600 mg Injection 4 ml may affect the vaccine's activity.
  • Pregnant and breastfeeding women should consult their doctor before taking Premycin 600 mg Injection 4 ml.
  • Avoid alcohol consumption to prevent any undesired effects while using Premycin 600 mg Injection 4 ml.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Premycin 600 mg Injection 4 ml may interact with antibiotics (erythromycin, rifampin) and neuromuscular blocking agents (atracurium, vecuronium).

Drug-Food Interaction: Premycin 600 mg Injection 4 ml may interact with St. John's Wort (a herbal supplement).

Drug-Disease Interaction: Before taking Premycin 600 mg Injection 4 ml, let your doctor know if you have any liver or kidney diseases, colitis, asthma, hay fever, yellow food dye allergy, and eczema.

ClindamycinFosphenytoin
Severe
ClindamycinCeritinib
Severe

Drug-Drug Interactions

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ClindamycinFosphenytoin
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
When Premycin 600 mg Injection 4 ml is taken with Fosphenytoin, it can cause the body to process Premycin 600 mg Injection 4 ml faster.

How to manage the interaction:
Although there is a possible interaction between Premycin 600 mg Injection 4 ml and Fosphenytoin, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like sudden drowsiness, fatigue, confusion, itching, burning, or tingling sensation, abnormal body movements, or loss of coordination, make sure to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
ClindamycinCeritinib
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
Concomitant use of Premycin 600 mg Injection 4 ml with ceritinib can increase the effects of Premycin 600 mg Injection 4 ml

How to manage the interaction:
Although there is a possible interaction, Premycin 600 mg Injection 4 ml can be taken with ceritinib if prescribed by the doctor. Consult the prescriber if you experience persistent vomiting, nausea, abdominal pain, or diarrhoea.
ClindamycinAtracurium
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
Co-administration of Premycin 600 mg Injection 4 ml with Atracurium can increase the risk of muscle weakness.

How to manage the interaction:
Taking Premycin 600 mg Injection 4 ml with Atracurium together can possibly result in an interaction, but it can be taken if a doctor has advised it. "Premycin 600 mg Injection 4 ml can affect the muscles and nerves in your body. When used with other medications that also affect the muscles and nerves, it can cause a serious problem called neuromuscular blockade. If you have trouble breathing or can't breathe at all, please call your doctor right away." Do not stop using any medications without a doctor's advice.
ClindamycinCholera, live attenuated
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
Co-administration of Premycin 600 mg Injection 4 ml may reduce the activity of the cholera vaccine.

How to manage the interaction:
Talk to your doctor before receiving the Cholera vaccine if you are currently being treated with Premycin 600 mg Injection 4 ml or have been treated within the last 14 days. To ensure adequate vaccine response, you should not receive cholera vaccine until at least 14 days after you complete antibiotic therapy. Do not discontinue the medication without consulting a doctor.
ClindamycinAtazanavir
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
Co-administration of Premycin 600 mg Injection 4 ml with Atazanavir may increase the effects of Premycin 600 mg Injection 4 ml.

How to manage the interaction:
Although there is a possible interaction, Premycin 600 mg Injection 4 ml can be taken with atazanavir if prescribed by the doctor. Consult the prescriber if you experience persistent nausea, vomiting, diarrhea, or abdominal pain. Do not discontinue the medication without consulting a doctor.
ClindamycinBalsalazide
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
Co-administration of Premycin 600 mg Injection 4 ml with Balsalazide may reduce the effectiveness of Balsalazide.

How to manage the interaction:
Although there is a possible interaction, Premycin 600 mg Injection 4 ml can be taken with balsalazide if prescribed by the doctor. Consult the prescriber if you have any concerns, the doctor may prescribe alternatives that do not interact, dose adjustment, or more frequent monitoring to safely use both medications. Do not discontinue the medication without consulting a doctor.
ClindamycinAmprenavir
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
Co-administration of Amprenavir together with Premycin 600 mg Injection 4 ml can increase the effects of Premycin 600 mg Injection 4 ml.

How to manage the interaction:
Co-administration of Premycin 600 mg Injection 4 ml with Amprenavir can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have ongoing feelings of sickness, throwing up, having loose stools, or pain in your stomach, it's important to contact your doctor right away. Do not stop using any medications without talking to a doctor.
ClindamycinBoceprevir
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
Co-administration of Boceprevir together with Premycin 600 mg Injection 4 ml can increase the effects of Premycin 600 mg Injection 4 ml.

How to manage the interaction:
Although there is a possible interaction between Premycin 600 mg Injection 4 ml and Boceprevir, you can take these medicines together if prescribed by your doctor. If you have ongoing feelings of sickness, throwing up, having loose stools, or pain in your stomach, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ClindamycinIndinavir
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
Concomitant use of Premycin 600 mg Injection 4 ml with indinavir may increase the effects of Premycin 600 mg Injection 4 ml.

How to manage the interaction:
Although there is a possible interaction, Premycin 600 mg Injection 4 ml can be taken with indinavir if prescribed by the doctor. Consult the prescriber if you experience persistent vomiting, nausea, abdominal pain, or diarrhoea.
ClindamycinBotulinum toxin
Severe
How does the drug interact with Premycin 600 mg Injection 4 ml:
Taking Premycin 600 mg Injection 4 ml with Botulinum toxin can increase the risk or severity of side effects.

How to manage the interaction:
Taking Premycin 600 mg Injection 4 ml with Botulinum toxin together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Premycin 600 mg Injection 4 ml belongs to the class of antibiotics primarily used to treat serious bacterial infections such as lower respiratory tract infections like pneumonia, empyema, and lung abscess; gynaecological infections like endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infection; intra-abdominal infections; septicaemia or sepsis (blood poisoning by bacteria), and bone and joint infections.

Premycin 600 mg Injection 4 ml is an antibiotic that treats bacterial infections. It works by inhibiting bacterial protein synthesis, which retards bacterial growth.

Premycin 600 mg Injection 4 ml should be used with proper caution and under the guidance of a doctor if you have any liver disease, kidney disease, gastrointestinal diseases (such as colitis, severe stomach cramps, or diarrhoea), a yellow food dye allergy, or allergic conditions (such as asthma, hay fever, or eczema).

Premycin 600 mg Injection 4 ml can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Premycin 600 mg Injection 4 ml if you are undergoing any vaccinations.

Premycin 600 mg Injection 4 ml may cause abnormal liver function tests as a side effect. Please ask your doctor before starting Premycin 600 mg Injection 4 ml if you have any history of liver problems.

Diarrhoea can be a side-effect of Premycin 600 mg Injection 4 ml. Clostridium difficile-associated diarrhoea (CDAD) is also reported during usage of antibiotics like Premycin 600 mg Injection 4 ml. Therefore, if you experience diarrhoea, you are advised to undergo an examination to rule out the chances of CDAD following Premycin 600 mg Injection 4 ml therapy.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

88, Om Shiv Nagar Lalghati Bhopal Bhopal Mp 462030 In
Other Info - PRE2002

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