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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Premoquin 64.5mg Injection is an anti-malarial medication used in the treatment of malaria and extraintestinal Amebiasis. This medicine contains chloroquine, which kills the parasite by increasing the concentration of a toxic compound within it. Common side effects include nausea, vomiting, diarrhoea, stomach cramps, headache, hair loss, changes in mood, etc. Most of these side effects are temporary and gradually resolve over time. However, consult the doctor if any of these symptoms persist or worsen.

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Whats That

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Synonym :

CHLOROQUINE PHOSPHATE

Composition :

CHLOROQUINE-64.5MG

Manufacturer/Marketer :

Prem Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Premoquin 64.5mg Injection

Premoquin 64.5mg Injection belongs to the class of 'anti-malarial drugs', primarily used to treat and prevent malaria. It may also be used to treat extraintestinal amebiasis/amoebiasis. Malaria is a disease caused by a plasmodium parasite transmitted by the bite of infected Anopheles mosquitoes. When an infected mosquito bites a healthy person, it transmits the 'Plasmodium parasite' into the bloodstream, which affects the red blood cells and liver cells. Extraintestinal amebiasis is a parasitic infection caused by Entamoeba histolytica that spreads to various organs, most commonly the liver.

Premoquin 64.5mg Injection contains Chloroquine. It works by increasing the concentration of a toxic compound in the parasite, leading to its death. It also has amoebicidal action, destroying the parasitic amoebas that cause amoebiasis. Thus, it treats malaria and extraintestinal amebiasis.

Your doctor will decide the dose and duration of treatment with Premoquin 64.5mg Injection based on your medical condition. Common side effects of Premoquin 64.5mg Injection include nausea, vomiting, diarrhoea, stomach cramps, headache, hair loss, changes in mood/confusion, vision changes/blurred vision, black or tarry stools, bleeding gums, and dizziness. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Inform your doctor if you are allergic to Premoquin 64.5mg Injection or any ingredients in it before receiving Premoquin 64.5mg Injection. Also, let your doctor know if you have liver or kidney issues, seizures, heart conditions, hearing or vision problems, or a history of retinal damage. It is important to inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Premoquin 64.5mg Injection may cause dizziness, so avoid driving or operating machinery until you feel alert. Alcohol should be avoided during treatment to prevent worsening side effects. Premoquin 64.5mg Injection is administered for children only if prescribed for children.

Uses of Premoquin 64.5mg Injection

Premoquin 64.5mg Injection is used to treat parasitic infections. The detailed uses of Premoquin 64.5mg Injection are as follows:<br/> • Treatment of Malaria: Premoquin 64.5mg Injection is used to prevent and treat malaria caused by Plasmodium parasites, especially in areas where the parasite is sensitive to the drug.<br/> • Management of Extraintestinal Amebiasis: Premoquin 64.5mg Injection helps treat extraintestinal amebiasis, an infection caused by Entamoeba histolytica outside the intestines, commonly affecting the liver.<br/>

Directions for Use

  • Premoquin 64.5mg Injection will be given by a doctor or healthcare professional; do not self-administer.
  • Follow your doctor's instructions on dosage and timing for safe and effective use.

Medicinal Benefits

Premoquin 64.5mg Injection contains Chloroquine, which works by increasing the concentration of a toxic compound in the parasite, leading to its death. It is effective against parasitic species, including Plasmodium vivax, Plasmodium malaria, and susceptible strains of Plasmodium falciparum. Premoquin 64.5mg Injection helps extend the interval between treatment and relapse in patients with malaria, particularly vivax malaria. It also has amoebicidal action, destroying parasitic amoebas that cause amoebiasis. Additionally, Chloroquine has off-label uses in treating autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.

How Premoquin 64.5mg Injection Works

Premoquin 64.5mg Injection contains Chloroquine. It works by increasing the concentration of a toxic compound in the parasite, leading to its death. It also has amoebicidal action, destroying the parasitic amoebas that cause amoebiasis. Thus, it treats malaria and extraintestinal amebiasis.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Premoquin 64.5mg Injection

The possibility of an overdose with Premoquin 64.5mg Injection is low since a healthcare professional gives it in a hospital setting. However, if it happens, your doctor will take immediate action to manage it and ensure your safety.

Drug Warnings

Before receiving Premoquin 64.5mg Injection, inform your doctor if you have recently used any prescription and non-prescription medications, including other anti-malarial drugs. Inform your doctor if you have any allergic reactions, liver or kidney problems, heart diseases, diabetes, G-6-PD (glucose-6 phosphate dehydrogenase) deficiency, electrolyte imbalance, psoriasis, alcoholism, porphyria, hearing problems, vision-related issues, fits, and damaged retina or vision problems before receiving Premoquin 64.5mg Injection. Please seek medical advice if you are pregnant or breastfeeding before receiving Premoquin 64.5mg Injection. This medicine may cause dizziness; hence, do not drive or operate machinery until you are alert. Do not consume alcohol while being treated with Premoquin 64.5mg Injection.

Drug-Drug Interactions

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ChloroquineSaquinavir
Critical

Drug-Drug Interactions

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How does the drug interact with Premoquin 64.5mg Injection:
When Premoquin 64.5mg Injection is taken with Dronedarone, it may increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Dronedarone is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineSaquinavir
Critical
How does the drug interact with Premoquin 64.5mg Injection:
Using saquinavir together with Premoquin 64.5mg Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Saquinavir is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Premoquin 64.5mg Injection:
Taking Premoquin 64.5mg Injection with Cisapride can increase the risk of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Cisapride is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.
ChloroquineAgalsidase beta
Critical
How does the drug interact with Premoquin 64.5mg Injection:
Using Premoquin 64.5mg Injection with Agalsidase beta can reduce the effectiveness of agalsidase beta.

How to manage the interaction:
Taking Agalsidase beta with Premoquin 64.5mg Injection is not recommended, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
ChloroquineAgalsidase alfa
Critical
How does the drug interact with Premoquin 64.5mg Injection:
When Agalsidase alfa is used with Premoquin 64.5mg Injection, it may decrease the effectiveness of the Agalsidase alfa.

How to manage the interaction:
Taking Agalsidase alfa with Premoquin 64.5mg Injection is not recommended, it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Premoquin 64.5mg Injection:
When Pimozide and Premoquin 64.5mg Injection are taken together, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Pimozide is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineAuranofin
Critical
How does the drug interact with Premoquin 64.5mg Injection:
Taking Auranofin with Premoquin 64.5mg Injection can increase the risk of blood disorders and other severe side effects

How to manage the interaction:
Taking Auranofin with Premoquin 64.5mg Injection is not recommended, as it may lead to an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChloroquineTelavancin
Critical
How does the drug interact with Premoquin 64.5mg Injection:
Using Premoquin 64.5mg Injection together with telavancin can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Telavancin with Premoquin 64.5mg Injection is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Premoquin 64.5mg Injection:
Taking Premoquin 64.5mg Injection with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Ziprasidone is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, confusion, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
ChloroquineBepridil
Critical
How does the drug interact with Premoquin 64.5mg Injection:
Using Premoquin 64.5mg Injection together with bepridil can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Bepridil is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Malaria:

  • Take nutritious food, including fresh fruits and vegetables, to help recover from malarial fever.
  • During malarial fever, the patient may experience appetite loss. In such cases, drink glucose water, fresh fruit juices, and coconut water.
  • Include high-fibre foods like green leafy vegetables and fruits to aid digestion.
  • Take proper rest to help your body relax and heal faster.
  • Avoid or limit the intake of alcohol and caffeine.

Extraintestinal Amebiasis:

  • Include fruits, vegetables, whole-grain bread, low-fat dairy products, beans, lean meats, and fish in your diet.
  • Avoid alcohol consumption that can further damage your liver in liver abscess.
  • Wash your hands often to prevent infection.
  • Stay away from patients who are infected with amebiasis.

Habit Forming

No

Therapeutic Class

ANTI- MALARIALS

Premoquin 64.5mg Injection Substitute

Substitutes safety advice
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Alcohol

Caution

Avoid alcohol consumption while receiving Premoquin 64.5mg Injection since it may worsen your side effects.

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Pregnancy

Caution

Please inform your doctor if you are pregnant or planning to conceive. Your doctor will administer Premoquin 64.5mg Injection only if the benefits outweigh the risks.

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Breast Feeding

Caution

Premoquin 64.5mg Injection may pass into breast milk and cause potential harm to infant. Please consult your doctor before receiving Premoquin 64.5mg Injection if you are a breastfeeding mother.

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Driving

Caution

Premoquin 64.5mg Injection may cause dizziness or blurry vision. In such cases, do not drive or operate machinery until you are alert and have a clear vision.

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Liver

Caution

Please inform your doctor if you have a history of liver disease before receiving Premoquin 64.5mg Injection to ensure your safety.

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Kidney

Caution

Please inform your doctor if you have a history of kidney disease before receiving Premoquin 64.5mg Injection to ensure your safety.

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Children

Caution

Premoquin 64.5mg Injection should be used for children only when prescribed by a doctor. Your doctor will decide the dose based on your child's age and body weight.

Have a query?

FAQs

Premoquin 64.5mg Injection belongs to the class of 'anti-malarial drugs', primarily used to treat and prevent malaria. It may also be used to treat extraintestinal amebiasis/amoebiasis. Premoquin 64.5mg Injection treats malaria by increasing the concentration of a toxic compound in the parasite that leads to its death.

Premoquin 64.5mg Injection may cause irreversible retinal damage with long-term therapy. Retinopathy (disease related to the retina) is also reported with Chloroquine usage. You may not be advised Premoquin 64.5mg Injection by your doctor if you have vision changes or retina damage. If the doctor has prescribed you this medicine knowing your medical history, you may be further advised to take ophthalmological examinations, including visual acuity, expert slit-lamp, funduscopic, and visual field tests. If there are any changes in these examinations, you may be asked to discontinue the treatment.

Inform your doctor in advance if you have any liver or kidney problems, heart diseases, diabetes, G-6-PD (glucose-6 phosphate dehydrogenase) deficiency (a genetic enzyme deficiency), electrolyte imbalance, psoriasis, alcoholism, porphyria (a blood disorder), hearing problems, vision-related issues, fits, and damaged retina or vision problems before starting Premoquin 64.5mg Injection. Also, inform your doctor if you have recently received treatment with other antimalarial drugs.

The common side effects of Premoquin 64.5mg Injection include nausea, vomiting, diarrhoea, stomach cramps, headache, hair loss, changes in mood/confusion, vision changes/blurred vision, black or tarry stools, bleeding gums, and dizziness. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

501, Alankar Point, Geeta Bhawan Square, P Box No. 117, G P O, A B. Road, Indore 452 001 India
Other Info - PR70547

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