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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Pregatryp 50 Tablet is used for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. It contains Pregabalin and Nortriptyline, which affects the chemicals in the brain that send pain signals across the nervous system. Also, it increases nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. In some cases, you may experience certain common side effects such as dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of lower legs and hands), weight gain and dry mouth. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Propel Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pregatryp 50 Tablet

Pregatryp 50 Tablet is a combination medicine indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to nerve damage or a malfunctioning nervous system.

Pregatryp 50 Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Nortriptyline (antidepressant). Pregabalin affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Pregatryp 50 Tablet helps to treat neuropathic pain.

In some cases, you may experience certain common side-effects such as dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of lower legs and hands), weight gain and dry mouth. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Pregatryp 50 Tablet may cause drowsiness and dizziness, so drive only if you are alert. Pregatryp 50 Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregatryp 50 Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Pregatryp 50 Tablet

Pregatryp 50 Tablet is used in the treatment of neuropathic pain. The detailed uses of Pregatryp 50 Tablet are as follows:

  • Neuropathic Pain Management: Pregatryp 50 Tablet is commonly prescribed to help alleviate pain caused by nerve damage or neuropathy, which can result from conditions such as diabetes or shingles.
  • Management of Epilepsy: Pregatryp 50 Tablet may be used as part of the treatment plan for patients with epilepsy, specifically for controlling certain types of seizures.
  • Anxiety Disorder Treatment: Pregatryp 50 Tablet can assist in managing generalized anxiety disorder, providing relief from excessive worry and improving overall emotional well-being.
  • Fibromyalgia Treatment: Pregatryp 50 Tablet is often utilized to help reduce aches, pain, and discomfort associated with fibromyalgia, enhancing patient’s quality of life.

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Directions for Use

  • Take Pregatryp 50 Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Pregatryp 50 Tablet is a combination of two medicines, namely: Pregabalin and Nortriptyline. Pregatryp 50 Tablet is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Pregabalin is an anti-convulsant which affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline is an antidepressant which works by increasing the levels of nerve transmitters (serotonin and noradrenaline) in the brain, thereby reduces the pain messages arriving in the brain. Together, Pregatryp 50 Tablet helps to treat neuropathic pain (pain due to nerve damage).

How Pregatryp 50 Tablet Works

Pregatryp 50 Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Nortriptyline (antidepressant). Pregabalin affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Pregatryp 50 Tablet helps to treat neuropathic pain.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Pregatryp 50 Tablet

Do not take more than the prescribed dose of Pregatryp 50 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Pregatryp 50 Tablet if you are allergic to any of its contents. Inform your doctor before taking Pregatryp 50 Tablet if you have or had heart problems, bipolar syndrome, severe liver disease or if you have taken MAO inhibitors in the last 14 days. Consult your doctor before taking cough-cold medicines containing adrenaline-like drugs such as ephedrine, phenylpropanolamine, isoprenaline, noradrenaline or phenylephrine. Consult your doctor if you are pregnant or breastfeeding. Pregatryp 50 Tablet may cause drowsiness and dizziness, so drive only if you are alert. Pregatryp 50 Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregatryp 50 Tablet as it could lead to increased drowsiness and sleepiness.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Pregatryp 50 Tablet:
Coadministration of Pregatryp 50 Tablet with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Pregatryp 50 Tablet with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregatryp 50 Tablet:
Co-administration of Pregatryp 50 Tablet with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Pregatryp 50 Tablet with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregatryp 50 Tablet:
Coadministration of Pregatryp 50 Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Pregatryp 50 Tablet with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Pregatryp 50 Tablet:
Using Pregatryp 50 Tablet together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Pregatryp 50 Tablet is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregatryp 50 Tablet:
Coadministration of Pregatryp 50 Tablet with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregatryp 50 Tablet with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Pregatryp 50 Tablet:
Coadministration of Pregatryp 50 Tablet with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregatryp 50 Tablet with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
NortriptylinePotassium citrate
Critical
How does the drug interact with Pregatryp 50 Tablet:
Coadministration of Pregatryp 50 Tablet with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Pregatryp 50 Tablet with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregatryp 50 Tablet:
Using Tapentadol together with Pregatryp 50 Tablet may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Pregatryp 50 Tablet with Tapentadol can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without consulting a doctor.
PregabalinCodeine
Severe
How does the drug interact with Pregatryp 50 Tablet:
Using Pregatryp 50 Tablet together with Codeine may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Codeine and Pregatryp 50 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinPethidine
Severe
How does the drug interact with Pregatryp 50 Tablet:
Using Pregatryp 50 Tablet together with Pethidine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking pethidine and Pregatryp 50 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain.
  • Rest well, get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pregatryp 50 Tablet as it may cause increased drowsiness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Pregatryp 50 Tablet ; your doctor will decide whether Pregatryp 50 Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Pregatryp 50 Tablet may cause drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Pregatryp 50 Tablet should not be given to children as safety and efficacy have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Pregatryp 50 Tablet in elderly patients. Please consult your doctor.

FAQs

Pregatryp 50 Tablet is used to treat neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc.

Pregatryp 50 Tablet affects the chemicals in the brain that send pain signals across the nervous system. It increases nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain.

Dry mouth could be a side-effect of Pregatryp 50 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

To treat your condition effectually, continue taking Pregatryp 50 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Pregatryp 50 Tablet .

Pregatryp 50 Tablet is used to treat nerve pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in the legs and feet.

Country of origin

INDIA
Other Info - PRE1221

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