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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Pregabanyl-Plus Capsule is a combination medicine used in the treatment of neuropathic pain, and nutritional deficiencies. This medicine works by altering the nerve signals that cause pain and thereby protects nerve fibres. It helps provide a protective effect on the nerve tissues and the brain. You may experience common side effects like nausea, vomiting, diarrhoea, and stomach upset.
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About Pregabanyl-Plus Capsule

Pregabanyl-Plus Capsule is a combination medicine used to treat neuropathic pain. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to damage to sensory nerves. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping and evoked pain (pain caused by events that are usually not painful).

Pregabanyl-Plus Capsule contains Pregabalin, mecobalamin, alpha-lipoic acid, folic acid and pyridoxine. Pregabalin works by binding to the specific site on voltage-gated calcium channels, this helps relieve nerve pain and lowers the risk of seizures. Mecobalamin and Pyridoxine help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain. Folic acid helps in providing essential nutrients to the nerves. Together, Pregabanyl-Plus Capsule helps in providing relief from neuropathic pain.

You are advised to take Pregabanyl-Plus Capsule for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, sleepiness, tiredness, dry mouth and oedema. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Pregabanyl-Plus Capsule without consulting your doctor as it could cause withdrawal symptoms. Consult your doctor if you are pregnant or breastfeeding. Pregabanyl-Plus Capsule causes drowsiness and dizziness, so drive only if you are alert. Pregabanyl-Plus Capsule is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregabanyl-Plus Capsule as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Pregabanyl-Plus Capsule

Pregabanyl-Plus Capsule is used in the treatment of Neuropathic pain. The detailed uses of Pregabanyl-Plus Capsule are as follows:<br/>• Diabetic Neuropathy: Pregabanyl-Plus Capsule helps relieve burning, tingling, and numbness in the limbs caused by diabetes-related nerve damage.<br/>• Peripheral Neuropathy: Pregabanyl-Plus Capsule is used in various conditions where nerves outside the brain and spinal cord are damaged.<br/>• Sciatica & Radiculopathy: Pregabanyl-Plus Capsule eases nerve pain radiating from the spine to the legs or arms.<br/>• Post-Herpetic Neuralgia: Pregabanyl-Plus Capsule manages lingering nerve pain after shingles.<br/>• Vitamin B Deficiency–Related Neuropathy: Pregabanyl-Plus Capsule replenishes essential B vitamins to support nerve repair and function.<br/>

Directions for Use

• Pregabanyl-Plus Capsule can be taken with or without food, or as advised by the doctor. • Follow your doctor's instructions regarding dosage and timing to ensure optimal effectiveness. • Swallow Pregabanyl-Plus Capsule as a whole with a glass of water. • Do not crush, chew, or break Pregabanyl-Plus Capsule , as this may impact absorption.

Medicinal Benefits

Pregabanyl-Plus Capsule is a combination of five drugs: Pregabalin, mecobalamin, alpha-lipoic acid, folic acid and pyridoxine. Pregabanyl-Plus Capsule is used to treat neuropathic pain. Pregabalin is an anti-convulsant that affects the chemicals in the brain that send pain signals across the nervous system. It works by binding to the specific site on voltage-gated calcium channels, this helps relieve nerve pain and lowers the risk of seizures. Mecobalamin is a vitamin that helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Pyridoxine (Vitamin B6) is also very useful in facilitating myelin and neurotransmitter synthesis. Alpha-lipoic acid is an antioxidant that helps in providing a protective effect on the nerve tissues and brain. Folic acid is a vitamin that helps in providing essential nutrients to the nerves. Together, Pregabanyl-Plus Capsule helps in providing relief from neuropathic pain.  Additionally, Pregabanyl-Plus Capsule may also be used to treat diabetic neuropathy, fibromyalgia and postherpetic neuralgia.

How Pregabanyl-Plus Capsule Works

Pregabanyl-Plus Capsule contains Pregabalin, mecobalamin, alpha-lipoic acid, folic acid and pyridoxine. Pregabalin works by binding to the specific site on voltage-gated calcium channels, this helps relieve nerve pain and lowers the risk of seizures. Mecobalamin and Pyridoxine help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain. Folic acid helps in providing essential nutrients to the nerves. Together, Pregabanyl-Plus Capsule helps in providing relief from neuropathic pain.

Storage

• Store in a cool and dry place away from sunlight.
• Store at temperatures not exceeding 25 degrees C. Protect from heat and moisture.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Pregabanyl-Plus Capsule

Never take more than the recommended dose. An overdose of Pregabanyl-Plus Capsule may cause symptoms like sleepiness, confusion state, agitation, restlessness, nausea, rashes and itching. Seek immediate medical help in case of accidental overdose.

Drug Warnings

Do not take Pregabanyl-Plus Capsule if you are allergic to any of its contents. Inform your doctor before taking Pregabanyl-Plus Capsule if you have or had heart problems or bipolar syndrome. Please do not stop taking Pregabanyl-Plus Capsule without consulting your doctor as it could cause withdrawal symptoms. Consult your doctor before starting Pregabanyl-Plus Capsule if you are pregnant or breastfeeding. Pregabanyl-Plus Capsule may cause drowsiness and dizziness, so drive only if you are alert. Pregabanyl-Plus Capsule is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregabanyl-Plus Capsule as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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PregabalinHydromorphone
Severe

Drug-Drug Interactions

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PregabalinHydromorphone
Severe
How does the drug interact with Pregabanyl-Plus Capsule:
Using Pregabanyl-Plus Capsule together with Hydromorphone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydromorphone and Pregabanyl-Plus Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregabanyl-Plus Capsule:
Using Pregabanyl-Plus Capsule together with Pentazocine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking pentazocine and Pregabanyl-Plus Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinSufentanil
Severe
How does the drug interact with Pregabanyl-Plus Capsule:
Using Pregabanyl-Plus Capsule together with Sufentanil causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking sufentanil and Pregabanyl-Plus Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregabanyl-Plus Capsule:
Taking Ketamine with Pregabanyl-Plus Capsule may increase the risk of side effects.

How to manage the interaction:
Although taking Pregabanyl-Plus Capsule and ketamine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as dizziness, drowsiness, confusion, difficulty concentrating, breathing difficulty, consult the doctor. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinMethadone
Severe
How does the drug interact with Pregabanyl-Plus Capsule:
Using Pregabanyl-Plus Capsule together with Methadone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking methadone and Pregabanyl-Plus Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregabanyl-Plus Capsule:
Using Pregabanyl-Plus Capsule together with Butorphanol causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Butorphanol and Pregabanyl-Plus Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinSodium oxybate
Severe
How does the drug interact with Pregabanyl-Plus Capsule:
Using Sodium oxybate together with Pregabanyl-Plus Capsule may increase the risk of side effects.

How to manage the interaction:
Although taking Pregabanyl-Plus Capsule with Sodium oxybate together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult the doctor. For at least six hours after taking sodium oxybate, avoid operating machinery or engaging in potentially dangerous activities. Also, be careful when getting up from a sitting or lying down posture. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregabanyl-Plus Capsule:
Using Pregabanyl-Plus Capsule together with Fentanyl can increase the risk of side effects.

How to manage the interaction:
Although taking fentanyl together with Pregabanyl-Plus Capsule can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you have dizziness, sleepiness, difficulty concentrating, or impairment in judgment. Do not stop taking any medication without consulting a doctor.
How does the drug interact with Pregabanyl-Plus Capsule:
Using Pregabanyl-Plus Capsule together with Buprenorphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Buprenorphine and Pregabanyl-Plus Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in- judgment, reaction speed and motor coordination, consult the doctor immediately. Avoid driving or operating dangerous machinery. Do not exceed the doses, frequency, or duration of usage advised by the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregabanyl-Plus Capsule:
Using Tapentadol together with Pregabanyl-Plus Capsule may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Pregabanyl-Plus Capsule with Tapentadol can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain. 
  • Rest well, get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pregabanyl-Plus Capsule as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or planning for pregnancy; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Pregabanyl-Plus Capsule if you are breastfeeding; your doctor will decide whether Pregabanyl-Plus Capsule can be taken by breastfeeding mothers or not.

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Driving

Caution

Pregabanyl-Plus Capsule may cause drowsiness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Pregabanyl-Plus Capsule should not be given to children as the safety and efficacy have not been established.

Have a query?

FAQs

Pregabanyl-Plus Capsule is a combination medicine used to treat neuropathic pain. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to damage to sensory nerves.

Pregabanyl-Plus Capsule contains Pregabalin, mecobalamin, pyridoxine, alpha-lipoic acid and folic acid. Pregabalin works by binding to the specific site on voltage-gated calcium channels, this helps in relieving nerve pain. Mecobalamin and Pyridoxine help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain. Folic acid helps in providing essential nutrients to the nerves. Together, Pregabanyl-Plus Capsule helps in providing relief from neuropathic pain.

Pregabanyl-Plus Capsule is used to treat diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly causes pain in legs and feet.

Pregabanyl-Plus Capsule may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.

Pregabanyl-Plus Capsule may be used to treat fibromyalgia. Fibromyalgia is a condition which is characterised by musculoskeletal pain, tenderness, fatigue, sleep and mood issues.

Do not discontinue Pregabanyl-Plus Capsule without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually continue taking Pregabanyl-Plus Capsule for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Pregabanyl-Plus Capsule .

Dry mouth could be a side-effect of Pregabanyl-Plus Capsule . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent mouth drying.

Country of origin

INDIA

Manufacturer/Marketer address

Leeford Healthcare Limited , Leo House, Shaheed Bhagat Singh Nagar, Dugri-Dhandra Road, Near Joseph School , Ludhiana-141116
Other Info - PRE0707

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