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compositionComposition:IDARUCIZUMAB-50MG
prescription
Prescription Medicine
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Praxbind 2.5gm/50ml Solution For Injection is used in the treatment of severe or uncontrolled bleeding that has been caused by taking dabigatran (a medicine used to prevent blood clots). It contains Idarucizumab, a humanised monoclonal antibody fragment (Fab) which rapidly traps dabigatran to inactivate its effect. Common side effects of Praxbind 2.5gm/50ml Solution For Injection are headaches, constipation, fever, low potassium levels, and confusion.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IDARUCIZUMAB-50MG

Manufacturer/Marketer :

Boehringer Ingelheim India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Praxbind 2.5gm/50ml Solution For Injection

Praxbind 2.5gm/50ml Solution For Injection is a prescription injection used to quickly reverse the blood-thinning effects of a specific medicine called dabigatran. It is used in emergency situations, such as when a patient experiences life-threatening or uncontrolled bleeding, or when they need to undergo an unplanned, urgent surgery. This medicine is only given by a healthcare professional in a hospital setting.

Because Praxbind 2.5gm/50ml Solution For Injection is an emergency treatment, it is not used on a regular schedule or taken at home. It is injected directly into a vein, so food intake does not affect how it works. Since this is a critical rescue treatment, there are no specific long-term diet or lifestyle changes that directly alter its immediate effects, but managing your underlying heart or clotting conditions afterward is highly important.

Most people tolerate this injection well, but some may experience mild side effects like headache, constipation, or skin redness at the injection site. However, you should tell your healthcare team immediately if you experience signs of a serious allergic reaction, such as trouble breathing, a rapid heart rate, or severe itching.

Before receiving Praxbind 2.5gm/50ml Solution For Injection, your healthcare team will review your medical history, particularly if you have a rare genetic condition called hereditary fructose intolerance, as some formulations may contain sorbitol. Do not take this if you have had a severe, life-threatening allergic reaction to this medicine in the past, though in emergencies, your doctor will carefully weigh the risks and benefits.

This medicine has very few direct interactions with other drugs, but restarting your usual blood-thinning therapy after receiving it must be carefully timed with your doctor. If you are pregnant, breastfeeding, or an older adult, your healthcare provider will closely monitor you, though emergency reversal is typically prioritized to protect your life.

Uses of Praxbind 2.5gm/50ml Solution For Injection

This medicine is used to rapidly reverse the blood-thinning effects of dabigatran during medical emergencies. The detailed uses of this medicine are as follows:

  • Uncontrolled or life-threatening bleeding: Praxbind 2.5gm/50ml Solution For Injection rapidly binds to dabigatran, neutralizing its blood-thinning effect so normal blood clotting can resume and help control severe bleeding.
  • Emergency surgery or urgent procedures: It quickly reverses the anticoagulant effect of dabigatran before emergency surgery or other urgent procedures, helping reduce the risk of excessive bleeding during the intervention.

Key Benefits

Praxbind 2.5gm/50ml Solution For Injection provides rapid reversal of dabigatran's blood-thinning effects during medical emergencies. Its benefits include:

  • Rapidly neutralizes the anticoagulant effect of dabigatran, allowing normal blood clotting to resume within minutes.
  • Helps control uncontrolled or life-threatening bleeding, reducing the risk of severe blood loss and related complications.
  • Enables emergency surgery or urgent medical procedures to be performed more safely by reversing the blood-thinning effect before the procedure.
  • Supports faster stabilization during critical situations, improving the chances of successful emergency treatment.
  • Helps reduce the risk of prolonged bleeding complications when administered promptly under medical supervision.
Side effects of Praxbind 2.5gm/50ml Solution For Injection
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Praxbind 2.5gm/50ml Solution For Injection will be administered by a healthcare professional.
  • Do not self-administer it.

How Praxbind 2.5gm/50ml Solution For Injection Works

Praxbind 2.5gm/50ml Solution For Injection works as a highly specific targeted reversal agent. When injected into your bloodstream, it acts like a magnet, seeking out and binding tightly to the blood-thinning medicine dabigatran. Once Praxbind 2.5gm/50ml Solution For Injection attaches itself to the blood thinner, it neutralizes it completely, preventing the blood thinner from blocking thrombin (a protein in your blood that is essential for clotting). With the blood thinner deactivated, your body can naturally form clots again to stop any active bleeding. Because it only targets this specific blood thinner, it does not affect other processes in your body.
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Alcohol

Consult your doctor

It is not known if alcohol affects Praxbind 2.5gm/50ml Solution For Injection. Please consult your doctor.

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Pregnancy

Caution

Praxbind 2.5gm/50ml Solution For Injection should be given to pregnant women only if clearly needed. Inform the doctor if you are pregnant or think you may be pregnant.

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Breast Feeding

Caution

Caution is advised while administering Praxbind 2.5gm/50ml Solution For Injection to a nursing woman.

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Driving

Not applicable

This medicine is for hospital use only.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Praxbind 2.5gm/50ml Solution For Injection.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before receiving Praxbind 2.5gm/50ml Solution For Injection.

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Children

Caution

The safety and effectiveness of Praxbind 2.5gm/50ml Solution For Injection in children have not been established.

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Heart

Safe if prescribed

Praxbind 2.5gm/50ml Solution For Injection is generally safe for heart patients when used only under medical supervision. However, it is important to consult your doctor if you have any concerns or underlying conditions.

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Geriatrics

Consult your doctor

Please consult your doctor before using Praxbind 2.5gm/50ml Solution For Injection in elderly people. Your doctor will prescribe Praxbind 2.5gm/50ml Solution For Injection if the benefits outweigh the risk.

What if I have taken an overdose of Praxbind 2.5gm/50ml Solution For Injection

An overdose is highly unlikely because a trained healthcare provider administers the exact required amount in a hospital. If an excess amount is given, your medical team will monitor you closely and treat any symptoms.

Diet & Lifestyle Advise

  • Follow blood thinner instructions carefully: Once your doctor determines it is safe to restart your regular blood-thinning medicine, take it exactly as prescribed to prevent stroke or blood clots.
  • Prevent falls and injuries: Since you are on blood thinners, minor injuries can cause serious bleeding. Use a soft-bristled toothbrush, shave with an electric razor, and avoid contact sports.
  • Eat a balanced diet: Maintain a steady diet and discuss any significant dietary changes with your healthcare provider, especially if you are transitioning to other types of blood thinners.
  • Limit alcohol intake: Alcohol can increase your risk of stomach bleeding and increase your risk of falls. Discuss safe alcohol limits with your doctor.
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How Soon It Starts Working

The time required for Praxbind 2.5gm/50ml Solution For Injection to start to work: Praxbind 2.5gm/50ml Solution For Injection ideally shows its action within 2 hours after administration. The time for which the effects of Praxbind 2.5gm/50ml Solution For Injection last: The effect of Praxbind 2.5gm/50ml Solution For Injection lasts for 24 hours.

What if you forget to take Praxbind 2.5gm/50ml Solution For Injection

Since Praxbind 2.5gm/50ml Solution For Injection is an emergency, one-time treatment administered by a healthcare professional in a hospital, a missed dose is not possible under normal circumstances.

Storage

•Store Praxbind 2.5gm/50ml Solution For Injection in a refrigerator between 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Verify solution appearance: The medical professional will inspect the vial before use; the solution should be clear to slightly opalescent, and colorless to slightly yellow. Do not use if there is visible discoloration or floating particles.
  • Watch for blood clot symptoms: Reversing your blood thinner increases your risk of developing a blood clot. Alert your doctor immediately if you experience sudden leg swelling, chest pain, or trouble speaking.
  • Plan the Restart of Blood Thinners: This medicine only reverses dabigatran temporarily. Once bleeding is controlled and it is medically safe, dabigatran can often be restarted after about 24 hours, although the exact timing depends on your condition, surgery, and bleeding risk. Follow your doctor's instructions carefully to reduce the risk of stroke or new blood clots.
  • Inform all healthcare providers: Always tell any doctor, dentist, or surgeon that you have recently received Praxbind 2.5gm/50ml Solution For Injection and what blood-thinning medicines you normally take.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners and antiplatelet medicines: While Praxbind 2.5gm/50ml Solution For Injection does not have direct drug interactions, restarting blood thinners (like heparin or oral anticoagulants) too soon or too late can affect your clotting and bleeding risks.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • No clinically significant food interactions are known with Praxbind 2.5gm/50ml Solution For Injection when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Praxbind 2.5gm/50ml Solution For Injection is used to treat severe or uncontrolled bleeding that has been caused by taking dabigatran (a medicine used to prevent blood clots).
Praxbind 2.5gm/50ml Solution For Injection rapidly traps dabigatran in order to inactivate its effect.
Praxbind 2.5gm/50ml Solution For Injection may contain sorbitol, which can cause serious or life-threatening metabolic problems in people with hereditary fructose intolerance (a genetic disorder). Therefore, inform the doctor if you have hereditary fructose intolerance.
Praxbind 2.5gm/50ml Solution For Injection does not remove other medicines used to prevent the formation of blood clots. It will only remove dabigatran from your body.
No, Praxbind 2.5gm/50ml Solution For Injection is strictly for hospital use and must be injected by a qualified healthcare professional in an emergency or surgical setting. Talk to your doctor if you have concerns about bleeding risks.
While generally well-tolerated, serious side effects can include severe allergic reactions or an increased risk of developing a new blood clot. Talk to your doctor immediately if you notice signs like sudden leg swelling or difficulty breathing.
Your doctor will decide the safest time to restart anticoagulation based on your bleeding risk and overall condition. In many patients, dabigatran can be restarted approximately 24 hours after receiving Praxbind 2.5gm/50ml Solution For Injection once adequate bleeding control has been achieved. Delaying anticoagulation longer than necessary may increase the risk of stroke or blood clots, so always follow your doctor's advice.
This medicine is only given in emergency situations when the benefits of stopping life-threatening bleeding outweigh the potential risks. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
There are no major known drug-drug interactions, but it is crucial to tell your healthcare team about all the medications and supplements you take, especially other blood thinners. Talk to your doctor or pharmacist for personalized advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

1102, Hallmark Business Plaza, 11Th Floor, Gurunanak Hospital Road, Near Gurunanak Hospital, Bandra (East), Mumbai 400051
Other Info - PRA0330
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