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compositionComposition:DABIGATRAN ETEXILATE MESILATE-75MG
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Prescription Medicine
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Pradaxa 75 Capsule is used to prevent the formation of blood clots. It contains Dabigatran etexilate mesylate which works by blocking coagulation factor (thrombin) in the blood and prevents blood clot formation. In some cases, this medicine may cause side effects such as bleeding, stomach pain, nausea, and indigestion. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DABIGATRAN ETEXILATE MESILATE-75MG

Manufacturer/Marketer :

Boehringer Ingelheim India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pradaxa 75 Capsule

Pradaxa 75 Capsule is an oral prescription medication used to lower the risk of stroke and prevent dangerous blood clots in people with certain heart rhythm conditions. It is also commonly prescribed to treat existing blood clots in the veins of your legs or lungs and to stop them from coming back. By helping your blood flow smoothly, this medication protects vital organs from the damage that blood clots can cause.

For this medication to work safely and effectively, you must take it consistently and exactly as prescribed by your doctor, usually once or twice a day. You can take it with or without food, but taking it with a full glass of water can help prevent stomach irritation. Making healthy lifestyle choices, such as eating a balanced diet, staying hydrated, and engaging in light, doctor-approved physical activity, can also support your overall vascular health.

Like all medicines that affect blood clotting, the most common side effects of Pradaxa 75 Capsule relate to minor bleeding, such as easy bruising or stomach upset. However, you must seek medical attention immediately if you experience any signs of serious bleeding. This includes unusual or heavy bleeding that will not stop, coughing up blood, pink or brown urine, or black, tarry stools.

Before you start taking Pradaxa 75 Capsule , it is important to tell your doctor if you have ever had kidney disease, liver problems, or a history of stomach ulcers. Do not take this if you have active, severe bleeding, or if you have an artificial (mechanical) heart valve. Always provide your complete medical history to your healthcare team so they can decide if this treatment is safe for you.

Pradaxa 75 Capsule can interact with several other drugs, including common over-the-counter pain relievers, which can significantly raise your risk of bleeding. You should also limit alcohol consumption while taking this medication, as alcohol can irritate your stomach lining and increase the risk of internal bleeding. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist about the specific risks and benefits for your situation.

Uses of Pradaxa 75 Capsule

Pradaxa 75 Capsule is used in the prevention and treatment of blood clots (thromboembolic disorders). The detailed uses of Pradaxa 75 Capsule are as follows:

  •  Preventing Stroke in Atrial Fibrillation: It helps reduce the risk of stroke and blood clots in adults with non-valvular atrial fibrillation by preventing clot formation.
  • Treating Deep Vein Thrombosis (DVT): It helps treat blood clots that form in the deep veins, reducing pain and swelling while preventing the clot from growing or spreading.
  • Treating Pulmonary Embolism (PE): It helps treat blood clots in the lungs, improving blood flow and reducing the risk of serious complications.
  • Preventing Recurrent DVT and PE: It lowers the risk of developing blood clots again after initial treatment for deep vein thrombosis or pulmonary embolism.
  • Preventing Blood Clots After Hip or Knee Replacement Surgery: It helps prevent the formation of blood clots during recovery following major hip or knee replacement surgery.

Key Benefits

Pradaxa 75 Capsule helps prevent and treat harmful blood clots, reducing the risk of serious complications such as stroke and pulmonary embolism. By providing reliable blood-thinning effects, it supports long-term cardiovascular health and overall well-being.
Benefits may include:

• Helps prevent the formation of harmful blood clots.
• Reduces the risk of stroke in appropriate patients with certain heart rhythm disorders.
• Helps treat and prevent the recurrence of deep vein thrombosis (DVT) and pulmonary embolism (PE).
• Supports safer long-term management of clot-related conditions.
• Does not usually require routine blood monitoring to measure its anticoagulant effect.
• Offers a convenient treatment option with fewer dietary restrictions compared with some older anticoagulants.

Side effects of Pradaxa 75 Capsule
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Avoid other medicines that increase the risk of bleeding.
  • Use an electric razor and a soft-bristled toothbrush.
  • Monitor for signs of bleeding like bleeding gums, unusual bruising, blood in stool, nosebleeds, or heavy menstrual bleeding.
  • If you experience severe bleeding, apply direct pressure on the wound and consult a doctor promptly.
  • If the risk of bleeding is high, discuss with your doctor about possibility of switching to different medicine with a lower bleeding risk.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Pradaxa 75 Capsule can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Pradaxa 75 Capsule as a whole with a glass of water.
  • Do not open, break, or chew it.

How Pradaxa 75 Capsule Works

Pradaxa 75 Capsule helps prevent harmful blood clots by reducing the blood's ability to clot. This helps keep blood flowing smoothly, lowers the risk of stroke and other clot-related complications, and prevents existing blood clots from getting larger while the body gradually breaks them down naturally.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Pradaxa 75 Capsule as it may increase the risk of bleeding.

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Pregnancy

Caution

Pradaxa 75 Capsule is a Category C pregnancy drug as the effect of Pradaxa 75 Capsule is unknown on the mother and the unborn baby. Avoid the use of Pradaxa 75 Capsule if you are pregnant and inform your doctor.

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Breast Feeding

Unsafe

Pradaxa 75 Capsule should not be used while taking Pradaxa 75 Capsule . Inform your doctor if you are a breastfeeding mother.

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Driving

Safe if prescribed

Pradaxa 75 Capsule usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Take Pradaxa 75 Capsule with caution, especially if you have a history of Liver diseases/conditions. Pradaxa 75 Capsule may increase the chances of mild liver injury. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Pradaxa 75 Capsule with caution, especially if you have a history of Kidney diseases/conditions, as this Pradaxa 75 Capsule may cause side effects. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Pradaxa 75 Capsule should not be used for children below 18 years as it is not approved for children.

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Heart

Caution

Pradaxa 75 Capsule should be taken with caution in patients with heart problems. Therefore, please inform your doctor before using Pradaxa 75 Capsule .

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Geriatrics

Caution

Pradaxa 75 Capsule should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Pradaxa 75 Capsule .

What if I have taken an overdose of Pradaxa 75 Capsule

If you take too much of this medication, seek emergency medical care immediately. An overdose can cause severe, life-threatening internal bleeding. Do not wait for symptoms to appear before seeking help.

Diet & Lifestyle Advise

  • Avoid activities with a high injury risk: Avoid contact sports or activities that could lead to falls, head injuries, or deep cuts, as bleeding will take longer to stop.
  • Use personal safety tools: Use a soft-bristled toothbrush and an electric razor instead of a manual blade to minimize the risk of cuts and bleeding gums.
  • Limit alcohol consumption: Keep alcohol intake to a minimum. Alcohol can irritate your stomach lining, increasing the risk of stomach ulcers and bleeding.
  • Stay hydrated: Drink plenty of water throughout the day, which helps support overall kidney health and aids in processing your medication safely.
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Have a query?

How Soon It Starts Working

The time required for Pradaxa 75 Capsule to start to work: Pradaxa 75 Capsule ideally shows its action within 30 minutes to 2 hours after administration. The time for which the effects of Pradaxa 75 Capsule last: The duration of action for Pradaxa 75 Capsule is clinically unknown.

What if you forget to take Pradaxa 75 Capsule

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is less than 6 hours away, skip the missed dose entirely and take your next dose at your regular time. Do not take a double dose to make up for the missed one.

Storage

•Keep the capsules in their original blister package or bottle until you are ready to take them. Do not store them in daily pill organizers or pillboxes. •Store the package at a controlled room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Do not stop treatment abruptly: Do not stop taking Pradaxa 75 Capsule without consulting your doctor, as stopping treatment suddenly may increase your risk of developing a blood clot or having a stroke.
  • Inform healthcare providers before procedures: Tell your doctor, dentist, surgeon, physiotherapist, or other healthcare professionals that you are taking Pradaxa 75 Capsule before undergoing any medical, surgical, or dental procedure.
  • Monitor for signs of bleeding: Check your skin regularly for unusual or spreading bruises and report any unexpected bleeding or bruising to your doctor promptly.
  • Carry medical identification: Keep an up-to-date list of your medicines with you or wear a medical alert bracelet so emergency healthcare providers know you are taking a blood thinner.

Drug-Drug Interactions

verifiedApollotooltip
  • Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen): Taking these medicines alongside Pradaxa 75 Capsule may significantly increase the risk of stomach ulcers and serious bleeding.
  • Other blood thinners (e.g., warfarin, heparin): Combining these with Pradaxa 75 Capsule may cause excessive bleeding and should only be done if specifically advised and monitored by your doctor.
  • Certain antifungal medicines and antibiotics: These medicines may increase or decrease the amount of Pradaxa 75 Capsule in the body, affecting its effectiveness and changing the risk of bleeding.
Dabigatran etexilateMifepristone
Critical
Dabigatran etexilateTinzaparin
Severe

Drug-Drug Interactions

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Dabigatran etexilateMifepristone
Critical
How does the drug interact with Pradaxa 75 Capsule:
When Mifepristone is taken with Pradaxa 75 Capsule, it may increase the risk of severe vaginal bleeding in women.

How to manage the interaction:
Taking Mifepristone with Pradaxa 75 Capsule is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.
Dabigatran etexilateTinzaparin
Severe
How does the drug interact with Pradaxa 75 Capsule:
Taking Pradaxa 75 Capsule with Tinzaparin can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Pradaxa 75 Capsule with Tinzaparin together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateKetoconazole
Severe
How does the drug interact with Pradaxa 75 Capsule:
Coadministration of Ketoconazole and Pradaxa 75 Capsule may increase the blood levels and effects Pradaxa 75 Capsule. This may increase the risk of anemia and bleeding issues.

How to manage the interaction:
Although taking Ketoconazole and Pradaxa 75 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you notice paleness, exhaustion, dizziness, fainting, unusual bleeding or bruising, swelling, nausea, vomiting, blood in your urine or stools, headache, or weakness, consult a doctor. Do not discontinue any medication without consulting a doctor.
Dabigatran etexilateDiclofenac
Severe
How does the drug interact with Pradaxa 75 Capsule:
Concomitant use of diclofenac with dabigatran may increase the risk of stomach bleeding.

How to manage the interaction:
Taking diclofenac with dabigatran together possibly results in an interaction, it can be taken if your doctor has advised it. You should consult a doctor immediately if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness, light headedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness. Do not stop using any medications without first talking to your doctor.
Dabigatran etexilateLepirudin
Severe
How does the drug interact with Pradaxa 75 Capsule:
Taking Pradaxa 75 Capsule with Lepirudin can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Pradaxa 75 Capsule with Lepirudin together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateAcalabrutinib
Severe
How does the drug interact with Pradaxa 75 Capsule:
Taking Pradaxa 75 Capsule with Acalabrutinib can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Pradaxa 75 Capsule with Acalabrutinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilatePrasugrel
Severe
How does the drug interact with Pradaxa 75 Capsule:
Taking Pradaxa 75 Capsule with Prasugrel can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Although taking Prasugrel and Pradaxa 75 Capsule together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateFenoprofen
Severe
How does the drug interact with Pradaxa 75 Capsule:
Taking Pradaxa 75 Capsule with Fenoprofen can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Pradaxa 75 Capsule with Fenoprofen together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateFosphenytoin
Severe
How does the drug interact with Pradaxa 75 Capsule:
When Pradaxa 75 Capsule is taken with Fosphenytoin, it can lower the rate at which the body breaks down Pradaxa 75 Capsule. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Fosphenytoin with Pradaxa 75 Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having symptoms like sudden breathlessness, sharp chest pain, throbbing, cramping pain, swelling, redness or warmth in legs or arms, it's important to let your doctor know right away. They can recommend other options that won't cause any problems with your current medications. Do not discontinue any medications without first consulting your doctor.
Dabigatran etexilateFlurbiprofen
Severe
How does the drug interact with Pradaxa 75 Capsule:
Taking Flurbiprofen with Pradaxa 75 Capsule can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Although taking Flurbiprofen and Pradaxa 75 Capsule together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you experience bleeding, feeling dizzy or lightheaded, dark or sticky stools, throwing up blood, severe headache, or feeling weak contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid or limit alcohol while taking Pradaxa 75 Capsule , as it may increase the risk of stomach irritation and serious internal bleeding.
DABIGATRAN ETEXILATE MESILATE-75MGHerbal products/medicines

Drug-Food Interactions

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DABIGATRAN ETEXILATE MESILATE-75MGHerbal products/medicines
Common Foods to Avoid:
St. John’S Wort, Garlic Pill

How to manage the interaction:
Herbs and supplements may interact with Pradaxa 75 Capsule. Avoid St. John's Wort, herbs including garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba during Pradaxa 75 Capsule treatment.

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Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Pradaxa 75 Capsule is used to prevent blood clots. It is used to prevent and treat deep vein thrombosis (blood clots in leg veins), and pulmonary embolism (blood clots in the lung).
People experiencing any uncommon bleeding or people allergic to Pradaxa 75 Capsule should not take Pradaxa 75 Capsule . People with artificial heart valves should also prevent Pradaxa 75 Capsule . Pradaxa 75 Capsule should not take those patients who have bleeding problems and heart disease. The use of this Pradaxa 75 Capsule is not suggested in patients with serious kidney disease.
As compared to other blood thinner medicines, Pradaxa 75 Capsule does not normally cause hair loss. Though, there do exist some unusual reports of hair loss related to Pradaxa 75 Capsule . Inform your doctor if you observe hair loss while taking Pradaxa 75 Capsule .
Yes, Pradaxa 75 Capsule increases the risk of bleeding. Always be cautious while doing activities that may lead to an injury or bleeding. Inform your doctor immediately if you notice any abnormal staining or bleeding.
Pradaxa 75 Capsule works by blocking a substance (a protein known as thrombin) in the blood and preventing blood clot formation. Therefore, Pradaxa 75 Capsule preventing blood clot formation in the body.
Unlike other blood thinners, Pradaxa 75 Capsule generally does not affect the functioning of the liver. But long-term use of Pradaxa 75 Capsule may raise the chances of mild liver injury in patients with a high level of liver enzymes. However, the complete chances of developing any such problem are lesser than other blood thinners. It is advisable to you that before starting this Pradaxa 75 Capsule inform your doctor if you have a history of liver disease.
Pradaxa 75 Capsule may increase the risk of bleeding during surgery. Therefore, the doctor might ask you to stop taking Pradaxa 75 Capsule a few days before surgery.
You can take Pradaxa 75 Capsule with or without food but try to take it at the same time every day. Pradaxa 75 Capsule should be swallowed as a whole with water; do not crush or chew it.
Pradaxa 75 Capsule should be taken as advised by the doctor. To help you remember to take Pradaxa 75 Capsule , take it at around the same time daily.
You are recommended to avoid alcohol consumption with Pradaxa 75 Capsule as it may increase the risk of bleeding.
Though Pradaxa 75 Capsule starts working within a few hours of taking the medicine, you may not feel any better. Keep taking Pradaxa 75 Capsule for the prescribed duration to treat your condition effectively.
Store Pradaxa 75 Capsule at room temperature, in a dry place. Keep out of sight and reach of children.
Pradaxa 75 Capsule may cause side effects like bleeding, stomach pain, nausea, and indigestion. Most of these side effects of Pradaxa 75 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No. You must swallow the capsules whole with a full glass of water. Opening, chewing, or crushing the capsules increases how much medicine your body absorbs, which can dangerously increase your risk of bleeding. Talk to your doctor or pharmacist if you have trouble swallowing capsules.
For minor cuts, apply firm, direct pressure with a clean cloth or bandage for at least 5 to 10 minutes. Because you are taking a blood thinner, it will take longer than usual for the bleeding to stop. If the bleeding does not stop after applying pressure, or if you feel dizzy, seek medical help immediately.
Unlike older blood thinners, Pradaxa 75 Capsule does not require frequent, routine laboratory monitoring to adjust your dose. However, your doctor will likely perform routine blood tests at least once a year to check your kidney function and ensure the medication remains safe for you to take.
No. Pain relievers like ibuprofen, naproxen, and aspirin can significantly increase your risk of internal bleeding when combined with Pradaxa 75 Capsule . For mild pain relief, paracetamol (acetaminophen) is generally a safer alternative, but you should always talk to your doctor or pharmacist before taking any new medication.
Once you open a bottle of Pradaxa 75 Capsule , you must use the capsules within 4 months. This medication is highly sensitive to moisture and loses its strength quickly when exposed to air. Always close the bottle tightly after taking your dose, and do not store the capsules in pill organizers. Talk to your pharmacist if you have unused capsules left after 4 months.
Yes, you can take this medication with or without food. If you experience stomach irritation, heartburn, or indigestion after taking a dose, taking it alongside a meal or with a full glass of water may help ease these symptoms. Talk to your doctor if stomach discomfort continues.
It is generally not recommended during pregnancy or breastfeeding, as there is limited safety data available, and it may increase the risk of bleeding for both mother and baby. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor immediately to discuss safer alternative treatments.

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Country of origin

India

Manufacturer/Marketer address

1102, Hallmark Business Plaza, 11th Floor, Gurunanak Hospital Road, Near Gurunanak Hospital, Bandra (East), Mumbai 400051
Other Info - PRA0214
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