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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Posanat 100 mg Tablet is used to prevent and treat fungal infections. It contains posaconazole which works by inhibiting fungal cell growth and causing cell death. In some cases, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, and cough. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

POSACONAZOLE-100MG

Manufacturer/Marketer :

Bonne Sante Therapeutics India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Posanat 100 mg Tablet

Posanat 100 mg Tablet is in a class of medications called azole antifungals. It is used to prevent and treat fungal infections when other antifungal medicines have not worked, or you have had to stop taking them. It is also indicated for preventing invasive Aspergillus and Candida infections in patients at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

Posanat 100 mg Tablet contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Take Posanat 100 mg Tablet as prescribed by your doctor. You are advised to take Posanat 100 mg Tablet for as long as your doctor has prescribed it based on your medical condition. In some cases, you may experience diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood. Most of these side effects of Posanat 100 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic or hypersensitive to any component present in Posanat 100 mg Tablet or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Posanat 100 mg Tablet only if the benefits outweigh the risk. Before taking the Posanat 100 mg Tablet , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of Posanat 100 mg Tablet

Posanat 100 mg Tablet is used in the treatment of Fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.

Directions for Use

• Posanat 100 mg Tablet should be taken with food, preferably a high-fat meal, to ensure proper absorption.• It is recommended to take Posanat 100 mg Tablet twice on the first day, then once daily afterward, or as advised by your doctor.• Swallow Posanat 100 mg Tablet as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Posaconazole is an antifungal medication present in Posanat 100 mg Tablet . It is effective in treating fungal infections in adults. It is also indicated for preventing invasive Aspergillus and Candida infections in patients who are severely immunocompromised and at high risk of developing these infections, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

How Posanat 100 mg Tablet Works

Posanat 100 mg Tablet contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Storage

Keep Posanat 100 mg Tablet out of the sight and reach of children.

What if I have taken an overdose of Posanat 100 mg Tablet

Take Posanat 100 mg Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Inform your doctor if you are allergic or hypersensitive to any component present in Posanat 100 mg Tablet or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Posanat 100 mg Tablet only if the benefits outweigh the risk. Before taking the Posanat 100 mg Tablet , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions. And also, let your doctor know before prescribing Posanat 100 mg Tablet if you have Arrhythmias and QTc Prolongation, liver problems, or low potassium, magnesium, or calcium levels in your blood.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Posanat 100 mg Tablet:
Co-administration of Posanat 100 mg Tablet with Ticagrelor can increase the risk of bleeding.

How to manage the interaction:
Taking Ticagrelor with Posanat 100 mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Posanat 100 mg Tablet:
Taking Posanat 100 mg Tablet with Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver problems and rhabdomyolysis (which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Posanat 100 mg Tablet and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by a doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Posanat 100 mg Tablet:
When Dronedarone is taken with Posanat 100 mg Tablet, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Posanat 100 mg Tablet with Dronedarone is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
PosaconazoleConivaptan
Critical
How does the drug interact with Posanat 100 mg Tablet:
When Posanat 100 mg Tablet is taken with Conivaptan, it can increase the blood levels and effects of conivaptan.

How to manage the interaction:
Although there is an interaction between Posanat 100 mg Tablet and conivaptan, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, or mood changes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Posanat 100 mg Tablet:
Taking Tolvaptan and Posanat 100 mg Tablet together results in an increase in the levels and effects of Tolvaptan.

How to manage the interaction:
Although there is an interaction between Tolvaptan and Posanat 100 mg Tablet, it can be taken if prescribed by a doctor. However, consult a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, or seizures (fits). Do not stop using any medications without a doctor's advice.
How does the drug interact with Posanat 100 mg Tablet:
Coadministration of Posanat 100 mg Tablet with eplerenone can increase the blood levels of eplerenone. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between Posanat 100 mg Tablet and eplerenone, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Posanat 100 mg Tablet:
Taking lovastatin with Posanat 100 mg Tablet can increase the levels of lovastatin in the blood which can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Lovastatin and Posanat 100 mg Tablet, they can be taken together if advised by a doctor. However, contact a doctor if you experience ever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Posanat 100 mg Tablet:
Taking atorvastatin with Posanat 100 mg Tablet can increase the blood levels of atorvastatin. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Posanat 100 mg Tablet with atorvastatin, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
PosaconazoleEliglustat
Critical
How does the drug interact with Posanat 100 mg Tablet:
Taking eliglustat with Posanat 100 mg Tablet can increase the levels of eliglustat in the blood.

How to manage the interaction:
Although there is an interaction between Posanat 100 mg Tablet and eliglustat, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, a slow heart rate, or a weak pulse. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Posanat 100 mg Tablet:
When Isavuconazole is taken with Posanat 100 mg Tablet, it can increase the levels of isavuconazole in the blood.

How to manage the interaction:
Although there is an interaction between isavuconazole and Posanat 100 mg Tablet, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take Posanat 100 mg Tablet for more than one day.
  • Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Posanat 100 mg Tablet .
  • Continue taking your normal regular diet unless your doctor prescribes a specific diet.
  • It is advisable to follow a candida diet during yeast infections. This diet excludes sugar, gluten, certain dairy products, alcohol and switches to low-sugar fruits, non-starchy vegetables, and gluten-free foods.
  • A very high sugar or high-carbohydrate diet may increase the count of Candida in some people. It is better to avoid or limit alcohol and caffeine intake during Posanat 100 mg Tablet treatment to enhance a healthy lifestyle practice.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS
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Alcohol

Consult your doctor

The interaction of Posanat 100 mg Tablet with alcohol is unknown. If you have any concerns regarding this, please discuss with your doctor.

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Pregnancy

Consult your doctor

Posanat 100 mg Tablet should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Posanat 100 mg Tablet .

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Breast Feeding

Consult your doctor

There is no substantial research yet on using Posanat 100 mg Tablet in breastfeeding/nursing mothers. Inform your doctor if you are a nursing mother before taking Posanat 100 mg Tablet ; your doctor will decide whether Posanat 100 mg Tablet can be taken by breastfeeding mothers.

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Driving

Caution

It is unknown whether Posanat 100 mg Tablet alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Consult your doctor

Inform your doctor before taking the Posanat 100 mg Tablet if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor before taking the Posanat 100 mg Tablet if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Consult your doctor

Please consult a doctor before using Posanat 100 mg Tablet for children.

Have a query?

FAQs

Posanat 100 mg Tablet is used to treat fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.

Posanat 100 mg Tablet contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in inhibiting fungal cell growth and, ultimately, cell death. Thus, it treats infections.

Posanat 100 mg Tablet is not recommended for coadministration with anticoagulants, So if you are under anticoagulant therapy, inform your doctor before prescribing Posanat 100 mg Tablet .

If you are allergic to posaconazole or similar antifungals such as fluconazole, itraconazole, ketoconazole, or voriconazole, you should not use it. When combined with certain medications, posaconazole can have unfavourable or dangerous side effects.

Like all medicines, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood, although not everybody gets them. Most of these side effects of Posanat 100 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Take Posanat 100 mg Tablet as prescribed by your doctor. You are advised to take Posanat 100 mg Tablet for as long as your doctor has prescribed it for you based on your medical condition.

Country of origin

India

Manufacturer/Marketer address

2201/2202 -B, Tharwani Heights, Plotno:4, Sector -18 , Palm Beach Road, Sanpada, Navi Mumbai-400705
Other Info - POS0115

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