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compositionComposition:ALPELISIB-250MG
prescriptionPrescription Medicine
Pivikto 200 mg/50 mg Tablet 28's

Pivikto 200 mg/50 mg Tablet is used to treat advanced or metastatic breast cancer. It contains Alpelisib. In breast cancers with a PIK3CA gene mutation, a protein called PI3K is involved in helping the cancer cells multiply and grow. By blocking the action of PI3K, Alpelisib helps stop the growth and spread of the cancer. Common side effects of this medication are rash, decreased appetite, weight loss, nausea, mouth sores, hair loss, tiredness and weakness, vomiting, allergic reactions, skin reactions, high blood sugar levels, lung problems, and diarrhoea.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ALPELISIB-250MG

Manufacturer/Marketer :

Medicines India

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pivikto 200 mg/50 mg Tablet

Pivikto 200 mg/50 mg Tablet belongs to a class of kinase inhibitors. It is used in conjunction with fulvestrant to treat postmenopausal women and men with hormone receptor (HR)-positive, HER2-negative, PIK3CA-mutated, advanced, or metastatic breast cancer.

Pivikto 200 mg/50 mg Tablet contains Alpelisib. In breast cancers with a PIK3CA gene mutation, a protein called PI3K is involved in helping the cancer cells multiply and grow. By blocking the action of PI3K, Alpelisib helps stop the growth and spread of the cancer.

To treat your condition effectually, continue using Pivikto 200 mg/50 mg Tablet for as long as your doctor has prescribed it. The most common side effects include rash, decreased appetite, weight loss, nausea, mouth sores, hair loss, tiredness and weakness, vomiting, changes in certain blood tests, allergic reactions, skin reactions, high blood sugar levels, lung problems, and diarrhea. You should talk to your doctor if you persistently experience these side effects.

Avoid taking Pivikto 200 mg/50 mg Tablet if you are allergic to it. It is not recommended for use in pregnancy. Lactating women do not breastfeed during treatment with Pivikto 200 mg/50 mg Tablet and for one week after the last dose. Alcohol should be avoided during treatment with this medicine. Safety and effectiveness in children have not been established.

Uses of Pivikto 200 mg/50 mg Tablet

Pivikto 200 mg/50 mg Tablet is used in the treatment of Advanced or metastatic breast cancer. The detailed uses of Pivikto 200 mg/50 mg Tablet are as follows:

  • Advanced or metastatic breast cancer: Pivikto 200 mg/50 mg Tablet is used for hormone receptor (HR)-positive, HER2-negative, and PIK3CA-mutated breast cancer that has progressed or spread to other parts of the body. It is typically used in combination with fulvestrant, a hormonal therapy, especially in patients who have already undergone endocrine-based treatment.
  • Targeted cancer therapy: Pivikto 200 mg/50 mg Tablet works by inhibiting the PI3K (phosphatidylinositol-3-kinase) pathway, which is often overactive in certain cancers. By blocking this pathway, it helps slow down or stop the growth of cancer cells.

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Directions for Use

  • Take Pivikto 200 mg/50 mg Tablet with meals, as it helps with absorption and reducing stomach upset.
  • Pivikto 200 mg/50 mg Tablet is usually taken once daily at the same time. However, follow the recommended dose and timing as directed by your doctor for optimal results.
  • Swallow the tablet as a whole with water.
  • Do not crush, chew or break it.

Key Benefits

Pivikto 200 mg/50 mg Tablet contains Alpelisib, which belongs to a class of kinase inhibitors. It is used in conjunction with fulvestrant to treat postmenopausal women and men with hormone receptor (HR)-positive, HER2-negative, PIK3CA-mutated, advanced, or metastatic breast cancer. In breast cancers with a PIK3CA gene mutation, a protein called PI3K is involved in helping the cancer cells multiply and grow. By blocking the action of PI3K, Alpelisib helps stop the growth and spread of the cancer.

How Pivikto 200 mg/50 mg Tablet Works

Pivikto 200 mg/50 mg Tablet contains Alpelisib. In breast cancers with a PIK3CA gene mutation, a protein called PI3K is involved in helping the cancer cells multiply and grow. By blocking the action of PI3K, Alpelisib helps stop the growth and spread of the cancer.

Storage

Store in a cool and dry place away from sunlight
Side effects of Pivikto 200 mg/50 mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Inflammation in the lungs needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Intake of cod liver oil can smoothen the functioning of the body process.
  • Rest and refrain from physical activity, and restart after a few days.
  • Avoid smoking as it can worsen the swelling.
  • Practice meditation and yoga to enhance lung efficiency gradually after consulting with your doctor.

What if I have taken an overdose of Pivikto 200 mg/50 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Pivikto 200 mg/50 mg Tablet may include nausea, lack of energy, rash, increased thirst and appetite, dry mouth, and urinating more often or more significant amounts. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

It is not advised during pregnancy, nursing, or for children or young adults under 18. Before taking the Pivikto 200 mg/50 mg Tablet , inform your doctor about all your medical conditions (especially lung infections, diarrhoea, diabetics, kidney or liver impairment), sensitivities or allergic conditions, and all medications you use. Consult your doctor right away if you become pregnant while taking Pivikto 200 mg/50 mg Tablet . Exposure of an unborn child to this medication could cause congenital disabilities, so you should not become pregnant or father a child while on this medication. Effective birth control is required throughout treatment and at least one week after treatment. You should not breastfeed while taking this medication for two weeks after your last dose.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

[KINASE INHIBITORS]

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Alcohol

Caution

Avoid alcohol consumption while on treatment with Pivikto 200 mg/50 mg Tablet .

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Pregnancy

Unsafe

Pivikto 200 mg/50 mg Tablet should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Caution

Lactating women should not breastfeed throughout Pivikto 200 mg/50 mg Tablet treatment and for one week following the final dosage.

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Driving

Caution

Pivikto 200 mg/50 mg Tablet does not influence the ability to drive or use machines. However, go only if you are alert, as the Pivikto 200 mg/50 mg Tablet may cause weakness or tiredness in some people.

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Liver

Caution

Limited information is available. Inform your doctor before taking the Pivikto 200 mg/50 mg Tablet if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

No dose adjustment is recommended for patients with mild to moderate renal impairment (CLcr 30 to < 90 mL/min). The effect of severe renal impairment (CLcr < 30 mL/min) on alpelisib is unknown. So, inform your doctor before taking the Pivikto 200 mg/50 mg Tablet if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

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Heart

Take Pivikto 200 mg/50 mg Tablet with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Caution

Pivikto 200 mg/50 mg Tablet should be used with caution in elderly patients. Please consult your doctor before use.

FAQs

Pivikto 200 mg/50 mg Tablet is used to treat Advanced or metastatic breast cancer.

Pivikto 200 mg/50 mg Tablet contains Alpelisib. In breast cancers with a PIK3CA gene mutation, a protein called PI3K is involved in helping the cancer cells multiply and grow. By blocking the action of PI3K, Alpelisib helps stop the growth and spread of the cancer.

Hyperglycemia is common with Pivikto 200 mg/50 mg Tablet and can be severe. Your healthcare provider will monitor your blood sugar levels before you start and during treatment with Pivikto 200 mg/50 mg Tablet . Your healthcare provider may monitor your blood sugar levels more often if you have a history of Type 2 diabetes. Tell your healthcare provider right away if you develop symptoms of hyperglycemia, including excessive thirst, dry mouth, more frequent urination than usual or a higher amount of urine than normal and increased appetite with weight loss.

It is critical to understand that Alpelisib is not a traditional chemotherapy drug and functions in a different manner. It works by specifically targeting cancer cells and preventing their growth and spread.

While taking Pivikto 200 mg/50 mg Tablet , make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Pivikto 200 mg/50 mg Tablet .

Based on findings from animal studies, Pivikto 200 mg/50 mg Tablet may impair fertility in males and females of reproductive potential. Discuss the risks of taking this medication with your doctor.

Country of origin

Switzerland
Other Info - PIV0020

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