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compositionComposition:PIRFENIDONE-200MG
prescription
Prescription Medicine
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Pirfenex 200 mg Table is used to treat idiopathic pulmonary fibrosis (lung disease). It contains Pirfenidone, which helps reduce the scarring and swelling in the lungs. In some cases, this medicine may cause side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, and headache. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PIRFENIDONE-200MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pirfenex 200 mg Table

Pirfenex 200 mg Table is a prescription medication used to treat a specific, progressive lung condition known as idiopathic pulmonary fibrosis (IPF). This condition causes the deep tissues of your lungs to become thick, stiff, and scarred over time, making it increasingly difficult to breathe. By targeting this scarring process, Pirfenex 200 mg Table helps to preserve your remaining lung function and manage how quickly the disease progresses.


For Pirfenex 200 mg Table to work effectively, you must take it consistently every day exactly as your doctor prescribes. It is highly recommended to take this medication with food, as this simple step significantly reduces stomach-related side effects like nausea or indigestion. Making specific lifestyle adjustments, such as protecting your skin from the sun and staying well-hydrated, can also greatly improve your comfort during treatment.


While taking Pirfenex 200 mg Table , you may experience some mild, common side effects such as nausea, skin rashes, fatigue, or a decreased appetite. However, it is vital to consult your doctor immediately if you experience signs of liver damage, which is a serious but recognised risk. These signs include yellowing of your skin or eyes, unusually dark urine, pale stools, or severe pain in your upper abdomen.


Before you begin taking Pirfenex 200 mg Table , you must discuss your complete medical history with your doctor, especially if you have a history of liver or kidney problems. Do not take this medication if you have severe liver disease or end-stage kidney disease, as your body will not be able to process and eliminate the medicine safely.


You must avoid smoking while taking Pirfenex 200 mg Table because tobacco smoke causes your body to break down the medicine much faster, making it far less effective. Additionally, let your healthcare provider know if you are taking other medications or if you are pregnant, breastfeeding, or an older adult, so they can ensure this treatment is safe for your specific situation.

Uses of Pirfenex 200 mg Table

Pirfenex 200 mg Table is used to slow the progression of idiopathic pulmonary fibrosis in adults. Its main use includes:

  • Idiopathic pulmonary fibrosis (IPF): Helps slow the progression of lung scarring and the decline in lung function. This may help preserve lung function for longer, but Pirfenex 200 mg Table does not cure IPF or reverse lung scarring that has already occurred.

Key Benefits

Pirfenex 200 mg Table helps slow the progression of idiopathic pulmonary fibrosis (IPF) and supports the preservation of lung function. Pirfenex 200 mg Table does not cure IPF or reverse lung scarring that has already occurred. The response to treatment varies between individuals, and regular monitoring is needed to assess how well the treatment is working. Its main benefits include:

  • Slows the progression of lung scarring: Helps reduce the processes involved in fibrosis (the formation of scar tissue), slowing further scarring in the lungs.
  • Helps preserve lung function: Slows the decline in how well the lungs work, which may help maintain breathing capacity for longer.
  • Supports long-term management of IPF: Regular treatment may help slow disease progression when taken consistently as prescribed.
  • May reduce the risk of sudden worsening: Treatment may help lower the risk of acute exacerbations (sudden episodes of worsening symptoms) in some people with IPF.
Side effects of Pirfenex 200 mg Table
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • Pirfenex 200 mg Table should be taken with food, or as advised by the doctor.
  • It is usually taken three times a day or as directed by the doctor.
  • Swallow Pirfenex 200 mg Table as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Pirfenex 200 mg Table Works

Pirfenex 200 mg Table contains pirfenidone, an antifibrotic medicine (a medicine that helps slow the formation of scar tissue). In idiopathic pulmonary fibrosis (IPF), ongoing processes in the lungs cause excessive scar tissue to form. This makes the lung tissue thicker and stiffer, reducing its ability to expand and transfer oxygen effectively. Pirfenidone reduces the activity of certain substances involved in fibrosis and inflammation. This helps slow the formation and build-up of scar tissue in the lungs. By slowing further lung scarring, Pirfenex 200 mg Table helps reduce the rate at which lung function declines. However, it does not remove existing scar tissue or cure IPF.
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Alcohol

Caution

It is not known if alcohol interacts with Pirfenex 200 mg Table . However, avoid consumption of alcohol while taking Pirfenex 200 mg Table as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Pirfenex 200 mg Table can be taken by breastfeeding mothers or not.

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Driving

Caution

Pirfenex 200 mg Table might cause dizziness and tiredness. Drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this. Pirfenex 200 mg Table is not recommended for patients with severe hepatic impairment.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns. Pirfenex 200 mg Table is not recommended for patients with an end-stage renal disease requiring dialysis.

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Children

Unsafe

Pirfenex 200 mg Table is not recommended for children below 18years as the safety and effectiveness has not been established.

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Heart

Caution

Pirfenex 200 mg Table should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Pirfenex 200 mg Table .

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Geriatrics

Caution

Pirfenex 200 mg Table should be used with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Pirfenex 200 mg Table .

What if I have taken an overdose of Pirfenex 200 mg Table

If you take more than your prescribed dose of Pirfenex 200 mg Table , seek immediate emergency medical attention. An overdose may lead to severe stomach pain, vomiting, or extreme dizziness.

Diet & Lifestyle Advise

  • Quit all smoking and tobacco use: Tobacco smoke drastically reduces the amount of Pirfenex 200 mg Table in your body, making the drug much less effective. Speak to your doctor if you need resources to help you quit.
  • Practise strict sun protection: This medication increases your skin's sensitivity to ultraviolet (UV) light. Always apply a broad-spectrum sunscreen with an SPF of 50 or higher, wear tightly woven long-sleeved clothing, wide-brimmed hats, and sunglasses when outdoors, and avoid tanning beds entirely.
  • Eat smaller, frequent meals: If you experience nausea or a loss of appetite, eating five or six small meals throughout the day rather than three large ones can keep your stomach settled.
  • Stay hydrated: Drink plenty of water throughout the day, especially if you experience mild diarrhoea, to keep your body properly hydrated.
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Have a query?

How Soon It Starts Working

The time required for Pirfenex 200 mg Table to start to work: Pirfenex 200 mg Table ideally shows its action within 30 minutes to 4 hours after administration. The time for which the effects of Pirfenex 200 mg Table last: The duration of action for Pirfenex 200 mg Table is clinically unknown.

What if you forget to take Pirfenex 200 mg Table

If you miss a dose of Pirfenex 200 mg Table , take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose entirely and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. If you stop taking Pirfenex 200 mg Table for 14 consecutive days or more, do not restart it on your own; contact your doctor or pharmacist immediately for instructions on how to safely restart your therapy.

Storage

• Store Pirfenex 200 mg Table at room temperature, ideally between 68°F and 77°F (20°C and 25°C). • Keep the medication in its original container to protect it from direct light and moisture.

Drug Warnings

  • Keep all blood test appointments: Your doctor will order regular blood tests to check your liver function before you start Pirfenex 200 mg Table , and monthly for the first several months to monitor for potential liver damage.
  • Always take with food: Never take this medication on an empty stomach, as food is crucial for preventing severe nausea and stomach pain.
  • Monitor your skin daily: Check your skin regularly for any new rashes, redness, or blisters, especially after you have been outdoors.
  • Inform all healthcare providers: Always tell any doctor, dentist, or pharmacist you visit that you are taking Pirfenex 200 mg Table before you begin any new prescription, over-the-counter medicine, or herbal supplement.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Pirfenex 200 mg Table and require closer monitoring or dose adjustments:

  • Fluvoxamine and other CYP1A2 inhibitors: Taking these medications with Pirfenex 200 mg Table can significantly increase the levels of the medicine in your body, greatly raising your risk of severe side effects.
  • Ciprofloxacin: This common antibiotic can raise the levels of Pirfenex 200 mg Table in your blood; your doctor may need to adjust your dose if you must take them together.
    Rifampin and other CYP1A2 inducers: These drugs can drastically lower the amount of Pirfenex 200 mg Table in your system, making your treatment much less effective.
PirfenidonePhenobarbital
Critical
PirfenidonePrimidone
Critical

Drug-Drug Interactions

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PirfenidonePhenobarbital
Critical
How does the drug interact with Pirfenex 200 mg Table:
When Pirfenex 200 mg Table is taken with Phenobarbital, it can decrease the effects of Pirfenex 200 mg Table.

How to manage the interaction:
Taking Pirfenex 200 mg Table with Phenobarbital is not recommended but can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
PirfenidonePrimidone
Critical
How does the drug interact with Pirfenex 200 mg Table:
Coadministration of Pirfenex 200 mg Table with primidone can reduce levels and the effects of Pirfenex 200 mg Table.

How to manage the interaction:
Although there is an interaction between Pirfenex 200 mg Table and primidone, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneRifampicin
Critical
How does the drug interact with Pirfenex 200 mg Table:
Taking Pirfenex 200 mg Table with rifampicin can reduce the levels and effects of Pirfenex 200 mg Table

How to manage the interaction:
Although there is an interaction between Pirfenex 200 mg Table and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneCarbamazepine
Critical
How does the drug interact with Pirfenex 200 mg Table:
Taking Pirfenex 200 mg Table with Carbamazepine it reduces the levels and effects of Pirfenex 200 mg Table.

How to manage the interaction:
Taking Pirfenex 200 mg Table with Carbamazepine is not recommended but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
PirfenidoneAminolevulinic acid
Severe
How does the drug interact with Pirfenex 200 mg Table:
Co-administration of Aminolevulinic acid and Pirfenex 200 mg Table may increase the risk of skin burn.

How to manage the interaction:
There may be a possibility of interaction between Pirfenex 200 mg Table and Aminolevulinic acid, but it can be taken if prescribed by a doctor. Avoid exposure of the eyes and skin to sunlight or bright indoor lights for 48 hours after treatment. Do not discontinue any medications without consulting a doctor.
PirfenidoneFluvoxamine
Severe
How does the drug interact with Pirfenex 200 mg Table:
When Pirfenex 200 mg Table is taken with Fluvoxamine, it can increase the risk of side effects.

How to manage the interaction:
Taking Pirfenex 200 mg Table with Fluvoxamine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneKetoconazole
Severe
How does the drug interact with Pirfenex 200 mg Table:
Coadministration of Ketoconazole and Pirfenex 200 mg Table may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Pirfenex 200 mg Table together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
PirfenidoneLeflunomide
Severe
How does the drug interact with Pirfenex 200 mg Table:
Taking Leflunomide with Pirfenex 200 mg Table may increase the risk of liver damage.

How to manage the interaction:
Co-administration of Pirfenex 200 mg Table with Leflunomide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
PirfenidoneLomitapide
Severe
How does the drug interact with Pirfenex 200 mg Table:
Taking Lomitapide with Pirfenex 200 mg Table may increase the risk of liver damage

How to manage the interaction:
There may be a possibility of interaction between Pirfenex 200 mg Table and Lomitapide, but it can be taken if prescribed by a doctor. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
PirfenidoneRucaparib
Severe
How does the drug interact with Pirfenex 200 mg Table:
Taking Pirfenex 200 mg Table with Rucaparib can increase the risk or severity of its side effects such as liver disease or gastric problems.

How to manage the interaction:
Co-administration of Pirfenex 200 mg Table with Rucaparib can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately.

Drug-Food Interactions

verifiedApollotooltip

Certain foods or drinks may affect the safety or tolerability of Pirfenex 200 mg Table . Important interactions include:

  • Grapefruit and grapefruit juice: Grapefruit products can interfere with how your liver breaks down Pirfenex 200 mg Table , potentially leading to increased and more severe side effects. Avoid consuming grapefruit while taking this medicine.
PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grape fruit and its products while using Pirfenex 200 mg Table can increase the risk of side effects. Avoid grape fruit and its products during treatment with Pirfenex 200 mg Table.

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FAQs

No. Do not stop taking Pirfenex 200 mg Table without consulting your doctor, even if your breathing improves or your disease appears stable. Pirfenex 200 mg Table is a long-term treatment that helps slow the progression of idiopathic pulmonary fibrosis (IPF) but does not cure it or reverse existing lung scarring. Stopping treatment may allow the disease to progress more quickly. Continue taking the medicine exactly as prescribed and speak with your doctor before making any changes.
You should always take Pirfenex 200 mg Table with food or a meal. Taking it with food slows its absorption and helps reduce common side effects such as nausea, stomach pain, dizziness, and stomach discomfort. Swallow the tablet or capsule whole with a glass of water unless your doctor advises otherwise. If you have difficulty eating because of nausea, talk to your doctor or pharmacist.
It is highly recommended to avoid or limit alcohol while taking Pirfenex 200 mg Table . Both alcohol and this medication are processed by your liver, and combining them can significantly increase your risk of liver damage. Talk to your doctor about your alcohol consumption habits.
If you develop a sun-related skin rash, redness, or blistering, stay out of the sun immediately and contact your doctor. They may need to adjust your dose or temporarily pause your treatment to allow your skin to heal. Talk to your doctor before going back into the sun.
No, Pirfenex 200 mg Table does not cure idiopathic pulmonary fibrosis and cannot reverse any lung scarring that has already occurred. Its clinical purpose is to slow down the rate of new scar tissue formation, helping you preserve your remaining lung function. Talk to your doctor to understand your long-term treatment goals.
If you stop taking Pirfenex 200 mg Table for 14 days or longer, you must not restart at your full previous dose. Your body will need to go through the process of a gradually increasing dose again to prevent severe side effects. Talk to your doctor or pharmacist immediately for instructions on how to safely resume.
The safety of Pirfenex 200 mg Table during pregnancy and breastfeeding has not been fully established. If you are pregnant, planning to become pregnant, or breastfeeding, you must discuss the potential risks and benefits with your healthcare provider. Talk to your doctor to discuss safe alternative options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.3705 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 208780S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Pirfenidone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Pipirfenidone - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. National Health Service (NHS). Pirfenidone Patient Information - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  6. Pirefenidone Pirefenidone. 2014. [Accessed on 01 Apr. 2019]Check here
  7. Esbriet 267 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. [Accessed on 18 December 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - PIR0134
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