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  3. Piotone-15 Tablet 10's

Piotone-15 Tablet 10's, Pack of 10 TabletS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Piotone-15 Tablet 10's is used to treat type 2 (non-insulin-dependent) diabetes mellitus. It contains Pioglitazone, which helps control the sugar level in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces. It may cause common side effects such as upper respiratory tract infection, headache, sinusitis, myalgia (muscle pain), and pharyngitis. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

PIOGLITAZONE-15MG

Manufacturer/Marketer :

Zenico Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Piotone-15 Tablet 10's

Piotone-15 Tablet 10's is an anti-diabetic medicine used to treat type 2 diabetes mellitus. Type 2 diabetes is an illness where the body doesn't make enough insulin, or the insulin that it makes doesn't work properly. This is diabetes that usually develops in adulthood.

Piotone-15 Tablet 10's contains pioglitazone, which helps control the sugar level in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces.

The most common side effects of Piotone-15 Tablet 10's are upper respiratory tract infection, headache, sinusitis, myalgia (muscle pain), and pharyngitis. Most of these side effects of Piotone-15 Tablet 10's do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Piotone-15 Tablet 10's should not be stopped even if you feel better without consulting your doctor. Please inform your doctor if you have any heart disease, are or are planning to get pregnant or are breastfeeding. The safety and efficacy of Piotone-15 Tablet 10's in children under 18 years have not been established, so it should not be given to them.

Uses of Piotone-15 Tablet 10's

Piotone-15 Tablet 10's is used in the treatment of Type 2 diabetes mellitus. The detailed uses of Piotone-15 Tablet 10's are as follows:

  • Type 2 Diabetes Mellitus: Piotone-15 Tablet 10's helps control blood sugar levels when diet, exercise, and other medications aren’t enough.
  • Insulin Resistance: Piotone-15 Tablet 10's enhances the body’s response to insulin, reducing insulin resistance in muscle, fat, and liver cells.

Directions for Use

  • Take Piotone-15 Tablet 10's with or without food as advised by your doctor.
  • It is advised to take Piotone-15 Tablet 10's once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Piotone-15 Tablet 10's as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Piotone-15 Tablet 10's is an antidiabetic drug (thiazolidinedione/glitazones) used along with a proper diet and exercise to control high blood sugar (hyperglycaemia) in patients with type 2 diabetes.
  • Piotone-15 Tablet 10's works by helping to restore your body's appropriate response to insulin, thereby lowering your blood sugar.

How Piotone-15 Tablet 10's Works

Piotone-15 Tablet 10's contains Pioglitazone, which helps control the sugar level in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Piotone-15 Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Eat fiber-rich foods, fruits, and vegetables, and track your food intake to monitor calorie consumption.
  • Limit takeout and restaurant meals, and weigh yourself weekly to stay motivated.
  • Build balanced meals, allow yourself to enjoy treats in moderation, and prioritize sleep and stress management through exercise and relaxation techniques.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Take care of change in your weight as there can be sudden changes.
  • Rest and refrain from physical activity, and restart after a few days.
  • Reduce your salt intake and control your diet with the help of a dietician.
  • Track your symptoms and keep your follow-up appointments to manage severe side effects.
  • Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Take care of change in your weight as there can be sudden changes.
  • Rest and refrain from physical activity, and restart after a few days.
  • Reduce your salt intake and control your diet with the help of a dietician.
  • Track your symptoms and keep your follow-up appointments to manage severe side effects.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

What if I have taken an overdose of Piotone-15 Tablet 10's

Do not take more than the prescribed dose of Piotone-15 Tablet 10's as it may cause overdose resulting in low blood sugar. The symptoms include sweating, tremors, stomach pain, extreme weakness, blurred vision, trouble speaking, seizures (fits) and confusion. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Fluid retention (oedema) may occur and can lead to congestive heart failure so, a combination of use with insulin and use in heart failure may increase the risk in patients taking Piotone-15 Tablet 10's.
  • You should not take Piotone-15 Tablet 10's if you have kidney disease, as measured by a blood test.
  • Piotone-15 Tablet 10's, when used with or without insulin, Piotone-15 Tablet 10's tends to lower the blood sugar level. So, the doctor may lower the dose of insulin.
  • Increased fractures may be reported in some women taking Piotone-15 Tablet 10's.
  • Patients with bladder cancer and macular oedema (fluid build-up in the macula part of the retina of the eye) should consult the doctor before using Piotone-15 Tablet 10's.
  • Before the doctor prescribes this medicine, it is always better that your physician knows about any underlying conditions like kidney or liver disease, prior heart attack, alcohol intake, etc.
  • Avoid drinking alcohol while on this drug as it increases the risk of hypoglycaemia (a decrease in blood sugar, which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).
  • Try to quit smoking and reduce your intake of carbohydrate-rich foods like potatoes, rice, mangoes, bread, sugar, etc.
  • Take short, frequent meals, and avoid prolonged fasting when taking this drug.
  • Beware of symptoms of hypoglycaemia, which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc.
  • Whenever you experience the symptoms mentioned above, immediately consume 5-6 candies, three glucose biscuits, or three teaspoons of honey/sugar and get in touch with your physician. Make sure to carry these with you at all times, especially for long travels. 

Drug-Drug Interactions

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PioglitazoneGatifloxacin
Critical
PioglitazoneTeriflunomide
Severe

Drug-Drug Interactions

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PioglitazoneGatifloxacin
Critical
How does the drug interact with Piotone-15 Tablet:
Co-administration of Piotone-15 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Piotone-15 Tablet can be taken with Gatifloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, excessive sweating, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue any medications without a doctor's advice.
PioglitazoneTeriflunomide
Severe
How does the drug interact with Piotone-15 Tablet:
Co-administration of Teriflunomide and Piotone-15 Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Piotone-15 Tablet and Teriflunomide together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
PioglitazoneLomitapide
Severe
How does the drug interact with Piotone-15 Tablet:
Co-administration of Piotone-15 Tablet and Lomitapide may increase the risk of liver damage.

How to manage the interaction:
Although taking Lomitapide and Piotone-15 Tablet together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
PioglitazoneKetoconazole
Severe
How does the drug interact with Piotone-15 Tablet:
Co-administration of Ketoconazole and Piotone-15 Tablet, can increase the risk of side effects.

How to manage the interaction:
Taking Ketoconazole with Piotone-15 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, consult the doctor, if you experience any unusual symptoms. Do not discontinue any medications without a doctor's advice.
PioglitazoneGemfibrozil
Severe
How does the drug interact with Piotone-15 Tablet:
When Piotone-15 Tablet is taken with Gemfibrozil, the level of Piotone-15 Tablet in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Piotone-15 Tablet with Gemfibrozil together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience visual abnormalities, excessive or quick weight gain, swelling in the ankles or legs, trouble breathing, unusual fatigue, chest discomfort or tightness, fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, light coloured stools, or yellowing of the skin or eyes, seek medical attention immediately. Do not discontinue any medications without consulting a doctor.
PioglitazoneMipomersen
Severe
How does the drug interact with Piotone-15 Tablet:
Co-administration of Mipomersen and Piotone-15 Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Piotone-15 Tablet and Mipomersen together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
PioglitazoneClopidogrel
Severe
How does the drug interact with Piotone-15 Tablet:
Taking Piotone-15 Tablet with Clopidogrel can increases the blood levels of Piotone-15 Tablet, when these medicines are taken together, you may experience hypoglycemia (low blood sugar).

How to manage the interaction:
Taking Clopidogrel together with Piotone-15 Tablet may lead to interaction, but it can be taken if prescribed by your doctor. Consult a doctor immediately if you experience headache, dizziness, drowsiness, nervousness, weakness, shaking, or sweating. Do not discontinue any medication without consulting the doctor.
PioglitazoneLeflunomide
Severe
How does the drug interact with Piotone-15 Tablet:
Co-administration of Piotone-15 Tablet and Leflunomide may increase the risk of liver damage.

How to manage the interaction:
Although taking Piotone-15 Tablet and Leflunomide together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grains.
  • Eat at regular intervals. Do not take a long gap between meals or snacks.
  • Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
  • Invest at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrate-containing foods with whole grain foods and increase intake of fruits and veggies and other fibre-enriched foods.
  • Reduce intake of saturated fat (or hidden fats) in foods like chips, crisps, pastries, biscuits and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques, such as mindfulness, yoga, or meditation, to help control stress related to blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk and cheese, etc.).
  • Keep your blood pressure as normal (120/80) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Piotone-15 Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Piotone-15 Tablet 10's to avoid unpleasant side-effects.

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Pregnancy

Unsafe

Piotone-15 Tablet 10's is not generally recommended in pregnancy. It's not clear whether pioglitazone can harm your unborn baby. It is highly recommended to consult your doctor before taking this drug in case you are pregnant.

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Breast Feeding

Consult your doctor

It is highly recommended to consult your doctor before taking Piotone-15 Tablet 10's.

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Driving

Caution

Piotone-15 Tablet 10's will not affect your ability to drive or use machines but take care if you experience abnormal vision.

bannner image

Liver

Caution

Piotone-15 Tablet 10's to be taken with caution, especially if you have a history of liver diseases/conditions.

bannner image

Kidney

Caution

Piotone-15 Tablet 10's to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Children

Unsafe

The safety and efficacy of Piotone-15 Tablet 10's in children have not been established. Piotone-15 Tablet 10's is not recommended in children.

Have a query?

FAQs

Piotone-15 Tablet 10's is used to treat type 2 (non-insulin-dependent) diabetes mellitus. It helps control the sugar level in your blood by helping your body make better use of the insulin it produces.

Type-2 diabetes generally does not affect healthy children and teens, but it may affect children who are obese, which is also known as Childhood Obesity.

Hypoglycemia refers to low blood sugar levels, and it is one of the side effects of Piotone-15 Tablet 10's. Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with this medicine. It is important to monitor blood sugar levels regularly.

If you have symptoms like increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sores healing, and frequent infections, contact doctor as it can be a condition of type 2 diabetes.

In case you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.

If you have or have ever had urinary bladder cancer, diabetic eye disease (retinopathy), or kidney or liver disease, avoid use of Piotone-15 Tablet 10's. If it is urgent consult with the doctor.

Swallow the tablet whole with a drink of water. Do not chew it. Piotone-15 Tablet 10's can be taken with or without food.

The safety and efficacy of Piotone-15 Tablet 10's in children under 18 years have not been established, so it should not be given to them.

Piotone-15 Tablet 10's contains Pioglitazone, which helps control the sugar level in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces.

The most common side effects of Piotone-15 Tablet 10's are upper respiratory tract infection, headache, sinusitis, myalgia (muscle pain), and pharyngitis. Most of these side effects of Piotone-15 Tablet 10's do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

You can take Piotone-15 Tablet 10's at any time with or without food, for example, in the morning or the evening. Try to take it at the same time every day.

Some people increase body fat after using pioglitazone. This can make them gain weight. To avoid gaining too much weight, try to eat a healthy balanced diet while keeping your portion sizes consistent. Regular exercise will also help to maintain your weight.

Pioglitazone-induced heart failure is known in patients with underlying heart disease but is not well documented in patients with normal. Please discuss with your doctor if you have underlying heart disease before taking Piotone-15 Tablet 10's.

Yes, Piotone-15 Tablet 10's and metformin combination is used with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes.

You can take Piotone-15 Tablet 10's at any time with or without food, for example, in the morning or the evening. Try to take it at the same time every day.

Piotone-15 Tablet 10's is used to treat diabetes. Diabetes therapy is usually lifelong. Do not discontinue taking pioglitazone without consulting your doctor. If you stop taking pioglitazone suddenly, your blood sugar levels can drop. If you want to discontinue taking your medication, consult your doctor. They may be able to recommend an alternative treatment for your diabetes.

Patients should avoid self-discontinuing diabetes medication when symptoms improve because symptoms may not reflect the actual condition. Doing so is very dangerous, not controlling blood sugar and making complications appear early. However, a person can stop using this drug safely if they can effectively manage their Type 2 diabetes mellitus (T2DM) through sustainable lifestyle changes. Please discuss this with your doctor for personalized guidance.

Piotone-15 Tablet 10's is usually safe to take for a long time. Your doctor will give you regular tests to check whether it's OK for you to continue taking it.

Piotone-15 Tablet 10's to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor. So, let your doctor know about your medical condition.

Piotone-15 Tablet 10's is an anti-diabetic medicine belonging to the class of thiazolidinedione (TZD), also called glitazones, used to treat type 2 (non-insulin-dependent) diabetes mellitus.

Pioglitazone, a thiazolidinedione, improves glycemic control in type 2 diabetics by enhancing peripheral insulin sensitivity, whereas metformin, a biguanide, works mostly by lowering hepatic glucose production.

Pioglitazone may raise bladder cancer risk in a dose- and time-dependent way, according to current research. Patients with long-term and high-dose pioglitazone exposure should be frequently examined for bladder cancer.

Piotone-15 Tablet 10's may be used alone or with other medicines, such as insulin, metformin, or sulfonylurea agents. Before using Piotone-15 Tablet 10's along with other medications, check with your doctor. The doctor will check for potential interactions and guide you through the process of taking them if necessary.

To avoid potential interactions and minimise side effects, before using this medication, you should inform your doctor about your medical history, including any ongoing medicines.

Pioglitazone is not suggested during pregnancy because there is limited information on its safety. If you are pregnant or planning to become pregnant, consult your doctor, as they will need to reassess your treatment. They will be able to recommend a different prescription that is safe for you to take throughout pregnancy.

Store in a cool and dry place away from sunlight. Keep out of sight and reach of children.

Country of origin

India

Manufacturer/Marketer address

Shanti Dham Apartment, Shree Aarti, 19A, Shanti Gardens Rd, Co Operative Housing Society, Mira Road East, Mira Bhayandar, Maharashtra 401107
Other Info - PIO0335

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 15, 2025 | 12:55 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.nhs.uk/medicines/pioglitazone/
  2. https://www.medicines.org.uk/emc/files/pil.4731.pdf
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