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compositionComposition:SODIUM PICOSULFATE-5MG/5ML
prescription
Prescription Medicine
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Picorag 50mg Syrup is used to treat constipation associated with piles, anal fissures, hernia, cardiovascular disorders, endoscopy, bowel clearance before radioscopy, pre/post-operative conditions, elderly and bedridden patients. It helps prevent the absorption of water in the colon and intestine, thus relieving constipation.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SODIUM PICOSULFATE-5MG/5ML

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Picorag 50mg Syrup

Picorag 50mg Syrup is an oral medicine primarily used to treat short-term constipation and to empty the bowels before certain medical procedures or surgeries. It works by stimulating the muscles of your intestines, helping to produce a bowel movement. This medicine is typically used when temporary digestive blockages or irregularities occur.

You should take this medicine exactly as recommended by your healthcare provider, usually as a single dose taken at bedtime. It can be taken with or without food, making it highly convenient for daily schedules. To support the action of this medicine, it is highly beneficial to make simple dietary changes, such as drinking more water and eating fibre-rich foods.

While taking Picorag 50mg Syrup, you may experience mild and temporary side effects, such as mild stomach cramps or diarrhoea. However, if you experience severe symptoms like extreme dizziness, persistent vomiting, or severe abdominal pain, you must stop taking the medicine and consult your doctor immediately.

Do not take this if you have a known blockage in your bowels, severe dehydration, or sudden, severe abdominal pain that has not been diagnosed. It is also important to talk to your doctor before starting this medicine if you have inflammatory bowel disease, kidney issues, or heart conditions.

This medicine can interact with other drugs, especially water tablets (diuretics) and steroids, which can lower your body's potassium levels. Always consult your doctor or pharmacist if you are pregnant, breastfeeding, or managing health conditions in the elderly before starting Picorag 50mg Syrup.

Uses of Picorag 50mg Syrup

Picorag 50mg Syrup is used to short-term constipation and to empty the bowels before certain medical procedures or surgeries. The detailed uses of Picorag 50mg Syrup are as follows:

  • Constipation: Picorag 50mg Syrup helps treat occasional constipation by speeding up the movement of stool through the digestive tract, ensuring comfortable relief.
  • Bowel preparation: Picorag 50mg Syrup helps thoroughly empty the bowels before medical examinations, X-rays, or surgeries, ensuring clear and accurate clinical results.
     

Key Benefits

Picorag 50mg Syrup helps provide effective relief from constipation by promoting regular bowel movements and improving overall digestive comfort. By supporting natural bowel function, it helps reduce discomfort associated with infrequent or difficult stools.

  • Helps Relieve Constipation: By stimulating bowel movements, Picorag 50mg Syrup helps provide predictable relief from constipation, supporting easier and more regular passage of stools.
  • Reduces Abdominal Discomfort: As bowel function improves, Picorag 50mg Syrup helps relieve symptoms such as bloating, abdominal fullness, hard stools, and straining during bowel movements, promoting greater digestive comfort.
  • Supports Flexible and Convenient Dosing: Available in an easy-to-administer liquid formulation, Picorag 50mg Syrup allows dose adjustments under medical guidance, helping tailor treatment to individual needs while supporting effective constipation management.
     

Directions for Use

  • Picorag 50mg Syrup can be taken with or without food.
  • It is usually taken once daily at bedtime or prescribed by your doctor.
  • Swallow Picorag 50mg Syrup as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Picorag 50mg Syrup Works

Picorag 50mg Syrup contains sodium picosulfate, which is a stimulant laxative that remains inactive until it reaches the large intestine. There, natural bacteria in the colon convert it into its active form. The active form stimulates the nerve endings in the bowel wall, encouraging the muscles of the colon to contract and move stool through the intestine more effectively. It also has a modest effect on increasing the amount of water retained in the bowel, which helps soften the stool and makes it easier to pass. If Picorag 50mg Syrup is a combination product containing additional active ingredients, those ingredients may contribute further to its overall laxative effect.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Picorag 50mg Syrup. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Consult your doctor

Please consult your doctor before taking Picorag 50mg Syrup if you are pregnant or planning to become pregnant. Your doctor will prescribe you Picorag 50mg Syrup if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Picorag 50mg Syrup if you are breastfeeding. Your doctor will decide if Picorag 50mg Syrup can be taken by breastfeeding mothers or not.

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Driving

Safe if prescribed

Picorag 50mg Syrup has negligible influence on your ability to drive.

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Liver

Consult your doctor

Please inform your doctor before taking Picorag 50mg Syrup if you have liver impairment/liver disease. Picorag 50mg Syrup may not be recommended in case of acute liver failure.

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Kidney

Consult your doctor

Please inform your doctor before taking Picorag 50mg Syrup if you have kidney impairment/kidney disease.

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Children

Unsafe

Picorag 50mg Syrup should not be given to children under 10 years old, as its safety and effectiveness have not been established.

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Heart

Consult your doctor

Picorag 50mg Syrup is not recommended for use in patients with cardiovascular disease due to its cardiovascular effects.

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Geriatrics

Caution

Picorag 50mg Syrup should be taken with caution in geriatric patients. Please inform your doctor before using Picorag 50mg Syrup.

What if I have taken an overdose of Picorag 50mg Syrup

If you take more than the recommended dose of Picorag 50mg Syrup, you may experience severe diarrhoea, intense stomach cramps, and significant fluid loss. In case of an accidental overdose, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Drink at least 8 to 10 glasses of water daily to help soften your stool and prevent dehydration while using laxatives.
  • Gradually increase your intake of dietary fibre by eating more fruits, vegetables, whole grains, and beans.
  • Engage in moderate physical activity, such as a daily 30-minute walk, to naturally stimulate bowel contractions.
  • Do not ignore the natural urge to have a bowel movement; delaying it can worsen constipation over time.
     
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How Soon It Starts Working

  • The time required for Picorag 50mg Syrup to start to work: The time required for Picorag 50mg Syrup to start to work is 6 to 8 hours of administration.
  • The time for which the effects of Picorag 50mg Syrup last: The duration of action for Picorag 50mg Syrup is unknown.

What if you forget to take Picorag 50mg Syrup

If you miss a dose of Picorag 50mg Syrup and are using it for occasional constipation, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. If you are using this as part of a bowel preparation routine for a medical procedure and miss a dose, contact your doctor or the clinic immediately for guidance.

Storage

•Store Picorag 50mg Syrup at room temperature, ideally below 25°C or 30°C as specified on the product packaging. • Keep the container tightly closed to protect it from direct light and moisture, and do not freeze oral liquids.

Drug Warnings

  • Only use Picorag 50mg Syrup for short-term relief (usually no more than 5 to 7 days) unless specifically directed otherwise by your doctor, as long-term use can lead to laxative dependence.
  • Take the medicine at bedtime so that its effects coincide with your morning routine, as it typically takes 6 to 12 hours to work.
  • If your bowel habits change suddenly and persist for more than two weeks, talk to your doctor before using any laxative.
     

verifiedApollotooltip
  • Diuretics (water tablets) or corticosteroids: Taking these alongside Picorag 50mg Syrup can increase the risk of potassium loss, which can lead to muscle weakness or heart rhythm issues.
  • Antibiotics: Certain broad-spectrum antibiotics can reduce the helpful bacteria in your gut, which may make Picorag 50mg Syrup less effective since these bacteria are needed to activate the medicine.
     

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verifiedApollotooltip

No clinically significant food interactions are known with Picorag 50mg Syrup when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[LAXATIVES]

FAQs

Picorag 50mg Syrup is used to treat constipation associated with piles, anal fissures, hernias, cardiovascular disorders, endoscopy, bowel clearance before radioscopy, pre/post-operative conditions, and elderly and bedridden patients.
Picorag 50mg Syrup consists of Sodium Picosulphate, which is a stimulant laxative. It prevents the absorption of water in the colonic lumen and stimulates the colon's propulsive activity, thereby promoting the accumulation of water.
Do not take Picorag 50mg Syrup for more than a week, as it might lead to dependency on Picorag 50mg Syrup for a bowel movement. Taking Picorag 50mg Syrup for longer durations may also cause dehydration and an imbalance of fluids and salts in the body, which can affect the tightness of muscles in the intestine. If your bowel movements are irregular, even after taking Picorag 50mg Syrup for a week, consult your doctor.
Picorag 50mg Syrup does not help with weight loss. It does not reduce the absorption of calories or nutrients. Picorag 50mg Syrup may cause dehydration, which can lead to a feeling of weight loss. Drink enough liquids to prevent dehydration.
Consult your doctor before taking Picorag 50mg Syrup with other medications, as Picorag 50mg Syrup may increase the rate of gastrointestinal transit, which could affect the absorption of other orally administered medicines taken simultaneously.
Overuse or prolonged use of Picorag 50mg Syrup may cause dehydration. Severe dehydration may cause weakness, tremors, fainting, and blurry vision. Consult your doctor immediately if you experience these symptoms. Drink enough fluids to avoid dehydration.
Diarrhoea might occur if Picorag 50mg Syrup is taken in larger doses. Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excessive diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
This medicine typically takes between 6 to 12 hours to produce a bowel movement. For this reason, it is usually recommended to take it at bedtime so that it can work overnight. Talk to your doctor if you do not have a bowel movement after taking it.
You should not take Picorag 50mg Syrup daily for more than 5 to 7 days in a row unless your doctor has specifically instructed you to do so. Overusing laxatives can cause your bowels to rely on them to function normally. Talk to your doctor if your constipation persists.
If you are pregnant or planning to become pregnant, you should avoid taking this medicine unless your doctor advises it is absolutely necessary. There is limited clinical safety data for its use during pregnancy. Talk to your doctor for safer alternatives.
It is best to avoid alcohol while taking Picorag 50mg Syrup. Alcohol can cause dehydration, which can worsen constipation or increase the risk of dehydration and dizziness caused by the laxative. Talk to your doctor if you have questions.
If you do not have a bowel movement after a couple of days of taking Picorag 50mg Syrup, do not increase your dose without consulting a healthcare professional. Persistent constipation may indicate an underlying issue. Talk to your doctor or pharmacist for advice.
You should not give Picorag 50mg Syrup to children unless specifically prescribed and directed by a paediatrician. Children's digestive systems are sensitive, and dosing must be carefully calculated by a professional. Talk to your doctor before giving this to a child.
Yes, you can take Picorag 50mg Syrup with or without food. It is highly flexible, though taking it with a large glass of water is highly recommended to support its stool-softening effects. Talk to your doctor if you experience any stomach upset.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 202535Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Sodium Picosulfate [EMC SmPC]. 2005. [Accessed on 27 Mar 2019]Check here
  3. CDSCO [Internet]. Cdscoonline.gov.in. 2025 [Accessed on 4th July 2025]Check here
  4. (Picolax Tab) Sodium Picosulphate 10 Mg Tablets Manufacturer & Supplier. [Accessed on 02 Jun. 2026]Check here
  5. Health Products Regulatory Authority (HPRA). Licensespc Pa1009 024 001 24052013132046 Human Medicine Product Information. Dublin, Ireland: HPRA; 2024. [Accessed on 02 Jun. 2026]Check here
  6. Healthcare Pharmaceuticals. [Accessed on 02 Jun. 2026]Check here
  7. The Health Products Regulatory Authority [Internet]. Sodium Picosulfate Ferring 10mg Tablets. The Health Products Regulatory Authority; 2025 [Accessed on 4th July 2025]Check here
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