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compositionComposition:MESALAZINE-2GM
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Prescription Medicine
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Pentasa Sachet 2 gm is used to treat Ulcerative colitis and Crohn's disease. It contains Mesalazine, an anti-inflammatory drug. It works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. This helps reduce inflammation (redness and swelling) in the intestines and relieves stomach pain or bleeding symptoms. Also, it may prevent further episodes of ulcerative colitis.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

MESALAZINE-2GM

Manufacturer/Marketer :

Ferring Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pentasa Sachet 2 gm

Pentasa Sachet 2 gm is an oral granule medication prescribed to treat and manage ulcerative colitis, an inflammatory bowel disease. It specifically works to reduce redness, swelling, and soreness in the lining of your large intestine. By calming active inflammation, this medicine helps control sudden flare-ups and supports long-term bowel healing.

To achieve the best results, you must take this medicine consistently every day at the frequency recommended by your doctor. You can typically take these granules with or without food, but you should choose one method and stick to it with every dose. Adopting a diet of low-irritant foods and drinking plenty of water can also help support your digestive tract during treatment.

While most patients tolerate this medicine well, some may experience common side effects like headaches or mild stomach upset. You must contact your doctor immediately if you experience serious symptoms, such as severe stomach cramping, fever, or changes in your urine. Your healthcare provider can help you manage these issues safely.

Talk to your doctor before starting this medicine if you have kidney disease, liver damage, or a history of active stomach ulcers. Do not take this if you are allergic to aspirin or other salicylate medications, as this can trigger a severe allergic reaction. Your safety depends on sharing your complete medical history with your doctor.

Some medicines, including certain pain relievers and immune-system drugs, can interact with Pentasa Sachet 2 gm and increase your risk of severe side effects. It is also important for pregnant individuals, breastfeeding mothers, or elderly patients to consult their doctor to ensure this medicine is appropriate for them.

Uses of Pentasa Sachet 2 gm

Pentasa Sachet 2 gm is used in the treatment of ulcerative colitis. The detailed uses of Pentasa Sachet 2 gm are as follows:

  • Ulcerative colitis flare-ups: This medicine helps reduce active swelling and pain in the large intestine during sudden flare-ups, relieving symptoms like blood in the stool.
  • Maintenance of ulcerative colitis remission: It helps keep bowel inflammation under control over the long term to prevent your symptoms from returning.

Key Benefits

Pentasa Sachet 2 gm helps reduce inflammation in the bowel, relieving symptoms and supporting long-term control of inflammatory bowel disease. The following are the benefits of this medication:

  • Helps reduce inflammation in the lining of the bowel, promoting healing.
  • Decreases the frequency of bowel movements and helps improve bowel control.
  • Relieves abdominal pain and cramping associated with bowel inflammation.
  • Helps reduce rectal bleeding by allowing the inflamed bowel lining to heal.
  • Lowers the risk of disease flare-ups when taken regularly as prescribed.
  • Supports long-term bowel health and helps reduce the risk of complications associated with uncontrolled inflammation.
Side effects of Pentasa Sachet 2 gm
  • Eating and drinking slowly can help swallow less air, which reduces burps.
  • Avoid consuming foods like gum and hard candy and drinking carbonated drinks as they release carbon dioxide gas in your body.
  • Prevent smoking as it can impact your whole body.
  • Seek medical help to treat gastric problems and heart burn that may lead to frequent burps.
  • Check your dentures because if they are loosely fit, excess air can be swallowed that causes burbs more frequently.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Get ample rest; this helps your stomach to settle.
  • Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
  • Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
  • Wash your hands properly before preparing/eating food and after using the toilet.
  • Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
  • Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.

Directions for Use

  • Take Pentasa Sachet 2 gm with or without food as advised by your doctor.
  • It is advised to take Pentasa Sachet 2 gm once daily; however, follow your doctor's recommendation regarding the dosage and duration.
  • Check the label for directions and use as advised by the doctor. Empty the contents directly on the tongue and drink some water or orange juice. They can also be mixed with yoghurt and should be taken immediately without chewing.
  • Do not touch the granules with wet hands. Do not chew them.

How Pentasa Sachet 2 gm Works

Pentasa Sachet 2 gm works directly inside your large intestine to stop inflammation right where it begins. When you take the oral granules, they travel through your stomach and small intestine to reach your colon, releasing the active medication directly onto the irritated bowel wall. Once active in the colon, the medicine blocks the body's production of certain natural chemicals, such as prostaglandins, which are responsible for causing pain, redness, and swelling. By preventing these inflammatory chemicals from building up, the medicine cools the irritated gut lining, allowing the damaged tissues to rest and heal naturally.
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Alcohol

Consult your doctor

The interaction of alcohol with Pentasa Sachet 2 gm is unknown. If you have concerns, please discuss them with your doctor before taking Pentasa Sachet 2 gm.

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Pregnancy

Consult your doctor

Pentasa Sachet 2 gm should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy.

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Breast Feeding

Consult your doctor

Pentasa Sachet 2 gm should not be used in nursing mothers unless necessary. So, inform your doctor if you are a nursing mother.

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Driving

Consult your doctor

Pentasa Sachet 2 gm usually does not affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Please consult your doctor, if you have liver problems before using Pentasa Sachet 2 gm.

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Kidney

Caution

Pentasa Sachet 2 gm should be used with extreme caution in patients with mild to moderate kidney impairment. Avoid taking Pentasa Sachet 2 gm if you have severe kidney impairment.

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Children

Caution

Pentasa Sachet 2 gm is not recommended for children below six years. However, Pentasa Sachet 2 gm should be given to children only if recommended by a doctor.

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Heart

Caution

Pentasa Sachet 2 gm may rarely cause heart inflammation, so heart patients should use it cautiously. Always consult your doctor before use and report any chest pain promptly.

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Geriatrics

Caution

Geriatric patients can usually take Pentasa Sachet 2 gm safely, but it may be more sensitive to side effects like kidney issues. Regular monitoring and medical supervision are essential to ensure safe and effective use.

What if I have taken an overdose of Pentasa Sachet 2 gm

If you take too much of this medicine, seek immediate medical attention or contact your local poison control centre. Symptoms of taking too much may include ringing in your ears, rapid breathing, confusion, or severe dizziness.

Diet & Lifestyle Advise

  • Identify your trigger foods: Keep a detailed food diary to track what you eat and how your gut reacts. During active flares, you may want to avoid spicy foods, high-fat meals, caffeine, and alcohol to prevent bowel irritation.
  • Drink plenty of fluids: Staying well-hydrated is highly important to protect your kidneys while taking this medicine, especially if you are experiencing frequent bowel movements.
  • Eat smaller, frequent meals: Eating five or six small meals throughout the day instead of three large ones can reduce stress on your digestive tract.
  • Practice stress management: Emotional stress can trigger gut inflammation. Incorporate relaxing activities like deep breathing, gentle stretching, or light walking into your daily schedule.

Health Queries

I have been prescribed Pentasa 2g daily for Crohn's disease, but I am still experiencing abdominal pain and swelling near my navel. Is Pentasa a lifelong medication for managing this condition, or is it used only for short-term treatment?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Mesalamine is generally prescribed as a long-term, maintenance medication to keep Crohn's disease in remission and prevent flare-ups, rather than a short-term cure. Because you are still experiencing abdominal pain and swelling near your navel, your current treatment may need to be adjusted. Persistent symptoms or swelling should be evaluated by your gastroenterologist to check for active inflammation or other localized issues. Please contact your doctor's office to discuss these symptoms so they can safely adjust your treatment plan and help you find relief.
health query

Have a query?

How Soon It Starts Working

The time required for Pentasa Sachet 2 gm to start to work: The time required for Pentasa Sachet 2 gm to show its action is unknown. The time for which the effects of Pentasa Sachet 2 gm last: The duration of Pentasa Sachet 2 gm’s effect is clinically not established.

What if you forget to take Pentasa Sachet 2 gm

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular routine. Do not take a double dose to make up for a missed one.

Storage

• Store Pentasa Sachet 2 gm oral granules at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Never chew the granules: Swallowing the granules whole is essential to protect the medicine's special coating so it can reach your colon safely.
  • Get regular kidney checks: Your doctor will likely request routine blood and urine tests to monitor your kidney health while you are taking this medicine.
  • Stop use if symptoms worsen: If you experience sudden, severe stomach cramps, fever, or increased bleeding after starting this medicine, contact your doctor immediately.
  • Inspect your packet: Always check the granule packet before use, and do not take the medicine if the packaging is torn, wet, or damaged.
  • Inform your healthcare team: Tell all your doctors and dentists that you take Pentasa Sachet 2 gm, especially if you are scheduled for any medical tests or surgeries.

Drug-Drug Interactions

verifiedApollotooltip
  • Pain relievers (e.g., ibuprofen, naproxen): Taking these medicines with Pentasa Sachet 2 gm can increase the risk of kidney damage.
  • Immunosuppressants (e.g., azathioprine, 6-mercaptopurine): Combining these medicines with Pentasa Sachet 2 gm can increase the risk of serious blood disorders.
MesalazineCidofovir
Critical
MesalazineIodamide
Severe

Drug-Drug Interactions

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MesalazineCidofovir
Critical
How does the drug interact with Pentasa Sachet 2 gm:
Co-administration of Pentasa Sachet 2 gm with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Pentasa Sachet 2 gm with Cidofovir is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.
MesalazineIodamide
Severe
How does the drug interact with Pentasa Sachet 2 gm:
Co-administration of Iodamide with Pentasa Sachet 2 gm may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesalamine with Iodamine they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, itchy skin, shortness of breath, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineDeferasirox
Severe
How does the drug interact with Pentasa Sachet 2 gm:
Co-administration of Deferasirox with Pentasa Sachet 2 gm may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possibility of interaction between Pentasa Sachet 2 gm and Deferasirox but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as increased or decreased urination, abrupt weight gain or loss, weakness, or dizziness. Do not discontinue the medication without consulting a doctor.
MesalazineOmeprazole
Severe
How does the drug interact with Pentasa Sachet 2 gm:
Co-administration of omeprazole with Pentasa Sachet 2 gm can decrease the effects of Pentasa Sachet 2 gm.

How to manage the interaction:
There could be a possible interaction between Pentasa Sachet 2 gm and omeprazole, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineTenofovir alafenamide
Severe
How does the drug interact with Pentasa Sachet 2 gm:
Co-administration of Tenofovir alafenamide with Pentasa Sachet 2 gm may increase the risk of kidney problems.

How to manage the interaction:
There is a possibility of interaction between Pentasa Sachet 2 gm with Tenofovir alafenamide, but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience increased or decreased urination, swelling, shortness of breath, bone pain, cramping in the muscles. Do not discontinue the medication without consulting a doctor.
MesalazineMetrizamide
Severe
How does the drug interact with Pentasa Sachet 2 gm:
Co-administration of Metrizamide with Pentasa Sachet 2 gm may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Pentasa Sachet 2 gm with Metrizamide they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, dry, itchy skin, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineRanitidine
Severe
How does the drug interact with Pentasa Sachet 2 gm:
Co-administration of Ranitidine with Pentasa Sachet 2 gm can decrease the levels of Pentasa Sachet 2 gm, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Pentasa Sachet 2 gm with Ranitidine, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineIomeprol
Severe
How does the drug interact with Pentasa Sachet 2 gm:
Co-administration of Iomeprol with Pentasa Sachet 2 gm may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Pentasa Sachet 2 gm and Iomeprol they can be taken together if your doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineNizatidine
Severe
How does the drug interact with Pentasa Sachet 2 gm:
Co-administration of Nizatidine with Pentasa Sachet 2 gm can decrease the level or effect of Mesalamine by increasing gastric pH.

How to manage the interaction:
Although there may be a possible interaction between Pentasa Sachet 2 gm with Nizatidine, they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • There are no major food interactions, but you should take the granules consistently either always with food or always without food, as advised by your doctor.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- INFLAMMATORY AGENTS]

FAQs

Pentasa Sachet 2 gm is used to treat Ulcerative colitis and Crohn's disease.
Pentasa Sachet 2 gm contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby helps in reducing inflammation (swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.
You are not recommended to take Pentasa Sachet 2 gm with Ibuprofen as co-administration of these two medicines may increase the risk of kidney problems. However, please consult your doctor before taking Pentasa Sachet 2 gm with other medicines.
Yes, Pentasa Sachet 2 gm may cause kidney stones in some patients. It is not necessary for everyone taking Pentasa Sachet 2 gm to experience this side effect. However, if you notice blood in urine or pain in the sides of the stomach, please consult a doctor immediately. Drink adequate water while taking Pentasa Sachet 2 gm to prevent kidney stones.
Pentasa Sachet 2 gm should be used with caution in patients with stomach ulcers as it may increase the risk of worsening the condition. Therefore, please inform your doctor if you have a stomach ulcer before taking Pentasa Sachet 2 gm.
Yes, Pentasa Sachet 2 gm may cause diarrhoea as a common side effect. However, if the condition persists and worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while taking Pentasa Sachet 2 gm to prevent dehydration.
You are advised to take Pentasa Sachet 2 gm for the duration prescribed by the doctor. Talk to the doctor if you have any concerns.
No, Pentasa Sachet 2 gm is not addictive.
Side effects of Pentasa Sachet 2 gm include diarrhoea, stomach pain, headache, nausea, vomiting or flatulence (gas). If the side effects persist or worsen, please consult your doctor.
Yes, in some cases you can mix the granules with a small amount of soft food like applesauce or yoghurt. However, you must swallow the mixture immediately without chewing or crushing the granules. Talk to your doctor or pharmacist.
If you notice intact granules in your stool, it may mean the medicine is passing through your system too quickly without being absorbed. Contact your doctor to discuss this, as your treatment may need to be adjusted. Talk to your doctor.
This medicine should only be used during pregnancy if your doctor determines that the benefits outweigh the potential risks to the baby. If you are pregnant or planning to become pregnant, talk to your doctor.
Alcohol does not directly stop the medicine from working, but it can irritate your stomach and bowel, worsening your inflammatory bowel disease symptoms. To protect your digestive system, it is best to limit or avoid alcohol. Talk to your doctor.
No. Do not stop taking Pentasa Sachet 2 gm without consulting your doctor, even if your symptoms have improved or disappeared. This medicine is often prescribed long-term to keep your condition under control and help prevent future flare-ups. Always follow your doctor's advice before making any changes to your treatment.
Yes, in rare cases, this medicine can affect kidney function. Your doctor will monitor your kidneys with regular blood and urine tests while you are on this medication to ensure it remains safe for you. Talk to your doctor.
Do not take Pentasa Sachet 2 gm if you have a known allergy to aspirin or other salicylate medicines, as you may have a similar reaction to this medicine. Always tell your doctor about any allergies before starting a new treatment. Talk to your doctor.

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Country of origin

INDIA

Manufacturer/Marketer address

K-28/1, ADDITIONAL MIDC , ANAND NAGAR , AMBERNATH - 421506 , INDIA
Other Info - PEN0167

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